{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:34:40Z","timestamp":1789540480666,"version":"build-2803163510"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s00417-017-3651-8","type":"journal-article","created":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T04:13:47Z","timestamp":1498882427000},"page":"1573-1579","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Blockade of MMP-2 and MMP-9 inhibits corneal lymphangiogenesis"],"prefix":"10.1007","volume":"255","author":[{"given":"Hai-Tao","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Ling","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Ling","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Yan","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,7,1]]},"reference":[{"key":"3651_CR1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1089\/lrb.2006.4.83","volume":"4","author":"RC Ji","year":"2006","unstructured":"Ji RC (2006) Lymphatic endothelial cells, lymphangiogenesis, and extracellular matrix. Lymphat Res Biol 4:83\u2013100","journal-title":"Lymphat Res Biol"},{"key":"3651_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jdermsci.2003.10.006","volume":"35","author":"S Hirakawa","year":"2004","unstructured":"Hirakawa S, Detmar M (2004) New insights into the biology and pathology of the cutaneous lymphatic system. J Dermatol Sci 35:1\u20138","journal-title":"J Dermatol Sci"},{"key":"3651_CR3","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1158\/0008-5472.CAN-04-4576","volume":"65","author":"Y He","year":"2005","unstructured":"He Y, Rajantie I, Pajusola K, Jeltsch M, Holopainen T, Yla-Herttuala S et al (2005) Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res 65:4739\u20134746","journal-title":"Cancer Res"},{"key":"3651_CR4","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.mehy.2006.06.063","volume":"68","author":"H Hosseini","year":"2007","unstructured":"Hosseini H, Nejabat M (2007) A potential therapeutic strategy for inhibition of corneal neovascularization with new anti-VEGF agents. Med Hypotheses 68:799\u2013801","journal-title":"Med Hypotheses"},{"key":"3651_CR5","doi-asserted-by":"crossref","first-page":"535","DOI":"10.4049\/jimmunol.0903180","volume":"184","author":"T Dietrich","year":"2010","unstructured":"Dietrich T, Bock F, Yuen D, Hos D, Bachmann BO, Zahn G et al (2010) Cutting edge: lymphatic vessels, not blood vessels, primarily mediate immune rejections after transplantation. J Immunol 184:535\u2013539","journal-title":"J Immunol"},{"key":"3651_CR6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrc745","volume":"2","author":"M Egeblad","year":"2002","unstructured":"Egeblad M, Werb Z (2002) New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2:161\u2013174","journal-title":"Nat Rev Cancer"},{"key":"3651_CR7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1357-4310(00)01686-5","volume":"6","author":"LJ McCawley","year":"2000","unstructured":"McCawley LJ, Matrisian LM (2000) Matrix metalloproteinases: multifunctional contributors to tumor progression. Mol Med Today 6:149\u2013156","journal-title":"Mol Med Today"},{"key":"3651_CR8","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.preteyeres.2006.09.001","volume":"25","author":"DH Ma","year":"2006","unstructured":"Ma DH, Chen JK, Zhang F, Lin KY, Yao JY, Yu JS (2006) Regulation of corneal angiogenesis in limbal stem cell deficiency. Prog Retin Eye Res 25:563\u2013590","journal-title":"Prog Retin Eye Res"},{"key":"3651_CR9","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1097\/ICO.0b013e31812f6d14","volume":"26","author":"S Saika","year":"2007","unstructured":"Saika S (2007) Yin and yang in cytokine regulation of corneal wound healing: roles of TNF-alpha. Cornea 26:S70\u2013S74","journal-title":"Cornea"},{"key":"3651_CR10","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/bies.950140705","volume":"14","author":"LM Matrisian","year":"1992","unstructured":"Matrisian LM (1992) The matrix-degrading metalloproteinases. Bioessays 14:455\u2013463","journal-title":"Bioessays"},{"key":"3651_CR11","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.ceb.2004.07.010","volume":"16","author":"JD Mott","year":"2004","unstructured":"Mott JD, Werb Z (2004) Regulation of matrix biology by matrix metalloproteinases. Curr Opin Cell Biol 16:558\u2013564","journal-title":"Curr Opin Cell Biol"},{"key":"3651_CR12","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/35036374","volume":"2","author":"G Bergers","year":"2000","unstructured":"Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K et al (2000) Matrix metalloproteinase 9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol 2:737\u2013744","journal-title":"Nat Cell Biol"},{"key":"3651_CR13","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nmeth.1205","volume":"5","author":"F Bruyere","year":"2008","unstructured":"Bruyere F, Melen-Lamalle L, Blacher S, Roland G, Thiry M, Moons L et al (2008) Modeling lymphangiogenesis in a three-dimensional culture system. Nat Methods 5:431\u2013437","journal-title":"Nat Methods"},{"key":"3651_CR14","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1349-7006.2004.tb03166.x","volume":"95","author":"ES Nakamura","year":"2004","unstructured":"Nakamura ES, Koizumi K, Kobayashi M, Saiki I (2004) Inhibition of lymphangiogenesis-related properties of murine lymphatic endothelial cells and lymph node metastasis of lung cancer by the matrix metalloproteinase inhibitor MMI270. Cancer Sci 95:25\u201331","journal-title":"Cancer Sci"},{"key":"3651_CR15","doi-asserted-by":"crossref","first-page":"33992","DOI":"10.1074\/jbc.M504303200","volume":"280","author":"M Ikejiri","year":"2005","unstructured":"Ikejiri M, Bernardo MM, Bonfil RD, Toth M, Chang M, Fridman R et al (2005) Potent mechanism-based inhibitors for matrix metalloproteinases. J Biol Chem 280:33992\u201334002","journal-title":"J Biol Chem"},{"key":"3651_CR16","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1158\/0008-5472.CAN-04-3570","volume":"65","author":"A Kr\u00fcger","year":"2005","unstructured":"Kr\u00fcger A, Arlt MJ, Gerg M, Kopitz C, Bernardo MM, Chang M et al (2005) Antimetastatic activity of a novel mechanism-based gelatinase inhibitor. Cancer Res 65:3523\u20133526","journal-title":"Cancer Res"},{"key":"3651_CR17","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.1523\/JNEUROSCI.1563-05.2005","volume":"25","author":"Z Gu","year":"2005","unstructured":"Gu Z, Cui J, Brown S, Fridman R, Mobashery S, Strongin AY et al (2005) A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. J Neurosci 25:6401\u20136408","journal-title":"J Neurosci"},{"key":"3651_CR18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1750-1326-7-21","volume":"7","author":"J Cui","year":"2012","unstructured":"Cui J, Chen S, Zhang C, Meng F, Wu W, Hu R et al (2012) Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia. Mol Neurodegener 7:21","journal-title":"Mol Neurodegener"},{"key":"3651_CR19","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1038\/jcbfm.2009.77","volume":"29","author":"R Ota","year":"2009","unstructured":"Ota R, Kurihara C, Tsou TL, Young WL, Yeghiazarians Y, Chang M et al (2009) Roles of matrix metalloproteinases in flow-induced outward vascular remodeling. J Cereb Blood Flow Metab 29:1547\u20131558","journal-title":"J Cereb Blood Flow Metab"},{"key":"3651_CR20","doi-asserted-by":"crossref","first-page":"15593","DOI":"10.1073\/pnas.0507865102","volume":"102","author":"M Bj\u00f6rndahl","year":"2005","unstructured":"Bj\u00f6rndahl M, Cao R, Nissen LJ, Clasper S, Johnson LA, Xue Y et al (2005) Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo. Proc Natl Acad Sci U S A 102:15593\u201315598","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3651_CR21","doi-asserted-by":"crossref","first-page":"9261","DOI":"10.1158\/0008-5472.CAN-04-2345","volume":"65","author":"MA Bj\u00f6rndahl","year":"2005","unstructured":"Bj\u00f6rndahl MA, Cao R, Burton JB, Brakenhielm E, Religa P, Galter D et al (2005) Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis. Cancer Res 65:9261\u20139268","journal-title":"Cancer Res"},{"key":"3651_CR22","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.2353\/ajpath.2009.080515","volume":"175","author":"ES Chung","year":"2009","unstructured":"Chung ES, Chauhan SK, Jin Y, Nakao S, Hafezi-Moghadam A, van Rooijen N et al (2009) Contribution of macrophages to angiogenesis induced by vascular endothelial growth factor receptor-3-specific ligands. Am J Pathol 175:1984\u20131992","journal-title":"Am J Pathol"},{"key":"3651_CR23","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1172\/JCI20465","volume":"113","author":"C Cursiefen","year":"2004","unstructured":"Cursiefen C, Chen L, Borges LP, Jackson D, Cao J, Radziejewski C et al (2004) VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization by macrophage recruitment. J Clin Invest 113:1040\u20131050","journal-title":"J Clin Invest"},{"key":"3651_CR24","first-page":"2354","volume":"16","author":"XL Tang","year":"2010","unstructured":"Tang XL, Sun JF, Wang XY, Du LL, Liu P (2010) Blocking neuropilin-2 enhances corneal allograft survival by selectively inhibiting lymphangiogenesis on vascularized beds. Mol Vis 16:2354\u20132361","journal-title":"Mol Vis"},{"key":"3651_CR25","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.exer.2008.08.007","volume":"87","author":"F Bock","year":"2008","unstructured":"Bock F, Onderka J, Hos D, Horn F, Martus P, Cursiefen C (2008) Improved semiautomatic method for morphometry of angiogenesis and lymphangiogenesis in corneal flatmounts. Exp Eye Res 87:462\u2013470","journal-title":"Exp Eye Res"},{"key":"3651_CR26","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1167\/iovs.10-5404","volume":"52","author":"H Zhang","year":"2011","unstructured":"Zhang H, Hu X, Tse J, Tilahun F, Qiu M, Chen L (2011) Spontaneous lymphatic vessel formation and regression in the murine cornea. Invest Ophthalmol Vis Sci 52:334\u2013338","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3651_CR27","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.bbrc.2008.10.077","volume":"377","author":"K Watari","year":"2008","unstructured":"Watari K, Nakao S, Fotovati A, Basaki Y, Hosoi F, Bereczky B et al (2008) Role of macrophages in inflammatory lymphangiogenesis: Enhanced production of vascular endothelial growth factor C and D through NF-kappaB activation. Biochem Biophys Res Commun 377:826\u2013831","journal-title":"Biochem Biophys Res Commun"},{"key":"3651_CR28","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1172\/JCI23874","volume":"115","author":"K Maruyama","year":"2005","unstructured":"Maruyama K, Ii M, Cursiefen C, Jackson DG, Keino H, Tomita T et al (2005) Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. J Clin Invest 115:2363\u20132372","journal-title":"J Clin Invest"},{"key":"3651_CR29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nm0195-27","volume":"1","author":"J Folkman","year":"1995","unstructured":"Folkman J (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1:27\u201331","journal-title":"Nat Med"},{"key":"3651_CR30","first-page":"4189","volume":"41","author":"Z Dong","year":"2000","unstructured":"Dong Z, Ghabrial M, Katar M, Fridman R, Berk RS (2000) Membrane-type matrix metalloproteinases in mice intracorneally infected with Pseudomonas aeruginosa. Invest Ophthalmol Vis Sci 41:4189\u20134194","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3651_CR31","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0014-5793(01)02897-6","volume":"508","author":"T Kato","year":"2001","unstructured":"Kato T, Kure T, Chang JH, Gabison EE, Itoh T, Itohara S et al (2001) Diminished corneal angiogenesis in gelatinase A-deficient mice. FEBS Lett 508:187\u2013190","journal-title":"FEBS Lett"},{"key":"3651_CR32","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1001\/archopht.119.5.695","volume":"119","author":"N Dushku","year":"2001","unstructured":"Dushku N, John MK, Schultz GS, Reid TW (2001) Pterygia pathogenesis: corneal invasion by matrix metalloproteinase expressing altered limbal epithelial basal cells. Arch Ophthalmol 119:695\u2013706","journal-title":"Arch Ophthalmol"},{"key":"3651_CR33","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00003226-200201000-00020","volume":"21","author":"E Maguen","year":"2002","unstructured":"Maguen E, Zorapapel NC, Zieske JD, Ninomiya Y, Sado Y, Kenney MC (2002) Extracellular matrix and matrix metalloproteinase changes in human corneas after complicated laser-assisted in situ keratomi-leusis (LASIK). Cornea 21:95\u2013100","journal-title":"Cornea"},{"key":"3651_CR34","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1182\/blood-2011-12-400267","volume":"119","author":"B Detry","year":"2012","unstructured":"Detry B, Erpicum C, Paupert J, Blacher S, Maillard C, Bruy\u00e8re F et al (2012) Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase. Blood 119:5048\u20135056","journal-title":"Blood"},{"key":"3651_CR35","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/1097-0215(200002)9999:9999<::AID-IJC1133>3.0.CO;2-S","volume":"91","author":"M Ueda","year":"2001","unstructured":"Ueda M, Terai Y, Kumagai K, Ueki K, Kanemura M, Ueki M (2001) Correlation between thymidine phosphorylase expression and invasion phenotype in cervical carcinoma cells. Int J Cancer 91:778\u2013782","journal-title":"Int J Cancer"},{"key":"3651_CR36","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/gyno.2001.6229","volume":"82","author":"M Ueda","year":"2001","unstructured":"Ueda M, Terai Y, Kumagai K, Ueki K, Yamaguchi H, Akise D et al (2001) Vascularendothelial growth factor-C gene expression is closely related to invasion phenotype in gynecological tumor cells. Gynecol Oncol 82:162\u2013166","journal-title":"Gynecol Oncol"},{"key":"3651_CR37","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cell.2010.03.015","volume":"141","author":"K Kessenbrock","year":"2010","unstructured":"Kessenbrock K, Plaks V, Werb Z (2010) Matrix Metalloproteinases: Regulators of the Tumor Microenvironment. Cell 141:52\u201367","journal-title":"Cell"},{"key":"3651_CR38","doi-asserted-by":"crossref","first-page":"e76904","DOI":"10.1371\/journal.pone.0076904","volume":"8","author":"O Hadass","year":"2013","unstructured":"Hadass O, Tomlinson BN, Gooyit M, Chen S, Purdy JJ, Walker JM et al (2013) Selective inhibition of matrix metalloproteinase-9 attenuates secondary damage resulting from severe traumatic brain injury. PLoS One 8:e76904","journal-title":"PLoS One"},{"key":"3651_CR39","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1089\/neu.2007.0438","volume":"25","author":"F Yu","year":"2008","unstructured":"Yu F, Kamada H, Niizuma K, Endo H, Chan PH (2008) Induction of MMP-9 expression and endothelial injury by oxidative stress after spinal cord injury. J Neurotrauma 25:184\u2013195","journal-title":"J Neurotrauma"},{"key":"3651_CR40","doi-asserted-by":"crossref","first-page":"496","DOI":"10.2353\/ajpath.2010.080642","volume":"176","author":"Q Ebrahem","year":"2010","unstructured":"Ebrahem Q, Chaurasia SS, Vasanji A, Qi JH, Klenotic PA, Cutler A et al (2010) Cross-talk between vascular endothelial growth factor and matrix metalloproteinases in the induction of neovascularization in vivo. Am J Pathol 176:496\u2013503","journal-title":"Am J Pathol"},{"key":"3651_CR41","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00018-011-0848-6","volume":"69","author":"RC Ji","year":"2012","unstructured":"Ji RC (2012) Macrophages are important mediators of either tumor- or inflammation-induced lymphangiogenesis. Cell Mol Life Sci 69:897\u2013914","journal-title":"Cell Mol Life Sci"},{"key":"3651_CR42","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/sj.bjc.6603487","volume":"96","author":"JL Su","year":"2007","unstructured":"Su JL, Yen CJ, Chen PS, Chuang SE, Hong CC, Kuo IH et al (2007) The role of the VEGF-C\/VEGFR-3 axis in cancer progression. Br J Cancer 96:541\u2013545","journal-title":"Br J Cancer"},{"key":"3651_CR43","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00417-007-0683-5","volume":"246","author":"F Bock","year":"2008","unstructured":"Bock F, Onderka J, Dietrich T, Bachmann B, Pytowski B, Cursiefen C (2008) Blockade of VEGFR3-signalling specifically inhibits lymphangiogenesis in inflammatory corneal neovascularisation. Graefes Arch Clin Exp Ophthalmol 246:115\u2013119","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"3651_CR44","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1158\/1078-0432.CCR-04-1148","volume":"11","author":"M Ueda","year":"2005","unstructured":"Ueda M, Hung YC, Terai Y, Kanda K, Kanemura M, Futakuchi H et al (2005) Vascular endothelial growth factor-C expression and invasive phenotypein ovarian carcinomas. Clin Cancer Res 11:3225\u20133232","journal-title":"Clin Cancer Res"},{"key":"3651_CR45","doi-asserted-by":"crossref","first-page":"H789","DOI":"10.1152\/ajpheart.00559.2013","volume":"306","author":"T Zhao","year":"2014","unstructured":"Zhao T, Zhao W, Meng W, Liu C, Chen Y, Sun Y (2014) Vascular endothelial growth factor-C: its unrevealed role in fibrogenesis. Am J Physiol Heart Circ Physiol 306:H789\u2013796","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"3651_CR46","first-page":"240","volume":"39","author":"SQ Zheng","year":"2010","unstructured":"Zheng SQ, Huang RQ, Zhang YJ (2010) Role of matrix metalloproteinase (MMP)-2 and -9 and vascular endothelial growth factor C in lymph node metastasis of breast cancer. Zhonghua Bing Li Xue Za Zhi 39:240\u2013244","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"3651_CR47","first-page":"BR441","volume":"18","author":"HH Zhang","year":"2012","unstructured":"Zhang HH, Qi F, Zu XB, Cao YH, Miao JG, Xu L et al (2012) A proteomic study of potential VEGF-C-associated proteins in bladder cancer T24 cells. Med Sci Monit 18:BR441\u2013449","journal-title":"Med Sci Monit"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00417-017-3651-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-017-3651-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-017-3651-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T01:21:47Z","timestamp":1501636907000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00417-017-3651-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,1]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["3651"],"URL":"https:\/\/doi.org\/10.1007\/s00417-017-3651-8","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,1]]}}}