{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:22:25Z","timestamp":1786980145893,"version":"build-2736575974"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T00:00:00Z","timestamp":1495584000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["PR1569\/1-1"],"award-info":[{"award-number":["PR1569\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1007\/s00417-017-3678-x","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T19:09:38Z","timestamp":1495566578000},"page":"1395-1407","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Proteomic profiling reveals crucial retinal protein alterations in the early phase of an experimental glaucoma model"],"prefix":"10.1007","volume":"255","author":[{"given":"Fabian","family":"Anders","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Teister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebstian","family":"Funke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Pfeiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Grus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanos","family":"Solon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Prokosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,5,24]]},"reference":[{"key":"3678_CR1","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1001\/jama.2014.3192","volume":"311","author":"RN Weinreb","year":"2014","unstructured":"Weinreb RN, Aung T, Medeiros FA (2014) The pathophysiology and treatment of glaucoma: a review. JAMA 311:1901\u20131911. doi:\n10.1001\/jama.2014.3192","journal-title":"JAMA"},{"key":"3678_CR2","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1167\/iovs.12-11067","volume":"54","author":"SK Bhattacharya","year":"2013","unstructured":"Bhattacharya SK, Lee RK, Grus FH, Seventh APORICWG (2013) Molecular biomarkers in glaucoma. Invest Ophthalmol Vis Sci 54:121\u2013131. doi:\n10.1167\/iovs.12-11067","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3678_CR3","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1039\/c3mb25463a","volume":"9","author":"D Pieragostino","year":"2013","unstructured":"Pieragostino D, Agnifili L, Fasanella V, D\u2019Aguanno S, Mastropasqua R, Di Ilio C, Sacchetta P, Urbani A, Del Boccio P (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naive to therapy. Mol BioSyst 9:1108\u20131116. doi:\n10.1039\/c3mb25463a","journal-title":"Mol BioSyst"},{"key":"3678_CR4","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1002\/pmic.201500423","volume":"16","author":"AA Kliuchnikova","year":"2016","unstructured":"Kliuchnikova AA, Samokhina NI, Ilina IY, Karpov DS, Pyatnitskiy MA, Kuznetsova KG, Toropygin IY, Kochergin SA, Alekseev IB, Zgoda VG, Archakov AI, Moshkovskii SA (2016) Human aqueous humor proteome in cataract, glaucoma, and pseudoexfoliation syndrome. Proteomics 16:1938\u20131946. doi:\n10.1002\/pmic.201500423","journal-title":"Proteomics"},{"key":"3678_CR5","doi-asserted-by":"publisher","first-page":"5816","DOI":"10.1167\/iovs.15-17294","volume":"56","author":"X Yang","year":"2015","unstructured":"Yang X, Hondur G, Li M, Cai J, Klein JB, Kuehn MH, Tezel G (2015) Proteomics analysis of molecular risk factors in the ocular hypertensive human retina. Invest Ophthalmol Vis Sci 56:5816\u20135830. doi:\n10.1167\/iovs.15-17294","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3678_CR6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/02648725.1996.10647923","volume":"13","author":"MR Wilkins","year":"1996","unstructured":"Wilkins MR, Sanchez JC, Gooley AA, Appel RD, Humphery-Smith I, Hochstrasser DF, Williams KL (1996) Progress with proteome projects: why all proteins expressed by a genome should be identified and how to do it. Biotechnology & genetic engineering reviews 13:19\u201350","journal-title":"Biotechnology & genetic engineering reviews"},{"key":"3678_CR7","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1586\/epr.09.8","volume":"6","author":"Y Zhao","year":"2009","unstructured":"Zhao Y, Lee WN, Xiao GG (2009) Quantitative proteomics and biomarker discovery in human cancer. Expert review of proteomics 6:115\u2013118. doi:\n10.1586\/epr.09.8","journal-title":"Expert review of proteomics"},{"key":"3678_CR8","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1002\/jms.1692","volume":"44","author":"MH Elliott","year":"2009","unstructured":"Elliott MH, Smith DS, Parker CE, Borchers C (2009) Current trends in quantitative proteomics. Journal of mass spectrometry : JMS 44:1637\u20131660. doi:\n10.1002\/jms.1692","journal-title":"Journal of mass spectrometry : JMS"},{"key":"3678_CR9","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.archoralbio.2016.05.018","volume":"69","author":"T Kobayashi","year":"2016","unstructured":"Kobayashi T, Ishida K, Yoshie H (2016) Increased expression of interleukin-6 (IL-6) gene transcript in relation to IL-6 promoter hypomethylation in gingival tissue from patients with chronic periodontitis. Arch Oral Biol 69:89\u201394. doi:\n10.1016\/j.archoralbio.2016.05.018","journal-title":"Arch Oral Biol"},{"key":"3678_CR10","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1080\/09168451.2016.1158629","volume":"80","author":"S Shimamoto","year":"2016","unstructured":"Shimamoto S, Ijiri D, Nakashima K, Kawaguchi M, Ishimaru Y, Furukawa A, Ohtsuka A (2016) Clenbuterol changes phosphorylated FOXO1 localization and decreases protein degradation in the sartorius muscle of neonatal chicks. Biosci Biotechnol Biochem 80:1499\u20131504. doi:\n10.1080\/09168451.2016.1158629","journal-title":"Biosci Biotechnol Biochem"},{"key":"3678_CR11","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/j.eururo.2015.10.053","volume":"69","author":"D Iglesias-Gato","year":"2016","unstructured":"Iglesias-Gato D, Wikstrom P, Tyanova S, Lavallee C, Thysell E, Carlsson J, Hagglof C, Cox J, Andren O, Stattin P, Egevad L, Widmark A, Bjartell A, Collins CC, Bergh A, Geiger T, Mann M, Flores-Morales A (2016) The proteome of primary prostate cancer. Eur Urol 69:942\u2013952. doi:\n10.1016\/j.eururo.2015.10.053","journal-title":"Eur Urol"},{"key":"3678_CR12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0014-4835(05)80131-9","volume":"61","author":"SR Shareef","year":"1995","unstructured":"Shareef SR, Garcia-Valenzuela E, Salierno A, Walsh J, Sharma SC (1995) Chronic ocular hypertension following episcleral venous occlusion in rats. Exp Eye Res 61:379\u2013382","journal-title":"Exp Eye Res"},{"key":"3678_CR13","doi-asserted-by":"publisher","first-page":"29759","DOI":"10.1038\/srep29759","volume":"6","author":"S Funke","year":"2016","unstructured":"Funke S, Perumal N, Beck S, Gabel-Scheurich S, Schmelter C, Teister J, Gerbig C, Gramlich OW, Pfeiffer N, Grus FH (2016) Glaucoma related proteomic alterations in human retina samples. Scientific reports 6:29759. doi:\n10.1038\/srep29759","journal-title":"Scientific reports"},{"key":"3678_CR14","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/nbt.1511","volume":"26","author":"J Cox","year":"2008","unstructured":"Cox J, Mann M (2008) MaxQuant enables high peptide identification rates, individualized p.P.B.-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol 26:1367\u20131372. doi:\n10.1038\/nbt.1511","journal-title":"Nat Biotechnol"},{"key":"3678_CR15","first-page":"2151","volume":"19","author":"M Giovingo","year":"2013","unstructured":"Giovingo M, Nolan M, McCarty R, Pang IH, Clark AF, Beverley RM, Schwartz S, Stamer WD, Walker L, Grybauskas A, Skuran K, Kuprys PV, Yue BY, Knepper PA (2013) sCD44 overexpression increases intraocular pressure and aqueous outflow resistance. Mol Vis 19:2151\u20132164","journal-title":"Mol Vis"},{"key":"3678_CR16","doi-asserted-by":"publisher","DOI":"10.1667\/RR14277.1","author":"K Kita","year":"2016","unstructured":"Kita K, Sugita K, Sato C, Sugaya S, Sato T, Kaneda A (2016) Extracellular release of Annexin A2 is enhanced upon oxidative stress response via the p38 MAPK pathway after low-dose X-ray irradiation. Radiation research. doi:\n10.1667\/RR14277.1","journal-title":"Radiation research"},{"key":"3678_CR17","doi-asserted-by":"publisher","first-page":"308976","DOI":"10.1155\/2014\/308976","volume":"2014","author":"CY Wang","year":"2014","unstructured":"Wang CY, Lin CF (2014) Annexin A2: its molecular regulation and cellular expression in cancer development. Dis Markers 2014:308976. doi:\n10.1155\/2014\/308976","journal-title":"Dis Markers"},{"key":"3678_CR18","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.bbrc.2011.08.068","volume":"413","author":"T Kamisasanuki","year":"2011","unstructured":"Kamisasanuki T, Tokushige S, Terasaki H, Khai NC, Wang Y, Sakamoto T, Kosai K (2011) Targeting CD9 produces stimulus-independent antiangiogenic effects predominantly in activated endothelial cells during angiogenesis: a novel antiangiogenic therapy. Biochem Biophys Res Commun 413:128\u2013135. doi:\n10.1016\/j.bbrc.2011.08.068","journal-title":"Biochem Biophys Res Commun"},{"key":"3678_CR19","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1001\/archopht.1997.01100150754011","volume":"115","author":"H Tanihara","year":"1997","unstructured":"Tanihara H, Hangai M, Sawaguchi S, Abe H, Kageyama M, Nakazawa F, Shirasawa E, Honda Y (1997) Up-regulation of glial fibrillary acidic protein in the retina of primate eyes with experimental glaucoma. Arch Ophthalmol 115:752\u2013756","journal-title":"Arch Ophthalmol"},{"key":"3678_CR20","doi-asserted-by":"publisher","first-page":"e0129314","DOI":"10.1371\/journal.pone.0129314","volume":"10","author":"AM Ghaleb","year":"2015","unstructured":"Ghaleb AM, Bialkowska AB, Snider AJ, Gnatenko DV, Hannun YA, Yang VW, Schmidt VA (2015) IQ motif-containing GTPase-activating protein 2 (IQGAP2) is a novel regulator of colonic inflammation in mice. PLoS One 10:e0129314. doi:\n10.1371\/journal.pone.0129314","journal-title":"PLoS One"},{"key":"3678_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.06.028","author":"C Brisac","year":"2016","unstructured":"Brisac C, Salloum S, Yang V, Schaefer EA, Holmes JA, Chevaliez S, Hong J, Carlton-Smith C, Alatrakchi N, Kruger A, Lin W, Chung RT (2016) IQGAP2 is a novel interferon-alpha antiviral effector gene acting nonconventionally through the NF-kappaB pathway. Journal of hepatology. doi:\n10.1016\/j.jhep.2016.06.028","journal-title":"Journal of hepatology"},{"key":"3678_CR22","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1007\/s10495-006-0197-3","volume":"11","author":"NA Syed","year":"2006","unstructured":"Syed NA, Andersen PL, Warrington RC, Xiao W (2006) Uev1A, a ubiquitin conjugating enzyme variant, inhibits stress-induced apoptosis through NF-kappaB activation. Apoptosis : an international journal on programmed cell death 11:2147\u20132157. doi:\n10.1007\/s10495-006-0197-3","journal-title":"Apoptosis : an international journal on programmed cell death"},{"key":"3678_CR23","doi-asserted-by":"publisher","first-page":"18353","DOI":"10.1074\/jbc.M308160200","volume":"279","author":"BL Goodwin","year":"2004","unstructured":"Goodwin BL, Solomonson LP, Eichler DC (2004) Argininosuccinate synthase expression is required to maintain nitric oxide production and cell viability in aortic endothelial cells. J Biol Chem 279:18353\u201318360. doi:\n10.1074\/jbc.M308160200","journal-title":"J Biol Chem"},{"key":"3678_CR24","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1111\/cas.12881","volume":"107","author":"J Mori","year":"2016","unstructured":"Mori J, Tanikawa C, Funauchi Y, Lo PH, Nakamura Y, Matsuda K (2016) Cystatin C as a p53-inducible apoptotic mediator that regulates cathepsin L activity. Cancer Sci 107:298\u2013306. doi:\n10.1111\/cas.12881","journal-title":"Cancer Sci"},{"key":"3678_CR25","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.neulet.2011.03.091","volume":"496","author":"X Liang","year":"2011","unstructured":"Liang X, Nagai A, Terashima M, Sheikh AM, Shiota Y, Mitaki S, Kim SU, Yamaguchi S (2011) Cystatin C induces apoptosis and tyrosine hydroxylase gene expression through JNK-dependent pathway in neuronal cells. Neurosci Lett 496:100\u2013105. doi:\n10.1016\/j.neulet.2011.03.091","journal-title":"Neurosci Lett"},{"key":"3678_CR26","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1167\/iovs.06-0497","volume":"48","author":"K Stasi","year":"2007","unstructured":"Stasi K, Nagel D, Yang X, Ren L, Mittag T, Danias J (2007) Ceruloplasmin upregulation in retina of murine and human glaucomatous eyes. Invest Ophthalmol Vis Sci 48:727\u2013732. doi:\n10.1167\/iovs.06-0497","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3678_CR27","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1167\/iovs.03-0872","volume":"45","author":"RH Farkas","year":"2004","unstructured":"Farkas RH, Chowers I, Hackam AS, Kageyama M, Nickells RW, Otteson DC, Duh EJ, Wang C, Valenta DF, Gunatilaka TL, Pease ME, Quigley HA, Zack DJ (2004) Increased expression of iron-regulating genes in monkey and human glaucoma. Invest Ophthalmol Vis Sci 45:1410\u20131417","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3678_CR28","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1167\/iovs.11-9038","volume":"53","author":"SY Wang","year":"2012","unstructured":"Wang SY, Singh K, Lin SC (2012) The association between glaucoma prevalence and supplementation with the oxidants calcium and iron. Invest Ophthalmol Vis Sci 53:725\u2013731. doi:\n10.1167\/iovs.11-9038","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3678_CR29","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.3109\/02713683.2013.803124","volume":"38","author":"SY Wang","year":"2013","unstructured":"Wang SY, Singh K, Lin SC (2013) Glaucoma prevalence and the intake of iron and calcium in a population-based study. Curr Eye Res 38:1049\u20131056. doi:\n10.3109\/02713683.2013.803124","journal-title":"Curr Eye Res"},{"key":"3678_CR30","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2174\/1871525713666150123151731","volume":"12","author":"S Ganguly","year":"2014","unstructured":"Ganguly S, Mitra A, Sarkar S (2014) Role of alpha-crystallin B in regulation of stress induced cardiomyocyte apoptosis. Cardiovasc Hematol Agents Med Chem 12:60\u201365","journal-title":"Cardiovasc Hematol Agents Med Chem"},{"key":"3678_CR31","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0014-5793(98)00783-2","volume":"431","author":"A Coop","year":"1998","unstructured":"Coop A, Wiesmann KE, Crabbe MJ (1998) Translocation of beta crystallin in neural cells in response to stress. FEBS Lett 431:319\u2013321","journal-title":"FEBS Lett"},{"key":"3678_CR32","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.bbagen.2015.09.017","volume":"1860","author":"R Bakthisaran","year":"2016","unstructured":"Bakthisaran R, Akula KK, Tangirala R, Rao Ch M (2016) Phosphorylation of alphaB-crystallin: role in stress, aging and patho-physiological conditions. Biochim Biophys Acta 1860:167\u2013182. doi:\n10.1016\/j.bbagen.2015.09.017","journal-title":"Biochim Biophys Acta"},{"key":"3678_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2006.11.095","volume":"1141","author":"N Piri","year":"2007","unstructured":"Piri N, Song M, Kwong JM, Caprioli J (2007) Modulation of alpha and beta crystallin expression in rat retinas with ocular hypertension-induced ganglion cell degeneration. Brain Res 1141:1\u20139. doi:\n10.1016\/j.brainres.2006.11.095","journal-title":"Brain Res"},{"key":"3678_CR34","first-page":"1743","volume":"143","author":"MW Head","year":"1993","unstructured":"Head MW, Corbin E, Goldman JE (1993) Overexpression and abnormal modification of the stress proteins alpha B-crystallin and HSP27 in Alexander disease. Am J Pathol 143:1743\u20131753","journal-title":"Am J Pathol"},{"key":"3678_CR35","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/BF00296796","volume":"83","author":"K Renkawek","year":"1992","unstructured":"Renkawek K, de Jong WW, Merck KB, Frenken CW, van Workum FP, Bosman GJ (1992) Alpha B-crystallin is present in reactive glia in Creutzfeldt-Jakob disease. Acta Neuropathol 83:324\u2013327","journal-title":"Acta Neuropathol"},{"key":"3678_CR36","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1080\/02713680701375183","volume":"32","author":"SC Joachim","year":"2007","unstructured":"Joachim SC, Bruns K, Lackner KJ, Pfeiffer N, Grus FH (2007) Antibodies to alpha B-crystallin, vimentin, and heat shock protein 70 in aqueous humor of patients with normal tension glaucoma and IgG antibody patterns against retinal antigen in aqueous humor. Curr Eye Res 32:501\u2013509. doi:\n10.1080\/02713680701375183","journal-title":"Curr Eye Res"},{"key":"3678_CR37","first-page":"1199","volume":"12","author":"R Naskar","year":"2006","unstructured":"Naskar R, Thanos S (2006) Retinal gene profiling in a hereditary rodent model of elevated intraocular pressure. Mol Vis 12:1199\u20131210","journal-title":"Mol Vis"},{"key":"3678_CR38","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.mcn.2007.11.002","volume":"37","author":"D Fischer","year":"2008","unstructured":"Fischer D, Hauk TG, Muller A, Thanos S (2008) Crystallins of the beta\/gamma-superfamily mimic the effects of lens injury and promote axon regeneration. Mol Cell Neurosci 37:471\u2013479. doi:\n10.1016\/j.mcn.2007.11.002","journal-title":"Mol Cell Neurosci"},{"key":"3678_CR39","doi-asserted-by":"publisher","first-page":"e12578","DOI":"10.1371\/journal.pone.0012578","volume":"5","author":"PG Sreekumar","year":"2010","unstructured":"Sreekumar PG, Kannan R, Kitamura M, Spee C, Barron E, Ryan SJ, Hinton DR (2010) alphaB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells. PLoS One 5:e12578. doi:\n10.1371\/journal.pone.0012578","journal-title":"PLoS One"},{"key":"3678_CR40","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s00417-012-2157-7","volume":"251","author":"MR Bohm","year":"2013","unstructured":"Bohm MR, Melkonyan H, Oellers P, Thanos S (2013) Effects of crystallin-beta-b2 on stressed RPE in vitro and in vivo. Graefes Arch Clin Exp Ophthalmol 251:63\u201379. doi:\n10.1007\/s00417-012-2157-7","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"3678_CR41","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1006\/exnr.2001.7822","volume":"172","author":"D Fischer","year":"2001","unstructured":"Fischer D, Heiduschka P, Thanos S (2001) Lens-injury-stimulated axonal regeneration throughout the optic pathway of adult rats. Exp Neurol 172:257\u2013272. doi:\n10.1006\/exnr.2001.7822","journal-title":"Exp Neurol"},{"key":"3678_CR42","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0074-7696(03)30005-1","volume":"230","author":"GP Lewis","year":"2003","unstructured":"Lewis GP, Fisher SK (2003) Up-regulation of glial fibrillary acidic protein in response to retinal injury: its potential role in glial remodeling and a comparison to vimentin expression. Int Rev Cytol 230:263\u2013290","journal-title":"Int Rev Cytol"},{"key":"3678_CR43","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.bbrc.2006.06.061","volume":"347","author":"T Yi","year":"2006","unstructured":"Yi T, Kim HJ, Cho JY, Woo KM, Ryoo HM, Kim GS, Baek JH (2006) Tetraspanin CD9 regulates osteoclastogenesis via regulation of p44\/42 MAPK activity. Biochem Biophys Res Commun 347:178\u2013184. doi:\n10.1016\/j.bbrc.2006.06.061","journal-title":"Biochem Biophys Res Commun"},{"key":"3678_CR44","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/emm.2005.31","volume":"37","author":"IK Hong","year":"2005","unstructured":"Hong IK, Kim YM, Jeoung DI, Kim KC, Lee H (2005) Tetraspanin CD9 induces MMP-2 expression by activating p38 MAPK, JNK and c-Jun pathways in human melanoma cells. Exp Mol Med 37:230\u2013239. doi:\n10.1038\/emm.2005.31","journal-title":"Exp Mol Med"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00417-017-3678-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-017-3678-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-017-3678-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T06:06:11Z","timestamp":1497938771000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00417-017-3678-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,24]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["3678"],"URL":"https:\/\/doi.org\/10.1007\/s00417-017-3678-x","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,24]]}}}