{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:31:59Z","timestamp":1789720319391,"version":"4.0.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T00:00:00Z","timestamp":1517961600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s00417-018-3923-y","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T05:45:18Z","timestamp":1517982318000},"page":"1173-1178","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The effect of trabeculectomy on serum brain-derived neurotrophic factor levels in primary open-angle glaucoma"],"prefix":"10.1007","volume":"256","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7420-8934","authenticated-orcid":false,"given":"Mehmet Murat","family":"Uzel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ufuk","family":"Elgin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bar\u0131\u015f","family":"Boral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muharrem","family":"\u00c7i\u00e7ek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"\u015een","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bur\u00e7in","family":"\u015eener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelin","family":"Y\u0131lmazba\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,7]]},"reference":[{"key":"3923_CR1","doi-asserted-by":"crossref","unstructured":"Chang EE, Goldberg (2012) JLGlaucoma 2.0: neuroprotection, neuroregeneration, neuroenhancement. Ophthalmology 119:979\u2013986","DOI":"10.1016\/j.ophtha.2011.11.003"},{"key":"3923_CR2","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.coph.2012.09.014","volume":"13","author":"S Miglior","year":"2013","unstructured":"Miglior S, Bertuzzi F (2013) Relationship between intraocular pressure and glaucoma onset and progression. Curr Opin Pharmacol 13:32\u201335","journal-title":"Curr Opin Pharmacol"},{"issue":"524","key":"3923_CR3","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1002\/cne.24012","volume":"1","author":"MA Smith","year":"2016","unstructured":"Smith MA, Xia CZ, Dengler-Crish CM, Fening KM, Inman DM, Schofield BR, Crish SD (2016) Persistence of intact retinal ganglion cell terminals after axonal transport loss in the DBA\/2J mouse model of glaucoma. J Comp Neurol 1(524):3503\u20133517","journal-title":"J Comp Neurol"},{"key":"3923_CR4","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.exer.2016.03.001","volume":"146","author":"ET Fahy","year":"2016","unstructured":"Fahy ET, Chrysostomou V, Abbott CJ, van Wijngaarden P, Crowston JG (2016) Axonal transport along retinal ganglion cells is grossly intact during reduced function post-injury. Exp Eye Res 146:289\u2013292","journal-title":"Exp Eye Res"},{"key":"3923_CR5","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.exer.2010.05.016","volume":"93","author":"TV Johnson","year":"2011","unstructured":"Johnson TV, Bull ND, Martin KR (2011) Neurotrophic factor delivery as a protective treatment for glaucoma. Exp Eye Res 93:196\u2013203","journal-title":"Exp Eye Res"},{"key":"3923_CR6","doi-asserted-by":"publisher","first-page":"3793","DOI":"10.1167\/iovs.16-19825","volume":"57","author":"L Feng","year":"2016","unstructured":"Feng L, Chen H, Yi J, Troy JB, Zhang HF, Liu X (2016) Long-term protection of retinal ganglion cells and visual function by brain-derived neurotrophic factor in mice with ocular hypertension. Invest Ophthalmol Vis Sci 57:3793\u20133802","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3923_CR7","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1097\/OPX.0b013e3181fc329f","volume":"88","author":"A Ghaffariyeh","year":"2011","unstructured":"Ghaffariyeh A, Honarpisheh N, Heidari MH, Puyan S, Abasov F (2011) Brain-derived neurotrophic factor as a biomarker in primary open-angle glaucoma. Optom Vis Sci 88:80\u201385","journal-title":"Optom Vis Sci"},{"key":"3923_CR8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/ICU.0000000000000346","volume":"28","author":"EM Schehlein","year":"2017","unstructured":"Schehlein EM, Novack GD, Robin AL (2017) New classes of glaucoma medications. Curr Opin Ophthalmol 28:161\u2013168","journal-title":"Curr Opin Ophthalmol"},{"key":"3923_CR9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/ICU.0000000000000336","volume":"28","author":"K Vinod","year":"2017","unstructured":"Vinod K, Gedde SJ (2017) Clinical investigation of new glaucoma procedures. Curr Opin Ophthalmol 28:187\u2013193","journal-title":"Curr Opin Ophthalmol"},{"key":"3923_CR10","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1097\/ICU.0000000000000236","volume":"27","author":"AK Sawchyn","year":"2016","unstructured":"Sawchyn AK, Slabaugh MA (2016) Innovations and adaptations in trabeculectomy. Curr Opin Ophthalmol 27:158\u2013163","journal-title":"Curr Opin Ophthalmol"},{"key":"3923_CR11","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1007\/s00417-009-1220-5","volume":"248","author":"E Wittstr\u00f6m","year":"2010","unstructured":"Wittstr\u00f6m E, Schatz P, L\u00f6vestam-Adrian M, Ponjavic V, Bergstr\u00f6m A, Andr\u00e9asson S (2010) Improved retinal function after trabeculectomy in glaucoma patients. Graefes Arch Clin Exp Ophthalmol 248:485\u2013495","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"3923_CR12","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/j.1600-0420.2005.00583.x","volume":"84","author":"L Magacho","year":"2006","unstructured":"Magacho L, Henderer JD, Lankaranian D, Steinmann WC, Spaeth GL (2006) Improvement in colour vision parameters following successful trabeculectomy. Acta Ophthalmol Scand 84:201\u2013205","journal-title":"Acta Ophthalmol Scand"},{"key":"3923_CR13","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.ophtha.2015.09.027","volume":"123","author":"J Caprioli","year":"2016","unstructured":"Caprioli J, de Leon JM, Azarbod P, Chen A, Morales E, Nouri-Mahdavi K, Coleman A, Yu F, Afifi A (2016) Trabeculectomy can improve long-term visual function in glaucoma. Ophthalmology 123:117\u2013128","journal-title":"Ophthalmology"},{"key":"3923_CR14","first-page":"3460","volume":"41","author":"HA Quigley","year":"2000","unstructured":"Quigley HA, McKinnon SJ, Zack DJ, Pease ME, Kerrigan-Baumrind LA, Kerrigan DF, Mitchell RS (2000) Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats. Invest Ophthalmol Vis Sci 41:3460\u20133466","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3923_CR15","first-page":"764","volume":"41","author":"ME Pease","year":"2000","unstructured":"Pease ME, McKinnon SJ, Quigley HA, Kerrigan-Baumrind LA, Zack DJ (2000) Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma. Invest Ophthalmol Vis Sci 41:764\u2013774","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"3923_CR16","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1016\/S0161-6420(94)31171-7","volume":"101","author":"The Advanced Glaucoma Intervention Study Investigators","year":"1994","unstructured":"The Advanced Glaucoma Intervention Study Investigators (1994) Advanced Glaucoma Intervention Study. 2. Visual field test scoring and reliability. Ophthalmology 101(8):1445\u20131455","journal-title":"Ophthalmology"},{"key":"3923_CR17","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/j.ajo.2008.11.015","volume":"147","author":"Y Takihara","year":"2009","unstructured":"Takihara Y, Inatani M, Fukushima M, Iwao K, Iwao M, Tanihara H (2009) Trabeculectomy with mitomycin C for neovascular glaucoma: prognostic factors for surgical failure. Am J Ophthalmol 147:912\u2013918","journal-title":"Am J Ophthalmol"},{"issue":"52","key":"3923_CR18","doi-asserted-by":"publisher","first-page":"4506","DOI":"10.1167\/iovs.11-7346","volume":"23","author":"MM Harper","year":"2011","unstructured":"Harper MM, Grozdanic SD, Blits B, Kuehn MH, Zamzow D, Buss JE, Kardon RH, Sakaguchi DS (2011) Transplantation of BDNF-secreting mesenchymal stem cells provides neuroprotection in chronically hypertensive rat eyes. Invest Ophthalmol Vis Sci 23(52):4506\u20134515","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"3923_CR19","doi-asserted-by":"publisher","first-page":"e0168565","DOI":"10.1371\/journal.pone.0168565","volume":"12","author":"F Oddone","year":"2017","unstructured":"Oddone F, Roberti G, Micera A, Busanello A, Bonini S, Quaranta L, Agnifili L, Manni G (2017) Exploring serum levels of brain derived neurotrophic factor and nerve growth factor across glaucoma stages. PLoS One. 9 12(1):e0168565","journal-title":"PLoS One. 9"},{"key":"3923_CR20","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1016\/S0028-3908(98)00141-5","volume":"37","author":"W Pan","year":"1998","unstructured":"Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ (1998) Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 37:1553\u20131561","journal-title":"Neuropharmacology"},{"key":"3923_CR21","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.1523\/JNEUROSCI.18-08-02891.1998","volume":"18","author":"KH Herzog","year":"1998","unstructured":"Herzog KH, von Bartheld CS (1998) Contributions of the optic tectum and the retina as sources of brain-derived neurotrophic factor for retinal ganglion cells in the chick embryo. J Neurosci 18:2891\u20132906","journal-title":"J Neurosci"},{"key":"3923_CR22","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.optm.2008.09.014","volume":"80","author":"A Ghaffariyeh","year":"2009","unstructured":"Ghaffariyeh A, Honarpisheh N, Shakiba Y, Puyan S, Chamacham T, Zahedi F, Zarrineghbal M (2009) Brain-derived neurotrophic factor in patients with normal-tension glaucoma. Optometry 80:635\u2013638","journal-title":"Optometry"},{"key":"3923_CR23","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.neurobiolaging.2004.03.002","volume":"26","author":"M Lommatzsch","year":"2005","unstructured":"Lommatzsch M, Zingler D, Schuhbaeck K, Schloetcke K, Zingler C, Schuff-Werner P, Virchow JC (2005) The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiol Aging 26:115\u2013123","journal-title":"Neurobiol Aging"},{"key":"3923_CR24","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.jpsychires.2006.01.014","volume":"41","author":"C Laske","year":"2007","unstructured":"Laske C, Stransky E, Leyhe T, Eschweiler GW, Maetzler W, Wittorf A, Soekadar S, Richartz Z, Koehler N, Bartels M, Buchkremer G, Schott K (2007) BDNF serum and CSF concentrations in Alzheimer\u2019s disease, normal pressure hydrocephalus and healthy controls. J Psychiatr Res 41:387\u2013394","journal-title":"J Psychiatr Res"},{"key":"3923_CR25","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.jneuroim.2008.01.010","volume":"195","author":"D Azoulay","year":"2008","unstructured":"Azoulay D, Urshansky N, Karni A (2008) Low and dysregulated BDNF secretion from immune cells of MS patients is related to reduced neuroprotection. J Neuroimmunol 195:186\u2013193","journal-title":"J Neuroimmunol"},{"issue":"4","key":"3923_CR26","doi-asserted-by":"publisher","first-page":"e386","DOI":"10.1097\/IJG.0000000000000380","volume":"25","author":"I Goldshtein","year":"2016","unstructured":"Goldshtein I, Shalev V, Zigman N, Chodick G, Levkovitch-Verbin H (2016) The Maccabi Glaucoma Study: treatment patterns and persistence with glaucoma therapy in a large Israeli health maintenance organization. J Glaucoma 25(4):e386\u2013e391","journal-title":"J Glaucoma"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00417-018-3923-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-018-3923-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-018-3923-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T07:57:41Z","timestamp":1570694261000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00417-018-3923-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,7]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["3923"],"URL":"https:\/\/doi.org\/10.1007\/s00417-018-3923-y","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,7]]},"assertion":[{"value":"28 September 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee (name the institution\/committee) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}