{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:26:25Z","timestamp":1792787185400,"version":"4.5.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T00:00:00Z","timestamp":1529280000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["13N13766"],"award-info":[{"award-number":["13N13766"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s00417-018-4040-7","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T16:28:56Z","timestamp":1529339336000},"page":"1623-1629","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Retinal volume change is a reliable OCT biomarker for disease activity in neovascular AMD"],"prefix":"10.1007","volume":"256","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2163-5905","authenticated-orcid":false,"given":"Claus","family":"von der Burchard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Treumer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Ehlken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Koinzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantine","family":"Purtskhvanidze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Tode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Roider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,18]]},"reference":[{"key":"4040_CR1","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1056\/NEJMoa054481","volume":"355","author":"PJ Rosenfeld","year":"2006","unstructured":"Rosenfeld PJ, Brown DM, Heier JS et al (2006) Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 355:1419\u20131431. \n                    https:\/\/doi.org\/10.1056\/NEJMoa054481","journal-title":"N Engl J Med"},{"key":"4040_CR2","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/j.ophtha.2012.03.053","volume":"119","author":"DF Martin","year":"2012","unstructured":"Comparison of Age-related Macular Degeneration Treatments Trials (CATT) Research Group, Martin DF, Maguire MG et al (2012) Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results. Ophthalmology 119:1388\u20131398. \n                    https:\/\/doi.org\/10.1016\/j.ophtha.2012.03.053","journal-title":"Ophthalmology"},{"key":"4040_CR3","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.ophtha.2010.09.004","volume":"118","author":"U Schmidt-Erfurth","year":"2011","unstructured":"Schmidt-Erfurth U, Eldem B, Guymer R et al (2011) Efficacy and safety of monthly versus quarterly ranibizumab treatment in neovascular age-related macular degeneration: the EXCITE study. Ophthalmology 118:831\u2013839. \n                    https:\/\/doi.org\/10.1016\/j.ophtha.2010.09.004","journal-title":"Ophthalmology"},{"key":"4040_CR4","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1016\/j.ophtha.2014.05.009","volume":"121","author":"AC Ho","year":"2014","unstructured":"Ho AC, Busbee BG, Regillo CD et al (2014) Twenty-four-month efficacy and safety of 0.5 mg or 2.0 mg ranibizumab in patients with subfoveal neovascular age-related macular degeneration. Ophthalmology 121:2181\u20132192. \n                    https:\/\/doi.org\/10.1016\/j.ophtha.2014.05.009","journal-title":"Ophthalmology"},{"key":"4040_CR5","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.ophtha.2014.07.041","volume":"122","author":"K Berg","year":"2015","unstructured":"Berg K, Pedersen TR, Sandvik L, Bragad\u00f3ttir R (2015) Comparison of ranibizumab and bevacizumab for neovascular age-related macular degeneration according to LUCAS treat-and-extend protocol. Ophthalmology 122:146\u2013152. \n                    https:\/\/doi.org\/10.1016\/j.ophtha.2014.07.041","journal-title":"Ophthalmology"},{"key":"4040_CR6","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1136\/bjophthalmol-2014-305702","volume":"98","author":"U Schmidt-Erfurth","year":"2014","unstructured":"Schmidt-Erfurth U, Chong V, Loewenstein A et al (2014) Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA). Br J Ophthalmol 98:1144\u20131167. \n                    https:\/\/doi.org\/10.1136\/bjophthalmol-2014-305702","journal-title":"Br J Ophthalmol"},{"key":"4040_CR7","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1055\/s-0032-1328113","volume":"230","author":"D Pauleikhoff","year":"2013","unstructured":"Pauleikhoff D, Bertram B, Holz FG et al (2013) Anti-VEGF therapy of neovascular age-related macular degeneration: therapeutic strategies status December 2012. Klin Monatsbl Augenheilkd 230:170\u2013177. \n                    https:\/\/doi.org\/10.1055\/s-0032-1328113","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"4040_CR8","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1097\/IAE.0000000000000465","volume":"35","author":"C Gianniou","year":"2015","unstructured":"Gianniou C, Dirani A, Jang L, Mantel I (2015) Refractory intraretinal or subretinal fluid in neovascular age-related macular degeneration treated with intravitreal ranizubimab: functional and structural outcome. Retina 35:1195\u20131201. \n                    https:\/\/doi.org\/10.1097\/IAE.0000000000000465","journal-title":"Retina"},{"key":"4040_CR9","doi-asserted-by":"publisher","first-page":"3940","DOI":"10.1093\/bioinformatics\/bti623","volume":"21","author":"T Sing","year":"2005","unstructured":"Sing T, Sander O, Beerenwinkel N, Lengauer T (2005) ROCR: visualizing classifier performance in R. Bioinformatics 21:3940\u20133941. \n                    https:\/\/doi.org\/10.1093\/bioinformatics\/bti623","journal-title":"Bioinformatics"},{"key":"4040_CR10","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.ajo.2007.01.028","volume":"143","author":"AE Fung","year":"2007","unstructured":"Fung AE, Lalwani GA, Rosenfeld PJ et al (2007) An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration. Am J Ophthalmol 143:566\u2013583. \n                    https:\/\/doi.org\/10.1016\/j.ajo.2007.01.028","journal-title":"Am J Ophthalmol"},{"key":"4040_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.07.007","volume":"50","author":"U Schmidt-Erfurth","year":"2016","unstructured":"Schmidt-Erfurth U, Waldstein SM (2016) A paradigm shift in imaging biomarkers in neovascular age-related macular degeneration. Prog Retin Eye Res 50:1\u201324. \n                    https:\/\/doi.org\/10.1016\/j.preteyeres.2015.07.007","journal-title":"Prog Retin Eye Res"},{"key":"4040_CR12","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1001\/archophthalmol.2009.326","volume":"127","author":"SA Zweifel","year":"2009","unstructured":"Zweifel SA, Engelbert M, Laud K et al (2009) Outer retinal tubulation: a novel optical coherence tomography finding. Arch Ophthalmol 127:1596\u20131602. \n                    https:\/\/doi.org\/10.1001\/archophthalmol.2009.326","journal-title":"Arch Ophthalmol"},{"key":"4040_CR13","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1097\/IAE.0000000000000471","volume":"35","author":"KB Schaal","year":"2015","unstructured":"Schaal KB, Freund KB, Litts KM et al (2015) Outer retinal tubulation in advanced age-related macular degeneration: optical coherence tomographic findings correspond to histology. Retina (Philadelphia, Pa) 35:1339\u20131350. \n                    https:\/\/doi.org\/10.1097\/IAE.0000000000000471","journal-title":"Retina (Philadelphia, Pa)"},{"key":"4040_CR14","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1136\/bjophthalmol-2015-307141","volume":"100","author":"M Espina","year":"2016","unstructured":"Espina M, Arcinue CA, Ma F et al (2016) Outer retinal tubulations response to anti-VEGF treatment. Br J Ophthalmol 100:819\u2013823. \n                    https:\/\/doi.org\/10.1136\/bjophthalmol-2015-307141","journal-title":"Br J Ophthalmol"},{"key":"4040_CR15","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1016\/j.ophtha.2016.04.005","volume":"123","author":"U Chakravarthy","year":"2016","unstructured":"Chakravarthy U, Goldenberg D, Young G et al (2016) Automated identification of lesion activity in neovascular age-related macular degeneration. Ophthalmology 123:1731\u20131736. \n                    https:\/\/doi.org\/10.1016\/j.ophtha.2016.04.005","journal-title":"Ophthalmology"},{"key":"4040_CR16","doi-asserted-by":"publisher","unstructured":"Xu X, Lee K, Zhang L et al (2015) Stratified sampling voxel classification for segmentation of intraretinal and subretinal fluid in longitudinal clinical OCT data. IEEE Trans Med Imaging. \n                    https:\/\/doi.org\/10.1109\/TMI.2015.2408632","DOI":"10.1109\/TMI.2015.2408632"},{"key":"4040_CR17","doi-asserted-by":"publisher","unstructured":"Wang C, Li Y, Wang YX (2017) Automatic choroidal layer segmentation using Markov random field and level set method. J biomed health inform. \n                    https:\/\/doi.org\/10.1109\/JBHI.2017.2675382","DOI":"10.1109\/JBHI.2017.2675382"},{"key":"4040_CR18","first-page":"104","volume":"5","author":"MR Sabouri","year":"2016","unstructured":"Sabouri MR, Kazemnezhad E, Hafezi V (2016) Assessment of macular thickness in healthy eyes using cirrus HD-OCT: a cross-sectional study. Med Hypothesis Discov Innov Ophthalmol 5:104\u2013111","journal-title":"Med Hypothesis Discov Innov Ophthalmol"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00417-018-4040-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-018-4040-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-018-4040-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T19:06:43Z","timestamp":1560798403000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00417-018-4040-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,18]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["4040"],"URL":"https:\/\/doi.org\/10.1007\/s00417-018-4040-7","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,18]]},"assertion":[{"value":"29 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"For this type of study, formal consent is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}