{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:52:31Z","timestamp":1790189551017,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T00:00:00Z","timestamp":1541203200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Spanish Ministry of Health","award":["PI06\/0184 and PS09\/01762"],"award-info":[{"award-number":["PI06\/0184 and PS09\/01762"]}]},{"name":"Spanish Ministry of Economy and competitiveness","award":["TEC2013-40442"],"award-info":[{"award-number":["TEC2013-40442"]}]},{"name":"pre-doctoral fellowship awarded by Complutense University of Madrid and Santander bank","award":["CT27\/16 - CT28\/16"],"award-info":[{"award-number":["CT27\/16 - CT28\/16"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s00417-018-4176-5","type":"journal-article","created":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T01:33:10Z","timestamp":1541208790000},"page":"111-123","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Alteration of lens and retina textures from mice embryos with folic acid deficiency: image processing analysis"],"prefix":"10.1007","volume":"257","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0513-0229","authenticated-orcid":false,"given":"Ouafa","family":"Sijilmassi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"L\u00f3pez-Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Del Carmen","family":"Barrio Asensio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Del R\u00edo Sevilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,3]]},"reference":[{"key":"4176_CR1","first-page":"398","volume":"4","author":"GK Smelser","year":"1965","unstructured":"Smelser GK (1965) Embryology and morphology of the lens. Invest Ophthalmol Vis Sci 4:398\u2013410","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4176_CR2","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.semcdb.2006.10.011","volume":"17","author":"PV Rao","year":"2006","unstructured":"Rao PV, Maddala R (2006) The role of the lens actin cytoskeleton in fiber cell elongation and differentiation. Semin Cell Dev Biol 17:698\u2013711. \n                    https:\/\/doi.org\/10.1016\/j.semcdb.2006.11.011","journal-title":"Semin Cell Dev Biol"},{"key":"4176_CR3","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1002\/ar.1091680109","volume":"168","author":"Y Pei","year":"1970","unstructured":"Pei Y, Rhodin J (1970) The prenatal development of the mouse eye. Anat Rec 168:105\u2013125","journal-title":"Anat Rec"},{"key":"4176_CR4","doi-asserted-by":"publisher","DOI":"10.1201\/9781420041606","volume-title":"Systematic evaluation of the mouse eye: anatomy, pathology, and biomethods","author":"RS Smith","year":"2001","unstructured":"Smith RS, John SW, Nishina PM, Sundberg JP (2001) Systematic evaluation of the mouse eye: anatomy, pathology, and biomethods. CRC press, Boca Ratan"},{"key":"4176_CR5","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1083\/jcb.110.6.2099","volume":"110","author":"PV Sarthy","year":"1990","unstructured":"Sarthy PV, Fu M (1990) Localization of laminin B1 mRNA in retinal ganglion cells by in situ hybridization. J Cell Biol 110:2099\u20132108","journal-title":"J Cell Biol"},{"key":"4176_CR6","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.ijdevneu.2015.03.002","volume":"42","author":"L Taylor","year":"2015","unstructured":"Taylor L, Arn\u00e9r K, Engelsberg K, Ghosh F (2015) Scaffolding the retina: the interstitial extracellular matrix during rat retinal development. Int J Dev Neurosci 42:46\u201358","journal-title":"Int J Dev Neurosci"},{"key":"4176_CR7","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s00441-009-0821-y","volume":"339","author":"L Schaefer","year":"2010","unstructured":"Schaefer L, Schaefer RM (2010) Proteoglycans: from structural compounds to signaling molecules. Cell Tissue Res 339:237\u2013246. \n                    https:\/\/doi.org\/10.1007\/s00441-009-0821-y","journal-title":"Cell Tissue Res"},{"key":"4176_CR8","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.3181\/0703-MR-72","volume":"232","author":"VS LeBleu","year":"2007","unstructured":"LeBleu VS, MacDonald B, Kalluri R (2007) Structure and function of basement membranes. Exp Biol Med 232:1121\u20131129","journal-title":"Exp Biol Med"},{"key":"4176_CR9","doi-asserted-by":"publisher","first-page":"4195","DOI":"10.1242\/jcs.023820","volume":"123","author":"C Frantz","year":"2010","unstructured":"Frantz C, Stewart KM, Weaver VM (2010) The extracellular matrix at a glance. J Cell Sci 123:4195\u20134200","journal-title":"J Cell Sci"},{"key":"4176_CR10","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ydbio.2009.10.026","volume":"341","author":"T Rozario","year":"2010","unstructured":"Rozario T, DeSimone DW (2010) The extracellular matrix in development and morphogenesis: a dynamic view. Dev Biol 341:126\u2013140","journal-title":"Dev Biol"},{"key":"4176_CR11","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nrg2520","volume":"10","author":"JF Bateman","year":"2009","unstructured":"Bateman JF, Boot-Handford RP, Lamand\u00e9 SR (2009) Genetic diseases of connective tissues: cellular and extracellular effects of ECM mutations. Nat Rev Genet 10:173\u2013183","journal-title":"Nat Rev Genet"},{"key":"4176_CR12","doi-asserted-by":"publisher","first-page":"e16106","DOI":"10.1371\/journal.pone.0016106","volume":"6","author":"PG Hirrlinger","year":"2011","unstructured":"Hirrlinger PG, Pannicke T, Winkler U, Claudepierre T, Varshney S, Schulze C, Reichenbach A, Brunken WJ, Hirrlinger J (2011) Genetic deletion of laminin isoforms \u03b22 and \u03b33 induces a reduction in Kir4. 1 and aquaporin-4 expression and function in the retina. PLoS One 6:e16106","journal-title":"PLoS One"},{"key":"4176_CR13","volume-title":"The eye: basic sciences in practice","author":"JV Forrester","year":"2015","unstructured":"Forrester JV, Dick AD, McMenamin PG, Roberts F, Pearlman E (2015) The eye: basic sciences in practice. Elsevier Health Sciences, Edimburgh"},{"key":"4176_CR14","first-page":"583","volume":"5","author":"RW Young","year":"1966","unstructured":"Young RW, Ocumpaugh DE (1966) Autoradiographic studies on the growth and development of the lens capsule in the rat. Investig Ophthalmol 5:583\u2013589","journal-title":"Investig Ophthalmol"},{"key":"4176_CR15","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.exer.2008.08.002","volume":"88","author":"BP Danysh","year":"2009","unstructured":"Danysh BP, Duncan MK (2009) The lens capsule. Exp Eye Res 88:151\u2013164","journal-title":"Exp Eye Res"},{"key":"4176_CR16","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.exer.2014.07.001","volume":"133","author":"J Reinhard","year":"2015","unstructured":"Reinhard J, Joachim SC, Faissner A (2015) Extracellular matrix remodeling during retinal development. Exp Eye Res 133:132\u2013140","journal-title":"Exp Eye Res"},{"key":"4176_CR17","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.preteyeres.2006.11.001","volume":"26","author":"RE Hausman","year":"2007","unstructured":"Hausman RE (2007) Ocular extracellular matrices in development. Prog Retin Eye Res 26:162\u2013188","journal-title":"Prog Retin Eye Res"},{"key":"4176_CR18","doi-asserted-by":"crossref","unstructured":"Tang LS, Santillano DR, Wlodarczyk BJ, Miranda RC, Finnell RH (2005) Role of Folbp1 in the regional regulation of apoptosis and cell proliferation in the developing neural tube and craniofacies. American Journal of Medical Genetics Part C: Seminars in Medical Genetics. Wiley Online Library, pp. 48\u201358","DOI":"10.1002\/ajmg.c.30053"},{"key":"4176_CR19","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1471-213X-3-6","volume":"3","author":"DM Maddox","year":"2003","unstructured":"Maddox DM, Manlapat A, Roon P, Prasad P, Ganapathy V, Smith SB (2003) Reduced-folate carrier (RFC) is expressed in placenta and yolk sac, as well as in cells of the developing forebrain, hindbrain, neural tube, craniofacial region, eye, limb buds and heart. BMC Dev Biol 3:6","journal-title":"BMC Dev Biol"},{"key":"4176_CR20","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jnutbio.2016.08.009","volume":"38","author":"Y Zhao","year":"2016","unstructured":"Zhao Y, Huang G, Chen S, Gou Y, Dong Z, Zhang X (2016) Folic acid deficiency increases brain cell injury via autophagy enhancement after focal cerebral ischemia. J Nutr Biochem 38:41\u201349","journal-title":"J Nutr Biochem"},{"key":"4176_CR21","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.nbd.2014.08.004","volume":"71","author":"T-T Kao","year":"2014","unstructured":"Kao T-T, Chu C-Y, Lee G-H, Hsiao T-H, Cheng N-W, Chang N-S, Chen B-H, Fu T-F (2014) Folate deficiency-induced oxidative stress contributes to neuropathy in young and aged zebrafish\u2014implication in neural tube defects and Alzheimer's diseases. Neurobiol Dis 71:234\u2013244","journal-title":"Neurobiol Dis"},{"key":"4176_CR22","doi-asserted-by":"publisher","unstructured":"Sijilmassi O, L\u00f3pez Alonso JM, Barrio Asensio MC, Del R\u00edo Sevilla A (2018) Collagen IV and laminin-1 expression in embryonic mouse lens using principal components analysis technique. J Microsc. \n                    https:\/\/doi.org\/10.1111\/jmi.12709","DOI":"10.1111\/jmi.12709"},{"key":"4176_CR23","doi-asserted-by":"crossref","unstructured":"Nassif R, Pellen F, Magne C, Le Jeune B, Le Brun G, Abboud M (2012) Laser speckle dynamic for monitoring fruits maturation Speckle 2012: V International Conference on Speckle Metrology. International Society for Optics and Photonics, pp. 84131G","DOI":"10.1117\/12.975782"},{"key":"4176_CR24","volume-title":"Nutrient requirements of poultry","author":"COUNCIL NR COMMITTEE ON ANIMAL NUTRITION. SUBCOMMITTEE ON POULTRY NUTRITION","year":"1995","unstructured":"COUNCIL NR COMMITTEE ON ANIMAL NUTRITION. SUBCOMMITTEE ON POULTRY NUTRITION (1995) Nutrient requirements of poultry. National Academy Press, Washington"},{"key":"4176_CR25","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1002\/ar.1091200104","volume":"120","author":"EM Otis","year":"1954","unstructured":"Otis EM, Brent R (1954) Equivalent ages in mouse and human embryos. Anat Rec 120:33\u201363","journal-title":"Anat Rec"},{"key":"4176_CR26","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1111\/j.1432-0436.2007.00226.x","volume":"76","author":"E Mart\u00ednez-Sanz","year":"2008","unstructured":"Mart\u00ednez-Sanz E, Del R\u00edo A, Barrio C, Murillo J, Maldonado E, Garcill\u00e1n B, Amor\u00f3s M, Fuerte T, Fern\u00e1ndez \u00c1, Trinidad E (2008) Alteration of medial-edge epithelium cell adhesion in two Tgf-\u03b23 null mouse strains. Differentiation 76:417\u2013430","journal-title":"Differentiation"},{"key":"4176_CR27","volume-title":"Digital image processing using MATLAB","author":"RC Gonzalez","year":"2004","unstructured":"Gonzalez RC, Woods RE, Eddins SL (2004) Digital image processing using MATLAB. Pearson Prentice Hall, Upper Saddle River"},{"key":"4176_CR28","doi-asserted-by":"crossref","unstructured":"Canny J (1986) A computational approach to edge detection. IEEE Trans Pattern Anal Mach Intell PAMI 8(6):679\u2013698","DOI":"10.1109\/TPAMI.1986.4767851"},{"key":"4176_CR29","doi-asserted-by":"publisher","first-page":"e63552","DOI":"10.1371\/journal.pone.0063552","volume":"8","author":"J Hwang","year":"2013","unstructured":"Hwang J, Kim M, Kim S, Lee J (2013) Quantifying morphological parameters of the terminal branching units in a mouse lung by phase contrast synchrotron radiation computed tomography. PLoS One 8:e63552","journal-title":"PLoS One"},{"key":"4176_CR30","doi-asserted-by":"publisher","first-page":"20505-20501-205","DOI":"10.2352\/J.ImagingSci.Technol.(2008)52:5(050502)","volume":"52","author":"D-S Shim","year":"2008","unstructured":"Shim D-S, Chang S (2008) Sub-pixel retinal vessel tracking and measurement using modified canny edge detection method. J Imaging Sci Technol 52:20505-20501-20505-20506","journal-title":"J Imaging Sci Technol"},{"key":"4176_CR31","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1117\/1.1462035","volume":"7","author":"Y Li","year":"2002","unstructured":"Li Y, Chen WR, Zhang Y, Qian W, Liu H (2002) Comparison of analog and digital Fourier transforms in medical image analysis. J Biomed Opt 7:255\u2013261","journal-title":"J Biomed Opt"},{"key":"4176_CR32","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-4541-9","volume-title":"An introduction to the bootstrap: monographs on statistics and applied probability","author":"B Efron","year":"1993","unstructured":"Efron B, Tibshirani RJ (1993) An introduction to the bootstrap: monographs on statistics and applied probability, vol 57. Chapman and Hall\/CRC, New York and London"},{"key":"4176_CR33","doi-asserted-by":"crossref","unstructured":"Goodhue DL, Lewis W, Thompson R (2012) Does PLS have advantages for small sample size or non-normal data? MIS Q 36(3):981\u20131001","DOI":"10.2307\/41703490"},{"key":"4176_CR34","volume-title":"Exploratory data analysis","author":"JW Tukey","year":"1977","unstructured":"Tukey JW (1977) Exploratory data analysis. Addison-Wesley, Reading, Massachusetts"},{"key":"4176_CR35","first-page":"145","volume":"34","author":"V Sarthy","year":"1993","unstructured":"Sarthy V (1993) Collagen IV mRNA expression during development of the mouse retina: an in situ hybridization study. Invest Ophthalmol Vis Sci 34:145\u2013152","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4176_CR36","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/j.1432-0436.1984.tb00266.x","volume":"28","author":"C Parmigiani","year":"1984","unstructured":"Parmigiani C, McAvoy J (1984) Localisation of laminin and fibronectin during rat lens morphogenesis. Differentiation 28:53\u201361","journal-title":"Differentiation"},{"key":"4176_CR37","first-page":"1","volume":"10","author":"H Rafighdoost","year":"2013","unstructured":"Rafighdoost H, Jalali M, Nikravesh MR (2013) Evaluation of laminin expression during mouse lens development. Anat Sci J 10:1\u20136","journal-title":"Anat Sci J"},{"issue":"10","key":"4176_CR38","first-page":"2825","volume":"34","author":"DK Olivero","year":"1993","unstructured":"Olivero DK, Furcht LT (1993) Type IV collagen, laminin, and fibronectin promote the adhesion and migration of rabbit lens epithelial cells in vitro. Invest Ophthalmol Vis Sci 34(10):2825\u20132834","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4176_CR39","first-page":"321","volume":"36","author":"RC Hughes","year":"1979","unstructured":"Hughes RC, Mills G, Courtois Y (1979) Role of fibronectin in the adhesiveness of bovine lens epithelial cells. Biol Cell 36:321\u2013329","journal-title":"Biol Cell"},{"key":"4176_CR40","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/0092-8674(80)90548-6","volume":"22","author":"VP Terranova","year":"1980","unstructured":"Terranova VP, Rohrbach DH, Martin GR (1980) Role of laminin in the attachment of PAM 212 (epithelial) cells to basement membrane collagen. Cell 22:719\u2013726","journal-title":"Cell"},{"key":"4176_CR41","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1083\/jcb.88.3.473","volume":"88","author":"HK Kleinman","year":"1981","unstructured":"Kleinman HK, Klebe RJ, Martin GR (1981) Role of collagenous matrices in the adhesion and growth of cells. J Cell Biol 88:473\u2013485. \n                    https:\/\/doi.org\/10.1083\/jcb.88.3.473","journal-title":"J Cell Biol"},{"key":"4176_CR42","doi-asserted-by":"publisher","first-page":"703","DOI":"10.2215\/CJN.10581014","volume":"10","author":"J Savige","year":"2015","unstructured":"Savige J, Sheth S, Leys A, Nicholson A, Mack HG, Colville D (2015) Ocular features in Alport syndrome: pathogenesis and clinical significance. Clin J Am Soc Nephrol 10:703\u2013709. \n                    https:\/\/doi.org\/10.2215\/cjn.10581014","journal-title":"Clin J Am Soc Nephrol"},{"key":"4176_CR43","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1001\/archopht.121.6.846","volume":"121","author":"S Ohkubo","year":"2003","unstructured":"Ohkubo S, Takeda H, Higashide T, Ito M, Sakurai M, Shirao Y, Yanagida T, Oda Y, Sado Y (2003) Immunohistochemical and molecular genetic evidence for type IV collagen alpha 5 chain abnormality in the anterior lenticonus associated with Alport syndrome. Arch Ophthalmol 121:846\u2013850. \n                    https:\/\/doi.org\/10.1001\/archopht.121.6.846","journal-title":"Arch Ophthalmol"},{"key":"4176_CR44","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/384368a0","volume":"384","author":"K Kuida","year":"1996","unstructured":"Kuida K, Zheng TS, Na SQ, Kuan CY, Yang D, Karasuyama H, Rakic P, Flavell RA (1996) Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384:368\u2013372. \n                    https:\/\/doi.org\/10.1038\/384368a0","journal-title":"Nature"},{"key":"4176_CR45","doi-asserted-by":"publisher","first-page":"9399","DOI":"10.1523\/JNEUROSCI.19-21-09399.1999","volume":"19","author":"RT Libby","year":"1999","unstructured":"Libby RT, Lavallee CR, Balkema GW, Brunken WJ, Hunter DD (1999) Disruption of laminin beta 2 chain production causes alterations in morphology and function in the CNS. J Neurosci 19:9399\u20139411","journal-title":"J Neurosci"},{"key":"4176_CR46","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1534\/genetics.106.064733","volume":"175","author":"J Favor","year":"2007","unstructured":"Favor J, Gloeckner CJ, Janik D, Klempt M, Neuhauser-Klaus A, Pretsch W, Schmahl W, Quintanilla-Fend L (2007) Type IV procollagen missense mutations associated with defects of the eye, vascular stability, the brain, kidney function and embryonic or postnatal viability in the mouse, Mus musculus: an extension of the Col4 alpha 1 allelic series and the identification of the first two Col4a2 mutant alleles. Genetics 175:725\u2013736. \n                    https:\/\/doi.org\/10.1534\/genetics.106.064733","journal-title":"Genetics"},{"key":"4176_CR47","doi-asserted-by":"publisher","first-page":"13136","DOI":"10.1523\/JNEUROSCI.0474-09.2009","volume":"29","author":"JS Satz","year":"2009","unstructured":"Satz JS, Philp AR, Nguyen H, Kusano H, Lee J, Turk R, Riker MJ, Hernandez J, Weiss RM, Anderson MG, Mullins RF, Moore SA, Stone EM, Campbell KP (2009) Visual impairment in the absence of dystroglycan. J Neurosci 29:13136\u201313146. \n                    https:\/\/doi.org\/10.1523\/jneurosci.0474-09.2009","journal-title":"J Neurosci"},{"key":"4176_CR48","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1167\/iovs.09-4645","volume":"51","author":"G Pinzon-Duarte","year":"2010","unstructured":"Pinzon-Duarte G, Daly G, Li YN, Koch M, Brunken WJ (2010) Defective formation of the inner limiting membrane in laminin beta 2-and gamma 3-null mice produces retinal dysplasia. Invest Ophthalmol Vis Sci 51:1773\u20131782. \n                    https:\/\/doi.org\/10.1167\/iovs.09-4645","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00417-018-4176-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-018-4176-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-018-4176-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T20:07:01Z","timestamp":1572725221000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00417-018-4176-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,3]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["4176"],"URL":"https:\/\/doi.org\/10.1007\/s00417-018-4176-5","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,3]]},"assertion":[{"value":"12 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Animal experiments: All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving animals were in accordance with the ethical standards of the Animal Experimentation Committee of the Universidad Complutense of Madrid (UCM). The mice were maintained at animal house of the School of Medicine at the UCM.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}