{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:57:33Z","timestamp":1790711853432,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1007\/s00417-019-04354-7","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T07:11:53Z","timestamp":1561705913000},"page":"2221-2231","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Acute and chronic optic nerve head biomechanics and intraocular pressure changes in patients receiving multiple intravitreal injections of anti-VEGF"],"prefix":"10.1007","volume":"257","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4900-9359","authenticated-orcid":false,"given":"M.","family":"G\u00f3mez-Mariscal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Puerto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. J.","family":"Mu\u00f1oz-Negrete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"de Juan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Rebolleda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,28]]},"reference":[{"key":"4354_CR1","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S0079-6123(09)17517-9","volume":"175","author":"R Schlingemann","year":"2009","unstructured":"Schlingemann R, Witmer A (2009) Treatment of retinal diseases with VEGF antagonists. Prog Brain Res 175:253\u2013267. \nhttps:\/\/doi.org\/10.1016\/S0079-6123(09)17517-9","journal-title":"Prog Brain Res"},{"key":"4354_CR2","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1097\/IAE.0b013e3180592ba6","volume":"27","author":"I Falkenstein","year":"2007","unstructured":"Falkenstein I, Cheng L, Freeman W (2007) Changes of intraocular pressure after intravitreal injection of bevacizumab (Avastin). Retina 27:1044\u20131047","journal-title":"Retina"},{"key":"4354_CR3","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1016\/j.ajo.2008.07.007","volume":"146","author":"J Kim","year":"2008","unstructured":"Kim J, Mantravadi A, Hur E, Covert D (2008) Short-term intraocular pressure changes immediately after intravitreal injections of anti-vascular endothelial growth factor agents. Am J Ophthalmol 146:930\u2013934. \nhttps:\/\/doi.org\/10.1016\/j.ajo.2008.07.007","journal-title":"Am J Ophthalmol"},{"key":"4354_CR4","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/sj.eye.6702938","volume":"23","author":"S Bakri","year":"2009","unstructured":"Bakri S, Pulido J, McCannel C et al (2009) Immediate intraocular pressure changes following intravitreal injections of triamcinolone, pegaptanib, and bevacizumab. Eye 23:181\u2013185","journal-title":"Eye"},{"key":"4354_CR5","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1111\/j.1600-0420.2007.00939.x","volume":"85","author":"K Kotliar","year":"2007","unstructured":"Kotliar K, Maier M, Bauer S, Al E (2007) Effect of intravitreal injections and volume changes on intraocular pressure: clinical results and biomechanical model. Acta Ophthalmol Scand 85:777\u2013781","journal-title":"Acta Ophthalmol Scand"},{"key":"4354_CR6","doi-asserted-by":"publisher","first-page":"5688","DOI":"10.1167\/iovs.16-20111","volume":"57","author":"G Rebolleda","year":"2016","unstructured":"Rebolleda G, Puerto B, de Juan V et al (2016) Optic nerve head biomechanic and IOP changes before and after the injection of aflibercept for neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 57:5688\u20135695. \nhttps:\/\/doi.org\/10.1167\/iovs.16-20111","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4354_CR7","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1007\/s00417-008-0819-2","volume":"246","author":"S Bakri","year":"2008","unstructured":"Bakri S, McCannel C, Edwards A, Moshfeghi D (2008) Persistent ocular hypertension following intravitreal ranibizumab. Graefes Arch Clin Exp Ophthalmol 246:955\u2013958. \nhttps:\/\/doi.org\/10.1007\/s00417-008-0819-2","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"4354_CR8","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1089\/jop.2009.0076","volume":"26","author":"R Adelman","year":"2010","unstructured":"Adelman R, Zheng Q, Mayer H (2010) Persistent ocular hypertension following intravitreal bevacizumab and ranibizumab injections. J Ocul Pharmacol Ther 26:105\u2013110. \nhttps:\/\/doi.org\/10.1089\/jop.2009.0076","journal-title":"J Ocul Pharmacol Ther"},{"key":"4354_CR9","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1136\/bjo.2010.180729","volume":"95","author":"T Good","year":"2011","unstructured":"Good T, Kimura A, Mandava N, Kahook M (2011) Sustained elevation of intraocular pressure after intravitreal injections of anti-VEGF agents. Br J Ophthalmol 95:1111\u20131114. \nhttps:\/\/doi.org\/10.1136\/bjo.2010.180729","journal-title":"Br J Ophthalmol"},{"key":"4354_CR10","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1007\/s00417-012-1981-0","volume":"250","author":"N Mathalone","year":"2012","unstructured":"Mathalone N, Arodi-Golan A, Sar S, Al E (2012) Sustained elevation of intraocular pressure after intravitreal injections of bevacizumab in eyes with neovascular age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 250:1435\u20131440. \nhttps:\/\/doi.org\/10.1007\/s00417-012-1981-0","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"4354_CR11","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1097\/IJG.0b013e31820d7d19","volume":"21","author":"J Tseng","year":"2012","unstructured":"Tseng J, Vance S, Della Torre K, Al E (2012) Sustained increased intraocular pressure related to intravitreal antivascular endothelial growth factor therapy for neovascular age-related macular degeneration. J Glaucoma 21:241\u2013247. \nhttps:\/\/doi.org\/10.1097\/IJG.0b013e31820d7d19","journal-title":"J Glaucoma"},{"key":"4354_CR12","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1016\/j.ophtha.2013.11.029","volume":"121","author":"S Bakri","year":"2014","unstructured":"Bakri S, Moshfeghi D, Francom S et al (2014) Intraocular pressure in eyes receiving monthly ranibizumab in 2 pivotal age-related macular degeneration clinical trials. Ophthalmology 121:1102. \nhttps:\/\/doi.org\/10.1016\/j.ophtha.2013.11.029","journal-title":"Ophthalmology"},{"key":"4354_CR13","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1001\/jamaophthalmol.2017.0059","volume":"135","author":"B Eadie","year":"2017","unstructured":"Eadie B, Etminan M, Carleton B et al (2017) Association of repeated intravitreous bevacizumab injections with risk for glaucoma surgery. JAMA Ophthalmol 135:363\u2013368. \nhttps:\/\/doi.org\/10.1001\/jamaophthalmol.2017.0059","journal-title":"JAMA Ophthalmol"},{"key":"4354_CR14","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.ophtha.2017.11.027","volume":"125","author":"E Atchison","year":"2018","unstructured":"Atchison E, Wood K, Mattox C et al (2018) The real-world effect of intravitreous anti-vascular endothelial growth factor drugs on intraocular pressure: an analysis using the IRIS registry. Ophthalmology 125:676\u2013682. \nhttps:\/\/doi.org\/10.1016\/j.ophtha.2017.11.027","journal-title":"Ophthalmology"},{"key":"4354_CR15","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ajo.2011.01.024","volume":"152","author":"E Lee","year":"2011","unstructured":"Lee E, Kim T, Weinreb R et al (2011) Visualization of the lamina cribrosa using enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol 152:87\u201395. \nhttps:\/\/doi.org\/10.1016\/j.ajo.2011.01.024","journal-title":"Am J Ophthalmol"},{"key":"4354_CR16","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1167\/iovs.08-2365","volume":"50","author":"J Liu","year":"2009","unstructured":"Liu J, He X (2009) Corneal stiffness affects IOP elevation during rapid volume change in the eye. Invest Ophthalmol Vis Sci 50:2224\u20132229. \nhttps:\/\/doi.org\/10.1167\/iovs.08-2365","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4354_CR17","doi-asserted-by":"publisher","first-page":"7215","DOI":"10.1167\/iovs.13-12441","volume":"54","author":"H Morris","year":"2013","unstructured":"Morris H, Tang J, Cruz Perez B et al (2013) Correlation between biomechanical responses of posterior sclera and IOP elevations during micro intraocular volume change. Invest Ophthalmol Vis Sci 54:7215\u20137222. \nhttps:\/\/doi.org\/10.1167\/iovs.13-12441","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4354_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1167\/iovs.13-12724","volume":"55","author":"I Sigal","year":"2014","unstructured":"Sigal I, Grimm J, Jan N et al (2014) Eye-specific IOP-induced displacements and deformations of human lamina cribrosa. Invest Ophthalmol Vis Sci 55:1\u201315. \nhttps:\/\/doi.org\/10.1167\/iovs.13-12724","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4354_CR19","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1097\/OPX.0b013e31817841cb","volume":"85","author":"J Downs","year":"2008","unstructured":"Downs J, Roberts M, Burgoyne C (2008) Mechanical environment of the optic nerve head in glaucoma. Optom Vis Sci 85:425\u2013435. \nhttps:\/\/doi.org\/10.1097\/OPX.0b013e31817841cb","journal-title":"Optom Vis Sci"},{"key":"4354_CR20","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.exer.2006.10.004","volume":"84","author":"L Shelton","year":"2007","unstructured":"Shelton L, Rada J (2007) Effects of cyclic mechanical stretch on extracellular matrix synthesis by human scleral fibroblasts. Exp Eye Res 84:314\u2013322","journal-title":"Exp Eye Res"},{"key":"4354_CR21","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1258\/ebm.2012.012196","volume":"237","author":"G Wang","year":"2012","unstructured":"Wang G, Chen W (2012) Effects of mechanical stimulation on viscoelasticity of rabbit scleral fibroblasts after posterior scleral reinforcement. Exp Biol Med 237:1150\u20131154. \nhttps:\/\/doi.org\/10.1258\/ebm.2012.012196","journal-title":"Exp Biol Med"},{"key":"4354_CR22","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3109\/15569527.2012.696569","volume":"32","author":"A Goktas","year":"2013","unstructured":"Goktas A, Goktas S, Atas M et al (2013) Short-term impact of intravitreal ranibizumab injection on axial ocular dimension and intraocular pressure. Cutan Ocul Toxicol 32:23\u201326. \nhttps:\/\/doi.org\/10.3109\/15569527.2012.696569","journal-title":"Cutan Ocul Toxicol"},{"key":"4354_CR23","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1097\/IJG.0b013e31819c4893","volume":"18","author":"M Gismondi","year":"2009","unstructured":"Gismondi M, Salati C, Salvetat M et al (2009) Short term effect of intravitreal injection of ranibizumab (Lucentis) on intraocular pressure. J Glaucoma 18:658\u2013661. \nhttps:\/\/doi.org\/10.1097\/IJG.0b013e31819c4893","journal-title":"J Glaucoma"},{"key":"4354_CR24","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1007\/s00347-008-1882-0","volume":"106","author":"C Menzel","year":"2009","unstructured":"Menzel C, Kotliar K, Lanzl I (2009) Retrospective investigation of seasonal factors influencing intraocular pressure in glaucoma patients. Ophthalmologe 106:1006\u20131011. \nhttps:\/\/doi.org\/10.1007\/s00347-008-1882-0","journal-title":"Ophthalmologe"},{"key":"4354_CR25","first-page":"345","volume":"40","author":"I Qureshi","year":"1999","unstructured":"Qureshi I, Xiao R, Yang B et al (1999) Seasonal and diurnal variations of ocular pressure in ocular hypertensive subjects in Pakistan. Singap Med J 40:345\u2013348","journal-title":"Singap Med J"},{"key":"4354_CR26","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s10384-012-0194-8","volume":"57","author":"A Cacciamani","year":"2013","unstructured":"Cacciamani A, Oddone F, Parravano M et al (2013) Intravitreal injection of bevacizumab: changes in intraocular pressure related to ocular axial length. Jpn J Ophthalmol 57:63\u201367. \nhttps:\/\/doi.org\/10.1007\/s10384-012-0194-8","journal-title":"Jpn J Ophthalmol"},{"key":"4354_CR27","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1001\/archopht.1981.03930010480020","volume":"99","author":"R Radius","year":"1981","unstructured":"Radius R (1981) Regional specificity in anatomy at the lamina cribrosa. Arch Ophthalmol 99:478\u2013480","journal-title":"Arch Ophthalmol"},{"key":"4354_CR28","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1001\/archopht.1981.03930010139020","volume":"99","author":"H Quigley","year":"1981","unstructured":"Quigley H, Addicks E (1981) Regional differences in the structure of the lamina cribrosa and their relation to glaucomatous optic nerve damage. Arch Ophthalmol 99:137\u2013143","journal-title":"Arch Ophthalmol"},{"key":"4354_CR29","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.brainresbull.2009.06.001","volume":"81","author":"M Winkler","year":"2010","unstructured":"Winkler M, Jester B, Nien-Shy C et al (2010) High resolution three-dimensional reconstruction of the collagenous matrix of the human optic nerve head. Brain Res Bull 81:339\u2013348","journal-title":"Brain Res Bull"},{"key":"4354_CR30","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1167\/iovs.09-4016","volume":"51","author":"M Roberts","year":"2010","unstructured":"Roberts M, Liang Y, Sigal I, Al E (2010) Correlation between local stress and strain and lamina cribrosa connective tissue volume fraction in normal monkey eyes. Invest Ophthalmol Vis Sci 51:295\u2013307. \nhttps:\/\/doi.org\/10.1167\/iovs.09-4016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4354_CR31","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.survophthal.2017.08.008","volume":"63","author":"P Bracha","year":"2018","unstructured":"Bracha P, Moore N, Ciulla T et al (2018) The acute and chronic effects of intravitreal anti-vascular endothelial growth factor injections on intraocular pressure: a review. Surv Ophthalmol 63:281\u2013295. \nhttps:\/\/doi.org\/10.1016\/j.survophthal.2017.08.008","journal-title":"Surv Ophthalmol"},{"key":"4354_CR32","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.ophtha.2018.11.019","volume":"126","author":"A Hoguet","year":"2019","unstructured":"Hoguet A, Chen P, Junk A et al (2019) The effect of anti-vascular endothelial growth factor agents on intraocular pressure and glaucoma: a report by the american academy of ophthalmology. Ophthalmology 126:611\u2013622. \nhttps:\/\/doi.org\/10.1016\/j.ophtha.2018.11.019","journal-title":"Ophthalmology"},{"key":"4354_CR33","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1167\/iovs.15-18404","volume":"57","author":"H Shin","year":"2016","unstructured":"Shin H, Kim S, Chung H et al (2016) Intravitreal anti-vascular endothelial growth factor therapy and retinal nerve fiber layer loss in eyes with age-related macular degeneration: a meta-analysis. Invest Ophthalmol Vis Sci 57:1798\u20131806. \nhttps:\/\/doi.org\/10.1167\/iovs.15-18404","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4354_CR34","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1007\/s00417-017-3702-1","volume":"255","author":"M Soheilian","year":"2017","unstructured":"Soheilian M, Karimi S, Montahae T et al (2017) Effects of intravitreal injection of bevacizumab with or without anterior chamber paracentesis on intraocular pressure and peripapillary retinal nerve fiber layer thickness: a prospective study. Graefes Arch Clin Exp Ophthalmol 255:1705\u20131712. \nhttps:\/\/doi.org\/10.1007\/s00417-017-3702-1","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"4354_CR35","doi-asserted-by":"publisher","first-page":"6214","DOI":"10.1167\/iovs.12-9875","volume":"53","author":"J Martinez-de-la-Casa","year":"2012","unstructured":"Martinez-de-la-Casa J, Ruiz-Calvo A, Saenz-Frances F et al (2012) Retinal nerve fiber layer thickness changes in patients with age-related macular degeneration treated with intravitreal ranibizumab. Invest Ophthalmol Vis Sci 53:6214\u20136218. \nhttps:\/\/doi.org\/10.1167\/iovs.12-9875","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4354_CR36","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.ajo.2010.04.029","volume":"150","author":"M Horsley","year":"2010","unstructured":"Horsley M, Mandava N, Maycotte M, Kahook M (2010) Retinal nerve fiber layer thickness in patients receiving chronic anti-vascular endothelial growth factor therapy. Am J Ophthalmol 150:558\u2013561. \nhttps:\/\/doi.org\/10.1016\/j.ajo.2010.04.029","journal-title":"Am J Ophthalmol"},{"key":"4354_CR37","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1167\/iovs.13-13769","volume":"55","author":"H Shin","year":"2014","unstructured":"Shin H, Shin K, Chung H, Kim H (2014) Change of retinal nerve fiber layer thickness in various retinal diseases treated with multiple intravitreal antivascular endothelial growth factor. Invest Ophthalmol Vis Sci 55:2403\u20132411. \nhttps:\/\/doi.org\/10.1167\/iovs.13-13769","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4354_CR38","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1097\/IAE.0000000000001360","volume":"37","author":"I Zucchiatti","year":"2017","unstructured":"Zucchiatti I, Cicinelli M, Parodi M et al (2017) Effect of intravitreal ranibizumab on ganglion cell complex and peripapillary retinal nerve fiber layer in neovascular age-related macular degeneration using spectral domain optical coherence tomography. Retina 37:1314\u20131319. \nhttps:\/\/doi.org\/10.1097\/IAE.0000000000001360","journal-title":"Retina"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-019-04354-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00417-019-04354-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-019-04354-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T02:29:54Z","timestamp":1593224994000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00417-019-04354-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,28]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["4354"],"URL":"https:\/\/doi.org\/10.1007\/s00417-019-04354-7","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,28]]},"assertion":[{"value":"6 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in the current study were in accordance with the ethical standards of Institutional Research Ethics Committee of Ram\u00f3n y Cajal University Hospital and with the tenets of 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}