{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:19:16Z","timestamp":1777263556038,"version":"3.51.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s00417-019-04516-7","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T08:03:16Z","timestamp":1573545796000},"page":"23-30","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association of retinal biomarkers and choroidal vascularity index on optical coherence tomography using binarization method in retinitis pigmentosa"],"prefix":"10.1007","volume":"258","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1327-0539","authenticated-orcid":false,"given":"Ebru N.","family":"Cetin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Parca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan Samed","family":"Akkaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6khan","family":"Pekel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"issue":"9549","key":"4516_CR1","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1016\/S0140-6736(06)69740-7","volume":"368","author":"DT Hartong","year":"2006","unstructured":"Hartong DT, Berson EL, Dryja TP (2006) Retinitis pigmentosa. Lancet 368(9549):1795\u20131809","journal-title":"Lancet"},{"issue":"7","key":"4516_CR2","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1097\/IAE.0000000000001716","volume":"38","author":"S Arepalli","year":"2018","unstructured":"Arepalli S, Traboulsi EI, Ehlers JP (2018) Ellipsoid zone mapping and outer retinal assessment in Stargardt disease. Retina 38(7):1427\u20131431","journal-title":"Retina"},{"key":"4516_CR3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s40662-018-0119-9","volume":"5","author":"A Campos","year":"2018","unstructured":"Campos A, Campos EJ, do Carmo A, Caramelo F, Martins J, Sousa JP, Ambr\u00f3sio AF, Silva R (2018) Evaluation of markers of outcome in real-world treatment of diabetic macular edema. Eye Vis (Lond) 5:27","journal-title":"Eye Vis (Lond)"},{"issue":"4","key":"4516_CR4","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1097\/IAE.0000000000001599","volume":"38","author":"TF Eliwa","year":"2018","unstructured":"Eliwa TF, Hussein MA, Zaki MA, Raslan OA (2018) Outer retinal layer thickness as good visual predictor in patients with diabetic macular edema. Retina 38(4):805\u2013811","journal-title":"Retina"},{"issue":"4","key":"4516_CR5","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s00417-018-04234-6","volume":"257","author":"VKL Takahashi","year":"2019","unstructured":"Takahashi VKL, Takiuti JT, Carvalho-Jr JRL, Xu CL, Duong JK, Mahajan VB, Tsang SH (2019) Fundus autofluorescence and ellipsoid zone (EZ) line width can be an outcome measurement in RHO-associated autosomal dominant retinitis pigmentosa. Graefes Arch Clin Exp Ophthalmol 257(4):725\u2013731","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"4516_CR6","doi-asserted-by":"publisher","unstructured":"Tang F, Qin X, Lu J, Song P, Li M, Ma X (2019) Optical coherence tomography predictors of short-term visual acuity in eyes with macular edema secondary to retinal vein occlusion treated with intravitreal conbercept. Retina. https:\/\/doi.org\/10.1097\/IAE.0000000000002444","DOI":"10.1097\/IAE.0000000000002444"},{"issue":"2","key":"4516_CR7","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s00417-018-4185-4","volume":"257","author":"K Sousa","year":"2018","unstructured":"Sousa K, Fernandes T, Gentil R, Mendon\u00e7a L, Falc\u00e3o M (2018) Outer retinal layers as predictors of visual acuity in retinitis pigmentosa: a cross-sectional study. Graefes Arch Clin Exp Ophthalmol 257(2):265\u2013271","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"4516_CR8","first-page":"2507","volume":"8","author":"S Saxena","year":"2014","unstructured":"Saxena S, Srivastav K, Cheung CM, Ng JY, Lai TY (2014) Photoreceptor inner segment ellipsoid band integrity on spectral domain optical coherence tomography. Clin Ophthalmol 8:2507\u20132522","journal-title":"Clin Ophthalmol"},{"issue":"11","key":"4516_CR9","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1097\/IAE.0000000000001465","volume":"37","author":"H Kawano","year":"2017","unstructured":"Kawano H, Sonoda S, Saito S, Terasaki H, Sakamoto T (2017) Choroidal structure altered by degeneration of retina in eyes with retinitis pigmentosa. Retina 37(11):2175\u20132182","journal-title":"Retina"},{"issue":"2","key":"4516_CR10","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1167\/iovs.17-23050","volume":"59","author":"Y Murakami","year":"2018","unstructured":"Murakami Y, Funatsu J, Nakatake S, Fujiwara K, Tachibana T, Koyanagi Y, Hisatomi T, Yoshida S, Sonoda S, Sakamoto T, Sonoda KH, Ikeda Y (2018) Relations among foveal blood flow, retinal-choroidal structure, and visual function in retinitis pigmentosa. Invest Ophthalmol Vis Sci 59(2):1134\u20131143","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4516_CR11","doi-asserted-by":"publisher","unstructured":"Egawa M, Mitamura Y, Niki M, Sano H, Miura G, Chiba A, Yamamoto S, Sonoda S, Sakamoto T (2018) Correlations between choroidal structures and visual functions in eyes with retinitis pigmentosa. Retina. https:\/\/doi.org\/10.1097\/IAE.0000000000002285","DOI":"10.1097\/IAE.0000000000002285"},{"issue":"11","key":"4516_CR12","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1001\/jamaophthalmol.2014.2350","volume":"132","author":"JK Sun","year":"2014","unstructured":"Sun JK, Lin MM, Lammer J, Prager S, Sarangi R, Silva PS, Aiello LP (2014) Disorganization of the retinal inner layers as a predictor of visual acuity in eyes with center-involved diabetic macular edema. JAMA Ophthalmol 132(11):1309\u20131316","journal-title":"JAMA Ophthalmol"},{"issue":"9","key":"4516_CR13","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1016\/j.ophtha.2013.01.066","volume":"120","author":"LA Branchini","year":"2013","unstructured":"Branchini LA, Adhi M, Regatieri CV, Nandakumar N, Liu JJ, Laver N, Fujimoto JG, Duker JS (2013) Analysis of choroidal morphologic features and vasculature in healthy eyes using spectral-domain optical coherence tomography. Ophthalmology 120(9):1901\u20131908","journal-title":"Ophthalmology"},{"key":"4516_CR14","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1109\/TSMC.1979.4310076","volume":"9","author":"N Otsu","year":"1979","unstructured":"Otsu N (1979) A threshold selection method from gray-level histograms. IEEE Trans Syst Man Cybernetics 9:62\u201366 (https:\/\/ieeexplore.ieee.org\/stamp\/stamp.jsp?arnumber=4310076)","journal-title":"IEEE Trans Syst Man Cybernetics"},{"key":"4516_CR15","doi-asserted-by":"publisher","first-page":"3538","DOI":"10.1167\/iovs.13-11728","volume":"54","author":"W Wang","year":"2013","unstructured":"Wang W, Zhou M, Huang W, Chen S, Ding X, Zhang X (2013) Does acute primary angle-closure cause an increased choroidal thickness? Invest Ophthalmol Vis Sci 54:3538\u20133545","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"4516_CR16","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/ceo.13458","volume":"47","author":"M Iftikhar","year":"2019","unstructured":"Iftikhar M, Usmani B, Sanyal A, Kherani S, Sodhi S, Bagheri S, Sch\u00f6nbach EM, Junaid N, Scholl HPN, Shah SMA (2019) Progression of retinitis pigmentosa on multimodal imaging: the PREP-1 study. Clin Exp Ophthalmol 47(5):605\u2013613","journal-title":"Clin Exp Ophthalmol"},{"issue":"52","key":"4516_CR17","doi-asserted-by":"publisher","first-page":"e5785","DOI":"10.1097\/MD.0000000000005785","volume":"95","author":"G Liu","year":"2016","unstructured":"Liu G, Li H, Liu X, Xu D, Wang F (2016) Structural analysis of retinal photoreceptor ellipsoid zone and postreceptor retinal layer associated with visual acuity in patients with retinitis pigmentosa by ganglion cell analysis combined with OCT imaging. Medicine (Baltimore) 95(52):e5785","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"4516_CR18","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1159\/000496941","volume":"242","author":"G Son","year":"2019","unstructured":"Son G, Lee S, Kim YJ, Lee JY, Kim JG, Yoon YH (2019) Correlation between visual function and structural characteristics of the macula in advanced retinitis pigmentosa. Ophthalmologica 242(1):22\u201330","journal-title":"Ophthalmologica"},{"issue":"1","key":"4516_CR19","doi-asserted-by":"publisher","first-page":"52","DOI":"10.5301\/ejo.5000961","volume":"28","author":"A Sodi","year":"2018","unstructured":"Sodi A, Lenzetti C, Murro V, Caporossi O, Mucciolo DP, Bacherini D, Cipollini F, Passerini I, Virgili G, Rizzo S (2018) EDI-OCT evaluation of choroidal thickness in retinitis pigmentosa. Eur J Ophthalmol 28(1):52\u201357","journal-title":"Eur J Ophthalmol"},{"issue":"1","key":"4516_CR20","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1136\/bjophthalmol-2012-301917","volume":"97","author":"DS Dhoot","year":"2013","unstructured":"Dhoot DS, Huo S, Yuan A, Xu D, Srivistava S, Ehlers JP, Traboulsi E, Kaiser PK (2013) Evaluation of choroidal thickness in retinitis pigmentosa using enhanced depth imaging optical coherence tomography. Br J Ophthalmol 97(1):66\u201369","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"4516_CR21","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1111\/j.1442-9071.2012.02867.x","volume":"41","author":"LN Ayton","year":"2013","unstructured":"Ayton LN, Guymer RH, Luu CD (2013) Choroidal thickness profiles in retinitis pigmentosa. Clin Exp Ophthalmol 41(4):396\u2013403","journal-title":"Clin Exp Ophthalmol"},{"issue":"3","key":"4516_CR22","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3928\/23258160-20180221-07","volume":"49","author":"R Tan","year":"2018","unstructured":"Tan R, Agrawal R, Taduru S, Gupta A, Vupparaboina K, Chhablani J (2018) Choroidal vascularity index in retinitis pigmentosa: an OCT study. Ophthalmic Surg Lasers Imaging Retina 49(3):191\u2013197","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"issue":"1","key":"4516_CR23","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.sjopt.2015.09.003","volume":"30","author":"J Chhablani","year":"2016","unstructured":"Chhablani J, Jonnadula GB, Srinivasa Rao P, Venkata A, Jalali S (2016) Choroidal thickness profile in retinitis pigmentosa - correlation with outer retinal structures. Saudi J Ophthalmol 30(1):9\u201313","journal-title":"Saudi J Ophthalmol"},{"issue":"5","key":"4516_CR24","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1111\/aos.13210","volume":"95","author":"A Campos","year":"2017","unstructured":"Campos A, Campos EJ, Martins J, Ambr\u00f3sio AF, Silva R (2017) Viewing the choroid: where we stand, challenges and contradictions in diabetic retinopathy and diabetic macular oedema. Acta Ophthalmol 95(5):446\u2013459","journal-title":"Acta Ophthalmol"},{"issue":"1","key":"4516_CR25","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s41598-017-18511-7","volume":"8","author":"M Kim","year":"2018","unstructured":"Kim M, Ha MJ, Choi SY, Park YH (2018) Choroidal vascularity index in type-2 diabetes analyzed by swept-source optical coherence tomography. Sci Rep 8(1):70","journal-title":"Sci Rep"},{"issue":"1","key":"4516_CR26","doi-asserted-by":"publisher","first-page":"e116","DOI":"10.1111\/aos.13836","volume":"97","author":"X Wei","year":"2019","unstructured":"Wei X, Mishra C, Kannan NB, Holder GE, Khandelwal N, Kim R, Agrawal R (2019) Choroidal structural analysis and vascularity index in retinal dystrophies. Acta Ophthalmol 97(1):e116\u2013e121","journal-title":"Acta Ophthalmol"},{"issue":"8","key":"4516_CR27","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1097\/IAE.0000000000002187","volume":"39","author":"JH Lee","year":"2019","unstructured":"Lee JH, Kim JY, Jung BJ, Lee WK (2019) Focal disruptions in ellipsoid zone and interdigitation zone on spectral-domain optical coherence tomography in pachychoroid pigment epitheliopathy. Retina 39(8):1562\u20131570","journal-title":"Retina"},{"issue":"12","key":"4516_CR28","doi-asserted-by":"publisher","first-page":"e0189376","DOI":"10.1371\/journal.pone.0189376","volume":"12","author":"Z Lin","year":"2017","unstructured":"Lin Z, Huang S, Huang P, Guo L, Shen X, Zhong Y (2017) The diagnostic use of choroidal thickness analysis and its correlation with visual field indices in glaucoma using spectral domain optical coherence tomography. PLoS One 12(12):e0189376","journal-title":"PLoS One"},{"issue":"2","key":"4516_CR29","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1167\/iovs.18-25407","volume":"60","author":"H Yang","year":"2019","unstructured":"Yang H, Luo H, Gardiner SK, Hardin C, Sharpe GP, Caprioli J, Demirel S, Girkin CA, Liebmann JM, Mardin CY, Quigley HA, Scheuerle AF, Fortune B, Chauhan BC, Burgoyne CF (2019) Factors influencing optical coherence tomography peripapillary choroidal thickness: a multicenter study. Invest Ophthalmol Vis Sci 60(2):795\u2013806","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"4516_CR30","doi-asserted-by":"publisher","first-page":"4282","DOI":"10.1167\/iovs.16-19686","volume":"57","author":"K Fujiwara","year":"2016","unstructured":"Fujiwara K, Ikeda Y, Murakami Y, Nakatake S, Tachibana T, Yoshida N, Nakao S, Hisatomi T, Yoshida S, Yoshitomi T, Sonoda KH, Ishibashi T (2016) Association between aqueous flare and epiretinal membrane in retinitis pigmentosa. Invest Ophthalmol Vis Sci 57(10):4282\u20134286","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"4516_CR31","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1007\/s00417-019-04418-8","volume":"257","author":"S Fragiotta","year":"2019","unstructured":"Fragiotta S, Rossi T, Carnevale C, Cutini A, Tricarico S, Casillo L, Scuderi G, Vingolo EM (2019) Vitreo-macular interface disorders in retinitis pigmentosa. Graefes Arch Clin Exp Ophthalmol 257(10):2137\u20132146","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"8","key":"4516_CR32","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1136\/bjophthalmol-2018-311964","volume":"103","author":"G Liew","year":"2019","unstructured":"Liew G, Strong S, Bradley P, Severn P, Moore AT, Webster AR, Mitchell P, Kifley A, Michaelides M (2019) Prevalence of cystoid macular oedema, epiretinal membrane and cataract in retinitis pigmentosa. Br J Ophthalmol 103(8):1163\u20131166","journal-title":"Br J Ophthalmol"},{"issue":"8","key":"4516_CR33","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1136\/bjophthalmol-2015-307313","volume":"100","author":"YH Lee","year":"2016","unstructured":"Lee YH, Bae HW, Seo SJ, Lee SY, Beon SH, Kang S, Kim CY (2016) Influence of epiretinal membrane on the measurement of peripapillary retinal nerve fibre layer thickness using spectral-domain coherence tomography. Br J Ophthalmol 100(8):1035\u20131040","journal-title":"Br J Ophthalmol"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-019-04516-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00417-019-04516-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-019-04516-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T20:52:37Z","timestamp":1695415957000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00417-019-04516-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,12]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["4516"],"URL":"https:\/\/doi.org\/10.1007\/s00417-019-04516-7","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,12]]},"assertion":[{"value":"19 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}