{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:20:35Z","timestamp":1785878435118,"version":"3.56.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s00417-019-04587-6","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T11:02:51Z","timestamp":1578481371000},"page":"821-827","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Deep anterior lamellar keratoplasty in eyes previously treated with collagen crosslinking for keratoconus: 3-year results"],"prefix":"10.1007","volume":"258","author":[{"given":"An\u0131l","family":"Kubaloglu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esin Sogutlu","family":"Sari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arif","family":"Koytak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,8]]},"reference":[{"key":"4587_CR1","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.survophthal.2015.02.004","volume":"60","author":"JS Parker","year":"2015","unstructured":"Parker JS, van Dijk K, Melles GR (2015) Treatment options for advanced keratoconus: a review. Surv Ophthalmol 60:459\u2013480","journal-title":"Surv Ophthalmol"},{"key":"4587_CR2","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.jcrs.2008.11.036","volume":"35","author":"G Wollensak","year":"2009","unstructured":"Wollensak G, Iomdina E (2009) Biomechanical and histological changes after corneal crosslinking with and without epithelial debridement. J Cataract Refract Surg 35:540\u2013546","journal-title":"J Cataract Refract Surg"},{"key":"4587_CR3","doi-asserted-by":"publisher","first-page":"249","DOI":"10.3109\/08820538.2010.518503","volume":"25","author":"A Keating","year":"2010","unstructured":"Keating A, Pineda R 2nd, Colby K (2010) Corneal cross linking for keratoconus. Semin Ophthalmol 25:249\u2013255","journal-title":"Semin Ophthalmol"},{"key":"4587_CR4","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.ajo.2009.10.021","volume":"149","author":"A Caporossi","year":"2010","unstructured":"Caporossi A, Mazzotta C, Baiocchi S et al (2010) Long-term results of riboflavin ultraviolet a corneal collagen cross-linking for keratoconus in Italy: the Siena eye cross study. Am J Ophthalmol 149:585\u2013593","journal-title":"Am J Ophthalmol"},{"key":"4587_CR5","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.ophtha.2010.11.002","volume":"118","author":"WJ Reinhart","year":"2011","unstructured":"Reinhart WJ, Musch DC, Jacobs DS et al (2011) Deep anterior lamellar keratoplasty as an alternative to penetrating keratoplasty a report by the American Academy of Ophthalmology. Ophthalmology 118:209\u2013218","journal-title":"Ophthalmology"},{"key":"4587_CR6","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.ajo.2014.11.033","volume":"159","author":"V Romano","year":"2015","unstructured":"Romano V, Iovieno A, Parente G et al (2015) Long-term clinical outcomes of deep anterior lamellar keratoplasty in patients with keratoconus. Am J Ophthalmol 159:505\u2013511","journal-title":"Am J Ophthalmol"},{"key":"4587_CR7","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.ajo.2008.05.042","volume":"146","author":"C Mazzotta","year":"2008","unstructured":"Mazzotta C, Traversi C, Baiocchi S et al (2008) Corneal healing after riboflavin ultraviolet-A collagen cross-linking determined by confocal laser scanning microscopy in vivo: early and late modifications. Am J Ophthalmol 146:527\u2013533","journal-title":"Am J Ophthalmol"},{"key":"4587_CR8","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1097\/ICO.0b013e318030df5a","volume":"26","author":"C Mazzotta","year":"2007","unstructured":"Mazzotta C, Balestrazzi A, Traversi C et al (2007) Treatment of progressive keratoconus by riboflavin-UVA-induced crosslinking of corneal collagen: ultrasctructural analysis by Heidelberg Retinal Tomograph II in vivo confocal microscopy in humans. Cornea 26:390\u2013397","journal-title":"Cornea"},{"key":"4587_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.exer.2015.06.015","volume":"138","author":"J Dias","year":"2015","unstructured":"Dias J, Diakonis VF, Lorenzo M et al (2015) Corneal stromal elasticity and viscoelasticity assessed by atomic force microscopy after different cross linking protocols. Exp Eye Res 138:1\u20135","journal-title":"Exp Eye Res"},{"key":"4587_CR10","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1159\/000319465","volume":"225","author":"S Knappe","year":"2011","unstructured":"Knappe S, Stachs O, Zhivov A et al (2011) Results of confocal microscopy examinations after collagen cross-linking with riboflavin and UVA light in patients with progressive keratoconus. Ophthalmologica 225:95\u2013104","journal-title":"Ophthalmologica"},{"key":"4587_CR11","doi-asserted-by":"publisher","first-page":"801","DOI":"10.3928\/1081597X-20131115-02","volume":"29","author":"A Iovieno","year":"2013","unstructured":"Iovieno A, Moramarco A, Coassin M et al (2013) Big bubble DALK after CXL in keratoconic patients. J Refract Surg 29:801","journal-title":"J Refract Surg"},{"key":"4587_CR12","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.ophtha.2012.08.041","volume":"120","author":"V Scorcia","year":"2013","unstructured":"Scorcia V, Busin M, Lucisano A et al (2013) Anterior segment opticacoherence tomography-guided big-bubble technique. Ophthalmology 120:471\u2013476","journal-title":"Ophthalmology"},{"key":"4587_CR13","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s00417-017-3592-2","volume":"255","author":"F Schaub","year":"2017","unstructured":"Schaub F, Enders P, Bachmann BO et al (2017) Effect of corneal collagen crosslinking on subsequent deep anterior lamellar keratoplasty (DALK) in keratoconus. Graefes Arch Clin Exp Ophthalmol 255:811\u2013816","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"4587_CR14","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1001\/jama.2013.281053","volume":"310","author":"World Medical Association","year":"2013","unstructured":"World Medical Association (2013) Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 310:2191\u20132194","journal-title":"JAMA"},{"key":"4587_CR15","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","volume":"135","author":"G Wollensak","year":"2003","unstructured":"Wollensak G, Spoerl E, Seiler T (2003) Riboflavin\/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol 135:620\u2013627","journal-title":"Am J Ophthalmol"},{"key":"4587_CR16","first-page":"7","volume":"29","author":"BJ Blackburn","year":"2019","unstructured":"Blackburn BJ, Jenkins MW, Rollins AM et al (2019) A review of structural and biomechanical changes in the cornea in aging, disease, and photochemical crosslinking. Front Bioeng Biotechnol 29:7\u201366","journal-title":"Front Bioeng Biotechnol"},{"key":"4587_CR17","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.ajo.2009.05.028","volume":"148","author":"DC Han","year":"2009","unstructured":"Han DC, Mehta JS, Por YM et al (2009) Comparison of outcomes of lamellar keratoplasty and penetrating keratoplasty in keratoconus. Am J Ophthalmol 148:744\u2013751","journal-title":"Am J Ophthalmol"},{"key":"4587_CR18","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.ajo.2005.08.064","volume":"141","author":"R Fogla","year":"2006","unstructured":"Fogla R, Padmanabham P (2006) Results of deep lamellar keratoplasty using the big bubble technique in patients with keratoconus. Am J Ophthalmol 141:254\u2013259","journal-title":"Am J Ophthalmol"},{"key":"4587_CR19","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.ajo.2006.09.025","volume":"143","author":"L Fontana","year":"2007","unstructured":"Fontana L, Parente G, Tass\u0131nari G (2007) Clinical outcomes after deep anterior lamellar keratoplasty using the big-bubble technique in patients with keratoconus. Am J Ophthalmol 143:117\u2013124","journal-title":"Am J Ophthalmol"},{"key":"4587_CR20","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.ajo.2010.11.020","volume":"151","author":"A Kubaloglu","year":"2011","unstructured":"Kubaloglu A, Sari ES, Unal M et al (2011) Long-term results of deep anterior lamellar keratoplasty for the treatment of keratoconus. Am J Ophthalmol 151:760\u2013767","journal-title":"Am J Ophthalmol"},{"key":"4587_CR21","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1097\/ICO.0b013e3181e16d93","volume":"30","author":"M Hovakimyan","year":"2011","unstructured":"Hovakimyan M, Guthoff R, Knappe S et al (2011) Short-term corneal response to cross-linking in rabbit eyes assessed by in vivo confocal laser scanning microscopy and histology. Cornea 30:196\u2013203","journal-title":"Cornea"},{"key":"4587_CR22","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/j.jcrs.2011.12.038","volume":"38","author":"A Thorsrud","year":"2012","unstructured":"Thorsrud A, Nicolaissen B, Drolsum L (2012) Corneal collagen crosslinking in vitro: inhibited regeneration of human limbal epithelial cells after riboflavin-ultraviolet-A exposure. J Cataract Refract Sur 38:1072\u20131076.24","journal-title":"J Cataract Refract Sur"},{"key":"4587_CR23","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1097\/ICO.0b013e3182498902","volume":"31","author":"J Vimalin","year":"2012","unstructured":"Vimalin J, Gupta N, Jambulingam M et al (2012) The effect of riboflavin-UV-A treatment on corneal limbal epithelial cells--a study on human cadaver eyes. Cornea 31:1052\u20131059","journal-title":"Cornea"},{"key":"4587_CR24","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1097\/ICO.0000000000000047","volume":"33","author":"JH Krumeich","year":"2014","unstructured":"Krumeich JH, Brand-Saberi B, Chankiewitz V et al (2014) Induction of neoplasia after deep anterior lamellar keratoplasty in a CXL-treated cornea. Cornea 33:313\u2013316","journal-title":"Cornea"},{"key":"4587_CR25","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.jcjo.2011.07.003","volume":"46","author":"RS Mashor","year":"2011","unstructured":"Mashor RS, Rootman DB, Bahar I et al (2011) Outcomes of deep anterior lamellar keratoplasty versus intralase enabled penetrating keratoplasty in keratoconus. Can J Ophthalmol 46:403\u2013407","journal-title":"Can J Ophthalmol"},{"key":"4587_CR26","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1097\/ICO.0000000000000239","volume":"33","author":"S Feizi","year":"2014","unstructured":"Feizi S, Javadi F, Javadi MA (2014) Graft epithelial defects after deep anterior lamellar keratoplasty. Cornea 33:1145\u20131148","journal-title":"Cornea"},{"key":"4587_CR27","doi-asserted-by":"publisher","first-page":"63","DOI":"10.4274\/tjo.25675","volume":"47","author":"Y Ko\u00e7luk","year":"2017","unstructured":"Ko\u00e7luk Y, Alyama\u00e7 Sukgen E, Burcu A (2017) Comparison of outcomes in patients who underwent deep anterior lamellar keratoplasty and those converted to penetrating keratoplasty. Turk J Ophthalmol 47:63\u201367","journal-title":"Turk J Ophthalmol"},{"key":"4587_CR28","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1097\/ICO.0b013e3181a31aea","volume":"29","author":"V Sarnicola","year":"2010","unstructured":"Sarnicola V, Toro P, Gentile D et al (2010) Descemetic DALK and predescemetic DALK: outcomes in 236 cases of keratoconus. Cornea 29:53\u201359","journal-title":"Cornea"},{"key":"4587_CR29","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.ajo.2003.09.053","volume":"137","author":"BT Van Dooren","year":"2004","unstructured":"Van Dooren BT, Mulder PG, Nieuwendaal CP et al (2004) Endothelial cell density after deep anterior lamellar keratoplasty (Melles technique). Am J Ophthalmol 137:397\u2013400","journal-title":"Am J Ophthalmol"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-019-04587-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00417-019-04587-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-019-04587-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:25:39Z","timestamp":1609979139000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00417-019-04587-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,8]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["4587"],"URL":"https:\/\/doi.org\/10.1007\/s00417-019-04587-6","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,8]]},"assertion":[{"value":"20 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was in accordance with the ethical standards of the national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}