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Patients received either half-dose PDT or HSML treatment. CVI of the affected and unaffected eye was obtained before treatment, 6 to 8\u00a0weeks after treatment, and 7 to 8\u00a0months after treatment.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>At baseline, 29 eyes (29 patients) were included both in the PDT and in the HSML group. The mean (\u00b1\u2009standard deviation) CVI change in the HSML group between before PDT and 6 to 8\u00a0weeks after PDT was \u2212\u20090.009\u2009\u00b1\u20090.032 (<jats:italic>p<\/jats:italic>\u2009=\u20090.127), whereas this was 0.0025\u2009\u00b1\u20090.037 (<jats:italic>p<\/jats:italic>\u2009=\u20090.723) between the visit before PDT and final visit. The patients in the PDT group had a CVI change of \u2212\u20090.0025\u2009\u00b1\u20090.037 (<jats:italic>p<\/jats:italic>\u2009=\u20090.723) between the visit before PDT and first visit after PDT, and a mean CVI change of \u2212\u20090.013\u2009\u00b1\u20090.038 (<jats:italic>p<\/jats:italic>\u2009=\u20090.080) between the visit before PDT and final visit. There was no significant correlation between CVI and BCVA at the measured time points, in both the HSML group (<jats:italic>p<\/jats:italic>\u2009=\u20090.885), and in the PDT group (<jats:italic>p<\/jats:italic>\u2009=\u20090.904). Moreover, no significant changes in CVI occurred in the unaffected eye at any time point.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>PDT and HSML do not significantly affect CVI, and therefore a CVI change may not be primarily responsible for the treatment effect. The positive treatment effect of both interventions may rely on other mechanisms, such as an effect on choriocapillaris and\/or retinal pigment epithelium function.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00417-020-04619-6","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T06:35:31Z","timestamp":1584081331000},"page":"1191-1197","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Prospective evaluation of changes in choroidal vascularity index after half-dose photodynamic therapy versus micropulse laser treatment in chronic central serous chorioretinopathy"],"prefix":"10.1007","volume":"258","author":[{"given":"Thomas J.","family":"van Rijssen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit Randhir","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elon H. 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