{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T12:04:31Z","timestamp":1782302671722,"version":"3.54.5"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1007\/s00417-020-04805-6","type":"journal-article","created":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T12:41:55Z","timestamp":1593175315000},"page":"2517-2521","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Evaluation of retinal vessel density and choriocapillaris flow in migraine patients with and without aura"],"prefix":"10.1007","volume":"258","author":[{"given":"P\u0131nar","family":"Bing\u00f6l K\u0131z\u0131ltun\u00e7","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6k\u00e7en","family":"\u00d6zcan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferhad","family":"\u00d6zer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canan","family":"Togay I\u015f\u0131kay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huban","family":"Atilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,26]]},"reference":[{"key":"4805_CR1","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1097\/WCO.0b013e32833821c1","volume":"23","author":"KC Brennan","year":"2010","unstructured":"Brennan KC, Charles A (2010) An update on the blood vessel in migraine. Curr Opin Neurol 23:266\u2013274. https:\/\/doi.org\/10.1097\/WCO.0b013e32833821c1","journal-title":"Curr Opin Neurol"},{"key":"4805_CR2","doi-asserted-by":"publisher","first-page":"2904","DOI":"10.1523\/jneurosci.3390-16.2017","volume":"37","author":"AJ Schain","year":"2017","unstructured":"Schain AJ, Melo-Carrillo A, Strassman AM, Burstein R (2017) Cortical spreading depression closes paravascular space and impairs glymphatic flow: implications for migraine headache. J Neurosci 37:2904\u20132915. https:\/\/doi.org\/10.1523\/jneurosci.3390-16.2017","journal-title":"J Neurosci"},{"key":"4805_CR3","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1016\/j.jocn.2015.03.057","volume":"22","author":"F Benninger","year":"2015","unstructured":"Benninger F, Saban T, Steiner I (2015) Central retinal vein occlusion in a migraine patient. J Clin Neurosci 22:1833\u20131834. https:\/\/doi.org\/10.1016\/j.jocn.2015.03.057","journal-title":"J Clin Neurosci"},{"key":"4805_CR4","doi-asserted-by":"publisher","first-page":"e92","DOI":"10.1016\/j.jcjo.2017.08.023","volume":"53","author":"PG Christakis","year":"2018","unstructured":"Christakis PG, Alon R, Brent MH (2018) Recurrent visual field defect associated with migraine resulting in a hemiretinal artery occlusion. Can J Ophthalmol 53:e92\u2013e94. https:\/\/doi.org\/10.1016\/j.jcjo.2017.08.023","journal-title":"Can J Ophthalmol"},{"key":"4805_CR5","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1046\/j.1526-4610.1996.3608506.x","volume":"36","author":"AG Lee","year":"1996","unstructured":"Lee AG, Brazis PW, Miller NR (1996) Posterior ischemic optic neuropathy associated with migraine. Headache 36:506\u2013510. https:\/\/doi.org\/10.1046\/j.1526-4610.1996.3608506.x","journal-title":"Headache"},{"key":"4805_CR6","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1001\/jamaophthalmol.2013.4686","volume":"131","author":"I Ota","year":"2013","unstructured":"Ota I, Kuroshima K, Nagaoka T (2013) Fundus video of retinal migraine. JAMA Ophthalmol 131:1481\u20131482. https:\/\/doi.org\/10.1001\/jamaophthalmol.2013.4686","journal-title":"JAMA Ophthalmol"},{"key":"4805_CR7","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1212\/01.wnl.0000261916.42871.05","volume":"68","author":"KM Rose","year":"2007","unstructured":"Rose KM, Wong TY, Carson AP, Couper DJ, Klein R, Sharrett AR (2007) Migraine and retinal microvascular abnormalities: the atherosclerosis risk in communities study. Neurology 68:1694\u20131700. https:\/\/doi.org\/10.1212\/01.wnl.0000261916.42871.05","journal-title":"Neurology"},{"key":"4805_CR8","doi-asserted-by":"publisher","first-page":"5477","DOI":"10.1167\/iovs.17-22477","volume":"58","author":"MY Chang","year":"2017","unstructured":"Chang MY, Phasukkijwatana N, Garrity S, Pineles SL, Rahimi M, Sarraf D, Johnston M, Charles A, Arnold AC (2017) Foveal and peripapillary vascular decrement in migraine with aura demonstrated by optical coherence tomography angiography. Invest Ophthalmol Vis Sci 58:5477\u20135484. https:\/\/doi.org\/10.1167\/iovs.17-22477","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4805_CR9","doi-asserted-by":"publisher","unstructured":"Ulusoy MO, Horasanli B, Kal A (2019) Retinal vascular density evaluation of migraine patients with and without aura and association with white matter hyperintensities. Acta Neurol Belg. https:\/\/doi.org\/10.1007\/s13760-019-01094-7","DOI":"10.1007\/s13760-019-01094-7"},{"key":"4805_CR10","doi-asserted-by":"publisher","first-page":"4710","DOI":"10.1364\/oe.20.004710","volume":"20","author":"Y Jia","year":"2012","unstructured":"Jia Y, Tan O, Tokayer J, Potsaid B, Wang Y, Liu JJ, Kraus MF, Subhash H, Fujimoto JG, Hornegger J, Huang D (2012) Split-spectrum amplitude-decorrelation angiography with optical coherence tomography. Opt Express 20:4710\u20134725. https:\/\/doi.org\/10.1364\/oe.20.004710","journal-title":"Opt Express"},{"key":"4805_CR11","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s11910-017-0729-y","volume":"17","author":"A Gryglas","year":"2017","unstructured":"Gryglas A, Smigiel R (2017) Migraine and stroke: What's the link? What to do? Current neurology and neuroscience reports 17:22. https:\/\/doi.org\/10.1007\/s11910-017-0729-y","journal-title":"Current neurology and neuroscience reports"},{"key":"4805_CR12","doi-asserted-by":"publisher","first-page":"c3966","DOI":"10.1136\/bmj.c3966","volume":"341","author":"LS Gudmundsson","year":"2010","unstructured":"Gudmundsson LS, Scher AI, Aspelund T, Eliasson JH, Johannsson M, Thorgeirsson G, Launer L, Gudnason V (2010) Migraine with aura and risk of cardiovascular and all cause mortality in men and women: prospective cohort study. BMJ 341:c3966. https:\/\/doi.org\/10.1136\/bmj.c3966","journal-title":"BMJ"},{"key":"4805_CR13","doi-asserted-by":"publisher","first-page":"a636","DOI":"10.1136\/bmj.a636","volume":"337","author":"T Kurth","year":"2008","unstructured":"Kurth T, Schurks M, Logroscino G, Gaziano JM, Buring JE (2008) Migraine, vascular risk, and cardiovascular events in women: prospective cohort study. BMJ 337:a636. https:\/\/doi.org\/10.1136\/bmj.a636","journal-title":"BMJ"},{"key":"4805_CR14","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1001\/jama.291.4.427","volume":"291","author":"MC Kruit","year":"2004","unstructured":"Kruit MC, van Buchem MA, Hofman PA, Bakkers JT, Terwindt GM, Ferrari MD, Launer LJ (2004) Migraine as a risk factor for subclinical brain lesions. JAMA 291:427\u2013434. https:\/\/doi.org\/10.1001\/jama.291.4.427","journal-title":"JAMA"},{"key":"4805_CR15","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1111\/head.12386","volume":"54","author":"K Eikermann-Haerter","year":"2014","unstructured":"Eikermann-Haerter K (2014) Spreading depolarization may link migraine and stroke. Headache 54:1146\u20131157. https:\/\/doi.org\/10.1111\/head.12386","journal-title":"Headache"},{"key":"4805_CR16","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1159\/000055622","volume":"32","author":"C Delaey","year":"2000","unstructured":"Delaey C, Van De Voorde J (2000) Regulatory mechanisms in the retinal and choroidal circulation. Ophthalmic Res 32:249\u2013256. https:\/\/doi.org\/10.1159\/000055622","journal-title":"Ophthalmic Res"},{"key":"4805_CR17","doi-asserted-by":"publisher","unstructured":"Bingol Kiziltunc P, Atilla H (2020) Vascular changes with optical coherence tomography angiography during aura of migraine: a case report. Eur J Ophthalmol. https:\/\/doi.org\/10.1177\/1120672119899900","DOI":"10.1177\/1120672119899900"},{"key":"4805_CR18","doi-asserted-by":"publisher","first-page":"814","DOI":"10.3109\/02713683.2015.1056373","volume":"41","author":"YF Feng","year":"2016","unstructured":"Feng YF, Guo H, Huang JH, Yu JG, Yuan F (2016) Retinal nerve fiber layer thickness changes in migraine: a meta-analysis of case-control studies. Curr Eye Res 41:814\u2013822. https:\/\/doi.org\/10.3109\/02713683.2015.1056373","journal-title":"Curr Eye Res"},{"key":"4805_CR19","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1007\/s00415-016-8364-0","volume":"264","author":"E Reggio","year":"2017","unstructured":"Reggio E, Chisari CG, Ferrigno G, Patti F, Donzuso G, Sciacca G, Avitabile T, Faro S, Zappia M (2017) Migraine causes retinal and choroidal structural changes: evaluation with ocular coherence tomography. J Neurol 264:494\u2013502. https:\/\/doi.org\/10.1007\/s00415-016-8364-0","journal-title":"J Neurol"},{"key":"4805_CR20","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/1471-2415-14-75","volume":"14","author":"M Ekinci","year":"2014","unstructured":"Ekinci M, Ceylan E, Ca\u011fatay HH, Kele\u015f S, H\u00fcseyino\u011flu N, Tanyildiz B, Cakici O, Kartal B (2014) Retinal nerve fibre layer, ganglion cell layer and choroid thinning in migraine with aura. BMC Ophthalmol 14:75. https:\/\/doi.org\/10.1186\/1471-2415-14-75","journal-title":"BMC Ophthalmol"},{"key":"4805_CR21","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3109\/08820538.2013.833270","volume":"30","author":"F Y\u00fclek","year":"2015","unstructured":"Y\u00fclek F, Dirik EB, Eren Y, Simavl\u0131 H, U\u011furlu N, \u00c7a\u011f\u0131l N, \u015eim\u015fek \u015e (2015) Macula and retinal nerve fiber layer in migraine patients: analysis by spectral domain optic coherence tomography. Semin Ophthalmol 30:124\u2013128. https:\/\/doi.org\/10.3109\/08820538.2013.833270","journal-title":"Semin Ophthalmol"},{"key":"4805_CR22","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1212\/01.wnl.0000154528.21485.3a","volume":"64","author":"T Kurth","year":"2005","unstructured":"Kurth T, Slomke MA, Kase CS, Cook NR, Lee IM, Gaziano JM, Diener HC, Buring JE (2005) Migraine, headache, and the risk of stroke in women: a prospective study. Neurology 64:1020\u20131026. https:\/\/doi.org\/10.1212\/01.wnl.0000154528.21485.3a","journal-title":"Neurology"},{"key":"4805_CR23","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1177\/0333102412451361","volume":"32","author":"S Sacco","year":"2012","unstructured":"Sacco S, Ricci S, Carolei A (2012) Migraine and vascular diseases: a review of the evidence and potential implications for management. Cephalalgia 32:785\u2013795. https:\/\/doi.org\/10.1177\/0333102412451361","journal-title":"Cephalalgia"},{"key":"4805_CR24","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1007\/s10072-012-1103-0","volume":"34","author":"S Gipponi","year":"2013","unstructured":"Gipponi S, Scaroni N, Venturelli E, Forbice E, Rao R, Liberini P, Padovani A, Semeraro F (2013) Reduction in retinal nerve fiber layer thickness in migraine patients. Neurol Sci 34:841\u2013845. https:\/\/doi.org\/10.1007\/s10072-012-1103-0","journal-title":"Neurol Sci"},{"key":"4805_CR25","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1080\/01658107.2016.1243131","volume":"41","author":"IB Simsek","year":"2017","unstructured":"Simsek IB (2017) Retinal nerve fibre layer thickness of migraine patients with or without white matter lesions. Neuroophthalmology 41:7\u201311. https:\/\/doi.org\/10.1080\/01658107.2016.1243131","journal-title":"Neuroophthalmology"},{"key":"4805_CR26","doi-asserted-by":"publisher","first-page":"78","DOI":"10.5935\/0004-2749.20160024","volume":"79","author":"HN Colak","year":"2016","unstructured":"Colak HN, Kantarc\u0131 FA, Tatar MG, Eryilmaz M, Uslu H, Goker H, Yildirim A, Gurler B (2016) Retinal nerve fiber layer, ganglion cell complex, and choroidal thicknesses in migraine. Arq Bras Oftalmol 79:78\u201381. https:\/\/doi.org\/10.5935\/0004-2749.20160024","journal-title":"Arq Bras Oftalmol"},{"key":"4805_CR27","doi-asserted-by":"publisher","first-page":"868967","DOI":"10.1155\/2015\/868967","volume":"2015","author":"S Demircan","year":"2015","unstructured":"Demircan S, Ata\u015f M, Ar\u0131k Y\u00fcksel S, Ulusoy MD, Yuvac\u0131 \u0130, Arifo\u011flu HB, Ba\u015fkan B, Zarars\u0131z G (2015) The impact of migraine on posterior ocular structures. J Ophthalmol 2015:868967. https:\/\/doi.org\/10.1155\/2015\/868967","journal-title":"J Ophthalmol"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-020-04805-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-020-04805-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-020-04805-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T23:34:53Z","timestamp":1624664093000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-020-04805-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,26]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["4805"],"URL":"https:\/\/doi.org\/10.1007\/s00417-020-04805-6","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,26]]},"assertion":[{"value":"6 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}