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The aim of this prospective multi-centre randomised trial was to compare two EDOF IOLs and one monofocal IOL.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Cataract patients between 50 and 80\u00a0years were randomised for bilateral implantation with either the AT LARA 829MP (EDOF), the TECNIS Symfony (EDOF) or the CT ASPHINA 409MP (monofocal). Follow-up was at 1 to 2\u00a0weeks, 1\u00a0month and 4 to 6\u00a0months.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 211 patients were randomised and included in the final analysis. Monocular depth of focus was significantly better for AT LARA 829MP eyes compared with that for TECNIS Symfony at all thresholds (<jats:italic>p<\/jats:italic>\u2009=\u20090.024, 0.001 and 0.006, for 0.1, 0.2 and 0.3 logMAR respectively) with no significant difference for binocular depth of focus. LARA eyes had significantly better monocular depth of focus at all levels compared with ASPHINA eyes (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), while there was no significant difference between Symfony and ASPHINA eyes at 0.1 logMAR and 0.2 logMAR. Both EDOF IOLs were significantly better than the monofocal ASPHINA at all levels for binocular depth of focus (LARA: all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001; Symfony: all <jats:italic>p<\/jats:italic>\u2009=\u20090.002). Distance visual acuity was similar for all IOLs at 6\u00a0months; intermediate and near visual acuity were significantly better for the EDOF IOLs than for the monofocal (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Refraction improved in all groups relative to baseline. Contrast sensitivity was higher with the CT ASPHINA 409MP but both EDOF lenses had a better spectacle independence rate. At 6\u00a0months, all IOLs were well centred with no cases of tilt. No general safety issues were raised for any of the groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The two EDOF intraocular lenses investigated provided good visual outcomes with comparable visual acuity at all distances. The AT LARA 829MP provided the widest monocular depth of focus at 0.1 and 0.2 logMAR, with a clear superiority compared with the monofocal IOL. TECNIS Symfony was superior to the monofocal control at 0.3 logMAR. Spectacle independence and patient satisfaction were comparable.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>Trial registered on <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/\">https:\/\/clinicaltrials.gov\/<\/jats:ext-link> under the identification NCT03172351 (date of registration 1 June May 2017).<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00417-020-04868-5","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T04:02:46Z","timestamp":1599796966000},"page":"431-442","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Comparison of two extended depth of focus intraocular lenses with a monofocal lens: a multi-centre randomised trial"],"prefix":"10.1007","volume":"259","author":[{"given":"Thomas","family":"Reinhard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"B\u00f6hringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckart","family":"Bertelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6939-1159","authenticated-orcid":false,"given":"Tobias","family":"Brockmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3603-9383","authenticated-orcid":false,"given":"Laszlo","family":"Kiraly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Salom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Piovella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Colonval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8603-6623","authenticated-orcid":false,"given":"Javier","family":"Mendicute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,11]]},"reference":[{"issue":"7","key":"4868_CR1","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1016\/j.jcrs.2007.03.034","volume":"33","author":"JF Alfonso","year":"2007","unstructured":"Alfonso JF, Fern\u00e1ndez-Vega L, Baamonde MB et al (2007) Prospective visual evaluation of apodized diffractive intraocular lenses. 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Dr. Mendicute is a consultant for Alcon Laboratories Inc. and received research support from Alcon Laboratories Inc., Johnson & Johnson, Novagali Pharma SA, Ophtec and Carl Zeiss Meditec, Inc. Prof Bertelmann participates to clinical studies sponsored by Carl Zeiss Meditec, Hoya, Human Optics, Allergan and Johnson & Johnson. The other authors have no competing interests to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}