{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:19:07Z","timestamp":1784956747197,"version":"3.55.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Leipzig"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>This study aims to investigate possible differences in clinical outcomes between precut and surgeon-cut grafts for Descemet membrane endothelial keratoplasty (DMEK).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>142 consecutive patients who underwent DMEK were included in the study. 44\u00a0patients received precut tissues, and 98 patients received surgeon-cut tissues. Precut grafts were allocated to the patient by the German Society for Tissue Transplantation if available. We compared the outcomes of both groups for changes in visual acuity, central corneal thickness, endothelial cell density, re-bubbling rate, and graft failure rate.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Patients who received precut tissues experienced similar increase in visual acuity (median change 0.4 logMAR) and decrease of corneal swelling (median change 132\u00a0\u03bcm) compared with those who received surgeon-cut tissues (median VA change 0.3 logMAR, <jats:italic>p<\/jats:italic>\u00a0=\u20090.55, CCT change 118\u00a0\u03bcm, <jats:italic>p<\/jats:italic>\u00a0=\u20090.63). There was no statistical difference in endothelial cell density (1436 vs. 1569 cells\/mm<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u00a0=\u20090.37), re-bubbling (32% vs. 35%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.85), and graft failure rate (5% vs. 1%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.23). No primary graft failure occurred in the group of precut grafts.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Both methods lead to comparable results for visual acuity, corneal deswelling, endothelial cell density, and re-bubbling rate. A previously described higher graft failure rate for precut tissues could not be confirmed in our study. Thus, we do not see medical reasons against the use of precut tissues. There are several advantages of precut DMEK tissues over surgeon-cut tissues, especially the prevention of graft loss during preparation in the operating theater.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00417-020-04901-7","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T07:02:42Z","timestamp":1598425362000},"page":"113-119","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Descemet membrane endothelial keratoplasty (DMEK): clinical results of precut versus surgeon-cut grafts"],"prefix":"10.1007","volume":"259","author":[{"given":"Doreen","family":"Koechel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan D.","family":"Unterlauft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wiedemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Girbardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,26]]},"reference":[{"issue":"8","key":"4901_CR1","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1097\/01.ico.0000248385.16896.34","volume":"25","author":"GRJ Melles","year":"2006","unstructured":"Melles GRJ, Ong TS, Ververs B et al (2006) Descemet membrane endothelial keratoplasty (DMEK). Cornea 25(8):987\u2013990. https:\/\/doi.org\/10.1097\/01.ico.0000248385.16896.34","journal-title":"Cornea"},{"issue":"6","key":"4901_CR2","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1055\/s-0031-1299522","volume":"229","author":"T Bayyoud","year":"2012","unstructured":"Bayyoud T, R\u00f6ck D, Hofmann J et al (2012) Precut Verfahren f\u00fcr Descemet-Membran-Endothelzelltransplantation, Pr\u00e4paration und Aufbewahrung in Kultur (precut technique for Descemet\u2019s membrane endothelial keratoplasty, preparation and storage in organ culture). Klin Monatsbl Augenheilkd 229(6):621\u2013623. https:\/\/doi.org\/10.1055\/s-0031-1299522","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"4901_CR3","doi-asserted-by":"publisher","unstructured":"Tausif HN, Johnson L, Titus M et al (2014) Corneal donor tissue preparation for Descemet\u2019s membrane endothelial keratoplasty. 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Approval for the study was obtained from the local ethics committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This type of study does not require informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}