{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:04:06Z","timestamp":1792415046816,"version":"4.4.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007065","name":"Universit\u00e0 degli Studi di Salerno","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007065","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Purpose<\/jats:title>\n<jats:p>To detect any choroidal thickness (CT) change in patients after alpha-lytic drugs withdrawal that could help in the cataract surgery timing decision.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Twenty-five eyes of 25 patients (mean age: 76\u2009\u00b1\u20097\u00a0years) under alpha-lytic therapy, and 25 eyes of 25 control subjects (CS) (mean age: 75\u2009\u00b1\u20097\u00a0years) without alpha-lytic therapy, both scheduled for cataract surgery in the fellow eye, were included in this observational, prospective, non-randomized study. All patients underwent EDI-OCT during the first preoperative visit and approximately 1\u00a0month (range 28\u201331\u00a0days) after alpha-lytic withdrawal. In the CS group, the OCT during preoperative visit and approximately 1\u00a0month after (range 28\u201331\u00a0days) the first examination was performed. Data normality with Kolmogorov-Smirnov test was checked and statistical evaluation with the Wilcoxon-signed rank test was performed.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The mean subfoveal CT was 224\u2009\u00b1\u200979.7\u00a0\u03bcm during therapy and 217\u2009\u00b1\u200970.4\u00a0\u03bcm after withdrawal; 1.5\u00a0mm nasally from the fovea CT was 198\u2009\u00b1\u200983.8\u00a0\u03bcm and 194\u2009\u00b1\u200982.8\u00a0\u03bcm, respectively; and 1.5\u00a0mm temporally from the fovea CT was 217\u2009\u00b1\u200955.9\u00a0\u03bcm and 205\u2009\u00b1\u200954.4\u00a0\u03bcm, respectively. A statistically significant reduction (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.05) in all the 3 measured CT points was found. In the CS no significant changes were detected (<jats:italic>p<\/jats:italic>\u00a0&gt;\u20090.05).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>No severe floppy iris syndrome was detected at the time of surgery. In these patients, CT decrease could be an important sign for cataract surgery timing decision.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00417-020-04907-1","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:02:27Z","timestamp":1599004947000},"page":"2729-2736","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Choroidal evaluation in patients under alpha-lytic therapy"],"prefix":"10.1007","volume":"258","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4566-0064","authenticated-orcid":false,"given":"Maddalena","family":"De Bernardo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Altieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Coppola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Gioia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"4907_CR1","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1111\/j.1755-3768.2012.02444.x","volume":"91","author":"E Prokofyeva","year":"2013","unstructured":"Prokofyeva E, Wegener A, Zrenner E (2013) Cataract prevalence and prevention in Europe: a literature review. 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