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Twenty patients (39 eyes) with ABCA4 mutations graded according to the Fishman STGD classification were included. RNFL measurement was performed using Heidelberg Spectralis SD-OCT. RNFL thickness in STGD patients was compared to age-matched data of healthy individuals provided by the device\u2019s manufacturer. A manual readjustment of the optic disc-fovea angle was performed when needed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The mean age at first diagnosis of STGD was 22.9\u00a0years (range 9 to 50) and 39.1\u00a0years (range 18 to 74) at the time of examination. Thirty-nine percent of eyes (15 eyes) needed manual adjustment of the optic disc-fovea angle due to malfixation of the patients during OCT. The temporal quadrant corresponding to the macula showed a RNFL 16% thinner than controls (mean \u2212\u200912\u00a0\u03bcm, 95%CI \u2212\u20099 to \u221215\u00a0\u03bcm). However, global RNFL thickness did not differ from controls due to increased RNFL thickness of 12% in the nasal sectors. Duration and stage of STGD were not correlated to thinner RNFL.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>STGD seems to be associated with thinner peripapillary RNFL in the sector of axons projecting to the degenerated macular area. It is yet unclear as to whether this results from anterograde transneuronal degeneration of direct injury to retinal ganglion cells.<\/jats:p>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00417-020-04992-2","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T11:03:22Z","timestamp":1605265402000},"page":"1521-1528","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Thinner temporal peripapillary retinal nerve fibre layer in Stargardt disease detected by optical coherence tomography"],"prefix":"10.1007","volume":"259","author":[{"given":"Michael","family":"Reich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"L\u00fcbke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz","family":"Joachimsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Stifter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"K\u00fcchlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"B\u00f6hringer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemens","family":"Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolf A.","family":"Lagr\u00e8ze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,11,13]]},"reference":[{"issue":"7","key":"4992_CR1","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1136\/bjo.2010.186924","volume":"95","author":"KR Sung","year":"2011","unstructured":"Sung KR, Kim JS, Wollstein G et al (2011) Imaging of the retinal nerve fibre layer with spectral domain optical coherence tomography for glaucoma diagnosis. 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