{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:09:12Z","timestamp":1740107352597,"version":"3.37.3"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007514","name":"Universit\u00e0 di Pisa","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007514","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To estimate the frequency of epiretinal membrane (ERM) in eyes with primary open-angle glaucoma (POAG) treated with Ex-Press shunt implant. Secondarily, we aimed to assess the role of concomitant cataract surgery and the impact of the ERM on central foveal thickness and macular volume.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this prospective, consecutive, case-control study, we enrolled 54 patients affected by PAOG and scheduled for Ex-Press device implant with or without contemporary phacoemulsification. Contralateral eyes affected by POAG and receiving anti-glaucomatous eyedrops constituted the control group. Complete ophthalmologic evaluation and spectral-domain optical coherence tomography (OCT) were performed before and 1, 3 and 6\u00a0months after surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Twenty-six eyes received the Ex-Press implant alone, and 28 eyes underwent the combined procedure. Six months postoperatively, we observed 18 (33%) cases of ERM: 15 (28%) of cellophane macular reflex (CMR) and 3 (6%) of pre-macular fibrosis (PMF). In the control group, 9 (17%) eyes developed an ERM: 8 (15%) were CMR, and 1 (2%) was PMF. The frequency of ERM statistically differs between treated and contralateral eyes (<jats:italic>P<\/jats:italic>\u2009=\u20090.032, <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> test). The ERM frequency did not statically differ between eyes subjected to simple or combined surgery (<jats:italic>P<\/jats:italic>\u2009=\u20090.846, <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> test). Mean central foveal thickness and mean macular volume did not significantly differ between groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The Ex-Press glaucoma shunt may increase the risk of ERM onset regardless of the concomitant cataract surgery; however, most cases were cellophane macular reflex with limited functional and anatomical impact.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00417-020-05025-8","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T13:04:48Z","timestamp":1606827888000},"page":"949-956","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Secondary epiretinal membrane after Ex-Press glaucoma filtration device implant"],"prefix":"10.1007","volume":"259","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8529-9897","authenticated-orcid":false,"given":"Pasquale","family":"Loiudice","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Sartini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Figus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Nardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Posarelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giamberto","family":"Casini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,12,1]]},"reference":[{"key":"5025_CR1","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1159\/000360462","volume":"54","author":"M Inoue","year":"2014","unstructured":"Inoue M, Kadonosono K (2014) Macular diseases: epiretinal membrane. Dev Ophthalmol 54:159\u2013163. https:\/\/doi.org\/10.1159\/000360462","journal-title":"Dev Ophthalmol"},{"key":"5025_CR2","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/0002-9394(86)90144-3","volume":"102","author":"RA Wiznia","year":"1986","unstructured":"Wiznia RA (1986) Posterior vitreous detachment and idiopathic preretinal macular gliosis. Am J Ophthalmol 102:196\u2013198","journal-title":"Am J Ophthalmol"},{"key":"5025_CR3","doi-asserted-by":"publisher","first-page":"192582","DOI":"10.1155\/2013\/192582","volume":"2013","author":"M Joshi","year":"2013","unstructured":"Joshi M, Agrawal S, Christoforidis JB (2013) Inflammatory mechanisms of idiopathic epiretinal membrane formation. Mediat Inflamm 2013:192582. https:\/\/doi.org\/10.1155\/2013\/192582","journal-title":"Mediat Inflamm"},{"key":"5025_CR4","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1007\/s00417-009-1082-x","volume":"247","author":"A Bringmann","year":"2009","unstructured":"Bringmann A, Wiedemann P (2009) Involvement of Muller glial cells in epiretinal membrane formation. Graefes Arch Clin Exp Ophthalmol 247:865\u2013883. https:\/\/doi.org\/10.1007\/s00417-009-1082-x","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"5025_CR5","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1097\/IAE.0000000000000013","volume":"34","author":"SC Bu","year":"2014","unstructured":"Bu SC, Kuijer R, van der Worp RJ, Huiskamp EA, Renardel de Lavalette VW, Li XR, Hooymans JM, Los LI (2014) Glial cells and collagens in epiretinal membranes associated with idiopathic macular holes. Retina 34:897\u2013906. https:\/\/doi.org\/10.1097\/IAE.0000000000000013","journal-title":"Retina"},{"key":"5025_CR6","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s00417-014-2731-2","volume":"253","author":"HM Kang","year":"2015","unstructured":"Kang HM, Koh HJ, Lee SC (2015) Visual outcome and prognostic factors after surgery for a secondary epiretinal membrane associated with branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 253:543\u2013550. https:\/\/doi.org\/10.1007\/s00417-014-2731-2","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"5025_CR7","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s00417-013-2479-0","volume":"252","author":"YR Hsu","year":"2014","unstructured":"Hsu YR, Yang CM, Yeh PT (2014) Clinical and histological features of epiretinal membrane after diabetic vitrectomy. Graefes Arch Clin Exp Ophthalmol 252:401\u2013410. https:\/\/doi.org\/10.1007\/s00417-013-2479-0","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"5025_CR8","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s12348-012-0074-x","volume":"2","author":"A Sheybani","year":"2012","unstructured":"Sheybani A, Harocopos GJ, Rao PK (2012) Immunohistochemical study of epiretinal membranes in patients with uveitis. J Ophthalmic Inflamm Infect 2:243\u2013248. https:\/\/doi.org\/10.1007\/s12348-012-0074-x","journal-title":"J Ophthalmic Inflamm Infect"},{"key":"5025_CR9","first-page":"505","volume":"43","author":"JK Hsu","year":"1994","unstructured":"Hsu JK, Haller JA, de la Cruz Z, Green WR (1994) Secondary epiretinal membrane after blunt trauma. Md Med J 43:505\u2013508","journal-title":"Md Med J"},{"key":"5025_CR10","doi-asserted-by":"publisher","first-page":"167","DOI":"10.4103\/0974-620x.192280","volume":"9","author":"V Castro-Navarro","year":"2016","unstructured":"Castro-Navarro V, Saktanasate J, Say EA, Chiang A, Shields CL (2016) Role of pars plana vitrectomy and membrane peel in vitreomacular traction associated with retinal vasoproliferative tumors. Oman J Ophthalmol 9:167\u2013169. https:\/\/doi.org\/10.4103\/0974-620x.192280","journal-title":"Oman J Ophthalmol"},{"key":"5025_CR11","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1136\/bjophthalmol-2016-308563","volume":"101","author":"N Cheung","year":"2017","unstructured":"Cheung N, Tan SP, Lee SY, Cheung GCM, Tan G, Kumar N, Cheng CY, Wong TY (2017) Prevalence and risk factors for epiretinal membrane: the Singapore epidemiology of eye disease study. Br J Ophthalmol 101:371\u2013376. https:\/\/doi.org\/10.1136\/bjophthalmol-2016-308563","journal-title":"Br J Ophthalmol"},{"key":"5025_CR12","doi-asserted-by":"publisher","first-page":"100508","DOI":"10.1016\/j.ajoc.2019.100508","volume":"15","author":"AG Elnahry","year":"2019","unstructured":"Elnahry AG, Sallam EM, Guirguis KJ, Talbet JH, Abdel-Kader AA (2019) Vitrectomy for a secondary epiretinal membrane following treatment of adult-onset Coats' disease. Am J Ophthalmol Case Rep 15:100508. https:\/\/doi.org\/10.1016\/j.ajoc.2019.100508","journal-title":"Am J Ophthalmol Case Rep"},{"key":"5025_CR13","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/s41598-020-57509-6","volume":"10","author":"YK Kang","year":"2020","unstructured":"Kang YK, Park HS, Park DH, Shin JP (2020) Incidence and treatment outcomes of secondary epiretinal membrane following intravitreal injection for diabetic macular edema. Sci Rep 10:528. https:\/\/doi.org\/10.1038\/s41598-020-57509-6","journal-title":"Sci Rep"},{"key":"5025_CR14","doi-asserted-by":"publisher","unstructured":"Perente I, Eri\u015f E, Erdo\u011fan G, \u00d6z\u00e7ali\u015fkan \u015e, Karasu B (2020) Secondary epiretinal membrane following to rhegmatogenous retinal detachment. Photodiagnosis Photodyn Ther:101833. https:\/\/doi.org\/10.1016\/j.pdpdt.2020.101833","DOI":"10.1016\/j.pdpdt.2020.101833"},{"key":"5025_CR15","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1007\/s10792-017-0591-6","volume":"38","author":"M Karacorlu","year":"2018","unstructured":"Karacorlu M, Sayman Muslubas I, Hocaoglu M, Arf S, Ersoz MG (2018) Correlation between morphological changes and functional outcomes of recent-onset macula-off rhegmatogenous retinal detachment: prognostic factors in rhegmatogenous retinal detachment. Int Ophthalmol 38:1275\u20131283. https:\/\/doi.org\/10.1007\/s10792-017-0591-6","journal-title":"Int Ophthalmol"},{"key":"5025_CR16","doi-asserted-by":"publisher","first-page":"e576","DOI":"10.1097\/IJG.0000000000000326","volume":"25","author":"L Vieira","year":"2016","unstructured":"Vieira L, Cabugueira A, Borges B, Carvalho V, Noronha M, Abegao Pinto L, Reina M, Dutra Medeiros M (2016) Secondary epiretinal membrane after trabeculectomy. J Glaucoma 25:e576\u2013e580. https:\/\/doi.org\/10.1097\/IJG.0000000000000326","journal-title":"J Glaucoma"},{"key":"5025_CR17","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1471-2415-14-41","volume":"14","author":"M Zhou","year":"2014","unstructured":"Zhou M, Wang W, Huang W, Zhang X (2014) Trabeculectomy with versus without releasable sutures for glaucoma: a meta-analysis of randomized controlled trials. BMC Ophthalmol 14:41. https:\/\/doi.org\/10.1186\/1471-2415-14-41","journal-title":"BMC Ophthalmol"},{"key":"5025_CR18","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1023\/a:1006345032639","volume":"22","author":"GA Zohdy","year":"1998","unstructured":"Zohdy GA, Lukaris A, Rogers ZA, Hill A, Roberts-Harry TJ (1998) Early results of punch trabeculectomy. Int Ophthalmol 22:253\u2013256. https:\/\/doi.org\/10.1023\/a:1006345032639","journal-title":"Int Ophthalmol"},{"key":"5025_CR19","doi-asserted-by":"publisher","unstructured":"Edmunds B, Thompson JR, Salmon JF, Wormald RP (2002) The national survey of trabeculectomy. III Early and late complications Eye (Lond) 16:297\u2013303. https:\/\/doi.org\/10.1038\/sj.eye.6700148","DOI":"10.1038\/sj.eye.6700148"},{"key":"5025_CR20","doi-asserted-by":"publisher","unstructured":"Zahid S, Musch DC, Niziol LM, Lichter PR, Collaborative Initial Glaucoma Treatment Study G (2013) Risk of endophthalmitis and other long-term complications of trabeculectomy in the collaborative initial glaucoma treatment study (CIGTS). Am J Ophthalmol 155:674\u2013680, 680 e671. https:\/\/doi.org\/10.1016\/j.ajo.2012.10.017","DOI":"10.1016\/j.ajo.2012.10.017"},{"issue":"433\u2013440","key":"5025_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.09.014","volume":"157","author":"PA Netland","year":"2014","unstructured":"Netland PA, Sarkisian SR Jr, Moster MR, Ahmed II, Condon G, Salim S, Sherwood MB, Siegfried CJ (2014) Randomized, prospective, comparative trial of EX-PRESS glaucoma filtration device versus trabeculectomy (XVT study). Am J Ophthalmol 157(433\u2013440):e433. https:\/\/doi.org\/10.1016\/j.ajo.2013.09.014","journal-title":"Am J Ophthalmol"},{"key":"5025_CR22","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1097\/IJG.0000000000000029","volume":"24","author":"LD Wagschal","year":"2015","unstructured":"Wagschal LD, Trope GE, Jinapriya D, Jin YP, Buys YM (2015) Prospective randomized study comparing ex-PRESS to trabeculectomy: 1-year results. J Glaucoma 24:624\u2013629. https:\/\/doi.org\/10.1097\/IJG.0000000000000029","journal-title":"J Glaucoma"},{"key":"5025_CR23","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1097\/IJG.0b013e31829e1b68","volume":"24","author":"L Beltran-Agullo","year":"2015","unstructured":"Beltran-Agullo L, Trope GE, Jin Y, Wagschal LD, Jinapriya D, Buys YM (2015) Comparison of visual recovery following ex-PRESS versus trabeculectomy: results of a prospective randomized controlled trial. J Glaucoma 24:181\u2013186. https:\/\/doi.org\/10.1097\/IJG.0b013e31829e1b68","journal-title":"J Glaucoma"},{"key":"5025_CR24","doi-asserted-by":"publisher","unstructured":"Milani P, Raimondi G, Morale D, Scialdone A (2012) Biomicroscopy versus optical coherence tomography screening of epiretinal membranes in patients undergoing cataract surgery. Retina (Philadelphia, Pa) 32:897-904. https:\/\/doi.org\/10.1097\/IAE.0b013e31822a8fec","DOI":"10.1097\/IAE.0b013e31822a8fec"},{"key":"5025_CR25","doi-asserted-by":"publisher","unstructured":"Mitchell P, Smith W, Chey T, Wang JJ, Chang A (1997) Prevalence and associations of epiretinal membranes. The Blue Mountains Eye Study, Australia. Ophthalmology 104:1033\u20131040. https:\/\/doi.org\/10.1016\/s0161-6420(97)30190-0","DOI":"10.1016\/s0161-6420(97)30190-0"},{"key":"5025_CR26","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1097\/ijg.0000000000000312","volume":"25","author":"M Figus","year":"2016","unstructured":"Figus M, Posarelli C, Nasini F, Casini G, Martinelli P, Nardi M (2016) Scleral flap-everting suture for glaucoma-filtering surgery. J Glaucoma 25:128\u2013131. https:\/\/doi.org\/10.1097\/ijg.0000000000000312","journal-title":"J Glaucoma"},{"key":"5025_CR27","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1159\/000458489","volume":"59","author":"M Nardi","year":"2017","unstructured":"Nardi M, Posarelli C, Nasini F, Figus M (2017) Mini drainage devices for anterior and intermediate filtration. Dev Ophthalmol 59:90\u201399. https:\/\/doi.org\/10.1159\/000458489","journal-title":"Dev Ophthalmol"},{"key":"5025_CR28","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/s0161-6420(02)01443-4","volume":"110","author":"S Fraser-Bell","year":"2003","unstructured":"Fraser-Bell S, Guzowski M, Rochtchina E, Wang JJ, Mitchell P (2003) Five-year cumulative incidence and progression of epiretinal membranes: the Blue Mountains eye study. Ophthalmology 110:34\u201340. https:\/\/doi.org\/10.1016\/s0161-6420(02)01443-4","journal-title":"Ophthalmology"},{"key":"5025_CR29","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.ophtha.2014.10.014","volume":"122","author":"SM Meuer","year":"2015","unstructured":"Meuer SM, Myers CE, Klein BE, Swift MK, Huang Y, Gangaputra S, Pak JW, Danis RP, Klein R (2015) The epidemiology of vitreoretinal interface abnormalities as detected by spectral-domain optical coherence tomography: the beaver dam eye study. Ophthalmology 122:787\u2013795. https:\/\/doi.org\/10.1016\/j.ophtha.2014.10.014","journal-title":"Ophthalmology"},{"key":"5025_CR30","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1167\/iovs.12-10727","volume":"54","author":"Y Ouyang","year":"2013","unstructured":"Ouyang Y, Heussen FM, Keane PA, Sadda SR, Walsh AC (2013) The retinal disease screening study: prospective comparison of nonmydriatic fundus photography and optical coherence tomography for detection of retinal irregularities. Invest Ophthalmol Vis Sci 54:1460\u20131468. https:\/\/doi.org\/10.1167\/iovs.12-10727","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"5025_CR31","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1136\/bjophthalmol-2015-306776","volume":"99","author":"SB Wang","year":"2015","unstructured":"Wang SB, Mitchell P, Plant AJ, Phan K, Liew G, Chiha J, Thiagalingam A, Burlutsky G, Gopinath B (2015) Prevalence and risk factors of epiretinal membrane in a cohort with cardiovascular disease risk, compared with the Blue Mountains eye study. Br J Ophthalmol 99:1601\u20131605. https:\/\/doi.org\/10.1136\/bjophthalmol-2015-306776","journal-title":"Br J Ophthalmol"},{"key":"5025_CR32","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1097\/IAE.0b013e3182733f25","volume":"33","author":"KZ Aung","year":"2013","unstructured":"Aung KZ, Makeyeva G, Adams MK, Chong EW, Busija L, Giles GG, English DR, Hopper J, Baird PN, Guymer RH, Robman LD (2013) The prevalence and risk factors of epiretinal membranes: the Melbourne collaborative cohort study. Retina 33:1026\u20131034. https:\/\/doi.org\/10.1097\/IAE.0b013e3182733f25","journal-title":"Retina"},{"key":"5025_CR33","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1097\/IAE.0b013e318242b965","volume":"32","author":"V Mart\u00ednez-Castillo","year":"2012","unstructured":"Mart\u00ednez-Castillo V, Boixadera A, Dist\u00e9fano L, Zapata M, Garc\u00eda-Arum\u00ed J (2012) Epiretinal membrane after pars plana vitrectomy for primary pseudophakic or aphakic rhegmatogenous retinal detachment: incidence and outcomes. Retina 32:1350\u20131355. https:\/\/doi.org\/10.1097\/IAE.0b013e318242b965","journal-title":"Retina"},{"key":"5025_CR34","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1097\/IAE.0b013e318162b031","volume":"28","author":"RC Katira","year":"2008","unstructured":"Katira RC, Zamani M, Berinstein DM, Garfinkel RA (2008) Incidence and characteristics of macular pucker formation after primary retinal detachment repair by pars plana vitrectomy alone. Retina 28:744\u2013748. https:\/\/doi.org\/10.1097\/IAE.0b013e318162b031","journal-title":"Retina"},{"key":"5025_CR35","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.oftal.2017.12.008","volume":"93","author":"JM Giambruni","year":"2018","unstructured":"Giambruni JM, Pagano C, Ortiz Basso T, Burchakchi AI, Pozzoni MC, Diamint DV, Challiol CF, Gossn G, Boietti B (2018) Topical prostaglandin analogues and development of epiretinal membrane. Arch Soc Esp Oftalmol 93:169\u2013173. https:\/\/doi.org\/10.1016\/j.oftal.2017.12.008","journal-title":"Arch Soc Esp Oftalmol"},{"key":"5025_CR36","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1097\/00061198-200306000-00017","volume":"12","author":"A Nyska","year":"2003","unstructured":"Nyska A, Glovinsky Y, Belkin M, Epstein Y (2003) Biocompatibility of the Ex-PRESS miniature glaucoma drainage implant. J Glaucoma 12:275\u2013280. https:\/\/doi.org\/10.1097\/00061198-200306000-00017","journal-title":"J Glaucoma"},{"key":"5025_CR37","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.arr.2016.05.013","volume":"29","author":"Y Subhi","year":"2016","unstructured":"Subhi Y, Forshaw T, Sorensen TL (2016) Macular thickness and volume in the elderly: a systematic review. Ageing Res Rev 29:42\u201349. https:\/\/doi.org\/10.1016\/j.arr.2016.05.013","journal-title":"Ageing Res Rev"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-020-05025-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00417-020-05025-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-020-05025-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T14:09:20Z","timestamp":1617286160000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00417-020-05025-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["5025"],"URL":"https:\/\/doi.org\/10.1007\/s00417-020-05025-8","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"type":"print","value":"0721-832X"},{"type":"electronic","value":"1435-702X"}],"subject":[],"published":{"date-parts":[[2020,12,1]]},"assertion":[{"value":"19 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"We received approval by the local Institutional Review Board (CEAVNO, Comitato Etico Area Vasta Nordovest, register number: 16554_CASINI).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable. There are no participants for whom identifying information is included in this article.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}}]}}