{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T22:43:21Z","timestamp":1792363401599,"version":"4.4.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T00:00:00Z","timestamp":1607385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T00:00:00Z","timestamp":1607385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Freiburg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Excimer laser trabeculotomy (ELT) is a minimally invasive procedure to lower the intraocular pressure (IOP) via a photo-ablative laser that is applied to the trabecular meshwork. With this procedure, it is possible to improve the outflow of the aqueous humor. Until now, a limited number of studies examining mostly relatively small sample sizes with midterm follow-up exist. We therefore present the analysis of a large ELT cohort in a long-term follow-up.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We recorded data from 580 patients who underwent ELT or combined ELT with cataract surgery at our institution from November 2000 until March 2011. A total of 512 patients with primary open angle glaucoma (POAG), pseudoexfoliation glaucoma (PEX), and ocular hypertension (OHT) were included in the analysis. At every follow-up examination, the usage of IOP-lowering medication and the IOP were recorded. Failure criteria were defined as the need for another surgical glaucoma procedure, when the IOP was not 21\u00a0mmHg or less and a reduction of 20% from the baseline was not achieved with (qualified success) or without (absolute success) additional medication. Statistical analysis was done using Kaplan-Meier analysis and Cox regression.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Four hundred twenty-eight patients underwent combined cataract and ELT surgery, and 84 underwent solitary ELT surgery. After a median follow-up time of 656\u00a0days, 87% (combined surgery) and 66% (ELT) of the patients did not have to undergo another IOP-lowering intervention; 47\/31% were classified as a qualified success and 31\/11% as a complete success. The IOP-lowering medication, however, could not be significantly reduced within that time period.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Especially when combined with cataract surgery, ELT is a feasible minimally invasive procedure to lower the IOP on a mid- to long-term basis. Over the long term, however, IOP-lowering medication could not be reduced.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00417-020-05029-4","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T09:04:59Z","timestamp":1607418299000},"page":"957-962","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Long-term follow-up of intraocular pressure and pressure-lowering medication in patients following Excimer laser trabeculotomy"],"prefix":"10.1007","volume":"259","author":[{"given":"C.","family":"Deubel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"B\u00f6hringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Anton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Reinhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"L\u00fcbke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,12,8]]},"reference":[{"key":"5029_CR1","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1007\/s00417-019-04259-5","volume":"257","author":"M Avar","year":"2019","unstructured":"Avar M, Jordan JF, Neuburger M et al (2019) Long-term follow-up of intraocular pressure and pressure-lowering medication in patients after ab-interno trabeculectomy with the Trabectome. Graefes Arch Clin Exp Ophthalmol Albrecht Von Graefes Arch Klin Exp Ophthalmol 257:997\u20131003. https:\/\/doi.org\/10.1007\/s00417-019-04259-5","journal-title":"Graefes Arch Clin Exp Ophthalmol Albrecht Von Graefes Arch Klin Exp Ophthalmol"},{"key":"5029_CR2","first-page":"597","volume":"106","author":"TS Dietlein","year":"2009","unstructured":"Dietlein TS, Hermann MM, Jordan JF (2009) Medikament\u00f6se und chirurgische Therapie des Glaukoms. Dtsch Arztebl Int 106:597\u2013606","journal-title":"Dtsch Arztebl Int"},{"key":"5029_CR3","doi-asserted-by":"publisher","unstructured":"Jonas JB, Aung T, Bourne RR et al (2017) Glaucoma. Lancet. https:\/\/doi.org\/10.1016\/S0140-6736(17)31469-1","DOI":"10.1016\/S0140-6736(17)31469-1"},{"key":"5029_CR4","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1007\/s00347-007-1598-6","volume":"104","author":"S Herdener","year":"2007","unstructured":"Herdener S, Pache M (2007) Minimal-invasive Glaukomchirurgie: Excimer-Laser-Trabekulotomie. Ophthalmol 104:730\u2013732. https:\/\/doi.org\/10.1007\/s00347-007-1598-6","journal-title":"Ophthalmol"},{"key":"5029_CR5","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.preteyeres.2016.12.004","volume":"57","author":"T Carreon","year":"2017","unstructured":"Carreon T, van der Merwe E, Fellman RL et al (2017) Aqueous outflow - a continuum from trabecular meshwork to episcleral veins. Prog Retin Eye Res 57:108\u2013133. https:\/\/doi.org\/10.1016\/j.preteyeres.2016.12.004","journal-title":"Prog Retin Eye Res"},{"key":"5029_CR6","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1471-2415-13-24","volume":"13","author":"M T\u00f6teberg-Harms","year":"2013","unstructured":"T\u00f6teberg-Harms M, Hanson JV, Funk J (2013) Cataract surgery combined with excimer laser trabeculotomy to lower intraocular pressure: effectiveness dependent on preoperative IOP. BMC Ophthalmol 13:24. https:\/\/doi.org\/10.1186\/1471-2415-13-24","journal-title":"BMC Ophthalmol"},{"key":"5029_CR7","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1055\/s-2005-858861","volume":"223","author":"M Pache","year":"2006","unstructured":"Pache M, Wilmsmeyer S, Funk J (2006) Laser surgery for glaucoma: excimer-laser trabeculotomy. Klin Monatsbl Augenheilkd 223:303\u2013307. https:\/\/doi.org\/10.1055\/s-2005-858861","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"5029_CR8","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1038\/eye.2009.172","volume":"24","author":"S Babighian","year":"2010","unstructured":"Babighian S, Caretti L, Tavolato M et al (2010) Excimer laser trabeculotomy vs 180 degrees selective laser trabeculoplasty in primary open-angle glaucoma. A 2-year randomized, controlled trial. Eye Lond Engl 24:632\u2013638. https:\/\/doi.org\/10.1038\/eye.2009.172","journal-title":"Eye Lond Engl"},{"key":"5029_CR9","unstructured":"Shaarawy T, Grehn F, Sherwood M, World Glaucoma Association (2009) WGA guidelines on design and reporting of glaucoma surgical trials. Kugler Publ Amst"},{"key":"5029_CR10","unstructured":"R Core Team (2019) R: a language and environment for statistical computing. http:\/\/www.r-project.org."},{"key":"5029_CR11","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s00347-011-2337-6","volume":"108","author":"M T\u00f6teberg-Harms","year":"2011","unstructured":"T\u00f6teberg-Harms M, Ciechanowski PP, Hirn C, Funk J (2011) One-year results after combined cataract surgery and excimer laser trabeculotomy for elevated intraocular pressure. Ophthalmol Z Dtsch Ophthalmol Ges 108:733\u2013738. https:\/\/doi.org\/10.1007\/s00347-011-2337-6","journal-title":"Ophthalmol Z Dtsch Ophthalmol Ges"},{"key":"5029_CR12","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1007\/s00417-005-0136-y","volume":"244","author":"S Wilmsmeyer","year":"2006","unstructured":"Wilmsmeyer S, Philippin H, Funk J (2006) Excimer laser trabeculotomy: a new, minimally invasive procedure for patients with glaucoma. Graefes Arch Clin Exp Ophthalmol Albrecht Von Graefes Arch Klin Exp Ophthalmol 244:670\u2013676. https:\/\/doi.org\/10.1007\/s00417-005-0136-y","journal-title":"Graefes Arch Clin Exp Ophthalmol Albrecht Von Graefes Arch Klin Exp Ophthalmol"},{"key":"5029_CR13","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.jcjo.2016.07.013","volume":"52","author":"R Conlon","year":"2017","unstructured":"Conlon R, Saheb H, Ahmed IIK (2017) Glaucoma treatment trends: a review. Can J Ophthalmol 52:114\u2013124. https:\/\/doi.org\/10.1016\/j.jcjo.2016.07.013","journal-title":"Can J Ophthalmol"},{"key":"5029_CR14","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1007\/s00417-017-3683-0","volume":"255","author":"T Wecker","year":"2017","unstructured":"Wecker T, Anton A, Neuburger M et al (2017) Trabeculotomy opening size and IOP reduction after Trabectome\u00ae surgery. Graefes Arch Clin Exp Ophthalmol 255:1643\u20131650. https:\/\/doi.org\/10.1007\/s00417-017-3683-0","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"5029_CR15","first-page":"167","volume":"23","author":"JF Jordan","year":"2011","unstructured":"Jordan JF, Neuburger M, Reinhard T (2011) Minimal-invasive Kammerwinkelchirurgie: das Trabektom. Ophthalmochirurgie 23:167\u2013171","journal-title":"Ophthalmochirurgie"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-020-05029-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00417-020-05029-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-020-05029-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T14:08:34Z","timestamp":1617286114000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00417-020-05029-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,8]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["5029"],"URL":"https:\/\/doi.org\/10.1007\/s00417-020-05029-4","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,8]]},"assertion":[{"value":"10 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The local ethics committee approved the study (vote no. 233\/19).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}}]}}