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Weighted mean differences and subgroup comparisons were used to integrate the different studies.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>This meta-analysis refers to 29 published series, including 27 independent samples and 5629 patients. In the pooled group, disease stability was reported in 62.9% and 56.0%, respectively, after 12 and 24\u00a0months of treatment, whereas treatment intervals were extended to \u2265\u200912\u00a0weeks in 37.7% and 42.6%, respectively. Ranibizumab, aflibercept, and brolucizumab differed regarding their potential to achieve disease stability (56.3%, 64.5%, and 71.5% after 12, and 50.0%, 52.7% and 75.7% after 24\u00a0months; <jats:italic>p<\/jats:italic>\u2009=\u2009&lt;\u20090.001) and to allow an interval extension to \u2265\u200912\u00a0weeks (28.6%, 34.2%, and 53.3% after 12, and 34.2%, 47.7%, and 41.7% after 24\u00a0months; <jats:italic>p<\/jats:italic>\u2009=\u2009&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The portion of eyes achieving disease stability regressed in the second year, whereas the portion of eyes under a \u2265\u200912-week interval increased. This discrepancy may reflect the challenges in balancing between under-treatment and a reduced treatment burden.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00417-020-05048-1","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T18:59:40Z","timestamp":1612292380000},"page":"2181-2192","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Disease stability and extended dosing under anti-VEGF treatment of exudative age-related macular degeneration (AMD)\u00a0\u2014\u00a0a meta-analysis"],"prefix":"10.1007","volume":"259","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3973-5082","authenticated-orcid":false,"given":"Justus G.","family":"Garweg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7705-1103","authenticated-orcid":false,"given":"Christin","family":"Gerhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"5048_CR1","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/eye.2008.86","volume":"22","author":"H Dadgostar","year":"2008","unstructured":"Dadgostar H, Waheed N (2008) The evolving role of vascular endothelial growth factor inhibitors in the treatment of neovascular age-related macular degeneration. 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