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Corvi, M. Cozzi and G. Corradetti declare no conflict of interest. G. Staurenghi: Heidelberg Engineering (Consultant), Quantel Medical (Consultant), Centervue (Consultant), Carl Zeiss Meditec (Consultant), Alcon (Consultant), Allergan (Consultant), Bayer (Consultant), Boheringer (Consultant), Genentech (Consultant), GSK (Consultant), Novartis (Consultant), Roche (Consultant) and has received grant support from Optos (Financial Support), Optovue (Financial Support), Centervue (Financial Support). D. Sarraf: Amgen (Consultant, Financial Support); Bayer (Consultant, Financial Support); Genentech (Consultant, Financial Support); Heidelberg (Financial Support); Novartis (Financial Support); Optovue (Consultant, Financial Support); Regeneron (Financial Support); Topcon (Financial Support). S.R. 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