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Using 1:1 matching of axial length (AL) of their eyes, patients were allocated into a PS group or no posterior staphyloma (NPS) group. All patients were examined using ultra-widefield fundus imaging, optical coherence tomography angiography, and ocular biometry to acquire microvasculature and microstructure parameters.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The anterior chamber depth (ACD) of the PS group was significantly different from that of the NPS group (3.56 mm vs 3.76 mm, <jats:italic>P<\/jats:italic> &lt; 0.001), as was 1ens thickness (3.72 mm vs 3.57 mm, <jats:italic>P<\/jats:italic> = 0.005) and spherical equivalent (SE)(-10.11D vs -8.80D, <jats:italic>P<\/jats:italic> = 0.014). The PS group had reduced choriocapillaris flow, subfoveal choroidal thickness (SFCT), and a thinner retinal layer compared with the NPS group. No difference in retinal blood flow between the two groups was observed. The PS group exhibited a smaller disc area (15082.89 vs 17,043.32, <jats:italic>P<\/jats:italic> = 0.003) and angle \u03b1 between temporal retinal arterial vascular arcades (113.29\u00b0vs 128.39\u00b0, <jats:italic>P<\/jats:italic> = 0.003), a larger disc tilt ratio (1.41 vs 1.24, <jats:italic>P<\/jats:italic> &lt; 0.001) and parapapillary atrophy (PPA) area (13840.98 vs 8753.86, <jats:italic>P<\/jats:italic> = 0.020), compared with the NPS group. Multivariate regression analysis indicated that disc tilt ratio (<jats:italic>P<\/jats:italic> = 0.031) and SFCT (<jats:italic>P<\/jats:italic> = 0.015) were significant predictors of PS. In addition, PS (<jats:italic>P<\/jats:italic> = 0.049), AL (<jats:italic>P<\/jats:italic> = 0.003), corneal refractive power (<jats:italic>P<\/jats:italic> &lt; 0.001), ACD (<jats:italic>P<\/jats:italic> = 0.022), relative lens position (<jats:italic>P<\/jats:italic> = 0.045), and disc area (<jats:italic>P<\/jats:italic> = 0.011) were significant predictors of SE.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>PS was found to be closely linked to a reduction in choriocapillaris perfusion and anatomical abnormalities including posterior and anterior segments. Furthermore, PS exacerbated the progression of myopia.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00417-020-05057-0","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T16:06:52Z","timestamp":1609949212000},"page":"2119-2130","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Posterior staphyloma is associated with the microvasculature and microstructure of myopic eyes"],"prefix":"10.1007","volume":"259","author":[{"given":"Fen","family":"Nie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenquan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijia","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lurong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daijin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1101-0602","authenticated-orcid":false,"given":"Xuanchu","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"key":"5057_CR1","first-page":"67","volume":"75","author":"BJ Curtin","year":"1977","unstructured":"Curtin BJ (1977) The posterior staphyloma of pathologic myopia. 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