{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:33:28Z","timestamp":1776832408984,"version":"3.51.2"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002345","name":"Eberhard Karls Universit\u00e4t T\u00fcbingen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002345","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To better assess clinical trajectories of patients with or without ocular comorbidity after Descemet membrane endothelial keratoplasty. Background: To report on the outcomes of eyes with differing starting conditions following surgery. Design: Retrospective study at a University Eye Hospital. Participants: 361 eyes separated into group 1 (<jats:italic>n<\/jats:italic>=229; eyes with endothelial disease only) and group 2 (<jats:italic>n<\/jats:italic>=132; eyes with additional ocular comorbid conditions, such as herpetic eye disease 18\/132 (13.6%), glaucoma 16\/132 (12.1%), dry age-related macular degeneration 14\/132 (10.6%), epiretinal membranes 10\/132 (7.6%), and wet age-related macular degeneration 9\/132 (6.8%)).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Consecutive eyes that underwent Descemet membrane endothelial keratoplasty over a follow-up period of up to 7 years at a tertiary referral center were reviewed. Main outcome measures were best-corrected visual acuity, postoperative complications, graft survival, central corneal thickness, and endothelial cell density.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Postoperative best-corrected visual acuity at year 1 improved in both groups significantly (Wilcoxon signed rank test: group 1, <jats:italic>p<\/jats:italic> =.002; .63 to .23 logMAR; group 2, <jats:italic>p<\/jats:italic> &lt;.001; 1.15 to .87 logMAR) with a group difference in favor of group 1 (<jats:italic>p<\/jats:italic> =.009, Mann-Whitney-Wilcoxon). A decrease of the endothelial cell density and central corneal thickness was noted at postoperative year 1 for both groups (paired <jats:italic>t<\/jats:italic>-tests (group 1, <jats:italic>p<\/jats:italic> &lt;.001; group 2, <jats:italic>p<\/jats:italic> =.045) and paired <jats:italic>t<\/jats:italic>-tests (group 1, <jats:italic>p<\/jats:italic> &lt;.001; group 2, <jats:italic>p<\/jats:italic> =.003). Complications were less common, and graft longevity was superior in group 1.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Eyes with different starting conditions might experience a visual improvement and benefit from surgery. Descemet membrane endothelial keratoplasty is a valid treatment for endothelial disorders in manifold of eyes. Further long-term studies are required.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00417-021-05152-w","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T18:02:58Z","timestamp":1615831378000},"page":"1907-1914","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Outcomes after Descemet membrane endothelial keratoplasty over a period of 7 years at a tertiary referral center: endothelial cell density, central corneal thickness, and visual acuity"],"prefix":"10.1007","volume":"259","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0848-0099","authenticated-orcid":false,"given":"Tarek","family":"Bayyoud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faik","family":"Gelisken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens Martin","family":"Rohrbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Blumenstock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl Ulrich","family":"Bartz-Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Thaler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,15]]},"reference":[{"key":"5152_CR1","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1097\/ICO.0000000000001111","volume":"36","author":"L Baydoun","year":"2017","unstructured":"Baydoun L, M\u00fcller T, Lavy I, Parker J, Rodriguez-Calvo-de-Mora M, Liarakos VS, Dapena I, Melles GRJ (2017) Ten-year clinical outcome of the first patient undergoing Descemet membrane endothelial keratoplasty. Cornea 36:379\u2013381","journal-title":"Cornea"},{"key":"5152_CR2","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/j.1755-3768.2012.02462.x","volume":"91","author":"EA Groeneveld-van Beek","year":"2013","unstructured":"Groeneveld-van Beek EA, Lie JT, van der Wees J, Bruinsma M, Melles GR (2013) Standardized \u2018no-touch\u2019 donor tissue preparation for DALK and DMEK: harvesting undamaged anterior and posterior transplants from the same donor cornea. Acta Ophthalmol 91:145\u2013150","journal-title":"Acta Ophthalmol"},{"key":"5152_CR3","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1097\/ICU.0b013e32832b8d18","volume":"20","author":"I Dapena","year":"2009","unstructured":"Dapena I, Ham L, Melles GR (2009) Endothelial keratoplasty: DSEK\/DSAEK or DMEK--the thinner the better? Curr Opin Ophthalmol 20:299\u2013307","journal-title":"Curr Opin Ophthalmol"},{"key":"5152_CR4","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ajo.2018.01.018","volume":"188","author":"E Flockerzi","year":"2018","unstructured":"Flockerzi E, Maier P, B\u00f6hringer D, Reinshagen H, Kruse F, Cursiefen C, Reinhard T, Geerling G, Torun N, Seitz B (2018) Trends in corneal transplantation from 2001 to 2016 in Germany: a report of the DOG-section cornea and its keratoplasty registry. Am J Ophthalmol 188:91\u201398","journal-title":"Am J Ophthalmol"},{"key":"5152_CR5","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.ophtha.2014.09.004","volume":"122","author":"M Rodr\u00edguez-Calvo-de-Mora","year":"2015","unstructured":"Rodr\u00edguez-Calvo-de-Mora M, Quilendrino R, Ham L, Liarakos VS, van Dijk K, Baydoun L, Dapena I, Oellerich S, Melles GRJ (2015) Clinical outcome of 500 consecutive cases undergoing Descemet\u2019s membrane endothelial keratoplasty. Ophthalmology 122:464\u2013470","journal-title":"Ophthalmology"},{"key":"5152_CR6","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.ajo.2016.08.038","volume":"171","author":"L Ham","year":"2016","unstructured":"Ham L, Dapena I, Liarakos VS, Baydoun L, van Dijk K, Ilyas A, Oellerich S, Melles GRJ (2016) Midterm results of Descemet membrane endothelial keratoplasty: 4 to 7 years clinical outcome. Am J Ophthalmol 171:113\u2013121","journal-title":"Am J Ophthalmol"},{"key":"5152_CR7","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1001\/jamaophthalmol.2014.1710","volume":"132","author":"C Monnereau","year":"2014","unstructured":"Monnereau C, Quilendrino R, Dapena I, Liarakos VS, Alfonso JF, Arnalich-Montiel F, B\u00f6hnke M, Pereira NC, Dirisamer M, Parker J, Droutsas K, Geerling G, Gerten G, Hashemi H, Kobayashi A, Naveiras M, Oganesyan O, Domingo EO, Priglinger S, Stodulka P, Silva JT Jr, Venzano D, Vetter JM, Yiu E, Melles GRJ (2014) Multicenter study of Descemet membrane endothelial keratoplasty: first case series of 18 surgeons. JAMA Ophthalmol 132:1192\u20131198","journal-title":"JAMA Ophthalmol"},{"key":"5152_CR8","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1097\/ICO.0000000000000625","volume":"34","author":"JM Weller","year":"2015","unstructured":"Weller JM, Tourtas T, Kruse FE (2015) Feasibility and outcome of Descemet membrane endothelial keratoplasty in complex anterior segment and vitreous disease. Cornea 34:1351\u20131357","journal-title":"Cornea"},{"key":"5152_CR9","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1097\/ICO.0b013e318254fa06","volume":"32","author":"E Yoeruek","year":"2013","unstructured":"Yoeruek E, Bayyoud T, Hofmann J, Bartz-Schmidt KU (2013) Novel maneuver facilitating Descemet membrane unfolding in the anterior chamber. Cornea 32:370\u2013373","journal-title":"Cornea"},{"key":"5152_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/ICO.0000000000000288","volume":"34","author":"E Yoeruek","year":"2015","unstructured":"Yoeruek E, Rubino G, Bayyoud T, Bartz-Schmidt KU (2015) Descemet membrane endothelial keratoplasty in vitrectomized eyes: clinical results. Cornea 34:1\u20135","journal-title":"Cornea"},{"key":"5152_CR11","first-page":"390","volume":"9","author":"K Spaniol","year":"2016","unstructured":"Spaniol K, Holtmann C, Schwinde JH, Deffaa S, Guthoff R, Geerling G (2016) Descemet-membrane endothelial keratoplasty in patients with retinal comorbidity-a prospective cohort study. Int J Ophthalmol 9:390\u2013394","journal-title":"Int J Ophthalmol"},{"key":"5152_CR12","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1097\/01.ico.0000243962.60392.4f","volume":"25","author":"GR Melles","year":"2006","unstructured":"Melles GR, Ong TS, Ververs B, van der Wees J (2006) Descemet membrane endothelial keratoplasty (DMEK). Cornea 25:987\u2013990","journal-title":"Cornea"},{"key":"5152_CR13","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/sj.eye.6702326","volume":"21","author":"M Tappin","year":"2007","unstructured":"Tappin M (2007) A method for true endothelial cell (Tencell) transplantation using a custom-made cannula for the treatment of endothelial cell failure. Eye (Lond) 21:775\u2013779","journal-title":"Eye (Lond)"},{"key":"5152_CR14","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.ajo.2007.09.021","volume":"145","author":"GR Melles","year":"2008","unstructured":"Melles GR, Ong TS, Ververs B, van der Wees J (2008) Preliminary clinical results of Descemet membrane endothelial keratoplasty. Am J Ophthalmol 145:222\u2013227","journal-title":"Am J Ophthalmol"},{"key":"5152_CR15","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.ajo.2018.11.014","volume":"199","author":"RS Birbal","year":"2019","unstructured":"Birbal RS, Tong CM, Dapena I, Parker JS, Parker JS, Oellerich S, Melles GRJ (2019) Clinical outcomes of Descemet membrane endothelial keratoplasty in eyes with a glaucoma drainage device. Am J Ophthalmol 199:150\u2013158","journal-title":"Am J Ophthalmol"},{"key":"5152_CR16","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1097\/ICO.0000000000001763","volume":"38","author":"A Pasari","year":"2019","unstructured":"Pasari A, Price MO, Feng MT, Price FW Jr (2019) Descemet membrane endothelial keratoplasty for failed penetrating keratoplasty: visual outcomes and graft survival. Cornea 38:151\u2013156","journal-title":"Cornea"},{"key":"5152_CR17","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1097\/ICO.0000000000001891","volume":"38","author":"Y Abdelmassih","year":"2019","unstructured":"Abdelmassih Y, Dubrulle P, Sitbon C, El-Khoury S, Guindolet D, Doan S, Labetoulle M, Cochereau I, Gabison EE (2019) Therapeutic challenges and prognosis of Descemet\u2019s membrane endothelial keratoplasty in herpes simplex eye disease. Cornea 38:553\u2013558","journal-title":"Cornea"},{"key":"5152_CR18","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.ajo.2016.07.002","volume":"169","author":"A Schl\u00f6gl","year":"2016","unstructured":"Schl\u00f6gl A, Tourtas T, Kruse FE, Weller JM (2016) Long-term clinical outcome after Descemet membrane endothelial keratoplasty. Am J Ophthalmol 169:218\u2013226","journal-title":"Am J Ophthalmol"},{"key":"5152_CR19","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1038\/eye.2008.393","volume":"23","author":"L Ham","year":"2009","unstructured":"Ham L, Dapena I, van Luijk C, van der Wees J, Melles GR (2009) Descemet membrane endothelial keratoplasty (DMEK) for Fuchs endothelial dystrophy: review of the first 50 consecutive cases. Eye (Lond) 23:1990\u20131998","journal-title":"Eye (Lond)"},{"key":"5152_CR20","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.clae.2012.10.066","volume":"36","author":"K van Dijk","year":"2013","unstructured":"van Dijk K, Ham L, Tse WH, Liarakos VS, Quilendrino R, Yeh RY, Melles GRJ (2013) Near complete visual recovery and refractive stability in modern corneal transplantation: Descemet membrane endothelial keratoplasty (DMEK). Cont Lens Anterior Eye 36:13\u201321","journal-title":"Cont Lens Anterior Eye"},{"key":"5152_CR21","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.ajo.2014.04.008","volume":"158","author":"K van Dijk","year":"2014","unstructured":"van Dijk K, Droutsas K, Hou J, Sangsari S, Liarakos VS, Melles GR (2014) Optical quality of the cornea after Descemet membrane endothelial keratoplasty. Am J Ophthalmol 158:71\u201379","journal-title":"Am J Ophthalmol"},{"key":"5152_CR22","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1097\/ICO.0b013e3182014668","volume":"30","author":"HY Patel","year":"2011","unstructured":"Patel HY, Ormonde S, Brookes NH, Moffatt SL, Sherwin T, Pendergrast DG, McGhee CNJ (2011) The New Zealand National Eye Bank: survival and visual outcome 1 year after penetrating keratoplasty. Cornea 30:760\u2013764","journal-title":"Cornea"},{"key":"5152_CR23","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s10384-016-0489-2","volume":"61","author":"T Ono","year":"2017","unstructured":"Ono T, Ishiyama S, Hayashidera T, Mori Y, Nejima R, Miyata K et al (2017) Twelve-year follow-up of penetrating keratoplasty. Jpn J Ophthalmol 61:131\u2013136","journal-title":"Jpn J Ophthalmol"},{"key":"5152_CR24","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/eye.2017.216","volume":"32","author":"C Croghan","year":"2018","unstructured":"Croghan C, Chou CY, Gajree S, Ramaesh K, Anijeet D (2018) Emergency therapeutic penetrating keratoplasty in a tertiary ophthalmic care facility. Eye (Lond) 32:655\u2013657","journal-title":"Eye (Lond)"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-021-05152-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-021-05152-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-021-05152-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T03:54:27Z","timestamp":1626234867000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-021-05152-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,15]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["5152"],"URL":"https:\/\/doi.org\/10.1007\/s00417-021-05152-w","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,15]]},"assertion":[{"value":"26 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved prior to commencement by the Ethics Committee of the University of Tuebingen (Project Number: 559\/2018BO2), and the study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Signed informed consent was obtained from all patients prior to surgery. Data was analyzed anonymously. No organs\/tissues were obtained from prisoners. The institution from which organs\/tissues were obtained was the Cornea Bank of the Department of Ophthalmology of the University of Tuebingen.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval\/Consent to participate\/Consent for publication"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}