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The ophthalmologic examination included best-corrected visual acuity, intraocular pressure, Schirmer test, tear film breakup time, slit-lamp examination, dilated fundus photography, in vivo corneal confocal microscopy (IVCCM), and optical coherence tomography (OCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study cohort consisted of 83 eyes of 83 individuals: a group of 44 participants with T2DM, and a control group of 39 obese participants with no history of diabetes. Comparing measurements on the two groups, participants with T2DM had lower values with statistical significance for retinal nerve fiber layer (RNFL) nasal superior thickness (<jats:italic>p<\/jats:italic>\u2009=\u20090.010) and three corneal nerve (CN) parameters: fiber length (<jats:italic>p<\/jats:italic>\u2009=\u20090.025), total branch density (<jats:italic>p<\/jats:italic>\u2009=\u20090.013), and fiber area (<jats:italic>p<\/jats:italic>\u2009=\u20090.009). There was a borderline significant difference in CN fiber width (<jats:italic>p<\/jats:italic>\u2009=\u20090.051) and RNFL nasal inferior thickness (<jats:italic>p<\/jats:italic>\u2009=\u20090.056). No other significant differences were observed in the IVCCM and OCT parameters. No statistically significant correlation was found between CN and RNFL parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Progression from a pre-diabetic obese state to a T2DM condition might entail a loss or diminishment of certain corneal nerve fibers or retinal nerve fibers, but not necessarily a loss of both corneal and retinal nerve fibers simultaneously. Using IVCCM and OCT together enables monitoring of both corneal and retinal health of the eye.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00417-021-05251-8","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T06:02:46Z","timestamp":1626760966000},"page":"3339-3350","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["In vivo corneal confocal microscopy and optical coherence tomography on eyes of participants with type 2 diabetes mellitus and obese participants without diabetes"],"prefix":"10.1007","volume":"259","author":[{"given":"No\u00e9mi","family":"T\u00f3th","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Silver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szabolcs","family":"Balla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"K\u00e1pl\u00e1r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7821-2412","authenticated-orcid":false,"given":"Adrienne","family":"Csutak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,20]]},"reference":[{"key":"5251_CR1","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.2522\/ptj.20080008","volume":"88","author":"WT Cade","year":"2008","unstructured":"Cade WT (2008) Diabetes-related microvascular and macrovascular diseases in the physical therapy setting. 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Silver none; Szabolcs Balla, none; Mikl\u00f3s K\u00e1pl\u00e1r, none; Adrienne Csutak MD, PhD, none.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Financial disclosures"}}]}}