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All patients underwent a complete ophthalmological examination including standard automated perimetry, stereoscopic photographs of the optic disc, peripapillary retinal nerve fibre layer analysis and examination of vascular parameters of the optic nerve head (ONH), the peripapillary region and macula using OCTA. In addition to the vascular parameters recorded by the device, the vascular images were graphically evaluated using Image J. All recorded vascular parameters were compared between both groups and correlated to structural and functional parameters.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The mean superficial perifoveal plexus perfusion density (PD) was significantly lower in PXG eyes than compared to POAG eyes using OCTA (32.57%\u2009\u00b1\u20093.57% vs. 34.92%\u2009\u00b1\u20092.11%, <jats:italic>p<\/jats:italic>\u2009=\u20090.007). The mean PD parameters for the superficial peripapillary plexus (40.98%\u2009\u00b1\u20093.04% vs. 42.09%\u2009\u00b1\u20092.29%, <jats:italic>p<\/jats:italic>\u2009=\u20090.152) as well as the size of the foveal avascular zone (FAZ) (0.23 mm<jats:sup>2<\/jats:sup>\u2009\u00b1\u20090.1 mm<jats:sup>2<\/jats:sup> vs. 0.23 mm<jats:sup>2<\/jats:sup>\u2009\u00b1\u20090.09 mm<jats:sup>2<\/jats:sup>) did not differ between both groups. Additional graphic evaluation using Image J showed no significant difference for superficial perifoveal plexus PD (32.97%\u2009\u00b1\u20091.11% vs. 33.35%\u2009\u00b1\u20090.95%, <jats:italic>p<\/jats:italic>\u2009=\u20090.194) and peripapillary plexus PD (46.65%\u2009\u00b1\u20090.83% vs. 46.95%\u2009\u00b1\u20090.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.127) between the groups. Retinal nerve fibre layer (RNFL) thickness correlated significantly with peripapillary plexus PD for both OCTA data and Image J data (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>p<\/jats:italic>\u2009=\u20090.032).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The severity of the glaucoma seems to be crucial for peripapillary and macular perfusion densities, and not the form of glaucoma. An additional graphic evaluation is a possible step that could be implemented to improve the comparability of OCTA scans and to optimize the possibility of quantitative perfusion analysis in the case of deviating quality criteria.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00417-021-05321-x","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T08:02:42Z","timestamp":1631174562000},"page":"957-965","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Macular, papillary and peripapillary perfusion densities measured with optical coherence tomography angiography in primary open angle glaucoma and pseudoexfoliation glaucoma"],"prefix":"10.1007","volume":"260","author":[{"given":"Anna","family":"Cornelius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3397-8139","authenticated-orcid":false,"given":"Daniel","family":"Pilger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5760-0996","authenticated-orcid":false,"given":"Aline","family":"Riechardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuel","family":"Reitemeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6202-1710","authenticated-orcid":false,"given":"Anne","family":"R\u00fcbsam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8509-5149","authenticated-orcid":false,"given":"Sibylle","family":"Winterhalter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8095-0254","authenticated-orcid":false,"given":"Anna-Karina B.","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"issue":"3","key":"5321_CR1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1159\/000504717","volume":"63","author":"C Chamard","year":"2020","unstructured":"Chamard C, Villain M, Bron A, Causse A, Bentaleb Y, Pelen F, Baudouin C, Daien V (2020) Prevalence of unknown ocular hypertension, glaucoma suspects, and glaucoma in patients seen in an ophthalmology center in France. 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Institutional ethical approval was obtained by the Ethics Committee of the Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin (EA4\/168\/17).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All participants provided their written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria, educational grants, participation in speakers\u2019 bureaus, membership, employment, consultancies, stock ownership, or other equity interest and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}