{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:05:41Z","timestamp":1760551541235,"version":"3.37.3"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002345","name":"Eberhard Karls Universit\u00e4t T\u00fcbingen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002345","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background\/objectives<\/jats:title>\n                <jats:p>The correct classification of a slowly progressing optic atrophy can be challenging. The aim of this work was to find out if the characteristics of peripapillary retinal nerve fiber layer (RNFL) thickness loss differ between open angle glaucoma (POAG), optic nerve sheath meningioma (ONSM), and sphenoid wing meningioma (SWM).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 45 patients with POAG, ONSM, and SWM were included in the retrospective study. The peripapillary RNFL thickness measured by spectral-domain optical coherence tomography was analyzed using the Heidelberg Engineering glaucoma module<jats:sup>\u00a9<\/jats:sup>.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Each group consisted of 15 patients. The temporal sector of the RNFL thickness showed a median decrease of\u2009\u2212\u200917\u00a0\u00b5m in glaucoma patients (range\u2009+\u20096\/\u201334\u00a0\u00b5m),\u2009\u2212\u200943\u00a0\u00b5m in ONSM (range\u2009\u2212\u200919\/\u2009\u2212\u200952\u00a0\u00b5m), and\u2009\u2212\u200944\u00a0\u00b5m in SWM patients (range\u2009\u2212\u200925\/\u2009\u2212\u200952\u00a0\u00b5m). The RNFL thickness of the temporal sector of glaucoma patients differed significantly from the other groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). All other sectors showed no significant difference between the 3 groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The peripapillary RNFL thickness of the temporal sector of patients with beginning to moderate POAG is usually inside normal limits or borderline. In contrast, patients with ONSM and SWM are much more likely to show a considerable reduction in RNFL thickness of the temporal sector. RNFL thickness of the temporal sector marked outside normal limits occurred exclusively in meningioma patients. Considering the presence of this condition as a predictor for meningioma, sensitivity and specificity were 0.8 and 1.0, respectively. In patients with significant reduction in RNFL thickness of the temporal sector, magnetic resonance imaging of the head should be considered to rule out compression of the optic nerves.<\/jats:p>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00417-021-05354-2","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T11:50:16Z","timestamp":1632397816000},"page":"577-581","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Characteristics of peripapillary retinal nerve fiber layer atrophy in glaucoma, optic nerve sheath meningioma, and sphenoid wing meningioma"],"prefix":"10.1007","volume":"260","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5192-0347","authenticated-orcid":false,"given":"Felix","family":"Tonagel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Wilhelm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carina","family":"Kelbsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Richter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,9,23]]},"reference":[{"key":"5354_CR1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1097\/00055735-199504000-00014","volume":"6","author":"JS Schuman","year":"1995","unstructured":"Schuman JS, Hee MR, Arya AV, Pedut-Kloizman T, Puliafito CA, Fujimoto JG, Swanson EA (1995) Optical coherence tomography: a new tool for glaucoma diagnosis. 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Curr Opin Ophthalmol 31:455\u2013461. https:\/\/doi.org\/10.1097\/ICU.0000000000000700","journal-title":"Curr Opin Ophthalmol"},{"key":"5354_CR8","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1159\/000508411","volume":"11","author":"E Interlandi","year":"2020","unstructured":"Interlandi E, Pellegrini F, Papayannis A, Cuna A, Mandara E, De Luca M, Cirone D, Ciabattoni C, Marullo M (2020) Optical coherence tomography angiography findings in optic nerve sheath meningioma. 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The ethics committee of the faculty of medicine of the Eberhardt-Karls-University Tuebingen approved the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}