{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:49:16Z","timestamp":1785415756786,"version":"3.56.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"\u00cemedos GmbH, Jena"},{"DOI":"10.13039\/501100002957","name":"Technische Universit\u00e4t Dresden","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002957","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The retinal venous pressure (RVP) is a determining factor for the blood supply of the retina as well as the optic nerve head and until recently has been measured by contact lens dynamometry (CLD). A new method has been developed, potentially offering better acceptance. The applicability and the results of both methods were compared.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The type of this study is cross sectional. The subjects were 36 healthy volunteers, age 26\u2009\u00b1\u20095\u00a0years (mean\u2009\u00b1\u2009s). Tonometry: rebound tonometer (RT) (iCare). The measurements were performed during an increase in airway pressure of 20\u00a0mmHg (Valsalva manoeuvre). Principle of RVP measurement: the central retinal vein (CRV) is observed during an increase of intraocular pressure (IOP) and at the start of pulsation, which corresponds with the RVP. Two different instruments for the IOP enhancement where used: contact lens dynamometry and the new instrument, IOPstim. Principle: a deflated balloon of 8\u00a0mm diameter\u2014placed on the sclera laterally of the cornea\u2014is filled with air. As soon as a venous pulsation occurs, filling is stopped and the IOP is measured, equalling the RVP. Examination procedure: randomization of the sequence: CLD or IOPstim, IOP, mydriasis, IOP three single measurements (SM) of the IOP with RT or of the pressure increase with CLD at an airway pressure of 20\u00a0mmHg, 5\u00a0min break, IOP, and three SM using the second method at equal pressure (20\u00a0mmHg).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Spontaneous pulsation of the CRV was present in all 36 subjects. Pressures are given in mmHg. IOP in mydriasis 15.6\u2009\u00b1\u20093.3\u00a0(m\u2009\u00b1\u2009s). Median RVP (MRVP)) of the three SM: CLD\/IOPstim, 37.7\u2009\u00b1\u20095.2\/24.7\u2009\u00b1\u20094.8 (<jats:italic>t<\/jats:italic> test: <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Range of SM: 3.2\u2009\u00b1\u20091.8\/2.9\u2009\u00b1\u20091.3 (<jats:italic>t<\/jats:italic> test: <jats:italic>p<\/jats:italic>\u2009=\u20090.36). Intraclass correlation coefficient (ICC) of SM: 0.88\/0.83. ANOVA in SM: <jats:italic>p<\/jats:italic>\u2009=\u20090.48\/0.08. MRVP CLD minus MRVP IOPstim: 13.0\u2009\u00b1\u20095.6. Ratio MRVP CLD\/MRVP IOPstim: 1.56\u2009\u00b1\u20093.1. Cooperation and agreeability were slightly better with the IOPstim.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This first study with the IOPstim in humans was deliberately performed in healthy volunteers using Valsalva conditions. As demonstrated by ICC and ANOVA, reproducible SM can be obtained by both methods and the range of the SM does not differ greatly. The higher MRVP in CLD could be explained by the different directions of the force vectors.<\/jats:p>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00417-021-05374-y","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T08:02:42Z","timestamp":1631174562000},"page":"1237-1244","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Measurement of the retinal venous pressure with a new instrument in healthy subjects"],"prefix":"10.1007","volume":"260","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8689-2913","authenticated-orcid":false,"given":"Richard","family":"Stodtmeister","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Wetzk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Herber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin R.","family":"Pillunat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz E.","family":"Pillunat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"5374_CR1","first-page":"648","volume":"154","author":"P Bailliart","year":"1917","unstructured":"Bailliart P (1917) La pression arterielle dans les branches de l\u2019artere centrale de la retine; nouvelle technique pur la determiner. 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Informed consent was obtained from all individual participants included in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The study was funded by Imedos GmbH, Jena, Germany. This company provided the IOPstim instrument and the iCare tonometer. The corresponding author received a travel grant by Imedos GmbH and is consultant to this company.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}