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Meibomian gland loss assessment was determined using a scale with four levels. The Ocular Surface Disease Index (OSDI) questionnaire, phenol red thread (PRT) test, and tear film break-up time (TFBUT) were also completed by the patients. Tear eye drops were formulated with 0.3 g of sodium hyaluronate, P-Plus \u2122, vitamin B12, sodium chloride, potassium chloride, calcium chloride, magnesium chloride, and SCO\u00ae (stabilized complex oxychloride). After 30 days, the patients were re-evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean meibomian gland loss percentage was 37.97 \u00b1 19.02 % (7.20 to 88.30%). Before treatment, the OSDI was 22.53 \u00b1 14.03 score points (6.25 to 77.08). Posterior OSDI decreased to 16.26 \u00b1 13.69 score points (0.00 to 70.83) (\n                      <jats:italic>W<\/jats:italic>\n                      = 58.00,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01). Before treatment, PRT was 10.31 \u00b1 4.48 mm (4.00 to 21.00). Posterior PRT increased to 15.41 \u00b1 6.27 mm (4.00 to 21.00) (\n                      <jats:italic>W<\/jats:italic>\n                      = 1520.50,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01). Before treatment, TFBUT was 6.23 \u00b1 1.75 s (3.00 to 9.00). The posterior TFBUT increased to 8.10 \u00b1 2.06 s (4.00 to 14.00) (\n                      <jats:italic>W<\/jats:italic>\n                      = 1382.50,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The hyaluronic acid 0.3% and vitamin B12 eye drops effectively decreased dry eye symptoms in menopausal women and improved tear stability and volume.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00417-021-05415-6","type":"journal-article","created":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T01:02:26Z","timestamp":1632531746000},"page":"529-535","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy of hyaluronic acid 0.3%, cyanocobalamin, electrolytes, and P-Plus in menopause patients with moderate dry eye disease"],"prefix":"10.1007","volume":"260","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0382-2053","authenticated-orcid":false,"given":"Concepci\u00f3n","family":"De-Hita-Cantalejo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Carmen","family":"S\u00e1nchez-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Silva-Viguera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta C.","family":"Garc\u00eda-Romera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Feria-Mantero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9-Mar\u00eda","family":"S\u00e1nchez-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,25]]},"reference":[{"key":"5415_CR1","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1097\/GME.0000000000001609","volume":"27","author":"Eduard Mension 1 Inmaculada Alonso 1 CC-B 2","year":"2020","unstructured":"Eduard Mension 1 Inmaculada Alonso 1 CC-B 2 (2020) The 2020 genitourinary syndrome of menopause position statement of The North American Menopause Society. 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