{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T07:16:03Z","timestamp":1782112563952,"version":"3.54.5"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To assess the safety and effectiveness of augmented MicroPulse (MP-TSCPC) with limited Continuous Wave Transscleral Cyclophotocoagulation (CW-TSCPC) in patients with refractory glaucoma.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Thirty-eight eyes of 38 patients underwent combined MP-TSCPC and CW-TSCPC at Massachusetts Eye and Ear. Kaplan\u2013Meier survival curves and Wilcoxon paired sign rank tests were performed to evaluate intraocular pressure (IOP), glaucoma medication burden, best corrected visual acuity (BCVA), and adverse events.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>With success defined as IOP reduction\u2009\u2265\u200930% and IOP between 5 and 18\u00a0mmHg, the cumulative probability of success at 1\u00a0year and 1.5\u00a0years were 0.81 (95% confidence interval (CI), 0.68\u20130.96) and 0.65 (95% CI, 0.50\u20130.86), respectively. With success defined as IOP reduction\u2009\u2265\u200950% and IOP between 5 and 18\u00a0mmHg, the success probability at 1\u00a0year and 1.5\u00a0years were 0.72 (95% CI, 0.57\u20130.89) and 0.56 (95% CI, 0.40\u20130.78), respectively. IOP and medication burden reductions were significant at all follow-up visits compared to baseline. Average IOP decreased from 27.9\u00a0mmHg at baseline to 11.4\u00a0mmHg at 1\u00a0year (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and 10.0\u00a0mmHg at 1.5\u00a0years (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Average medication burden decreased from 3.8 to 1.7 at 1.5\u00a0years (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). No significant differences in visual acuity were observed at any time point. No long-term sight-threatening complications due to the combined procedure were observed, and most of the complications observed were mild and transient.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In patients with refractory glaucoma, the combination of augmented MP-TSCPC with limited CW-TSCPC provides a significant IOP-lowering effect and decrease in medication burden without increased risk of postoperative complications.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00417-021-05436-1","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T08:03:41Z","timestamp":1635149021000},"page":"1583-1592","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Outcomes of a combination of augmented MicroPulse and limited Continuous Wave Cyclophotocoagulation in patients with refractory glaucoma"],"prefix":"10.1007","volume":"260","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9910-5405","authenticated-orcid":false,"given":"Sanchay","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6726-4508","authenticated-orcid":false,"given":"Enchi Kristina","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2845-160X","authenticated-orcid":false,"given":"Marika","family":"Chachanidze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Neeson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Klug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ta Chen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5636-6720","authenticated-orcid":false,"given":"David A.","family":"Sol\u00e1-Del Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,25]]},"reference":[{"issue":"5\u20136","key":"5436_CR1","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1080\/08820538.2020.1810711","volume":"35","author":"N Anand","year":"2020","unstructured":"Anand N, Klug E, Nirappel A, Valle DS (2020) A review of cyclodestructive procedures for the treatment of glaucoma. 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