{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:00:55Z","timestamp":1761897655611,"version":"3.37.3"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T00:00:00Z","timestamp":1641081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T00:00:00Z","timestamp":1641081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the Basic Science Research Program through the National Research Foundation of Korea","award":["NRF-2020R1F1A1072226"],"award-info":[{"award-number":["NRF-2020R1F1A1072226"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s00417-021-05454-z","type":"journal-article","created":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T17:02:33Z","timestamp":1641142953000},"page":"1139-1145","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Differences in the incidence of aflibercept-related sterile endophthalmitis according to types of disposable syringes used"],"prefix":"10.1007","volume":"260","author":[{"given":"Minjeong","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0818-6159","authenticated-orcid":false,"given":"Jee Taek","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,2]]},"reference":[{"key":"5454_CR1","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1056\/NEJMoa054481","volume":"355","author":"PJ Rosenfeld","year":"2006","unstructured":"Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, Kim RY (2006) Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 355:1419\u20131431. https:\/\/doi.org\/10.1056\/NEJMoa054481","journal-title":"N Engl J Med"},{"key":"5454_CR2","doi-asserted-by":"publisher","first-page":"627674","DOI":"10.1155\/2015\/627674","volume":"2015","author":"V Tah","year":"2015","unstructured":"Tah V, Orlans HO, Hyer J, Casswell E, Din N, Sri Shanmuganathan V, Ramskold L, Pasu S (2015) Anti-VEGF Therapy and the retina: an update. J Ophthalmol 2015:627674. https:\/\/doi.org\/10.1155\/2015\/627674","journal-title":"J Ophthalmol"},{"key":"5454_CR3","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.ajo.2014.06.019","volume":"158","author":"RA Goldberg","year":"2014","unstructured":"Goldberg RA, Shah CP, Wiegand TW, Heier JS (2014) Noninfectious inflammation after intravitreal injection of aflibercept: clinical characteristics and visual outcomes. Am J Ophthalmol 158:733-737.e731. https:\/\/doi.org\/10.1016\/j.ajo.2014.06.019","journal-title":"Am J Ophthalmol"},{"key":"5454_CR4","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1097\/iae.0000000000000801","volume":"36","author":"PD Williams","year":"2016","unstructured":"Williams PD, Chong D, Fuller T, Callanan D (2016) Noninfectious vitritis after intravitreal injection of anti-VEGF agents: variations in rates and presentation by medication. Retina 36:909\u2013913. https:\/\/doi.org\/10.1097\/iae.0000000000000801","journal-title":"Retina"},{"key":"5454_CR5","doi-asserted-by":"publisher","first-page":"1100\u20131101","DOI":"10.1016\/j.ophtha.2012.11.018","volume":"120","author":"P Hahn","year":"2013","unstructured":"Hahn P, Kim JE, Stinnett S, Chung MM, Dugel PU, Flynn HW Jr, Huang SS, Sadda SR, Mahmoud TH (2013) Aflibercept-related sterile inflammation. Ophthalmol 120:1100\u20131101-e1101 1105. https:\/\/doi.org\/10.1016\/j.ophtha.2012.11.018","journal-title":"Ophthalmol"},{"key":"5454_CR6","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1001\/jamaophthalmol.2014.5650","volume":"133","author":"P Hahn","year":"2015","unstructured":"Hahn P, Chung MM, Flynn HW Jr, Huang SS, Kim JE, Mahmoud TH, Sadda SR, Dugel PU (2015) Postmarketing analysis of aflibercept-related sterile intraocular inflammation. JAMA Ophthalmol 133:421\u2013426. https:\/\/doi.org\/10.1001\/jamaophthalmol.2014.5650","journal-title":"JAMA Ophthalmol"},{"key":"5454_CR7","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s10456-011-9249-6","volume":"15","author":"N Papadopoulos","year":"2012","unstructured":"Papadopoulos N, Martin J, Ruan Q, Rafique A, Rosconi MP, Shi E, Pyles EA, Yancopoulos GD, Stahl N, Wiegand SJ (2012) Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. Angiogenesis 15:171\u2013185. https:\/\/doi.org\/10.1007\/s10456-011-9249-6","journal-title":"Angiogenesis"},{"key":"5454_CR8","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ymeth.2005.01.001","volume":"36","author":"WY Hwang","year":"2005","unstructured":"Hwang WY, Foote J (2005) Immunogenicity of engineered antibodies. Methods 36:3\u201310. https:\/\/doi.org\/10.1016\/j.ymeth.2005.01.001","journal-title":"Methods"},{"key":"5454_CR9","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.ajo.2005.03.057","volume":"140","author":"DA Jabs","year":"2005","unstructured":"Jabs DA, Nussenblatt RB, Rosenbaum JT, Standardization of Uveitis Nomenclature Working G (2005) Standardization of uveitis nomenclature for reporting clinical data. Results of the first international workshop. Am J Ophthalmol 140:509\u2013516. https:\/\/doi.org\/10.1016\/j.ajo.2005.03.057","journal-title":"Am J Ophthalmol"},{"key":"5454_CR10","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3928\/23258160-20190503-05","volume":"50","author":"GB Melo","year":"2019","unstructured":"Melo GB, Figueira ACM, Batista FAH, Filho A, Rodrigues EB, Belfort R Jr, Maia M (2019) Inflammatory reaction after aflibercept intravitreal injections associated with silicone oil droplets released from syringes: a case-control study. Ophthalmic Surg Lasers Imaging Retina 50:288\u2013294. https:\/\/doi.org\/10.3928\/23258160-20190503-05","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"5454_CR11","first-page":"212","volume":"45","author":"TJ Speaker","year":"1991","unstructured":"Speaker TJ, Turco SJ, Nardone DA, Miripol JE (1991) A study of the interaction of selected drugs and plastic syringes. J Parenter Sci Technol 45:212\u2013217","journal-title":"J Parenter Sci Technol"},{"key":"5454_CR12","first-page":"210","volume":"29","author":"CI Hicks","year":"1972","unstructured":"Hicks CI, Gallardo JP, Guillory JK (1972) Stability of sodium bicarbonate injection stored in polypropylene syringes. Am J Hosp Pharm 29:210\u2013216","journal-title":"Am J Hosp Pharm"},{"key":"5454_CR13","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.xphs.2016.12.007","volume":"106","author":"H Kiminami","year":"2017","unstructured":"Kiminami H, Krueger AB, Abe Y, Yoshino K, Carpenter JF (2017) Impact of Sterilization method on protein aggregation and particle formation in polymer-based syringes. J Pharm Sci 106:1001\u20131007. https:\/\/doi.org\/10.1016\/j.xphs.2016.12.007","journal-title":"J Pharm Sci"},{"key":"5454_CR14","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.xphs.2018.09.029","volume":"108","author":"K Funatsu","year":"2019","unstructured":"Funatsu K, Kiminami H, Abe Y, Carpenter JF (2019) Impact of ethylene oxide sterilization of polymer-based prefilled syringes on chemical degradation of a model therapeutic protein during storage. J Pharm Sci 108:770\u2013774. https:\/\/doi.org\/10.1016\/j.xphs.2018.09.029","journal-title":"J Pharm Sci"},{"key":"5454_CR15","doi-asserted-by":"publisher","first-page":"175","DOI":"10.5935\/0004-2749.20200031","volume":"83","author":"GB Melo","year":"2020","unstructured":"Melo GB, Ferreira M, Maia M (2020) Survey among retina specialists in Brazil about inflammatory reactions after intravitreal antiangiogenic therapy. Arq Bras Oftalmol 83:175\u2013179. https:\/\/doi.org\/10.5935\/0004-2749.20200031","journal-title":"Arq Bras Oftalmol"},{"key":"5454_CR16","doi-asserted-by":"publisher","unstructured":"Melo GB, Cruz N, Emerson GG, Rezende FA, Meyer CH, Uchiyama S, Carpenter J, Shiroma HF, Farah ME, Maia M, Rodrigues EB (2020) Critical analysis of techniques and materials used in devices, syringes, and needles used for intravitreal injections. Prog Retin Eye Res: 100862 https:\/\/doi.org\/10.1016\/j.preteyeres.2020.100862","DOI":"10.1016\/j.preteyeres.2020.100862"},{"key":"5454_CR17","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1002\/jps.23973","volume":"103","author":"A Gerhardt","year":"2014","unstructured":"Gerhardt A, McGraw NR, Schwartz DK, Bee JS, Carpenter JF, Randolph TW (2014) Protein aggregation and particle formation in prefilled glass syringes. J Pharm Sci 103:1601\u20131612. https:\/\/doi.org\/10.1002\/jps.23973","journal-title":"J Pharm Sci"},{"key":"5454_CR18","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1016\/j.xphs.2017.02.008","volume":"106","author":"CF Chisholm","year":"2017","unstructured":"Chisholm CF, Soucie KR, Song JS, Strauch P, Torres RM, Carpenter JF, Ragheb JA, Randolph TW (2017) Immunogenicity of structurally perturbed hen egg lysozyme adsorbed to silicone oil microdroplets in wild-type and transgenic mouse models. J Pharm Sci 106:1519\u20131527. https:\/\/doi.org\/10.1016\/j.xphs.2017.02.008","journal-title":"J Pharm Sci"},{"key":"5454_CR19","doi-asserted-by":"publisher","first-page":"3681","DOI":"10.1002\/jps.24573","volume":"104","author":"CF Chisholm","year":"2015","unstructured":"Chisholm CF, Nguyen BH, Soucie KR, Torres RM, Carpenter JF, Randolph TW (2015) In vivo analysis of the potency of silicone oil microdroplets as immunological adjuvants in protein formulations. J Pharm Sci 104:3681\u20133690. https:\/\/doi.org\/10.1002\/jps.24573","journal-title":"J Pharm Sci"},{"key":"5454_CR20","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1016\/j.xphs.2016.02.019","volume":"105","author":"CF Chisholm","year":"2016","unstructured":"Chisholm CF, Baker AE, Soucie KR, Torres RM, Carpenter JF, Randolph TW (2016) Silicone oil microdroplets can induce antibody responses against recombinant murine growth hormone in mice. J Pharm Sci 105:1623\u20131632. https:\/\/doi.org\/10.1016\/j.xphs.2016.02.019","journal-title":"J Pharm Sci"},{"key":"5454_CR21","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1002\/jps.24184","volume":"104","author":"E Krayukhina","year":"2015","unstructured":"Krayukhina E, Tsumoto K, Uchiyama S, Fukui K (2015) Effects of syringe material and silicone oil lubrication on the stability of pharmaceutical proteins. J Pharm Sci 104:527\u2013535. https:\/\/doi.org\/10.1002\/jps.24184","journal-title":"J Pharm Sci"},{"key":"5454_CR22","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1016\/j.xphs.2016.04.015","volume":"105","author":"BM Teska","year":"2016","unstructured":"Teska BM, Brake JM, Tronto GS, Carpenter JF (2016) Aggregation and Particle formation of therapeutic proteins in contact with a novel fluoropolymer surface versus siliconized surfaces: effects of agitation in vials and in prefilled syringes. J Pharm Sci 105:2053\u20132065. https:\/\/doi.org\/10.1016\/j.xphs.2016.04.015","journal-title":"J Pharm Sci"},{"key":"5454_CR23","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1177\/2474126417735963","volume":"1","author":"GG Emerson","year":"2017","unstructured":"Emerson GG (2017) Silicone oil droplets are more common in fluid from BD insulin syringes as compared to other syringes. Journal of VitreoRetinal Diseases 1:401\u2013406. https:\/\/doi.org\/10.1177\/2474126417735963","journal-title":"Journal of VitreoRetinal Diseases"},{"key":"5454_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2020.07.021","author":"JT Thompson","year":"2020","unstructured":"Thompson JT (2020) Prospective study of silicone oil microdroplets in eyes receiving intravitreal anti-vascular endothelial growth factor therapy in 3 different syringes. Ophthalmol Retina. https:\/\/doi.org\/10.1016\/j.oret.2020.07.021","journal-title":"Ophthalmol Retina"},{"key":"5454_CR25","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1136\/bjophthalmol-2019-313823","volume":"104","author":"GB Melo","year":"2020","unstructured":"Melo GB, Emerson GG, Dias CS Jr, Morais FB, Lima Filho AS, Ota S, Farah ME, Rodrigues EB, Maia M, Belfort R Jr (2020) Release of silicone oil and the off-label use of syringes in ophthalmology. Br J Ophthalmol 104:291\u2013296. https:\/\/doi.org\/10.1136\/bjophthalmol-2019-313823","journal-title":"Br J Ophthalmol"},{"key":"5454_CR26","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1136\/ard.2006.065615","volume":"66","author":"GM Bartelds","year":"2007","unstructured":"Bartelds GM, Wijbrandts CA, Nurmohamed MT, Stapel S, Lems WF, Aarden L, Dijkmans BA, Tak PP, Wolbink GJ (2007) Clinical response to adalimumab: relationship to anti-adalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis. Ann Rheum Dis 66:921\u2013926. https:\/\/doi.org\/10.1136\/ard.2006.065615","journal-title":"Ann Rheum Dis"},{"key":"5454_CR27","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1002\/art.21671","volume":"54","author":"GJ Wolbink","year":"2006","unstructured":"Wolbink GJ, Vis M, Lems W, Voskuyl AE, de Groot E, Nurmohamed MT, Stapel S, Tak PP, Aarden L, Dijkmans B (2006) Development of antiinfliximab antibodies and relationship to clinical response in patients with rheumatoid arthritis. Arthritis Rheum 54:711\u2013715. https:\/\/doi.org\/10.1002\/art.21671","journal-title":"Arthritis Rheum"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-021-05454-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-021-05454-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-021-05454-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T02:06:53Z","timestamp":1646964413000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-021-05454-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,2]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["5454"],"URL":"https:\/\/doi.org\/10.1007\/s00417-021-05454-z","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"type":"print","value":"0721-832X"},{"type":"electronic","value":"1435-702X"}],"subject":[],"published":{"date-parts":[[2022,1,2]]},"assertion":[{"value":"9 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the Chung-Ang University Hospital, Seoul, South Korea, and with the 1964 Helsinki declaration.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The need for informed consent was waived owing to the retrospective study design.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}