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Globes were evaluated ex vivo with macroscopic, SLO and OCT imaging. Macula and peripheral regions were processed for Epon embedding and immunocytochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fundus analysis shows hemorrhagic spots and increased vitreous debris in several of the COVID-19 eyes compared to the controls. OCT-based measurements indicated an increased trend in retinal thickness in the COVID-19 eyes; however, the difference was not statistically significant. Histology of the retina showed presence of hemorrhages and central cystoid degeneration in several of the donors. Whole mount analysis of the retina labeled with markers showed changes in retinal microvasculature, increased inflammation, and gliosis in the COVID-19 eyes compared to the controls. The choroidal vasculature displayed localized changes in density and signs of increased inflammation in the COVID-19 samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In situ analysis of the retinal tissue suggests that there are severe subclinical abnormalities that could be detected in the COVID-19 eyes. This study provides a rationale for evaluating the ocular physiology of patients that have recovered from COVID-19 infections to further understand the long-term effects caused by this virus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00417-021-05460-1","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:02:41Z","timestamp":1635465761000},"page":"1275-1288","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Histopathological assessments reveal retinal vascular changes, inflammation, and gliosis in patients with lethal COVID-19"],"prefix":"10.1007","volume":"260","author":[{"given":"Vijay K.","family":"Jidigam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupesh","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia C.","family":"Batoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Milliner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onkar B.","family":"Sawant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera L.","family":"Bonilha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujata","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,29]]},"reference":[{"key":"5460_CR1","doi-asserted-by":"publisher","unstructured":"Chen L, Deng C, Chen X, Zhang X, Chen B, Yu H, Qin Y, Xiao K, Zhang H, Sun X (2020) Ocular manifestations and clinical characteristics of 534 cases of COVID-19 in China: a cross-sectional study. medRxiv: 2020.2003.2012.20034678 DOI https:\/\/doi.org\/10.1101\/2020.03.12.20034678","DOI":"10.1101\/2020.03.12.20034678"},{"key":"5460_CR2","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1080\/09273948.2020.1773868","volume":"28","author":"M Abrishami","year":"2020","unstructured":"Abrishami M, Tohidinezhad F, Daneshvar R, Omidtabrizi A, Amini M, Sedaghat A, Amini S, Reihani H, Allahyari A, Seddigh-Shamsi M, Tayyebi M, Naderi H, Bojdy A, Khodashahi R, Eslami S (2020) Ocular manifestations of hospitalized patients with COVID-19 in northeast of Iran. 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