{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T13:06:56Z","timestamp":1768914416502,"version":"3.49.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"capital clinical diagnosis and treatment technology research and demonstration application project of china","award":["Grant Z191100006619029"],"award-info":[{"award-number":["Grant Z191100006619029"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s00417-021-05531-3","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T08:03:31Z","timestamp":1642061011000},"page":"2175-2182","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Risk factors of persistent subretinal fluid after half-dose photodynamic therapy for treatment-na\u00efve central serous chorioretinopathy"],"prefix":"10.1007","volume":"260","author":[{"given":"Mengyang","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinfeng","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuou","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enzhong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6120-5654","authenticated-orcid":false,"given":"Mingwei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,13]]},"reference":[{"key":"5531_CR1","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1159\/000324599","volume":"46","author":"AC Fok","year":"2011","unstructured":"Fok AC, Chan PP, Lam DS, Lai TY (2011) Risk factors for recurrence of serous macular detachment in untreated patients with central serous chorioretinopathy. Ophthalmic Res 46:160\u2013163. https:\/\/doi.org\/10.1159\/000324599","journal-title":"Ophthalmic Res"},{"key":"5531_CR2","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1097\/IAE.0000000000001729","volume":"38","author":"A Matet","year":"2018","unstructured":"Matet A, Daruich A, Zola M, Behar-Cohen F (2018) Risk factors for recurrences of central serous chorioretinopathy. Retina 38:1403\u20131414. https:\/\/doi.org\/10.1097\/IAE.0000000000001729","journal-title":"Retina"},{"key":"5531_CR3","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1097\/IAE.0000000000001677","volume":"38","author":"C Nathaniel Roybal","year":"2018","unstructured":"Nathaniel Roybal C, Sledz E, Elshatory Y, Zhang L, Almeida DRP, Chin EK, Critser B, Abramoff MD, Russell SR (2018) Dysfunctional autonomic regulation of the choroid in central serous chorioretinopathy. Retina 38:1205\u20131210. https:\/\/doi.org\/10.1097\/IAE.0000000000001677","journal-title":"Retina"},{"key":"5531_CR4","doi-asserted-by":"publisher","first-page":"100770","DOI":"10.1016\/j.preteyeres.2019.07.003","volume":"73","author":"TJ van Rijssen","year":"2019","unstructured":"van Rijssen TJ, van Dijk EHC, Yzer S, Ohno-Matsui K, Keunen JEE, Schlingemann RO, Sivaprasad S, Querques G, Downes SM, Fauser S, Hoyng CB, Piccolino FC, Chhablani JK, Lai TYY, Lotery AJ, Larsen M, Holz FG, Freund KB, Yannuzzi LA, Boon CJF (2019) Central serous chorioretinopathy: towards an evidence-based treatment guideline. Prog Retin Eye Res 73:100770. https:\/\/doi.org\/10.1016\/j.preteyeres.2019.07.003","journal-title":"Prog Retin Eye Res"},{"key":"5531_CR5","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.preteyeres.2015.05.003","volume":"48","author":"A Daruich","year":"2015","unstructured":"Daruich A, Matet A, Dirani A, Bousquet E, Zhao M, Farman N, Jaisser F, Behar-Cohen F (2015) Central serous chorioretinopathy: recent findings and new physiopathology hypothesis. Prog Retin Eye Res 48:82\u2013118. https:\/\/doi.org\/10.1016\/j.preteyeres.2015.05.003","journal-title":"Prog Retin Eye Res"},{"key":"5531_CR6","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1097\/00006982-200602000-00027","volume":"26","author":"M Colucciello","year":"2006","unstructured":"Colucciello M (2006) Choroidal neovascularization complicating photodynamic therapy for central serous retinopathy. Retina 26:239\u2013242. https:\/\/doi.org\/10.1097\/00006982-200602000-00027","journal-title":"Retina"},{"key":"5531_CR7","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1007\/s10384-008-0613-z","volume":"53","author":"PY Lee","year":"2009","unstructured":"Lee PY, Kim KS, Lee WK (2009) Severe choroidal ischemia following photodynamic therapy for pigment epithelial detachment and chronic central serous chorioretinopathy. Jpn J Ophthalmol 53:52\u201356. https:\/\/doi.org\/10.1007\/s10384-008-0613-z","journal-title":"Jpn J Ophthalmol"},{"key":"5531_CR8","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000003067","author":"S Hwang","year":"2020","unstructured":"Hwang S, Noh H, Kang SW, Kang MC, Lee D, Kim SJ (2020) Choroidal neovascularization secondary to photodynamic therapy for central serous chorioretinopathy: incidence, risk factors, and clinical outcomes. Retina. https:\/\/doi.org\/10.1097\/IAE.0000000000003067","journal-title":"Retina"},{"key":"5531_CR9","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1016\/j.ophtha.2008.04.014","volume":"115","author":"WM Chan","year":"2008","unstructured":"Chan WM, Lai TY, Lai RY, Liu DT, Lam DS (2008) Half-dose verteporfin photodynamic therapy for acute central serous chorioretinopathy: one-year results of a randomized controlled trial. Ophthalmology 115:1756\u20131765. https:\/\/doi.org\/10.1016\/j.ophtha.2008.04.014","journal-title":"Ophthalmology"},{"key":"5531_CR10","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1097\/IAE.0000000000002795","volume":"41","author":"J Hu","year":"2021","unstructured":"Hu J, Qu J, Li M, Sun G, Piao Z, Liang Z, Yao Y, Sadda S, Zhao M (2021) Optical coherence tomography angiography-guided photodynamic therapy for acute central serous chorioretinopathy. Retina 41:189\u2013198. https:\/\/doi.org\/10.1097\/IAE.0000000000002795","journal-title":"Retina"},{"key":"5531_CR11","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.ajo.2020.04.022","volume":"217","author":"C Iovino","year":"2020","unstructured":"Iovino C, Au A, Chhablani J, Parameswarappa DC, Rasheed MA, Cennamo G, Cennamo G, Montorio D, Ho AC, Xu D, Querques G, Borrelli E, Sacconi R, Pichi F, Woodstock E, Sadda SR, Corradetti G, Boon CJF, van Dijk EHC, Loewenstein A, Zur D, Yoshimi S, Freund KB, Peiretti E, Sarraf D (2020) Choroidal anatomic alterations after photodynamic therapy for chronic central serous chorioretinopathy: a multicenter study. Am J Ophthalmol 217:104\u2013113. https:\/\/doi.org\/10.1016\/j.ajo.2020.04.022","journal-title":"Am J Ophthalmol"},{"key":"5531_CR12","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1159\/000484100","volume":"240","author":"CY Chung","year":"2018","unstructured":"Chung CY, Chan YY, Li KKW (2018) Angiographic and tomographic prognostic factors of chronic central serous chorioretinopathy treated with half-dose photodynamic therapy. Ophthalmologica 240:37\u201344. https:\/\/doi.org\/10.1159\/000484100","journal-title":"Ophthalmologica"},{"key":"5531_CR13","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1097\/IAE.0b013e318156777f","volume":"28","author":"WM Chan","year":"2008","unstructured":"Chan WM, Lai TY, Lai RY, Tang EW, Liu DT, Lam DS (2008) Safety enhanced photodynamic therapy for chronic central serous chorioretinopathy: one-year results of a prospective study. Retina 28:85\u201393. https:\/\/doi.org\/10.1097\/IAE.0b013e318156777f","journal-title":"Retina"},{"key":"5531_CR14","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1097\/00006982-200202000-00004","volume":"22","author":"RH Loo","year":"2002","unstructured":"Loo RH, Scott IU, Flynn HW Jr, Gass JD, Murray TG, Lewis ML, Rosenfeld PJ, Smiddy WE (2002) Factors associated with reduced visual acuity during long-term follow-up of patients with idiopathic central serous chorioretinopathy. Retina 22:19\u201324. https:\/\/doi.org\/10.1097\/00006982-200202000-00004","journal-title":"Retina"},{"key":"5531_CR15","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1097\/IAE.0000000000002092","volume":"39","author":"J Yu","year":"2019","unstructured":"Yu J, Jiang C, Xu G (2019) Correlations between changes in photoreceptor layer and other clinical characteristics in central serous chorioretinopathy. Retina 39:1110\u20131116. https:\/\/doi.org\/10.1097\/IAE.0000000000002092","journal-title":"Retina"},{"key":"5531_CR16","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1097\/IAE.0000000000001580","volume":"38","author":"E Bousquet","year":"2018","unstructured":"Bousquet E, Bonnin S, Mrejen S, Krivosic V, Tadayoni R, Gaudric A (2018) Optical coherence tomography angiography of flat irregular pigment epithelium detachment in chronic central serous chorioretinopathy. Retina 38:629\u2013638. https:\/\/doi.org\/10.1097\/IAE.0000000000001580","journal-title":"Retina"},{"key":"5531_CR17","doi-asserted-by":"publisher","unstructured":"Chronopoulos A, Kakkassery V, Strobel MA, Fornoff L, Hattenbach LO (2020) The significance of pigment epithelial detachment in central serous chorioretinopathy. Eur J Ophthalmol:1120672120904670.https:\/\/doi.org\/10.1177\/1120672120904670","DOI":"10.1177\/1120672120904670"},{"key":"5531_CR18","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1097\/00006982-200506000-00005","volume":"25","author":"D Bujarborua","year":"2005","unstructured":"Bujarborua D, Chatterjee S, Choudhury A, Bori G, Sarma AK (2005) Fluorescein angiographic features of asymptomatic eyes in central serous chorioretinopathy. Retina 25:422\u2013429. https:\/\/doi.org\/10.1097\/00006982-200506000-00005","journal-title":"Retina"},{"key":"5531_CR19","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.ajo.2012.02.031","volume":"154","author":"IS Song","year":"2012","unstructured":"Song IS, Shin YU, Lee BR (2012) Time-periodic characteristics in the morphology of idiopathic central serous chorioretinopathy evaluated by volume scan using spectral-domain optical coherence tomography. Am J Ophthalmol 154:366-375 e364. https:\/\/doi.org\/10.1016\/j.ajo.2012.02.031","journal-title":"Am J Ophthalmol"},{"key":"5531_CR20","doi-asserted-by":"publisher","first-page":"5859063","DOI":"10.1155\/2019\/5859063","volume":"2019","author":"K Sousa","year":"2019","unstructured":"Sousa K, Viana AR, Pires J, Ferreira C, Queiros L, Falcao M (2019) Outer nuclear layer as the main predictor to anatomic response to half dose photodynamic therapy in chronic central serous retinopathy. J Ophthalmol 2019:5859063. https:\/\/doi.org\/10.1155\/2019\/5859063","journal-title":"J Ophthalmol"},{"key":"5531_CR21","doi-asserted-by":"publisher","first-page":"4659","DOI":"10.1167\/iovs.12-10991","volume":"54","author":"L Yang","year":"2013","unstructured":"Yang L, Jonas JB, Wei W (2013) Optical coherence tomography-assisted enhanced depth imaging of central serous chorioretinopathy. Invest Ophthalmol Vis Sci 54:4659\u20134665. https:\/\/doi.org\/10.1167\/iovs.12-10991","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"5531_CR22","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/j.ajo.2015.08.028","volume":"160","author":"KK Dansingani","year":"2015","unstructured":"Dansingani KK, Balaratnasingam C, Klufas MA, Sarraf D, Freund KB (2015) Optical coherence tomography angiography of shallow irregular pigment epithelial detachments in pachychoroid spectrum disease. Am J Ophthalmol 160:1243-1254 e1242. https:\/\/doi.org\/10.1016\/j.ajo.2015.08.028","journal-title":"Am J Ophthalmol"},{"key":"5531_CR23","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1097\/IAE.0000000000002662","volume":"40","author":"H Hwang","year":"2020","unstructured":"Hwang H, Kim JY, Kim KT, Chae JB, Kim DY (2020) Flat irregular pigment epithelium detachment in central serous chorioretinopathy: a form of pachychoroid neovasculopathy? Retina 40:1724\u20131733. https:\/\/doi.org\/10.1097\/IAE.0000000000002662","journal-title":"Retina"},{"key":"5531_CR24","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.ajo.2015.02.002","volume":"159","author":"R Hage","year":"2015","unstructured":"Hage R, Mrejen S, Krivosic V, Quentel G, Tadayoni R, Gaudric A (2015) Flat irregular retinal pigment epithelium detachments in chronic central serous chorioretinopathy and choroidal neovascularization. Am J Ophthalmol 159:890-903 e893. https:\/\/doi.org\/10.1016\/j.ajo.2015.02.002","journal-title":"Am J Ophthalmol"},{"key":"5531_CR25","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1038\/s41433-020-0858-4","volume":"35","author":"Z Liang","year":"2021","unstructured":"Liang Z, Qu J, Huang L, Linghu D, Hu J, Jin E, Xu H, Li H, Tao Y, Xu X, Liu G, Li Y, Zhao M (2021) Comparison of the outcomes of photodynamic therapy for central serous chorioretinopathy with or without subfoveal fibrin. Eye (Lond) 35:418\u2013424. https:\/\/doi.org\/10.1038\/s41433-020-0858-4","journal-title":"Eye (Lond)"},{"key":"5531_CR26","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1038\/s41433-020-1018-6","volume":"35","author":"J Yu","year":"2021","unstructured":"Yu J, Ye X, Li L, Chang Q, Jiang C (2021) Relationship between photoreceptor layer changes before half-dose photodynamic therapy and functional and anatomic outcomes in central serous chorioretinopathy. Eye (Lond) 35:1002\u20131010. https:\/\/doi.org\/10.1038\/s41433-020-1018-6","journal-title":"Eye (Lond)"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-021-05531-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-021-05531-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-021-05531-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T08:04:39Z","timestamp":1655366679000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-021-05531-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,13]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["5531"],"URL":"https:\/\/doi.org\/10.1007\/s00417-021-05531-3","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,13]]},"assertion":[{"value":"30 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This retrospective study was approved by the Peking University People\u2019s Hospital Review Board and adhered to the tenets of the Declaration of Helsinki and Health Insurance Portability and Accountability Act.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}