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Here, we present a case series and comprehensive review of the literature on patients with isolated eyelid JXG.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We systematically extracted data from our institution\u2019s records of isolated eyelid JXG cases and conducted a search for additional cases from the literature utilising the PubMed, Wanfang, and Chinese National Knowledge Infrastructure (CNKI) databases. Patients with JXG were analysed with respect to age, sex, clinical presentation, therapy, and outcome. Group comparisons were performed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Thirty-two patients (including 13 at our institution and 19 from prior publications) were identified. The median age at first presentation was higher in current patients than in the patients from the published cases (median 9\u00a0years, range 1.2 to 47.0\u00a0years; median 2\u00a0years, range 0.5\u00a0months to 46.0\u00a0years, respectively, <jats:italic>P<\/jats:italic>\u2009=\u20090.014). Of the patients who had known characteristics, no significant differences were observed between the two groups in terms of sex, affected eye, eyelid site, type of cutaneous involvement, or duration of symptoms (each <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Seventeen (54.8%) patients were male. The most common lesion location was the upper eyelid (<jats:italic>n<\/jats:italic>\u2009=\u200910, 62.5%). Twenty-four (75.0%) cutaneous lesions had full-thickness skin involvement; 8 (25.0%) subcutaneous masses had a chalazion-like appearance. Histologically, the JXG masses were characterised by Touton giant cells with inflammatory cells. Additionally, there was no significant difference in treatment modalities between the two groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.072), and 24 (75.0%) patients underwent surgical excision. The overall recurrence-free survival was 3.6 to 52.8 (median 27.0) months in the current patients. For published cases with available follow-up information, there was no recurrence in 10 cases and improvement in 1 case, with a median follow-up of 9.5\u00a0months.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Solitary eyelid JXG is a rare clinical entity and should be included in the differential diagnosis of eyelid mass lesions in patients of all age groups. Surgical excision is often selected for efficient treatment and to obtain an excisional biopsy.<\/jats:p>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00417-022-05560-6","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T05:02:47Z","timestamp":1643259767000},"page":"2339-2345","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["On the knowledge of solitary juvenile xanthogranuloma of the eyelid: a case series and literature review"],"prefix":"10.1007","volume":"260","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4867-8331","authenticated-orcid":false,"given":"Rongxin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4013-5295","authenticated-orcid":false,"given":"Shu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2620-8734","authenticated-orcid":false,"given":"Lijuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5408-5538","authenticated-orcid":false,"given":"Xuanwei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"key":"5560_CR1","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1002\/dc.24430","volume":"48","author":"S Misra","year":"2020","unstructured":"Misra S, Gupta K, Gupta R (2020) Solitary adult xanthogranuloma in external auditory canal: cyto-histopathological correlation of an uncommon entity at an uncommon site. 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