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Subjects at 8 to 13\u00a0years of age with spherical equivalent refraction from\u2009\u2212\u20091.00 to\u2009\u2212\u20095.00 dioptres (D) were included in the OK group (<jats:italic>n<\/jats:italic>\u2009=\u200930) and MSCL group (<jats:italic>n<\/jats:italic>\u2009=\u200923). Relative peripheral corneal defocus (RPCD) and relative peripheral refraction (RPR) were measured before and after wearing lenses. HOAs including spherical aberration (SA), coma, trefoil, and total HOAs, and high (100%) and low (10%) CVA were compared between the groups. Axial length (AL) was measured before and after wearing the lenses for 1\u00a0year.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>After wearing the lenses, subjects in the MSCL group had RPCD and RPR values similar to the OK group at the paracentral (within 2\u00a0mm of the cornea or 20\u00b0 of the retina, all <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05) but larger than the OK group at the periphery (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). All HOAs increased after wearing the lenses except the trefoil in the MSCL group (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). HOAs increased more in the OK group (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The 100% and 10% CVAs were worse in the MSCL group (<jats:italic>p<\/jats:italic>\u2009=\u20090.02 and <jats:italic>p<\/jats:italic>\u2009=\u20090.004). After 1\u00a0year, AL elongation was 0.37\u00a0mm (SD\u2009=\u20090.16) in the MSCL group and 0.28\u00a0mm (0.16) in the OK group (<jats:italic>p<\/jats:italic>\u2009=\u20090.06).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>MSCL produced larger myopic defocus at the periphery, increased less HOAs and had worse CVA than OK lens. The high addition of this MSCL did not result in better myopia control efficacy<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>Chinese Clinical Trial Registry: ChiCTR1800018564. 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This study was approved by the Ethics Committee of the Eye Hospital of Wenzhou Medical University (Approval number: KYK2016-38).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All study subjects gave informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}