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With this knowledge, we expected to find some reason for surgical failure.<\/jats:p>\n            <\/jats:sec><jats:sec>\n              <jats:title>Methods<\/jats:title>\n              <jats:p>Nine CyPass microstents of 8 patients with primary open-angle glaucoma (<jats:italic>n<\/jats:italic>\u2009=\u20091), pseudoexfoliation glaucoma (<jats:italic>n<\/jats:italic>\u2009=\u20095), uveitic glaucoma (<jats:italic>n<\/jats:italic>\u2009=\u20091), and posttraumatic open-angle glaucoma (<jats:italic>n<\/jats:italic>\u2009=\u20091) were explanted due to recurrence of IOP elevation, corneal decompensation, or persistent hypotony. The explants were processed for light and transmission electron microscopy.<\/jats:p>\n            <\/jats:sec><jats:sec>\n              <jats:title>Results<\/jats:title>\n              <jats:p>Fibrotic material, consisting of collagen fibrils, microfibrils, pseudoexfoliation fibrils produced by activated fibroblasts, was detected in the stent lumen of 4\/5 pseudoexfoliation glaucoma patients and also in posttraumatic open-angle glaucoma. Fibrotic material was also present on the outer surface and within fenestrations of the majority of stents. Complete absence of fibrotic reaction was noticed in 3 of 9 microstents.<\/jats:p>\n            <\/jats:sec><jats:sec>\n              <jats:title>Conclusion<\/jats:title>\n              <jats:p>Although MIGS is known to be less invasive than conventional surgery, implants placed in the suprachoroidal space may be adversely affected by a fibrotic tissue reaction resulting in implant failure. Understanding mechanisms and risk factors leading to fibrotic scarring following antiglaucomatous surgery may help to develop novel strategies that improve surgical outcome.<\/jats:p>\n            <\/jats:sec>","DOI":"10.1007\/s00417-022-05620-x","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T08:02:21Z","timestamp":1646812941000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ultrastructural analysis of explanted CyPass microstents and correlation with clinical findings"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7410-2059","authenticated-orcid":false,"given":"Lisa","family":"H\u00fcbner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Schl\u00f6tzer-Schrehardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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The study was approved by ethic committee <i>Ethikkommission der Friedrich-Alexander-Universit\u00e4t<\/i>.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Informed consent was obtained from the patients with respect to microstent removal.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}