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Twenty-four eyes had evaluable postoperative SD-OCT examinations. Bruch\u2019s membrane opening minimum rim width (BMO-MRW) and peripapillary retinal nerve fiber layer (RNFL) thickness were analyzed at baseline before surgery, 1\u00a0day, 2 to 3\u00a0days, and 1\u00a0week after surgery. Changes compared to baseline were correlated to intraocular pressure (IOP).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>One day after surgery, the mean BMO-MRW changed by\u2009+\u200926.17\u00a0\u00b5m, <jats:italic>p<\/jats:italic>\u2009=\u20090.001 (mean IOP reduction by 17.01\u00a0mmHg). This increase persisted on day 2\u20133 with a mean increase of BMO-MRW of\u2009+\u200925.33\u00a0\u00b5m, <jats:italic>p<\/jats:italic>\u2009=\u20090.001 (mean IOP reduction by 20.46\u00a0mmHg) and by week 1 with a mean BMO-MRW increase of\u2009+\u200933.17\u00a0\u00b5m, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 (mean IOP reduction by 22.55\u00a0mmHg). The increase in BMO-MRW correlated significantly with the reduction of IOP on day 1 (Spearman\u2019s rho <jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.656, <jats:italic>p<\/jats:italic>\u2009=\u20090.003) and d2\u20133 (Spearman\u2019s rho <jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.479, <jats:italic>p<\/jats:italic>\u2009=\u20090.038). There was no statistically significant correlation found between the IOP and the increase in BMO-MRW in week 1.<\/jats:p>\n                <jats:p>RNFL thickness showed no significant changes at day 1 as well as days 2\u20133 (<jats:italic>p<\/jats:italic>\u2009\u2265\u20090.078, respectively). It showed a small but significant increase in week 1 by 3.94\u00a0\u00b5m, <jats:italic>p<\/jats:italic>\u2009=\u20090.015.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Structural reversal of disc cupping in BMO-MRW occurs as early as 1\u00a0day after trabeculectomy and correlates to the extent of the IOP reduction. During the whole first week after surgery, a strong increase in BMO-MRW can be noted. The changes in BMO-based parameters need to be considered when evaluating patients\u2019 longitudinal follow-up.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00417-022-05644-3","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T10:06:50Z","timestamp":1649412410000},"page":"3321-3329","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Short-term changes in Bruch\u2019s membrane opening-based morphometrics during the first week after trabeculectomy"],"prefix":"10.1007","volume":"260","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9145-7385","authenticated-orcid":false,"given":"Caroline","family":"Gietzelt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Niklas","family":"L\u00fcke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Adler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"Dietlein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Lappas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Prokosch-Willing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid","family":"Roters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig M.","family":"Heindl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Cursiefen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Enders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,8]]},"reference":[{"issue":"3","key":"5644_CR1","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.ajo.2013.11.007","volume":"157","author":"SK Gardiner","year":"2014","unstructured":"Gardiner SK, Ren R, Yang H, Fortune B, Burgoyne CF, Demirel S (2014) A method to estimate the amount of neuroretinal rim tissue in glaucoma: comparison with current methods for measuring rim area. 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Throughout the whole study, the 1964 Helsinki declaration and its later amendments as well as all applicable national regulations and laws were observed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from all patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}