{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T07:31:56Z","timestamp":1785655916714,"version":"3.56.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:00:00Z","timestamp":1656892800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:00:00Z","timestamp":1656892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s00417-022-05720-8","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T03:16:35Z","timestamp":1656904595000},"page":"3969-3975","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Memantine administration in patients with optic neuritis: a double blind randomized clinical trial"],"prefix":"10.1007","volume":"260","author":[{"given":"Dina","family":"Motamedi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Mayeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahan","family":"Shafie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Sattarpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam Rashidi","family":"Jazani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Tafakhori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payam","family":"Sarraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"key":"5720_CR1","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/j.ajo.2005.01.031","volume":"139","author":"AC Arnold","year":"2005","unstructured":"Arnold AC (2005) Evolving management of optic neuritis and multiple sclerosis. Am J Ophthalmol 139:1101\u20131108","journal-title":"Am J Ophthalmol"},{"key":"5720_CR2","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1136\/jnnp.50.6.758","volume":"50","author":"DA Francis","year":"1987","unstructured":"Francis DA, Compston DA, Batchelor JR, McDonald WI (1987) A reassessment of the risk of multiple sclerosis developing in patients with optic neuritis after extended follow-up. J Neurol Neurosurg Psychiatry 50:758\u2013765","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"5720_CR3","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.jneuroim.2005.02.002","volume":"162","author":"H Roed","year":"2005","unstructured":"Roed H, Frederiksen J, Langkilde A, S\u00f8rensen TL, Lauritzen M, Sellebjerg F (2005) Systemic T-cell activation in acute clinically isolated optic neuritis. J Neuroimmunol 162:165\u2013172","journal-title":"J Neuroimmunol"},{"key":"5720_CR4","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.survophthal.2019.06.001","volume":"64","author":"A Abel","year":"2019","unstructured":"Abel A, McClelland C, Lee MS (2019) Critical review: typical and atypical optic neuritis. Surv Ophthalmol 64:770\u2013779","journal-title":"Surv Ophthalmol"},{"key":"5720_CR5","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/S0161-6420(13)31589-9","volume":"100","author":"RW Beck","year":"1993","unstructured":"Beck RW, Kupersmith MJ, Cleary PA, Katz B, Group ONS (1993) Fellow eye abnormalities in acute unilateral optic neuritis: experience of the Optic Neuritis Treatment Trial. Ophthalmology 100:691\u2013698","journal-title":"Ophthalmology"},{"key":"5720_CR6","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s00417-011-1894-3","volume":"250","author":"MR Esfahani","year":"2012","unstructured":"Esfahani MR, Harandi ZA, Movasat M, Nikdel M, Adelpour M, Momeni A, Merat H, Fard MA (2012) Memantine for axonal loss of optic neuritis. Graefe\u2019s Arch Clin Exp Ophthalmol Albr von Graefes Arch fur Klin und Exp Ophthalmol 250:863\u2013869","journal-title":"Graefe\u2019s Arch Clin Exp Ophthalmol Albr von Graefes Arch fur Klin und Exp Ophthalmol"},{"key":"5720_CR7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S1474-4422(13)70259-X","volume":"13","author":"AT Toosy","year":"2014","unstructured":"Toosy AT, Mason DF, Miller DH (2014) Optic neuritis. Lancet Neurol 13:83\u201399","journal-title":"Lancet Neurol"},{"key":"5720_CR8","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1056\/NEJMoa013128","volume":"348","author":"B Reisberg","year":"2003","unstructured":"Reisberg B, Doody R, St\u00f6ffler A, Schmitt F, Ferris S, M\u00f6bius HJ (2003) Memantine in moderate-to-severe Alzheimer\u2019s disease. N Engl J Med 348:1333\u20131341","journal-title":"N Engl J Med"},{"key":"5720_CR9","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1186\/s12974-020-01913-2","volume":"17","author":"L-W Yick","year":"2020","unstructured":"Yick L-W, Tang C-H, Ma OK-F, Kwan JS-C, Chan K-H (2020) Memantine ameliorates motor impairments and pathologies in a mouse model of neuromyelitis optica spectrum disorders. J Neuroinflammation 17:236","journal-title":"J Neuroinflammation"},{"key":"5720_CR10","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1097\/NEN.0000000000000073","volume":"73","author":"K-W S\u00fchs","year":"2014","unstructured":"S\u00fchs K-W, Fairless R, Williams SK, Heine K, Cavali\u00e9 A, Diem R (2014) N-methyl-D-aspartate receptor blockade is neuroprotective in experimental autoimmune optic neuritis. J Neuropathol Exp Neurol 73:507\u2013518","journal-title":"J Neuropathol Exp Neurol"},{"key":"5720_CR11","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s10384-021-00840-w","volume":"65","author":"M Nakazawa","year":"2021","unstructured":"Nakazawa M, Ishikawa H, Sakamoto T (2021) Current understanding of the epidemiologic and clinical characteristics of optic neuritis. Jpn J Ophthalmol 65:439\u2013447","journal-title":"Jpn J Ophthalmol"},{"key":"5720_CR12","first-page":"CD003154","volume":"3","author":"R McShane","year":"2019","unstructured":"McShane R, Westby MJ, Roberts E, Minakaran N, Schneider L, Farrimond LE, Maayan N, Ware J, Debarros J (2019) Memantine for dementia. Cochrane database Syst Rev 3:CD003154","journal-title":"Cochrane database Syst Rev"},{"key":"5720_CR13","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jns.2016.02.012","volume":"363","author":"L Peyro Saint Paul","year":"2016","unstructured":"Peyro Saint Paul L, Creveuil C, Heinzlef O et al (2016) Efficacy and safety profile of memantine in patients with cognitive impairment in multiple sclerosis: a randomized, placebo-controlled study. J Neurol Sci 363:69\u201376","journal-title":"J Neurol Sci"},{"key":"5720_CR14","doi-asserted-by":"publisher","first-page":"574748","DOI":"10.3389\/fneur.2020.574748","volume":"11","author":"CWR Turalde","year":"2020","unstructured":"Turalde CWR, Espiritu AI, Anlacan VMM (2020) Memantine for multiple sclerosis: a systematic review and meta-analysis of randomized trials. Front Neurol 11:574748","journal-title":"Front Neurol"},{"key":"5720_CR15","doi-asserted-by":"publisher","first-page":"189","DOI":"10.4103\/tjo.tjo_22_20","volume":"10","author":"W Ong Chin Feng","year":"2020","unstructured":"Ong Chin Feng W, Wan Hitam WH (2020) Evaluation of retinal nerve fiber layer thickness and optic nerve functions in fellow eye of neuromyelitis optica with unilateral optic neuritis. Taiwan J Ophthalmol 10:189\u2013196","journal-title":"Taiwan J Ophthalmol"},{"key":"5720_CR16","doi-asserted-by":"publisher","first-page":"e0170847","DOI":"10.1371\/journal.pone.0170847","volume":"12","author":"H Stiebel-Kalish","year":"2017","unstructured":"Stiebel-Kalish H, Lotan I, Brody J, Chodick G, Bialer O, Marignier R, Bach M, Hellmann MA (2017) Retinal nerve fiber layer may be better preserved in MOG-IgG versus AQP4-IgG optic neuritis: a cohort study.\u00a0PLoS One\u00a012:e0170847","journal-title":"PLoS ONE"},{"key":"5720_CR17","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.jns.2019.02.015","volume":"399","author":"JJ Luo","year":"2019","unstructured":"Luo JJ, Bumanlag F, Dun N (2019) Low-contrast visual evoked potential and early detection of optic demyelination. J Neurol Sci 399:108\u2013110","journal-title":"J Neurol Sci"},{"key":"5720_CR18","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12974-021-02160-9","volume":"18","author":"J Havla","year":"2021","unstructured":"Havla J, Pakeerathan T, Schwake C et al (2021) Age-dependent favorable visual recovery despite significant retinal atrophy in pediatric MOGAD: how much retina do you really need to see well? J Neuroinflammation 18:121","journal-title":"J Neuroinflammation"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-022-05720-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-022-05720-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-022-05720-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T07:06:30Z","timestamp":1668495990000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-022-05720-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,4]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["5720"],"URL":"https:\/\/doi.org\/10.1007\/s00417-022-05720-8","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,4]]},"assertion":[{"value":"10 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the Tehran University of Medical Sciences and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}},{"value":"Written informed consent was obtained from all participants for research purposes.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers\u2019 bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}