{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:18:21Z","timestamp":1787854701062,"version":"build-2784847793"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s00417-022-05749-9","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T23:22:32Z","timestamp":1657063352000},"page":"3919-3925","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Changes in retinal vessel and retinal layer thickness after cross-linking in keratoconus via swept-source OCT angiography"],"prefix":"10.1007","volume":"260","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0196-8534","authenticated-orcid":false,"given":"Yusuf","family":"Ayaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1842-0906","authenticated-orcid":false,"given":"Olgar","family":"\u00d6cal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2544-6618","authenticated-orcid":false,"given":"\u00c7isil","family":"Erkan Pota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6876-554X","authenticated-orcid":false,"given":"Ersan","family":"\u00c7etinkaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1720-8065","authenticated-orcid":false,"given":"Muhammet Kaz\u0131m","family":"Erol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8358-6390","authenticated-orcid":false,"given":"Mustafa","family":"\u00dcnal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"5749_CR1","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S0039-6257(97)00119-7","volume":"42","author":"YS Rabinowitz","year":"1998","unstructured":"Rabinowitz YS (1998) Keratoconus. Surv Ophthalmol 42:297\u2013319","journal-title":"Surv Ophthalmol"},{"key":"5749_CR2","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1006\/exer.1997.0410","volume":"66","author":"E Spoerl","year":"1998","unstructured":"Spoerl E, Huhle M, Seiler T (1998) Induction of cross-links in corneal tissue. Exp Eye Res 66:97\u2013103","journal-title":"Exp Eye Res"},{"issue":"5","key":"5749_CR3","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/s0002-9394(02)02220-1","volume":"135","author":"G Wollensak","year":"2003","unstructured":"Wollensak G, Spoerl E, Seiler T (2003) Riboflavin\/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol 135(5):620\u2013627. https:\/\/doi.org\/10.1016\/s0002-9394(02)02220-1","journal-title":"Am J Ophthalmol"},{"issue":"5","key":"5749_CR4","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.jcrs.2007.12.039","volume":"34","author":"F Raiskup-Wolf","year":"2008","unstructured":"Raiskup-Wolf F, Hoyer A, Spoerl E, Pillunat LE (2008) Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results. J Cataract Refract Surg 34(5):796\u2013801. https:\/\/doi.org\/10.1016\/j.jcrs.2007.12.039","journal-title":"J Cataract Refract Surg"},{"issue":"4","key":"5749_CR5","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.ajo.2009.10.021","volume":"149","author":"A Caporossi","year":"2010","unstructured":"Caporossi A, Mazzotta C, Baiocchi S, Caporossi T (2010) Long-term results of riboflavin ultraviolet a corneal collagen cross-linking for keratoconus in Italy: the Siena eye cross study. Am J Ophthalmol 149(4):585\u2013593. https:\/\/doi.org\/10.1016\/j.ajo.2009.10.021","journal-title":"Am J Ophthalmol"},{"key":"5749_CR6","doi-asserted-by":"publisher","first-page":"375","DOI":"10.3928\/1081597X-20100114-03","volume":"26","author":"L Caporossi","year":"2010","unstructured":"Caporossi L (2010) Corneal collagen cross-linking with riboflavin and UVA irradiation in pellucid marginal degeneration. J Refract Surg 26:375\u2013377","journal-title":"J Refract Surg"},{"key":"5749_CR7","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1055\/s-2005-857950","volume":"222","author":"M Kohlhaas","year":"2005","unstructured":"Kohlhaas M, Spoerl E, Speck A et al (2005) A new treatment of keratectasia after LASIK by using collagen with riboflavin\/UVA light cross-linking [in Germany]. Klin Monbl Augenheilkd 222:430\u2013436","journal-title":"Klin Monbl Augenheilkd"},{"issue":"4","key":"5749_CR8","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1136\/bjo.2010.179424","volume":"95","author":"JP Salgado","year":"2011","unstructured":"Salgado JP, Khoramnia R, Lohmann CP, Winkler von Mohrenfels C (2011) Corneal collagen crosslinking in post-LASIK keratectasia. Br J Ophthalmol 95(4):493\u2013497. https:\/\/doi.org\/10.1136\/bjo.2010.179424","journal-title":"Br J Ophthalmol"},{"issue":"9","key":"5749_CR9","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1016\/s0886-3350(03)00407-3","volume":"29","author":"G Wollensak","year":"2003","unstructured":"Wollensak G, Spoerl E, Seiler T (2003) Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking. J Cataract Refract Surg 29(9):1780\u20131785. https:\/\/doi.org\/10.1016\/s0886-3350(03)00407-3","journal-title":"J Cataract Refract Surg"},{"issue":"2","key":"5749_CR10","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.jcrs.2005.12.092","volume":"32","author":"M Kohlhaas","year":"2006","unstructured":"Kohlhaas M, Spoerl E, Schilde T, Unger G, Wittig C, Pillunat LE (2006) Biomechanical evidence of the distribution of cross-links in corneas treated with riboflavin and ultraviolet A light. J Cataract Refract Surg 32(2):279\u2013283. https:\/\/doi.org\/10.1016\/j.jcrs.2005.12.092","journal-title":"J Cataract Refract Surg"},{"issue":"8","key":"5749_CR11","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1007\/s00417-011-1674-0","volume":"249","author":"E Lanchares","year":"2011","unstructured":"Lanchares E, del Buey MA, Crist\u00f3bal JA, Lavilla L, Calvo B (2011) Biomechanical property analysis after corneal collagen cross-linking in relation to ultraviolet A irradiation time. Graefes Arch Clin Exp Ophthalmol 249(8):1223\u20131227. https:\/\/doi.org\/10.1007\/s00417-011-1674-0","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"3","key":"5749_CR12","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.jcrs.2013.01.026","volume":"39","author":"IM Beshtawi","year":"2013","unstructured":"Beshtawi IM, O\u2019Donnell C, Radhakrishnan H (2013) Biomechanical properties of corneal tissue after ultraviolet-A-riboflavin crosslinking. J Cataract Refract Surg 39(3):451\u2013462. https:\/\/doi.org\/10.1016\/j.jcrs.2013.01.026","journal-title":"J Cataract Refract Surg"},{"key":"5749_CR13","doi-asserted-by":"publisher","first-page":"5273","DOI":"10.1167\/iovs.13-12576","volume":"54","author":"IM Beshtawi","year":"2013","unstructured":"Beshtawi IM, Akhtar R, Hillarby MC et al (2013) Biomechanical properties of human corneas following low- and high-intensity collagen cross-linking determined with scanning acoustic microscopy. Invest Ophthalmol Vis Sci 54:5273\u20135280","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"5749_CR14","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1159\/000076150","volume":"218","author":"E Spoerl","year":"2004","unstructured":"Spoerl E, Wollensak G, Dittert DD, Seiler T (2004) Thermomechanical behavior of collagen-cross-linked porcine cornea. Ophthalmologica 218(2):136\u2013140. https:\/\/doi.org\/10.1159\/000076150","journal-title":"Ophthalmologica"},{"issue":"1","key":"5749_CR15","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1080\/02713680490513182","volume":"29","author":"E Spoerl","year":"2004","unstructured":"Spoerl E, Wollensak G, Seiler T (2004) Increased resistance of crosslinked cornea against enzymatic digestion. Curr Eye Res 29(1):35\u201340. https:\/\/doi.org\/10.1080\/02713680490513182","journal-title":"Curr Eye Res"},{"issue":"9","key":"5749_CR16","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1016\/j.jcrs.2015.10.004","volume":"41","author":"NH Aldahlawi","year":"2015","unstructured":"Aldahlawi NH, Hayes S, O\u2019Brart DP, Meek KM (2015) Standard versus accelerated riboflavin-ultraviolet corneal collagen crosslinking: resistance against enzymatic digestion. J Cataract Refract Surg 41(9):1989\u20131996. https:\/\/doi.org\/10.1016\/j.jcrs.2015.10.004","journal-title":"J Cataract Refract Surg"},{"issue":"2","key":"5749_CR17","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.jcrs.2011.08.041","volume":"38","author":"SA Greenstein","year":"2012","unstructured":"Greenstein SA, Fry KL, Hersh MJ, Hersh PS (2012) Higher-order aberrations after corneal collagen crosslinking for keratoconus and corneal ectasia. J Cataract Refract Surg 38(2):292\u2013302. https:\/\/doi.org\/10.1016\/j.jcrs.2011.08.041","journal-title":"J Cataract Refract Surg"},{"issue":"6","key":"5749_CR18","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.survophthal.2017.06.009","volume":"62","author":"V Mas Tur","year":"2017","unstructured":"Mas Tur V, MacGregor C, Jayaswal R, O\u2019Brart D, Maycock N (2017) A review of keratoconus: diagnosis, pathophysiology, and genetics. Surv Ophthalmol 62(6):770\u2013783. https:\/\/doi.org\/10.1016\/j.survophthal.2017.06.009","journal-title":"Surv Ophthalmol"},{"issue":"4","key":"5749_CR19","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1097\/ICU.0b013e328354865e","volume":"23","author":"K Suri","year":"2012","unstructured":"Suri K, Hammersmith KM, Nagra PK (2012) Corneal collagen cross-linking: ectasia and beyond. Curr Opin Ophthalmol 23(4):280\u2013287. https:\/\/doi.org\/10.1097\/ICU.0b013e328354865e","journal-title":"Curr Opin Ophthalmol"},{"issue":"1","key":"5749_CR20","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jcrs.2010.07.030","volume":"37","author":"PS Hersh","year":"2011","unstructured":"Hersh PS, Greenstein SA, Fry KL (2011) Corneal collagen crosslinking for keratoconus and corneal ectasia: one-year results. J Cataract Refract Surg 37(1):149\u2013160. https:\/\/doi.org\/10.1016\/j.jcrs.2010.07.030","journal-title":"J Cataract Refract Surg"},{"key":"5749_CR21","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.2147\/OPTH.S176025","volume":"12","author":"PR Barbisan","year":"2018","unstructured":"Barbisan PR, Gon\u00e7alves Monteiro Viturino M, Silveira Souto FM et al (2018) Macular phototoxicity after corneal cross-linking. Clin Ophthalmol 12:1801\u20131807","journal-title":"Clin Ophthalmol"},{"issue":"4","key":"5749_CR22","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1097\/ICO.0b013e3180334f78","volume":"26","author":"E Spoerl","year":"2007","unstructured":"Spoerl E, Mrochen M, Sliney D, Trokel S, Seiler T (2007) Safety of UVA-riboflavin cross-linking of the cornea. Cornea 26(4):385\u2013389. https:\/\/doi.org\/10.1097\/ICO.0b013e3180334f78","journal-title":"Cornea"},{"issue":"3","key":"5749_CR23","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.jcrs.2008.11.046","volume":"35","author":"DS Grewal","year":"2009","unstructured":"Grewal DS, Brar GS, Jain R, Sood V, Singla M, Grewal SP (2009) Corneal collagen crosslinking using riboflavin and ultraviolet-A light for keratoconus: one-year analysis using Scheimpflug imaging. J Cataract Refract Surg 35(3):425\u2013432. https:\/\/doi.org\/10.1016\/j.jcrs.2008.11.046","journal-title":"J Cataract Refract Surg"},{"issue":"1","key":"5749_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/eye.2010.149","volume":"25","author":"PN Youssef","year":"2011","unstructured":"Youssef PN, Sheibani N, Albert DM (2011) Retinal light toxicity. Eye (Lond) 25(1):1\u201314. https:\/\/doi.org\/10.1038\/eye.2010.149","journal-title":"Eye (Lond)"},{"key":"5749_CR25","doi-asserted-by":"publisher","unstructured":"International Commission on Non-Ionizing Radiation Protection (ICNIRP) (2004) Guidelines on limits of exposure to ultraviolet radiation of wavelengths between 180 nm and 400 nm (incoherent optical radiation). Health Phys 87(2):171\u2013186. https:\/\/doi.org\/10.1097\/00004032-200408000-00006","DOI":"10.1097\/00004032-200408000-00006"},{"issue":"2","key":"5749_CR26","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1097\/ICO.0000000000002157","volume":"39","author":"A Lazaridis","year":"2020","unstructured":"Lazaridis A, Tsamassiotis S, Droutsas K et al (2020) Revisiting the safety of the corneal collagen crosslinking procedure: evaluation of the effect of ultraviolet A radiation on retinal function and structure. Cornea 39(2):237\u2013244. https:\/\/doi.org\/10.1097\/ICO.0000000000002157","journal-title":"Cornea"},{"key":"5749_CR27","doi-asserted-by":"publisher","first-page":"295","DOI":"10.2147\/OPTH.S189515","volume":"13","author":"H Nauman","year":"2019","unstructured":"Nauman H, Sharif H, Asif M et al (2019) Macular vascular density at the superficial capillary plexus using the optical coherence tomography angiography. Clin Ophthalmol 13:295\u2013302. https:\/\/doi.org\/10.2147\/OPTH.S189515","journal-title":"Clin Ophthalmol"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-022-05749-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-022-05749-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-022-05749-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T02:07:16Z","timestamp":1668478036000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-022-05749-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,6]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["5749"],"URL":"https:\/\/doi.org\/10.1007\/s00417-022-05749-9","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,6]]},"assertion":[{"value":"29 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of the Akdeniz University Medical Faculty (Approval Number KAEK-486). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent to participate and publish Informed consent for publication of their clinical details and\/or clinical images was obtained from all individual participants included in the study. A copy of the consent form is available for review by the Editor of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}