{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:10:44Z","timestamp":1790028644443,"version":"4.0.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["grant no. NU21J-01-00017"],"award-info":[{"award-number":["grant no. NU21J-01-00017"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["DRO (FNOL"],"award-info":[{"award-number":["DRO (FNOL"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["00098892)"],"award-info":[{"award-number":["00098892)"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s00417-022-05760-0","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T09:04:55Z","timestamp":1657789495000},"page":"3977-3984","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Ocular hypertension in patients with active thyroid-associated orbitopathy: a predictor of disease severity, particularly of extraocular muscle enlargement"],"prefix":"10.1007","volume":"260","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0879-3055","authenticated-orcid":false,"given":"Marta","family":"Karhanov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Kalitov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radim","family":"Kov\u00e1\u0159","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Schov\u00e1nek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kar\u00e1sek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"\u010civrn\u00fd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"H\u00fcbnerov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Ml\u010d\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"\u0160\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,14]]},"reference":[{"key":"5760_CR1","first-page":"80","volume":"41","author":"K Wessely","year":"1918","unstructured":"Wessely K (1918) Discussion of Hertel E. Der Dtsch Ophthlmol Ges 41:80\u201381","journal-title":"Der Dtsch Ophthlmol Ges"},{"issue":"5","key":"5760_CR2","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/S0002-9394(99)00473-0","volume":"129","author":"K Ohtsuka","year":"2000","unstructured":"Ohtsuka K, Nakamura Y (2000) Open-angle glaucoma associated with Graves disease. Am J Ophthalmol 129(5):613\u2013617","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"5760_CR3","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1097\/IJG.0b013e31802e644b","volume":"16","author":"Z Behrouzi","year":"2007","unstructured":"Behrouzi Z, Rabei HM, Azizi F, Daftarian N, Mehrabi Y, Ardeshiri M, Mohammadpour M (2007) Prevalence of open-angle glaucoma, glaucoma suspect, and ocular hypertension in thyroid-related immune orbitopathy. J Glaucoma 16(4):358\u2013362","journal-title":"J Glaucoma"},{"issue":"6","key":"5760_CR4","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/S0161-6420(97)30207-3","volume":"104","author":"KP Cockerham","year":"1997","unstructured":"Cockerham KP, Pal C, Jani B, Wolter A, Kennerdell JS (1997) The prevalence and implications of ocular hypertension and glaucoma in thyroid-associated orbitopathy. Ophthalmology 104(6):914\u2013917","journal-title":"Ophthalmology"},{"key":"5760_CR5","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1136\/bjo.82.7.754","volume":"82","author":"R Kalmann","year":"1998","unstructured":"Kalmann R, Mourits MP (1998) Prevalence and management of elevated intraocular pressure in patients with Graves\u2019 orbitopathy. Br J Ophthalmol 82:754\u2013757","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"5760_CR6","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1038\/eye.2008.155","volume":"23","author":"FLM Da Silva","year":"2009","unstructured":"Da Silva FLM, de Lourdes Veronese Rodrigues M, Akaishi PMS, Cruz AAV (2009) Graves\u2019 orbitopathy: frequency of ocular hypertension and glaucoma. Eye 23(4):957\u2013959","journal-title":"Eye"},{"issue":"11","key":"5760_CR7","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1007\/s00417-009-1144-0","volume":"247","author":"O Konuk","year":"2009","unstructured":"Konuk O, Onaran Z, Ozhan Oktar S, Yucel C, Unal M (2009) Intraocular pressure and superior ophthalmic vein blood flow velocity in Graves\u2019 orbitopathy: relation with the clinical features. Graefes Arch Clin Exp Ophthalmol 247(11):1555\u20131559","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"5760_CR8","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1136\/bjo.73.8.639","volume":"73","author":"MP Mouritz","year":"1989","unstructured":"Mouritz MP, Koornneef L, Wiersinga WM, Prummel MF, Berghout A, van der Gaag R (1989) Clinical criteria for the assessment of disease activity in Graves\u00b4 ophthalmopathy: a novel approach. Br J Ophthalmol 73:639\u2013644","journal-title":"Br J Ophthalmol"},{"key":"5760_CR9","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1034\/j.1600-0420.2003.00147.x","volume":"81","author":"P \u00c5sman","year":"2003","unstructured":"\u00c5sman P (2003) Ophthalmological evaluation in thyroid-associated ophthalmopathy. Acta Ophthalmol Scand 81:437\u2013448","journal-title":"Acta Ophthalmol Scand"},{"key":"5760_CR10","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1210\/jcem-44-1-203","volume":"44","author":"SC Werner","year":"1977","unstructured":"Werner SC (1977) Modification of the classification of the eye changes of Graves\u00b4 disease: recommendations of the Ad Hoc Commitee of the American Thyroid Association. J Clin Endocrinol Metab 44:203\u2013204","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"5760_CR11","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1159\/000443828","volume":"5","author":"L Bartalena","year":"2016","unstructured":"Bartalena L, Baldeschi L, Boboridis K, Eckstein A, Kahaly GJ, Marcocci C, European Group on Graves\u2019 orbitopathy (EUGOGO) (2016) The 2016 European Thyroid Association\/European Group on Graves\u2019 Orbitopathy Guidelines for the management of Graves\u2019 orbitopathy. Eur Thyroid J 5(1):9\u201326","journal-title":"Eur Thyroid J"},{"key":"5760_CR12","first-page":"33","volume-title":"Graves' orbitopathy: a multidisciplinary approach-questions and answers","year":"2010","unstructured":"Wiersinga WM, Kahaly GJ (eds) (2010) Graves\u2019 orbitopathy: a multidisciplinary approach-questions and answers, 2nd revised. Karger, Basel, pp 33\u201339","edition":"2nd revised"},{"key":"5760_CR13","doi-asserted-by":"publisher","first-page":"9879503","DOI":"10.1155\/2021\/9879503","volume":"2021","author":"SX Fan","year":"2021","unstructured":"Fan SX, Zeng P, Li ZJ, Wang J, Liang JQ, Liao YR, Hu YX, Xu MT, Wang M (2021) The clinical features of Graves\u2019 orbitopathy with elevated intraocular pressure. J Ophthalmol 2021:9879503. https:\/\/doi.org\/10.1155\/2021\/9879503","journal-title":"J Ophthalmol"},{"issue":"5","key":"5760_CR14","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.survophthal.2009.02.023","volume":"54","author":"MA Nassr","year":"2009","unstructured":"Nassr MA, Morris CL, Netland PA, Karcioglu ZA (2009) Intraocular pressure change in orbital disease. Surv Ophthalmol 54(5):519\u2013544","journal-title":"Surv Ophthalmol"},{"key":"5760_CR15","doi-asserted-by":"publisher","first-page":"9331","DOI":"10.3390\/ijerph17249331","volume":"17","author":"M Gumi\u0144ska","year":"2020","unstructured":"Gumi\u0144ska M, Go\u015b R, \u015amigielski J, Nowak MS (2020) Topical treatment of elevated intraocular pressure in patients with Grave\u2019s orbitopathy. Int J Environ Res Public Health 17:9331","journal-title":"Int J Environ Res Public Health"},{"issue":"2","key":"5760_CR16","first-page":"178","volume":"9","author":"S Gharib","year":"2018","unstructured":"Gharib S, Moazezi Z, Bayani MA (2018) Prevalence and severity of ocular involvement in Graves\u2019 disease according to sex and age: a clinical study from Babol, Iran. Caspian J Intern Med 9(2):178\u2013183","journal-title":"Caspian J Intern Med"},{"key":"5760_CR17","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1007\/s00417-019-04367-2","volume":"257","author":"AG Kuebler","year":"2019","unstructured":"Kuebler AG, Wiecha C, Reznicek L, Klingenstein A, Halfter K, Priglinger S, Hintschich, (2019) Comparison of different devices to measure the intraocular pressure in thyroid-associated orbitopathy. Graefes Arch Clin Exp Ophthalmol 257:2025\u20132032","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"1","key":"5760_CR18","doi-asserted-by":"publisher","first-page":"90","DOI":"10.2478\/folmed-2018-0050","volume":"61","author":"NS Stoyanova","year":"2019","unstructured":"Stoyanova NS, Konareva-Kostianeva M, Mitkova-Hristova V, Anglova I (2019) Correlation between intraocular pressure and thickness of extraocular muscles, the severity and activity of thyroid-associated orbitopathy. Folia Med (Plovdiv) 61(1):90\u201396","journal-title":"Folia Med (Plovdiv)"},{"key":"5760_CR19","first-page":"171","volume":"35","author":"RA Wilinsky","year":"1984","unstructured":"Wilinsky RA, Arenson AM, Hurwitz JJ, Szalai J (1984) Ultrasonic B-scan measurement of the extraocular muscles in Graves\u2019 orbitopathy. J Can Assoc Radiol 35:171\u2013173","journal-title":"J Can Assoc Radiol"},{"key":"5760_CR20","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1034\/j.1600-0420.2003.00037.x","volume":"81","author":"C Fledelius","year":"2003","unstructured":"Fledelius C, Zimmermann-Bielsing T, Feldt-Rasmussen U (2003) Ultrasonically measured horizontal eye muscle thickness in thyroid associated orbitopathy: cross-sectional and longitudinal aspects in a Danish series. Acta Oftalmol Scand 81:143\u2013150","journal-title":"Acta Oftalmol Scand"},{"key":"5760_CR21","doi-asserted-by":"publisher","first-page":"472","DOI":"10.3390\/medicina46070068","volume":"46","author":"D Imbrasien\u0117","year":"2010","unstructured":"Imbrasien\u0117 D, Jankauskien\u0117 J, Stanislovaitien\u0117 D (2010) Ultrasonic measurement of ocular rectus muscle thickness in patients with Graves\u2019 ophthalmopathy. Medicina (Kaunas) 46:472\u2013476","journal-title":"Medicina (Kaunas)"},{"issue":"2","key":"5760_CR22","doi-asserted-by":"publisher","first-page":"307","DOI":"10.5507\/bp.2014.001","volume":"159","author":"M Karhanova","year":"2015","unstructured":"Karhanova M, Kovar R, Frysak Z, Sin M, Zapletalova J, Rehak J, Herman M (2015) Correlation between magnetic resonance imaging and ultrasound measurements of eye muscle thickness in thyroid-associated orbitopathy. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 159(2):307\u2013312","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"5760_CR23","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1016\/S0161-6420(91)32100-6","volume":"98","author":"A Spierer","year":"1991","unstructured":"Spierer A, Eisenstein Z (1991) The role of increased intraocular pressure on upgaze in the assessment of Graves Ophthalmopathy. Ophthalmology 98:1491\u20131494","journal-title":"Ophthalmology"},{"key":"5760_CR24","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1111\/j.1600-0420.2006.00807.x","volume":"85","author":"G Lennerstrand","year":"2007","unstructured":"Lennerstrand G, Tiam S, Isberg B, Landau H\u00f6gbeck I, Bolzani R, Tallstedt L, Schworm (2007) Magnetic resonance imaging and ultrasound measurements of extraocular muscles in thyroid-associated ophthalmopathy at different stages of the disease. Acta Ophthalmol Scand 85:192\u2013201","journal-title":"Acta Ophthalmol Scand"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-022-05760-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-022-05760-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-022-05760-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T19:08:25Z","timestamp":1668539305000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-022-05760-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,14]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["5760"],"URL":"https:\/\/doi.org\/10.1007\/s00417-022-05760-0","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,14]]},"assertion":[{"value":"20 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethics Committee of the University Hospital Olomouc and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors declare that they have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}