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Each patient had a complete glaucoma work-up and 24-h IOP monitoring (6 measurements, including one in the supine position) taken before and on average 6\u00a0months after SLT. The main outcome measures were the reduction of 24-h IOP fluctuations and nocturnal peak IOP. Secondary outcome measures were success rates, factors influencing the reduction of high 24-h IOP fluctuations and nocturnal peak IOP, complications, and severe adverse events.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Medicated mean 24-h IOP (mmHg) was statistically significantly reduced from 15.1\u2009\u00b1\u20092.6 to 13.8\u2009\u00b1\u20092.4 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and IOP fluctuations from 6.5\u2009\u00b1\u20092.7 to 5.4\u2009\u00b1\u20092.6 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) 6\u00a0months after SLT. Ninety-four eyes (59.9%) initially had high IOP fluctuations (more than 5\u00a0mmHg). These were reduced from 8.1\u2009\u00b1\u20092.3 to 5.6\u2009\u00b1\u20092.7 at 6\u00a0months (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Fifty-two eyes (55.3%) had fluctuations below 5\u00a0mmHg post-SLT which was defined as success. Fifty-one patients (32.5%) had nocturnal IOP peaks. In these cases, nocturnal IOP was reduced by 19.2% from 20.1\u2009\u00b1\u20093.4 to 16.2\u2009\u00b1\u20093.3\u00a0mmHg at 6\u00a0months (<jats:italic>P<\/jats:italic>\u2009=\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The current study demonstrates that adjunctive SLT not only reduces mean 24-h IOP in treated POAG patients, but also has an additional benefit in reducing IOP fluctuations and nocturnal peak IOP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>Clinical trial registration: NCT02959242.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00417-022-05897-y","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T13:53:18Z","timestamp":1669297998000},"page":"1979-1985","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy of selective laser trabeculoplasty on lowering intraocular pressure fluctuations and nocturnal peak intraocular pressure in treated primary open-angle glaucoma patients"],"prefix":"10.1007","volume":"261","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4400-6004","authenticated-orcid":false,"given":"Karin R.","family":"Pillunat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta A.","family":"Kocket","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Herber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin S.","family":"Jasper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Lenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz E.","family":"Pillunat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,23]]},"reference":[{"key":"5897_CR1","doi-asserted-by":"publisher","unstructured":"Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK, 2nd, Wilson MR, Gordon MO (2002) The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. 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