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Comprehensive ophthalmic examinations, including best-corrected visual acuity, refraction, color vision test, intraocular pressure measurement, slit-lamp biomicroscopy, ophthalmoscopy, RAPD, exophthalmometry measurements, pVEP test, icVEP test, standard automated perimetry, and clinical activity score classification of TAO, as well as demographic information, were collected and analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In the DON group, the signal-to-noise ratio (SNR) value of icVEPs decreased significantly compared with that of the non-DON group as well as control (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The SNR values under 8%, 16% and 32% depth of modulation (DOM) were significantly negatively correlated with BCVA (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05, <jats:italic>r<\/jats:italic>\u2009=\u2009\u2009\u2212\u20090.9\u2009~\u2009\u2009\u2212\u20090.6), papilledema (Y\/N) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05, <jats:italic>r<\/jats:italic>\u2009=\u2009\u2009\u2212\u20090.8\u2009~\u20090.4) and DON (Y\/N) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>r<\/jats:italic>\u2009=\u2009\u2009\u2212\u20090.7\u2009~\u2009\u2009\u2212\u20090.5). The 8% DOM of icVEP had the largest area under the receiver operating characteristic curve (AUC) (0.842) for discriminating DON from non-DONs. Meanwhile, decision curve analysis (DCA) showed that patients clinically benefit most from 8% DOM of icVEP. Furthermore, the 8% DOM of icVEP combing with papilledema (Y\/N) and BCVA (Model 1) has significantly larger AUC than the 8% DOM of icVEP (<jats:italic>p<\/jats:italic>\u2009=\u20090.0364), and has better clinical benefit in DCA analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The SNR of 8% DOM from icVEP may represent a significant ancillary diagnostic method for DON detection. Furthermore, icVEP combined with papilledema (Y\/N) and BCVA should be considered as a diagnostic model in future clinical practice.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00417-023-05975-9","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T03:03:01Z","timestamp":1673838181000},"page":"2031-2040","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Utility of isolated-check visual evoked potential technique in dysthyroid optic neuropathy"],"prefix":"10.1007","volume":"261","author":[{"given":"Ban","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanluxi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weikun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boding","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,1,16]]},"reference":[{"issue":"4S Suppl 1","key":"5975_CR1","doi-asserted-by":"publisher","first-page":"S60","DOI":"10.1097\/IOP.0000000000001146","volume":"34","author":"P Saeed","year":"2018","unstructured":"Saeed P, Tavakoli Rad S, Bisschop P (2018) Dysthyroid optic neuropathy. 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Informed consent was obtained from all individual participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}