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Ophthalmic assessment included best-corrected visual acuity testing and multimodal retinal imaging with OCT, blue-light autofluorescence, fluorescein and indocyanine green angiography, fundus photography, and widefield pseudocolor and autofluorescence fundus imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The topographic distribution of MEWDS lesions was centered on or around the optic disc (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200917, 59%), centered on the macula (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097, 24%), sectoral (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092, 7%), or was indeterminate (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093, 10%). The MEWDS episodes either occurred in the absence (\u2018primary MEWDS\u2019;\n                      <jats:italic>n<\/jats:italic>\n                      = 14, 48%) or presence of concurrent chorioretinal pathology (\u2018secondary MEWDS\u2019;\n                      <jats:italic>n<\/jats:italic>\n                      = 15, 52%). In patients with the latter, MEWDS lesions were often centered around a coexisting chorioretinal lesion. The majority of patients in both groups experienced resolution of their symptoms and retinal changes on multimodal imaging by 3\u00a0months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Distinct distributions of MEWDS lesions were identified. MEWDS may occur in tandem with other chorioretinal pathology, which may impact the topography of MEWDS lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00417-023-06032-1","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T06:06:22Z","timestamp":1680069982000},"page":"2257-2264","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Topographic patterns of retinal lesions in multiple evanescent white dot syndrome"],"prefix":"10.1007","volume":"261","author":[{"given":"Ariel Yuhan","family":"Ong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Birtel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftherios","family":"Agorogiannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srilakshmi M.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0351-6673","authenticated-orcid":false,"given":"Peter","family":"Charbel Issa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"issue":"5","key":"6032_CR1","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1001\/archopht.1984.01040030527008","volume":"102","author":"LM Jampol","year":"1984","unstructured":"Jampol LM, Sieving PA, Pugh D, Fishman GA, Gilbert H (1984) Multiple evanescent white dot syndrome. 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