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Ocular complications have been reported such as thin corneas, low ocular rigidity, keratoconus, among others. The purpose of this study is to characterize corneal tomographic features in OI patients compared to unaffected patients, with particular focus on commonly studied keratoconus indices.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Cross-sectional case\u2013control study including 37 OI patients and 37 age-matched controls. Patients and controls underwent comprehensive ophthalmological examination including corneal Scheimpflug tomography with a Pentacam HR device (Oculus Optikger\u00e4te GmbH, Wetzlar, Germany) to analyse and compare topometric, tomographic, pachymetric and Belin-Ambr\u00f3sio Enhanced Ectasia Display III (BAD-D) data of both eyes of each patient.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Most OI patients had type I disease (<jats:italic>n<\/jats:italic>\u2009=\u200924; 65%) but type III\u2013VII patients were also included. Two patients had clinically overt bilateral keratoconus. OI patients had significantly higher maximum keratometry (45.2\u2009\u00b1\u20092.1 vs. 43.7\u2009\u00b1\u20091.2; <jats:italic>p<\/jats:italic>\u2009=\u20090.0416), front and back elevation (3.0\u2009\u00b1\u20093.3 vs. 2.1\u2009\u00b1\u20091.3, p\u2009=\u20090.0201; 11.1\u2009\u00b1\u20098.2 vs. 5.0\u2009\u00b1\u20093.7, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), index of surface variance (25.5\u2009\u00b1\u200913 vs. 17.4\u2009\u00b1\u20098.3; <jats:italic>p<\/jats:italic>\u2009=\u20090.0016), index of vertical asymmetry (0.21\u2009\u00b1\u20090.14 vs. 0.15\u2009\u00b1\u20090.06; <jats:italic>p<\/jats:italic>\u2009=\u20090.0215), index of height asymmetry (9.2\u2009\u00b1\u200914 vs. 6.0\u2009\u00b1\u20094.5; <jats:italic>p<\/jats:italic>\u2009=\u20090.0421), index of height decentration (0.02\u2009\u00b1\u20090.01 vs. 0.01\u2009\u00b1\u20090.01; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and average pachymetric progression (1.01\u2009\u00b1\u20090.19 vs. 0.88\u2009\u00b1\u20090.14;<jats:italic> p<\/jats:italic>\u2009&lt;\u20090.0001) readings. Thinnest corneal thickness and maximum Ambr\u00f3sio relational thickness were significantly lower (477\u2009\u00b1\u200952 vs. 543\u2009\u00b1\u200926; 387\u2009\u00b1\u200995 vs. 509\u2009\u00b1\u200949; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Two-thirds of OI patients had corneas with a minimum thickness\u2009&lt;\u2009500\u00a0\u00b5m. BAD-D value was significantly higher in OI patients (2.1\u2009\u00b1\u20091.4 vs. 0.9\u2009\u00b1\u20090.2; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>OI patients showed significant changes in corneal profiles compared with healthy subjects. A high proportion of patients had tomographically suspect corneas when using keratoconus diagnostic indices. Further studies are warranted to assess the true risk of corneal ectasia in OI patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00417-023-06059-4","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T08:02:39Z","timestamp":1681891359000},"page":"2585-2592","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Keratoconus tomographic indices in osteogenesis imperfecta"],"prefix":"10.1007","volume":"261","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3102-1969","authenticated-orcid":false,"given":"Rafael","family":"Correia Bar\u00e3o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel Esteves","family":"Marques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Miguel","family":"Quintas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,4,19]]},"reference":[{"key":"6059_CR1","first-page":"1993","volume-title":"COL1A1\/2 Osteogenesis Imperfecta. 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