{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T17:18:14Z","timestamp":1784567894505,"version":"3.55.0"},"reference-count":136,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"NARAYANA NETHRALAYA FOUNDATION"},{"DOI":"10.13039\/100007214","name":"Velux Stiftung","doi-asserted-by":"publisher","award":["1695"],"award-info":[{"award-number":["1695"]}],"id":[{"id":"10.13039\/100007214","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1007\/s00417-023-06064-7","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T08:02:39Z","timestamp":1681891359000},"page":"3051-3065","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Corneal stromal regeneration\u2014keratoconus cell therapy: a review"],"prefix":"10.1007","volume":"261","author":[{"given":"Rohit","family":"Shetty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krithikaa","family":"Mahendran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parth D.","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nallathambi","family":"Jeyabalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaitra","family":"Jayadev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9171-656X","authenticated-orcid":false,"given":"Debashish","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,19]]},"reference":[{"key":"6064_CR1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1167\/tvst.8.1.2","volume":"8","author":"R Shetty","year":"2019","unstructured":"Shetty R, Vunnava KP, Dhamodaran K, Matalia H, Murali S, Jayadev C, Murugeswari P, Ghosh A, Das D (2019) Characterization of corneal epithelial cells in keratoconus. Transl Vis Sci Technol 8:2. https:\/\/doi.org\/10.1167\/tvst.8.1.2","journal-title":"Transl Vis Sci Technol"},{"key":"6064_CR2","doi-asserted-by":"publisher","unstructured":"Loh IP, Sherwin T (2020) Is keratoconus an inflammatory disease? The implication of inflammatory pathways. Ocul Immunol Inflamm: 1\u201310. https:\/\/doi.org\/10.1080\/09273948.2020.1780271","DOI":"10.1080\/09273948.2020.1780271"},{"key":"6064_CR3","doi-asserted-by":"publisher","first-page":"392","DOI":"10.4103\/0301-4738.116057","volume":"61","author":"A Sinha Roy","year":"2013","unstructured":"Sinha Roy A, Shetty R, Kummelil MK (2013) Keratoconus: a biomechanical perspective on loss of corneal stiffness. Indian J Ophthalmol 61:392\u2013393. https:\/\/doi.org\/10.4103\/0301-4738.116057","journal-title":"Indian J Ophthalmol"},{"key":"6064_CR4","first-page":"2537","volume":"39","author":"K Zadnik","year":"1998","unstructured":"Zadnik K, Barr JT, Edrington TB, Everett DF, Jameson M, McMahon TT, Shin JA, Sterling JL, Wagner H, Gordon MO (1998) Baseline findings in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study. Invest Ophthalmol Vis Sci 39:2537\u20132546","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6064_CR5","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4103\/0974-9233.75876","volume":"18","author":"DM Nowak","year":"2011","unstructured":"Nowak DM, Gajecka M (2011) The genetics of keratoconus. Middle East Afr J Ophthalmol 18:2\u20136. https:\/\/doi.org\/10.4103\/0974-9233.75876","journal-title":"Middle East Afr J Ophthalmol"},{"key":"6064_CR6","doi-asserted-by":"publisher","first-page":"384","DOI":"10.4103\/0301-4738.116055","volume":"61","author":"N Jeyabalan","year":"2013","unstructured":"Jeyabalan N, Shetty R, Ghosh A, Anandula VR, Ghosh AS, Kumaramanickavel G (2013) Genetic and genomic perspective to understand the molecular pathogenesis of keratoconus. Indian J Ophthalmol 61:384\u2013388. https:\/\/doi.org\/10.4103\/0301-4738.116055","journal-title":"Indian J Ophthalmol"},{"key":"6064_CR7","first-page":"12","volume":"21","author":"R Shetty","year":"2015","unstructured":"Shetty R, Sathyanarayanamoorthy A, Ramachandra RA, Arora V, Ghosh A, Srivatsa PR, Pahuja N, Nuijts RM, Sinha-Roy A, Mohan RR, Ghosh A (2015) Attenuation of lysyl oxidase and collagen gene expression in keratoconus patient corneal epithelium corresponds to disease severity. Mol Vis 21:12\u201325","journal-title":"Mol Vis"},{"key":"6064_CR8","doi-asserted-by":"publisher","first-page":"e0184628","DOI":"10.1371\/journal.pone.0184628","volume":"12","author":"R Shetty","year":"2017","unstructured":"Shetty R, Sharma A, Pahuja N, Chevour P, Padmajan N, Dhamodaran K, Jayadev C, Mman R, Ghosh A, Nallathambi J (2017) Oxidative stress induces dysregulated autophagy in corneal epithelium of keratoconus patients. PLoS One 12:e0184628. https:\/\/doi.org\/10.1371\/journal.pone.0184628","journal-title":"PLoS One"},{"key":"6064_CR9","doi-asserted-by":"publisher","first-page":"5372","DOI":"10.1167\/iovs.16-19677","volume":"57","author":"N Pahuja","year":"2016","unstructured":"Pahuja N, Kumar NR, Shroff R, Shetty R, Nuijts RM, Ghosh A, Sinha-Roy A, Chaurasia SS, Mohan RR, Ghosh A (2016) Differential molecular expression of extracellular matrix and inflammatory genes at the corneal cone apex drives focal weakening in keratoconus. Invest Ophthalmol Vis Sci 57:5372\u20135382. https:\/\/doi.org\/10.1167\/iovs.16-19677","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6064_CR10","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1167\/iovs.14-14831","volume":"56","author":"R Shetty","year":"2015","unstructured":"Shetty R, Ghosh A, Lim RR, Subramani M, Mihir K, Reshma AR, Ranganath A, Nagaraj S, Nuijts RM, Beuerman R, Shetty R, Das D, Chaurasia SS, Sinha-Roy A, Ghosh A (2015) Elevated expression of matrix metalloproteinase-9 and inflammatory cytokines in keratoconus patients is inhibited by cyclosporine A. Invest Ophthalmol Vis Sci 56:738\u2013750. https:\/\/doi.org\/10.1167\/iovs.14-14831","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6064_CR11","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1097\/ICO.0000000000001393","volume":"36","author":"CA Greene","year":"2017","unstructured":"Greene CA, Kuo C, Sherwin T (2017) Aberrant patterns of key epithelial basement membrane components in keratoconus. Cornea 36:1549\u20131555. https:\/\/doi.org\/10.1097\/ICO.0000000000001393","journal-title":"Cornea"},{"key":"6064_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.exer.2015.01.007","volume":"132","author":"D Karamichos","year":"2015","unstructured":"Karamichos D, Zieske JD, Sejersen H, Sarker-Nag A, Asara JM, Hjortdal J (2015) Tear metabolite changes in keratoconus. Exp Eye Res 132:1\u20138. https:\/\/doi.org\/10.1016\/j.exer.2015.01.007","journal-title":"Exp Eye Res"},{"key":"6064_CR13","doi-asserted-by":"publisher","first-page":"9426","DOI":"10.1038\/s41598-020-66442-7","volume":"10","author":"TB McKay","year":"2020","unstructured":"McKay TB, Serjersen H, Hjortdal J, Zieske JD, Karamichos D (2020) Characterization of tear immunoglobulins in a small-cohort of keratoconus patients. Sci Rep 10:9426. https:\/\/doi.org\/10.1038\/s41598-020-66442-7","journal-title":"Sci Rep"},{"key":"6064_CR14","doi-asserted-by":"publisher","first-page":"108301","DOI":"10.1016\/j.exer.2020.108301","volume":"202","author":"Y Li","year":"2021","unstructured":"Li Y, Ismail S, McGhee JJ, Wadhwa H, Noord N, van der Werf B, Sherwin T (2021) Differences in sphere-forming cells from keratoconic and normal corneal tissue: Implications for keratoconus pathogenesis. Exp Eye Res 202:108301. https:\/\/doi.org\/10.1016\/j.exer.2020.108301","journal-title":"Exp Eye Res"},{"key":"6064_CR15","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1097\/01.ico.0000151548.46231.27","volume":"24","author":"JG Hollingsworth","year":"2005","unstructured":"Hollingsworth JG, Bonshek RE, Efron N (2005) Correlation of the appearance of the keratoconic cornea in vivo by confocal microscopy and in vitro by light microscopy. Cornea 24:397\u2013405. https:\/\/doi.org\/10.1097\/01.ico.0000151548.46231.27","journal-title":"Cornea"},{"key":"6064_CR16","doi-asserted-by":"publisher","first-page":"1468258","DOI":"10.1155\/2020\/1468258","volume":"2020","author":"S Crespo Millas","year":"2020","unstructured":"Crespo Millas S, Lopez JC, Garcia-Lagarto E, Obregon E, Hileeto D, Maldonado MJ, Pastor JC (2020) Histological patterns of epithelial alterations in keratoconus. J Ophthalmol 2020:1468258. https:\/\/doi.org\/10.1155\/2020\/1468258","journal-title":"J Ophthalmol"},{"key":"6064_CR17","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1038\/sj.eye.6702286","volume":"21","author":"KH Weed","year":"2007","unstructured":"Weed KH, MacEwen CJ, Cox A, McGhee CN (2007) Quantitative analysis of corneal microstructure in keratoconus utilising in vivo confocal microscopy. Eye (Lond) 21:614\u2013623. https:\/\/doi.org\/10.1038\/sj.eye.6702286","journal-title":"Eye (Lond)"},{"key":"6064_CR18","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1097\/00003226-200203000-00017","volume":"21","author":"RM Kaldawy","year":"2002","unstructured":"Kaldawy RM, Wagner J, Ching S, Seigel GM (2002) Evidence of apoptotic cell death in keratoconus. Cornea 21:206\u2013209. https:\/\/doi.org\/10.1097\/00003226-200203000-00017","journal-title":"Cornea"},{"key":"6064_CR19","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1006\/exer.1999.0719","volume":"69","author":"WJ Kim","year":"1999","unstructured":"Kim WJ, Rabinowitz YS, Meisler DM, Wilson SE (1999) Keratocyte apoptosis associated with keratoconus. Exp Eye Res 69:475\u2013481. https:\/\/doi.org\/10.1006\/exer.1999.0719","journal-title":"Exp Eye Res"},{"key":"6064_CR20","first-page":"738","volume":"20","author":"DA Newsome","year":"1981","unstructured":"Newsome DA, Foidart JM, Hassell JR, Krachmer JH, Rodrigues MM, Katz SI (1981) Detection of specific collagen types in normal and keratoconus corneas. Invest Ophthalmol Vis Sci 20:738\u2013750","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6064_CR21","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/s0021-5155(01)00328-8","volume":"45","author":"N Ebihara","year":"2001","unstructured":"Ebihara N, Watanabe Y, Nakayasu K, Kanai A (2001) The expression of laminin-5 and ultrastructure of the interface between basal cells and underlying stroma in the keratoconus cornea. Jpn J Ophthalmol 45:209\u2013215. https:\/\/doi.org\/10.1016\/s0021-5155(01)00328-8","journal-title":"Jpn J Ophthalmol"},{"key":"6064_CR22","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.ophtha.2007.04.067","volume":"115","author":"JY Ku","year":"2008","unstructured":"Ku JY, Niederer RL, Patel DV, Sherwin T, McGhee CN (2008) Laser scanning in vivo confocal analysis of keratocyte density in keratoconus. Ophthalmology 115:845\u2013850. https:\/\/doi.org\/10.1016\/j.ophtha.2007.04.067","journal-title":"Ophthalmology"},{"key":"6064_CR23","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.jcrs.2010.10.046","volume":"37","author":"JL Alio","year":"2011","unstructured":"Alio JL, Pinero DP, Aleson A, Teus MA, Barraquer RI, Murta J, Maldonado MJ, Castro de Luna G, Gutierrez R, Villa C, Uceda-Montanes A (2011) Keratoconus-integrated characterization considering anterior corneal aberrations, internal astigmatism, and corneal biomechanics. J Cataract Refract Surg 37:552\u2013568. https:\/\/doi.org\/10.1016\/j.jcrs.2010.10.046","journal-title":"J Cataract Refract Surg"},{"key":"6064_CR24","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1006\/exer.1996.0038","volume":"62","author":"SE Wilson","year":"1996","unstructured":"Wilson SE, He YG, Weng J, Li Q, McDowall AW, Vital M, Chwang EL (1996) Epithelial injury induces keratocyte apoptosis: hypothesized role for the interleukin-1 system in the modulation of corneal tissue organization and wound healing. Exp Eye Res 62:325\u2013327. https:\/\/doi.org\/10.1006\/exer.1996.0038","journal-title":"Exp Eye Res"},{"key":"6064_CR25","doi-asserted-by":"publisher","first-page":"252","DOI":"10.2174\/1874364101711010252","volume":"11","author":"U Soiberman","year":"2017","unstructured":"Soiberman U, Foster JW, Jun AS, Chakravarti S (2017) Pathophysiology of keratoconus: what do we know today. Open Ophthalmol J 11:252\u2013261. https:\/\/doi.org\/10.2174\/1874364101711010252","journal-title":"Open Ophthalmol J"},{"key":"6064_CR26","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.exer.2011.01.008","volume":"92","author":"R Joseph","year":"2011","unstructured":"Joseph R, Srivastava OP, Pfister RR (2011) Differential epithelial and stromal protein profiles in keratoconus and normal human corneas. Exp Eye Res 92:282\u2013298. https:\/\/doi.org\/10.1016\/j.exer.2011.01.008","journal-title":"Exp Eye Res"},{"key":"6064_CR27","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1046\/j.1442-9071.2001.d01-16.x","volume":"29","author":"M Edwards","year":"2001","unstructured":"Edwards M, McGhee CN, Dean S (2001) The genetics of keratoconus. Clin Exp Ophthalmol 29:345\u2013351. https:\/\/doi.org\/10.1046\/j.1442-9071.2001.d01-16.x","journal-title":"Clin Exp Ophthalmol"},{"key":"6064_CR28","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1002\/ar.24090","volume":"303","author":"TLA Volatier","year":"2020","unstructured":"Volatier TLA, Figueiredo FC, Connon CJ (2020) Keratoconus at a molecular level: a review. Anat Rec (Hoboken) 303:1680\u20131688. https:\/\/doi.org\/10.1002\/ar.24090","journal-title":"Anat Rec (Hoboken)"},{"key":"6064_CR29","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1097\/01.icl.0000189038.74139.4a","volume":"32","author":"OO Ucakhan","year":"2006","unstructured":"Ucakhan OO, Kanpolat A, Ylmaz N, Ozkan M (2006) In vivo confocal microscopy findings in keratoconus. Eye Contact Lens 32:183\u2013191. https:\/\/doi.org\/10.1097\/01.icl.0000189038.74139.4a","journal-title":"Eye Contact Lens"},{"key":"6064_CR30","doi-asserted-by":"publisher","first-page":"12567","DOI":"10.1038\/s41598-019-48983-8","volume":"9","author":"R Sharif","year":"2019","unstructured":"Sharif R, Khaled ML, McKay TB, Liu Y, Karamichos D (2019) Transcriptional profiling of corneal stromal cells derived from patients with keratoconus. Sci Rep 9:12567. https:\/\/doi.org\/10.1038\/s41598-019-48983-8","journal-title":"Sci Rep"},{"key":"6064_CR31","doi-asserted-by":"publisher","first-page":"2977","DOI":"10.1167\/iovs.18-24367","volume":"59","author":"JW Foster","year":"2018","unstructured":"Foster JW, Shinde V, Soiberman US, Sathe G, Liu S, Wan J, Qian J, Dauoud Y, Pandey A, Jun AS, Chakravarti S (2018) Integrated stress response and decreased ECM in cultured stromal cells from keratoconus corneas. Invest Ophthalmol Vis Sci 59:2977\u20132986. https:\/\/doi.org\/10.1167\/iovs.18-24367","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6064_CR32","doi-asserted-by":"publisher","first-page":"534","DOI":"10.3980\/j.issn.2222-3959.2015.03.17","volume":"8","author":"G Bitirgen","year":"2015","unstructured":"Bitirgen G, Ozkagnici A, Bozkurt B, Malik RA (2015) In vivo corneal confocal microscopic analysis in patients with keratoconus. Int J Ophthalmol 8:534\u2013539. https:\/\/doi.org\/10.3980\/j.issn.2222-3959.2015.03.17","journal-title":"Int J Ophthalmol"},{"key":"6064_CR33","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1167\/iovs.05-1139","volume":"47","author":"HF Edelhauser","year":"2006","unstructured":"Edelhauser HF (2006) The balance between corneal transparency and edema: the Proctor Lecture. Invest Ophthalmol Vis Sci 47:1754\u20131767. https:\/\/doi.org\/10.1167\/iovs.05-1139","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6064_CR34","first-page":"107","volume":"80","author":"GVP de Abreu Fiuza Gomes BGVPL","year":"2021","unstructured":"de Abreu Fiuza Gomes BGVPL GVP (2021) A correlation study between a corneal endothelial count in patients with different stages of keratoconus using specular microscopy. Revista Brasileira de Oftalmologia 80:107\u2013110","journal-title":"Revista Brasileira de Oftalmologia"},{"key":"6064_CR35","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000001805","author":"Z Shah","year":"2021","unstructured":"Shah Z, Shilpy N, Purohit D, Singh S (2021) Assessment and correlation of corneal endothelial cell changes in different stages of keratoconus in non-contact lens wearers. Optom Vis Sci. https:\/\/doi.org\/10.1097\/OPX.0000000000001805","journal-title":"Optom Vis Sci"},{"key":"6064_CR36","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s12886-021-01913-7","volume":"21","author":"A Elmassry","year":"2021","unstructured":"Elmassry A, Osman A, Sabry M, Elmassry M, Katkat M, Hatata MY, El-Kateb M (2021) Corneal endothelial cells changes in different stages of keratoconus: a multi-centre clinical study. BMC Ophthalmol 21:143. https:\/\/doi.org\/10.1186\/s12886-021-01913-7","journal-title":"BMC Ophthalmol"},{"key":"6064_CR37","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1016\/S0161-6420(03)00261-6","volume":"110","author":"M Dogru","year":"2003","unstructured":"Dogru M, Karakaya H, Ozcetin H, Erturk H, Yucel A, Ozmen A, Baykara M, Tsubota K (2003) Tear function and ocular surface changes in keratoconus. Ophthalmology 110:1110\u20131118. https:\/\/doi.org\/10.1016\/S0161-6420(03)00261-6","journal-title":"Ophthalmology"},{"key":"6064_CR38","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.4103\/ijo.IJO_233_17","volume":"65","author":"R Shetty","year":"2017","unstructured":"Shetty R, Deshmukh R, Ghosh A, Sethu S, Jayadev C (2017) Altered tear inflammatory profile in Indian keratoconus patients - the 2015 Col Rangachari Award paper. Indian J Ophthalmol 65:1105\u20131108. https:\/\/doi.org\/10.4103\/ijo.IJO_233_17","journal-title":"Indian J Ophthalmol"},{"key":"6064_CR39","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1097\/ICO.0b013e31816a3591","volume":"27","author":"I Lema","year":"2008","unstructured":"Lema I, Duran JA, Ruiz C, Diez-Feijoo E, Acera A, Merayo J (2008) Inflammatory response to contact lenses in patients with keratoconus compared with myopic subjects. Cornea 27:758\u2013763. https:\/\/doi.org\/10.1097\/ICO.0b013e31816a3591","journal-title":"Cornea"},{"key":"6064_CR40","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.ophtha.2004.11.050","volume":"112","author":"I Lema","year":"2005","unstructured":"Lema I, Duran JA (2005) Inflammatory molecules in the tears of patients with keratoconus. Ophthalmology 112:654\u2013659. https:\/\/doi.org\/10.1016\/j.ophtha.2004.11.050","journal-title":"Ophthalmology"},{"key":"6064_CR41","doi-asserted-by":"publisher","first-page":"e303","DOI":"10.1111\/j.1755-3768.2011.02369.x","volume":"90","author":"SA Balasubramanian","year":"2012","unstructured":"Balasubramanian SA, Mohan S, Pye DC, Willcox MD (2012) Proteases, proteolysis and inflammatory molecules in the tears of people with keratoconus. Acta Ophthalmol 90:e303-309. https:\/\/doi.org\/10.1111\/j.1755-3768.2011.02369.x","journal-title":"Acta Ophthalmol"},{"key":"6064_CR42","first-page":"509","volume":"19","author":"J You","year":"2013","unstructured":"You J, Hodge C, Wen L, McAvoy JW, Madigan MC, Sutton G (2013) Tear levels of SFRP1 are significantly reduced in keratoconus patients. Mol Vis 19:509\u2013xxx","journal-title":"Mol Vis"},{"key":"6064_CR43","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s40662-016-0051-9","volume":"3","author":"K Nishtala","year":"2016","unstructured":"Nishtala K, Pahuja N, Shetty R, Nuijts RM, Ghosh A (2016) Tear biomarkers for keratoconus. Eye Vis (Lond) 3:19. https:\/\/doi.org\/10.1186\/s40662-016-0051-9","journal-title":"Eye Vis (Lond)"},{"key":"6064_CR44","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3389\/fimmu.2012.00296","volume":"3","author":"I Benhar","year":"2012","unstructured":"Benhar I, London A, Schwartz M (2012) The privileged immunity of immune privileged organs: the case of the eye. Front Immunol 3:296. https:\/\/doi.org\/10.3389\/fimmu.2012.00296","journal-title":"Front Immunol"},{"key":"6064_CR45","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3389\/fimmu.2016.00037","volume":"7","author":"AW Taylor","year":"2016","unstructured":"Taylor AW (2016) Ocular immune privilege and transplantation. Front Immunol 7:37. https:\/\/doi.org\/10.3389\/fimmu.2016.00037","journal-title":"Front Immunol"},{"key":"6064_CR46","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1111\/joim.12502","volume":"280","author":"M Griffith","year":"2016","unstructured":"Griffith M, Alarcon EI, Brunette I (2016) Regenerative approaches for the cornea. J Intern Med 280:276\u2013286. https:\/\/doi.org\/10.1111\/joim.12502","journal-title":"J Intern Med"},{"key":"6064_CR47","doi-asserted-by":"publisher","first-page":"108062","DOI":"10.1016\/j.exer.2020.108062","volume":"196","author":"GHF Yam","year":"2020","unstructured":"Yam GHF, Riau AK, Funderburgh ML, Mehta JS, Jhanji V (2020) Keratocyte biology. Exp Eye Res 196:108062. https:\/\/doi.org\/10.1016\/j.exer.2020.108062","journal-title":"Exp Eye Res"},{"key":"6064_CR48","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s00441-015-2233-5","volume":"363","author":"D Massoudi","year":"2016","unstructured":"Massoudi D, Malecaze F, Galiacy SD (2016) Collagens and proteoglycans of the cornea: importance in transparency and visual disorders. Cell Tissue Res 363:337\u2013349. https:\/\/doi.org\/10.1007\/s00441-015-2233-5","journal-title":"Cell Tissue Res"},{"key":"6064_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jcp.1030510102","volume":"51","author":"AJ Coulombre","year":"1958","unstructured":"Coulombre AJ, Coulombre JL (1958) Corneal development. I Corneal transparency. J Cell Comp Physiol 51:1\u201311. https:\/\/doi.org\/10.1002\/jcp.1030510102","journal-title":"J Cell Comp Physiol"},{"key":"6064_CR50","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1083\/jcb.141.5.1277","volume":"141","author":"S Chakravarti","year":"1998","unstructured":"Chakravarti S, Magnuson T, Lass JH, Jepsen KJ, LaMantia C, Carroll H (1998) Lumican regulates collagen fibril assembly: skin fragility and corneal opacity in the absence of lumican. J Cell Biol 141:1277\u20131286. https:\/\/doi.org\/10.1083\/jcb.141.5.1277","journal-title":"J Cell Biol"},{"key":"6064_CR51","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1097\/01.ico.0000178743.06340.2c","volume":"24","author":"ME Fini","year":"2005","unstructured":"Fini ME, Stramer BM (2005) How the cornea heals: cornea-specific repair mechanisms affecting surgical outcomes. Cornea 24:S2\u2013S11. https:\/\/doi.org\/10.1097\/01.ico.0000178743.06340.2c","journal-title":"Cornea"},{"key":"6064_CR52","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1016\/j.biocel.2006.03.010","volume":"38","author":"JA West-Mays","year":"2006","unstructured":"West-Mays JA, Dwivedi DJ (2006) The keratocyte: corneal stromal cell with variable repair phenotypes. Int J Biochem Cell Biol 38:1625\u20131631. https:\/\/doi.org\/10.1016\/j.biocel.2006.03.010","journal-title":"Int J Biochem Cell Biol"},{"key":"6064_CR53","first-page":"452","volume":"92","author":"S Somodi","year":"1995","unstructured":"Somodi S, Guthoff R (1995) Visualization of keratocytes in the human cornea with fluorescence microscopy. Ophthalmologe 92:452\u2013457","journal-title":"Ophthalmologe"},{"key":"6064_CR54","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1097\/00003226-200003000-00012","volume":"19","author":"C Hahnel","year":"2000","unstructured":"Hahnel C, Somodi S, Weiss DG, Guthoff RF (2000) The keratocyte network of human cornea: a three-dimensional study using confocal laser scanning fluorescence microscopy. Cornea 19:185\u2013193. https:\/\/doi.org\/10.1097\/00003226-200003000-00012","journal-title":"Cornea"},{"key":"6064_CR55","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/s0014-4835(03)00188-x","volume":"77","author":"JV Jester","year":"2003","unstructured":"Jester JV, Ho-Chang J (2003) Modulation of cultured corneal keratocyte phenotype by growth factors\/cytokines control in vitro contractility and extracellular matrix contraction. Exp Eye Res 77:581\u2013592. https:\/\/doi.org\/10.1016\/s0014-4835(03)00188-x","journal-title":"Exp Eye Res"},{"key":"6064_CR56","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1016\/S0021-9258(18)94204-3","volume":"264","author":"RJ Midura","year":"1989","unstructured":"Midura RJ, Hascall VC (1989) Analysis of the proteoglycans synthesized by corneal explants from embryonic chicken. II. Structural characterization of the keratan sulfate and dermatan sulfate proteoglycans from corneal stroma. J Biol Chem 264:1423\u20131430","journal-title":"J Biol Chem"},{"key":"6064_CR57","first-page":"603","volume":"48","author":"GK Klintworth","year":"1983","unstructured":"Klintworth GK, Smith CF (1983) Abnormalities of proteoglycans and glycoproteins synthesized by corneal organ cultures derived from patients with macular corneal dystrophy. Lab Invest 48:603\u2013612","journal-title":"Lab Invest"},{"key":"6064_CR58","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1096\/fj.04-2770fje","volume":"19","author":"ML Funderburgh","year":"2005","unstructured":"Funderburgh ML, Du Y, Mann MM, SundarRaj N, Funderburgh JL (2005) PAX6 expression identifies progenitor cells for corneal keratocytes. FASEB J 19:1371\u20131373. https:\/\/doi.org\/10.1096\/fj.04-2770fje","journal-title":"FASEB J"},{"key":"6064_CR59","doi-asserted-by":"publisher","first-page":"31431","DOI":"10.1074\/jbc.271.49.31431","volume":"271","author":"JL Funderburgh","year":"1996","unstructured":"Funderburgh JL, Funderburgh ML, Mann MM, Prakash S, Conrad GW (1996) Synthesis of corneal keratan sulfate proteoglycans by bovine keratocytes in vitro. J Biol Chem 271:31431\u201331436. https:\/\/doi.org\/10.1074\/jbc.271.49.31431","journal-title":"J Biol Chem"},{"key":"6064_CR60","first-page":"1658","volume":"40","author":"MP Beales","year":"1999","unstructured":"Beales MP, Funderburgh JL, Jester JV, Hassell JR (1999) Proteoglycan synthesis by bovine keratocytes and corneal fibroblasts: maintenance of the keratocyte phenotype in culture. Invest Ophthalmol Vis Sci 40:1658\u20131663","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6064_CR61","doi-asserted-by":"publisher","first-page":"10839","DOI":"10.1038\/srep10839","volume":"5","author":"JW Foster","year":"2015","unstructured":"Foster JW, Gouveia RM, Connon CJ (2015) Low-glucose enhances keratocyte-characteristic phenotype from corneal stromal cells in serum-free conditions. Sci Rep 5:10839. https:\/\/doi.org\/10.1038\/srep10839","journal-title":"Sci Rep"},{"key":"6064_CR62","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.3727\/096368914X685069","volume":"24","author":"GH Yam","year":"2015","unstructured":"Yam GH, Yusoff NZ, Kadaba A, Tian D, Myint HH, Beuerman RW, Zhou L, Mehta JS (2015) Ex vivo propagation of human corneal stromal \u201cactivated keratocytes\u201d for tissue engineering. Cell Transplant 24:1845\u20131861. https:\/\/doi.org\/10.3727\/096368914X685069","journal-title":"Cell Transplant"},{"key":"6064_CR63","doi-asserted-by":"publisher","first-page":"3340","DOI":"10.1167\/iovs.17-23575","volume":"59","author":"GH Yam","year":"2018","unstructured":"Yam GH, Fuest M, Yusoff N, Goh TW, Bandeira F, Setiawan M, Seah XY, Lwin NC, Stanzel TP, Ong HS, Mehta JS (2018) Safety and feasibility of intrastromal injection of cultivated human corneal stromal keratocytes as cell-based therapy for corneal opacities. Invest Ophthalmol Vis Sci 59:3340\u20133354. https:\/\/doi.org\/10.1167\/iovs.17-23575","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6064_CR64","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1089\/ten.TEC.2011.0072","volume":"18","author":"MA Shafiq","year":"2012","unstructured":"Shafiq MA, Gemeinhart RA, Yue BY, Djalilian AR (2012) Decellularized human cornea for reconstructing the corneal epithelium and anterior stroma. Tissue Eng Part C Methods 18:340\u2013348. https:\/\/doi.org\/10.1089\/ten.TEC.2011.0072","journal-title":"Tissue Eng Part C Methods"},{"key":"6064_CR65","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1002\/stem.1100","volume":"30","author":"N Pinnamaneni","year":"2012","unstructured":"Pinnamaneni N, Funderburgh JL (2012) Concise review: Stem cells in the corneal stroma. Stem Cells 30:1059\u20131063. https:\/\/doi.org\/10.1002\/stem.1100","journal-title":"Stem Cells"},{"key":"6064_CR66","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1634\/stemcells.2004-0256","volume":"23","author":"Y Du","year":"2005","unstructured":"Du Y, Funderburgh ML, Mann MM, SundarRaj N, Funderburgh JL (2005) Multipotent stem cells in human corneal stroma. Stem Cells 23:1266\u20131275. https:\/\/doi.org\/10.1634\/stemcells.2004-0256","journal-title":"Stem Cells"},{"key":"6064_CR67","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.mehy.2012.11.006","volume":"80","author":"DV Patel","year":"2013","unstructured":"Patel DV, McKelvie J, Sherwin T, McGhee C (2013) Keratocyte progenitor cell transplantation: a novel therapeutic strategy for corneal disease. Med Hypotheses 80:122\u2013124. https:\/\/doi.org\/10.1016\/j.mehy.2012.11.006","journal-title":"Med Hypotheses"},{"key":"6064_CR68","first-page":"2952","volume":"51","author":"JL Funderburgh","year":"2010","unstructured":"Funderburgh JL, Mann MM, Funderburgh ML, Roh DS, Du Y (2010) CD271 is a Cell-Surface Marker of Keratocyte Progenitor Cells. Invest Ophthalmol Visual Sci 51:2952\u20132952","journal-title":"Invest Ophthalmol Visual Sci"},{"key":"6064_CR69","doi-asserted-by":"publisher","first-page":"S73","DOI":"10.1097\/01.ico.0000247218.10672.7e","volume":"25","author":"S Amano","year":"2006","unstructured":"Amano S, Yamagami S, Mimura T, Uchida S, Yokoo S (2006) Corneal stromal and endothelial cell precursors. Cornea 25:S73-77. https:\/\/doi.org\/10.1097\/01.ico.0000247218.10672.7e","journal-title":"Cornea"},{"key":"6064_CR70","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.ophtha.2006.07.042","volume":"114","author":"S Yamagami","year":"2007","unstructured":"Yamagami S, Yokoo S, Mimura T, Takato T, Araie M, Amano S (2007) Distribution of precursors in human corneal stromal cells and endothelial cells. Ophthalmology 114:433\u2013439. https:\/\/doi.org\/10.1016\/j.ophtha.2006.07.042","journal-title":"Ophthalmology"},{"key":"6064_CR71","doi-asserted-by":"publisher","first-page":"5109","DOI":"10.1167\/iovs.11-8673","volume":"53","author":"MJ Branch","year":"2012","unstructured":"Branch MJ, Hashmani K, Dhillon P, Jones DR, Dua HS, Hopkinson A (2012) Mesenchymal stem cells in the human corneal limbal stroma. Invest Ophthalmol Vis Sci 53:5109\u20135116. https:\/\/doi.org\/10.1167\/iovs.11-8673","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6064_CR72","doi-asserted-by":"publisher","first-page":"8813447","DOI":"10.1155\/2020\/8813447","volume":"2020","author":"JS Nurkovic","year":"2020","unstructured":"Nurkovic JS, Vojinovic R, Dolicanin Z (2020) Corneal stem cells as a source of regenerative cell-based therapy. Stem Cells Int 2020:8813447. https:\/\/doi.org\/10.1155\/2020\/8813447","journal-title":"Stem Cells Int"},{"key":"6064_CR73","doi-asserted-by":"publisher","first-page":"7583","DOI":"10.1167\/iovs.14-14448","volume":"55","author":"AK Kureshi","year":"2014","unstructured":"Kureshi AK, Funderburgh JL, Daniels JT (2014) Human corneal stromal stem cells exhibit survival capacity following isolation from stored organ-culture corneas. Invest Ophthalmol Vis Sci 55:7583\u20137588. https:\/\/doi.org\/10.1167\/iovs.14-14448","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6064_CR74","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.jtos.2015.12.006","volume":"14","author":"JL Funderburgh","year":"2016","unstructured":"Funderburgh JL, Funderburgh ML, Du Y (2016) Stem cells in the limbal stroma. Ocul Surf 14:113\u2013120. https:\/\/doi.org\/10.1016\/j.jtos.2015.12.006","journal-title":"Ocul Surf"},{"key":"6064_CR75","first-page":"828","volume":"21","author":"K Dhamodaran","year":"2015","unstructured":"Dhamodaran K, Subramani M, Jeyabalan N, Ponnalagu M, Chevour P, Shetty R, Matalia H, Shetty R, Prince SE, Das D (2015) Characterization of ex vivo cultured limbal, conjunctival, and oral mucosal cells: a comparative study with implications in transplantation medicine. Mol Vis 21:828\u2013845","journal-title":"Mol Vis"},{"key":"6064_CR76","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/scrt226","volume":"4","author":"K Hashmani","year":"2013","unstructured":"Hashmani K, Branch MJ, Sidney LE, Dhillon PS, Verma M, McIntosh OD, Hopkinson A, Dua HS (2013) Characterization of corneal stromal stem cells with the potential for epithelial transdifferentiation. Stem Cell Res Ther 4:75. https:\/\/doi.org\/10.1186\/scrt226","journal-title":"Stem Cell Res Ther"},{"key":"6064_CR77","doi-asserted-by":"publisher","first-page":"493","DOI":"10.18502\/jovr.v15i4.7780","volume":"15","author":"L Liu","year":"2020","unstructured":"Liu L, Yu Y, Peng Q, Porsborg SR, Nielsen FM, Jorgensen A, Grove A, Bath C, Hjortdal J, Christiansen OB, Fink T, Zachar V (2020) Distribution of stromal cell subsets in cultures from distinct ocular surface compartments. J Ophthalmic Vis Res 15:493\u2013501. https:\/\/doi.org\/10.18502\/jovr.v15i4.7780","journal-title":"J Ophthalmic Vis Res"},{"key":"6064_CR78","doi-asserted-by":"publisher","first-page":"5038","DOI":"10.1167\/iovs.07-0587","volume":"48","author":"Y Du","year":"2007","unstructured":"Du Y, Sundarraj N, Funderburgh ML, Harvey SA, Birk DE, Funderburgh JL (2007) Secretion and organization of a cornea-like tissue in vitro by stem cells from human corneal stroma. Invest Ophthalmol Vis Sci 48:5038\u20135045. https:\/\/doi.org\/10.1167\/iovs.07-0587","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6064_CR79","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.exer.2014.01.005","volume":"120","author":"J Wu","year":"2014","unstructured":"Wu J, Du Y, Mann MM, Funderburgh JL, Wagner WR (2014) Corneal stromal stem cells versus corneal fibroblasts in generating structurally appropriate corneal stromal tissue. Exp Eye Res 120:71\u201381. https:\/\/doi.org\/10.1016\/j.exer.2014.01.005","journal-title":"Exp Eye Res"},{"key":"6064_CR80","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1016\/j.jcyt.2015.08.003","volume":"17","author":"LE Sidney","year":"2015","unstructured":"Sidney LE, Branch MJ, Dua HS, Hopkinson A (2015) Effect of culture medium on propagation and phenotype of corneal stroma-derived stem cells. Cytotherapy 17:1706\u20131722. https:\/\/doi.org\/10.1016\/j.jcyt.2015.08.003","journal-title":"Cytotherapy"},{"key":"6064_CR81","doi-asserted-by":"publisher","first-page":"26227","DOI":"10.1038\/srep26227","volume":"6","author":"Z Vereb","year":"2016","unstructured":"Vereb Z, Poliska S, Albert R, Olstad OK, Boratko A, Csortos C, Moe MC, Facsko A, Petrovski G (2016) Role of human corneal stroma-derived mesenchymal-like stem cells in corneal immunity and wound healing. Sci Rep 6:26227. https:\/\/doi.org\/10.1038\/srep26227","journal-title":"Sci Rep"},{"key":"6064_CR82","doi-asserted-by":"publisher","first-page":"266ra172","DOI":"10.1126\/scitranslmed.3009644","volume":"6","author":"S Basu","year":"2014","unstructured":"Basu S, Hertsenberg AJ, Funderburgh ML, Burrow MK, Mann MM, Du Y, Lathrop KL, Syed-Picard FN, Adams SM, Birk DE, Funderburgh JL (2014) Human limbal biopsy-derived stromal stem cells prevent corneal scarring. Sci Transl Med 6:266ra172. https:\/\/doi.org\/10.1126\/scitranslmed.3009644","journal-title":"Sci Transl Med"},{"key":"6064_CR83","first-page":"1819","volume":"14","author":"T Mimura","year":"2008","unstructured":"Mimura T, Amano S, Yokoo S, Uchida S, Yamagami S, Usui T, Kimura Y, Tabata Y (2008) Tissue engineering of corneal stroma with rabbit fibroblast precursors and gelatin hydrogels. Mol Vis 14:1819\u20131828","journal-title":"Mol Vis"},{"key":"6064_CR84","doi-asserted-by":"publisher","first-page":"35","DOI":"10.4252\/wjsc.v12.i1.35","volume":"12","author":"H Wadhwa","year":"2020","unstructured":"Wadhwa H, Ismail S, McGhee JJ, Van der Werf B, Sherwin T (2020) Sphere-forming corneal cells repopulate dystrophic keratoconic stroma: implications for potential therapy. World J Stem Cells 12:35\u201354. https:\/\/doi.org\/10.4252\/wjsc.v12.i1.35","journal-title":"World J Stem Cells"},{"key":"6064_CR85","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1093\/bmb\/ldr026","volume":"100","author":"N Di Girolamo","year":"2011","unstructured":"Di Girolamo N (2011) Stem cells of the human cornea. Br Med Bull 100:191\u2013207. https:\/\/doi.org\/10.1093\/bmb\/ldr026","journal-title":"Br Med Bull"},{"key":"6064_CR86","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s40662-018-0122-1","volume":"5","author":"JL Alio Del Barrio","year":"2018","unstructured":"Alio Del Barrio JL, Alio JL (2018) Cellular therapy of the corneal stroma: a new type of corneal surgery for keratoconus and corneal dystrophies. Eye Vis (Lond) 5:28. https:\/\/doi.org\/10.1186\/s40662-018-0122-1","journal-title":"Eye Vis (Lond)"},{"key":"6064_CR87","doi-asserted-by":"publisher","unstructured":"Mansoor H, Ong HS, Riau AK, Stanzel TP, Mehta JS, Yam GH (2019) Current trends and future perspective of mesenchymal stem cells and exosomes in corneal diseases. Int J Mol Sci 20 https:\/\/doi.org\/10.3390\/ijms20122853","DOI":"10.3390\/ijms20122853"},{"key":"6064_CR88","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1111\/j.1365-2184.1970.tb00347.x","volume":"3","author":"AJ Friedenstein","year":"1970","unstructured":"Friedenstein AJ, Chailakhjan RK, Lalykina KS (1970) The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet 3:393\u2013403. https:\/\/doi.org\/10.1111\/j.1365-2184.1970.tb00347.x","journal-title":"Cell Tissue Kinet"},{"key":"6064_CR89","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1002\/jor.1100090504","volume":"9","author":"AI Caplan","year":"1991","unstructured":"Caplan AI (1991) Mesenchymal stem cells. J Orthop Res 9:641\u2013650. https:\/\/doi.org\/10.1002\/jor.1100090504","journal-title":"J Orthop Res"},{"key":"6064_CR90","doi-asserted-by":"publisher","first-page":"2896","DOI":"10.1634\/stemcells.2007-0637","volume":"25","author":"DG Phinney","year":"2007","unstructured":"Phinney DG, Prockop DJ (2007) Concise review: mesenchymal stem\/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair\u2013current views. Stem Cells 25:2896\u20132902. https:\/\/doi.org\/10.1634\/stemcells.2007-0637","journal-title":"Stem Cells"},{"issue":"Suppl 1","key":"6064_CR91","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1186\/s12886-015-0138-4","volume":"15","author":"L Zhang","year":"2015","unstructured":"Zhang L, Coulson-Thomas VJ, Ferreira TG, Kao WW (2015) Mesenchymal stem cells for treating ocular surface diseases. BMC Ophthalmol 15(Suppl 1):155. https:\/\/doi.org\/10.1186\/s12886-015-0138-4","journal-title":"BMC Ophthalmol"},{"key":"6064_CR92","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1002\/stem.1895","volume":"33","author":"DG Harkin","year":"2015","unstructured":"Harkin DG, Foyn L, Bray LJ, Sutherland AJ, Li FJ, Cronin BG (2015) Concise reviews: can mesenchymal stromal cells differentiate into corneal cells? A systematic review of published data. Stem Cells 33:785\u2013791. https:\/\/doi.org\/10.1002\/stem.1895","journal-title":"Stem Cells"},{"key":"6064_CR93","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/s0074-7696(08)61760-x","volume":"63","author":"ED Hay","year":"1980","unstructured":"Hay ED (1980) Development of the vertebrate cornea. Int Rev Cytol 63:263\u2013322. https:\/\/doi.org\/10.1016\/s0074-7696(08)61760-x","journal-title":"Int Rev Cytol"},{"key":"6064_CR94","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1097\/ICO.0000000000001228","volume":"36","author":"JL Alio Del Barrio","year":"2017","unstructured":"Alio Del Barrio JL, El Zarif M, de Miguel MP, Azaar A, Makdissy N, Harb W, El Achkar I, Arnalich-Montiel F, Alio JL (2017) Cellular therapy with human autologous adipose-derived adult stem cells for advanced keratoconus. Cornea 36:952\u2013960. https:\/\/doi.org\/10.1097\/ICO.0000000000001228","journal-title":"Cornea"},{"key":"6064_CR95","doi-asserted-by":"publisher","first-page":"448","DOI":"10.18240\/ijo.2021.03.19","volume":"14","author":"XN Liu","year":"2021","unstructured":"Liu XN, Mi SL, Chen Y, Wang Y (2021) Corneal stromal mesenchymal stem cells: reconstructing a bioactive cornea and repairing the corneal limbus and stromal microenvironment. Int J Ophthalmol 14:448\u2013455. https:\/\/doi.org\/10.18240\/ijo.2021.03.19","journal-title":"Int J Ophthalmol"},{"key":"6064_CR96","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1634\/stemcells.2007-0653","volume":"26","author":"F Arnalich-Montiel","year":"2008","unstructured":"Arnalich-Montiel F, Pastor S, Blazquez-Martinez A, Fernandez-Delgado J, Nistal M, Alio JL, De Miguel MP (2008) Adipose-derived stem cells are a source for cell therapy of the corneal stroma. Stem Cells 26:570\u2013579. https:\/\/doi.org\/10.1634\/stemcells.2007-0653","journal-title":"Stem Cells"},{"key":"6064_CR97","doi-asserted-by":"publisher","first-page":"650724","DOI":"10.3389\/fmed.2021.650724","volume":"8","author":"M El Zarif","year":"2021","unstructured":"El Zarif M, Alio JL, Alio Del Barrio JL, De Miguel MP, Abdul Jawad K, Makdissy N (2021) Corneal stromal regeneration: a review of human clinical studies in keratoconus treatment. Front Med (Lausanne) 8:650724. https:\/\/doi.org\/10.3389\/fmed.2021.650724","journal-title":"Front Med (Lausanne)"},{"issue":"Suppl 1","key":"6064_CR98","doi-asserted-by":"publisher","first-page":"S9","DOI":"10.1097\/ICO.0000000000001010","volume":"35","author":"WW Kao","year":"2016","unstructured":"Kao WW, Coulson-Thomas VJ (2016) Cell therapy of corneal diseases. Cornea 35(Suppl 1):S9\u2013S19. https:\/\/doi.org\/10.1097\/ICO.0000000000001010","journal-title":"Cornea"},{"key":"6064_CR99","doi-asserted-by":"publisher","first-page":"574","DOI":"10.2174\/156652412800619950","volume":"12","author":"MP De Miguel","year":"2012","unstructured":"De Miguel MP, Fuentes-Julian S, Blazquez-Martinez A, Pascual CY, Aller MA, Arias J, Arnalich-Montiel F (2012) Immunosuppressive properties of mesenchymal stem cells: advances and applications. Curr Mol Med 12:574\u2013591. https:\/\/doi.org\/10.2174\/156652412800619950","journal-title":"Curr Mol Med"},{"key":"6064_CR100","doi-asserted-by":"publisher","unstructured":"Zhu Q, Li M, Yan C, Lu Q, Wei S, Gao R, Yu M, Zou Y, Sriram G, Tong HJ, Hunziker W, Seneviratne CJ, Gong Z, Olsen BR, Cao T (2017) Directed differentiation of human embryonic stem cells to neural crest stem cells, functional peripheral neurons, and corneal keratocytes. Biotechnol J 12 https:\/\/doi.org\/10.1002\/biot.201700067","DOI":"10.1002\/biot.201700067"},{"key":"6064_CR101","doi-asserted-by":"publisher","first-page":"e56831","DOI":"10.1371\/journal.pone.0056831","volume":"8","author":"AA Chan","year":"2013","unstructured":"Chan AA, Hertsenberg AJ, Funderburgh ML, Mann MM, Du Y, Davoli KA, Mich-Basso JD, Yang L, Funderburgh JL (2013) Differentiation of human embryonic stem cells into cells with corneal keratocyte phenotype. PLoS One 8:e56831. https:\/\/doi.org\/10.1371\/journal.pone.0056831","journal-title":"PLoS One"},{"key":"6064_CR102","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/7651_2015_231","volume":"1341","author":"AJ Hertsenberg","year":"2016","unstructured":"Hertsenberg AJ, Funderburgh JL (2016) Generation of corneal keratocytes from human embryonic stem cells. Methods Mol Biol 1341:285\u2013294. https:\/\/doi.org\/10.1007\/7651_2015_231","journal-title":"Methods Mol Biol"},{"key":"6064_CR103","doi-asserted-by":"publisher","first-page":"857066","DOI":"10.3389\/fcell.2022.857066","volume":"10","author":"KH Kwack","year":"2022","unstructured":"Kwack KH, Lee HW (2022) Clinical potential of dental pulp stem cells in pulp regeneration: current endodontic progress and future perspectives. Front Cell Dev Biol 10:857066. https:\/\/doi.org\/10.3389\/fcell.2022.857066","journal-title":"Front Cell Dev Biol"},{"key":"6064_CR104","doi-asserted-by":"publisher","first-page":"e20","DOI":"10.1017\/erm.2015.16","volume":"17","author":"GH Yam","year":"2015","unstructured":"Yam GH, Peh GS, Singhal S, Goh BT, Mehta JS (2015) Dental stem cells: a future asset of ocular cell therapy. Expert Rev Mol Med 17:e20. https:\/\/doi.org\/10.1017\/erm.2015.16","journal-title":"Expert Rev Mol Med"},{"key":"6064_CR105","doi-asserted-by":"publisher","first-page":"204173141770253","DOI":"10.1177\/2041731417702531","volume":"8","author":"EP Chalisserry","year":"2017","unstructured":"Chalisserry EP, Nam SY, Park SH, Anil S (2017) Therapeutic potential of dental stem cells. J Tissue Eng 8:2041731417702531. https:\/\/doi.org\/10.1177\/2041731417702531","journal-title":"J Tissue Eng"},{"key":"6064_CR106","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.1111\/jcmm.13589","volume":"22","author":"GH Yam","year":"2018","unstructured":"Yam GH, Teo EP, Setiawan M, Lovatt MJ, Yusoff N, Fuest M, Goh BT, Mehta JS (2018) Postnatal periodontal ligament as a novel adult stem cell source for regenerative corneal cell therapy. J Cell Mol Med 22:3119\u20133132. https:\/\/doi.org\/10.1111\/jcmm.13589","journal-title":"J Cell Mol Med"},{"key":"6064_CR107","doi-asserted-by":"publisher","first-page":"276","DOI":"10.5966\/sctm.2014-0115","volume":"4","author":"FN Syed-Picard","year":"2015","unstructured":"Syed-Picard FN, Du Y, Lathrop KL, Mann MM, Funderburgh ML, Funderburgh JL (2015) Dental pulp stem cells: a new cellular resource for corneal stromal regeneration. Stem Cells Transl Med 4:276\u2013285. https:\/\/doi.org\/10.5966\/sctm.2014-0115","journal-title":"Stem Cells Transl Med"},{"key":"6064_CR108","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1186\/s13287-017-0715-y","volume":"8","author":"J Chen","year":"2017","unstructured":"Chen J, Zhang W, Kelk P, Backman LJ, Danielson P (2017) Substance P and patterned silk biomaterial stimulate periodontal ligament stem cells to form corneal stroma in a bioengineered three-dimensional model. Stem Cell Res Ther 8:260. https:\/\/doi.org\/10.1186\/s13287-017-0715-y","journal-title":"Stem Cell Res Ther"},{"key":"6064_CR109","doi-asserted-by":"publisher","first-page":"824","DOI":"10.3389\/fneur.2019.00824","volume":"10","author":"X Lan","year":"2019","unstructured":"Lan X, Sun Z, Chu C, Boltze J, Li S (2019) Dental pulp stem cells: an attractive alternative for cell therapy in ischemic stroke. Front Neurol 10:824. https:\/\/doi.org\/10.3389\/fneur.2019.00824","journal-title":"Front Neurol"},{"key":"6064_CR110","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3390\/jfb2030213","volume":"2","author":"D Karamichos","year":"2011","unstructured":"Karamichos D, Rich CB, Hutcheon AE, Ren R, Saitta B, Trinkaus-Randall V, Zieske JD (2011) Self-assembled matrix by umbilical cord stem cells. J Funct Biomater 2:213\u2013229. https:\/\/doi.org\/10.3390\/jfb2030213","journal-title":"J Funct Biomater"},{"key":"6064_CR111","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1002\/stem.1481","volume":"31","author":"VJ Coulson-Thomas","year":"2013","unstructured":"Coulson-Thomas VJ, Caterson B, Kao WW (2013) Transplantation of human umbilical mesenchymal stem cells cures the corneal defects of mucopolysaccharidosis VII mice. Stem Cells 31:2116\u20132126. https:\/\/doi.org\/10.1002\/stem.1481","journal-title":"Stem Cells"},{"key":"6064_CR112","doi-asserted-by":"publisher","first-page":"312","DOI":"10.4252\/wjsc.v6.i3.312","volume":"6","author":"W Tsuji","year":"2014","unstructured":"Tsuji W, Rubin JP, Marra KG (2014) Adipose-derived stem cells: Implications in tissue regeneration. World J Stem Cells 6:312\u2013321. https:\/\/doi.org\/10.4252\/wjsc.v6.i3.312","journal-title":"World J Stem Cells"},{"key":"6064_CR113","doi-asserted-by":"publisher","first-page":"e76103","DOI":"10.1371\/journal.pone.0076103","volume":"8","author":"XY Ma","year":"2013","unstructured":"Ma XY, Bao HJ, Cui L, Zou J (2013) The graft of autologous adipose-derived stem cells in the corneal stromal after mechanic damage. PLoS One 8:e76103. https:\/\/doi.org\/10.1371\/journal.pone.0076103","journal-title":"PLoS One"},{"key":"6064_CR114","first-page":"2680","volume":"16","author":"Y Du","year":"2010","unstructured":"Du Y, Roh DS, Funderburgh ML, Mann MM, Marra KG, Rubin JP, Li X, Funderburgh JL (2010) Adipose-derived stem cells differentiate to keratocytes in vitro. Mol Vis 16:2680\u20132689","journal-title":"Mol Vis"},{"key":"6064_CR115","doi-asserted-by":"publisher","unstructured":"Zhang S, Espandar L, Imhof KM, Bunnell BA (2013) Differentiation of human adipose-derived stem cells along the keratocyte lineage in vitro. J Clin Exp Ophthalmol 4. https:\/\/doi.org\/10.4172\/2155-9570.1000270","DOI":"10.4172\/2155-9570.1000270"},{"key":"6064_CR116","doi-asserted-by":"publisher","unstructured":"Zeppieri M, Salvetat ML, Beltrami A, Cesselli D, Russo R, Alcalde I, Merayo-Lloves J, Brusini P, Parodi PC (2017) Adipose derived stem cells for corneal wound healing after laser induced corneal lesions in mice. J Clin Med 6. https:\/\/doi.org\/10.3390\/jcm6120115","DOI":"10.3390\/jcm6120115"},{"key":"6064_CR117","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.exer.2015.01.020","volume":"132","author":"JL Alio del Barrio","year":"2015","unstructured":"Alio del Barrio JL, Chiesa M, Garagorri N, Garcia-Urquia N, Fernandez-Delgado J, Bataille L, Rodriguez A, Arnalich-Montiel F, Zarnowski T, Alvarez de Toledo JP, Alio JL, De Miguel MP (2015) Acellular human corneal matrix sheets seeded with human adipose-derived mesenchymal stem cells integrate functionally in an experimental animal model. Exp Eye Res 132:91\u2013100. https:\/\/doi.org\/10.1016\/j.exer.2015.01.020","journal-title":"Exp Eye Res"},{"key":"6064_CR118","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ajo.2017.10.026","volume":"186","author":"JL Alio Del Barrio","year":"2018","unstructured":"Alio Del Barrio JL, El Zarif M, Azaar A, Makdissy N, Khalil C, Harb W, El Achkar I, Jawad ZA, de Miguel MP, Alio JL (2018) Corneal stroma enhancement with decellularized stromal laminas with or without stem cell recellularization for advanced keratoconus. Am J Ophthalmol 186:47\u201358. https:\/\/doi.org\/10.1016\/j.ajo.2017.10.026","journal-title":"Am J Ophthalmol"},{"key":"6064_CR119","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.ajo.2019.02.009","volume":"203","author":"JL Alio","year":"2019","unstructured":"Alio JL, Alio Del Barrio JL, El Zarif M, Azaar A, Makdissy N, Khalil C, Harb W, El Achkar I, Jawad ZA, De Miguel MP (2019) Regenerative surgery of the corneal stroma for advanced keratoconus: 1-year outcomes. Am J Ophthalmol 203:53\u201368. https:\/\/doi.org\/10.1016\/j.ajo.2019.02.009","journal-title":"Am J Ophthalmol"},{"key":"6064_CR120","doi-asserted-by":"publisher","unstructured":"El Zarif M, K AJ, Alio Del Barrio JL, Z AJ, Palazon-Bru A, de Miguel MP, Saba P, Makdissy N, Alio JL (2020) Corneal stroma cell density evolution in keratoconus corneas following the implantation of adipose mesenchymal stem cells and corneal laminas: an in vivo confocal microscopy study. Invest Ophthalmol Vis Sci 61: 22.  https:\/\/doi.org\/10.1167\/iovs.61.4.22","DOI":"10.1167\/iovs.61.4.22"},{"key":"6064_CR121","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1097\/ICO.0000000000002646","volume":"40","author":"M El Zarif","year":"2021","unstructured":"El Zarif M, Alio JL, Alio Del Barrio JL, Abdul Jawad K, Palazon-Bru A, Abdul Jawad Z, De Miguel MP, Makdissy N (2021) Corneal stromal regeneration therapy for advanced keratoconus: long-term outcomes at 3 years. Cornea 40:741\u2013754. https:\/\/doi.org\/10.1097\/ICO.0000000000002646","journal-title":"Cornea"},{"key":"6064_CR122","doi-asserted-by":"publisher","first-page":"108314","DOI":"10.1016\/j.exer.2020.108314","volume":"202","author":"JL Alio Del Barrio","year":"2021","unstructured":"Alio Del Barrio JL, Arnalich-Montiel F, De Miguel MP, El Zarif M, Alio JL (2021) Corneal stroma regeneration: preclinical studies. Exp Eye Res 202:108314. https:\/\/doi.org\/10.1016\/j.exer.2020.108314","journal-title":"Exp Eye Res"},{"key":"6064_CR123","doi-asserted-by":"publisher","first-page":"e10707","DOI":"10.1371\/journal.pone.0010707","volume":"5","author":"H Liu","year":"2010","unstructured":"Liu H, Zhang J, Liu CY, Wang IJ, Sieber M, Chang J, Jester JV, Kao WW (2010) Cell therapy of congenital corneal diseases with umbilical mesenchymal stem cells: lumican null mice. PLoS One 5:e10707. https:\/\/doi.org\/10.1371\/journal.pone.0010707","journal-title":"PLoS One"},{"key":"6064_CR124","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1111\/j.1582-4934.2011.01418.x","volume":"16","author":"H Liu","year":"2012","unstructured":"Liu H, Zhang J, Liu CY, Hayashi Y, Kao WW (2012) Bone marrow mesenchymal stem cells can differentiate and assume corneal keratocyte phenotype. J Cell Mol Med 16:1114\u20131124. https:\/\/doi.org\/10.1111\/j.1582-4934.2011.01418.x","journal-title":"J Cell Mol Med"},{"key":"6064_CR125","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.exer.2012.05.009","volume":"101","author":"SH Park","year":"2012","unstructured":"Park SH, Kim KW, Chun YS, Kim JC (2012) Human mesenchymal stem cells differentiate into keratocyte-like cells in keratocyte-conditioned medium. Exp Eye Res 101:16\u201326. https:\/\/doi.org\/10.1016\/j.exer.2012.05.009","journal-title":"Exp Eye Res"},{"key":"6064_CR126","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1089\/scd.2016.0030","volume":"25","author":"P Trosan","year":"2016","unstructured":"Trosan P, Javorkova E, Zajicova A, Hajkova M, Hermankova B, Kossl J, Krulova M, Holan V (2016) The supportive role of insulin-like growth factor-I in the differentiation of murine mesenchymal stem cells into corneal-like cells. Stem Cells Dev 25:874\u2013881. https:\/\/doi.org\/10.1089\/scd.2016.0030","journal-title":"Stem Cells Dev"},{"key":"6064_CR127","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.stem.2020.09.014","volume":"27","author":"S Yamanaka","year":"2020","unstructured":"Yamanaka S (2020) Pluripotent stem cell-based cell therapy-promise and challenges. Cell Stem Cell 27:523\u2013531. https:\/\/doi.org\/10.1016\/j.stem.2020.09.014","journal-title":"Cell Stem Cell"},{"key":"6064_CR128","doi-asserted-by":"publisher","first-page":"3685","DOI":"10.1167\/iovs.16-19105","volume":"57","author":"R Joseph","year":"2016","unstructured":"Joseph R, Srivastava OP, Pfister RR (2016) Modeling keratoconus using induced pluripotent stem cells. Invest Ophthalmol Vis Sci 57:3685\u20133697. https:\/\/doi.org\/10.1167\/iovs.16-19105","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6064_CR129","doi-asserted-by":"publisher","first-page":"e0165464","DOI":"10.1371\/journal.pone.0165464","volume":"11","author":"RW Naylor","year":"2016","unstructured":"Naylor RW, McGhee CN, Cowan CA, Davidson AJ, Holm TM, Sherwin T (2016) Derivation of corneal keratocyte-like cells from human induced pluripotent stem cells. PLoS One 11:e0165464. https:\/\/doi.org\/10.1371\/journal.pone.0165464","journal-title":"PLoS One"},{"key":"6064_CR130","doi-asserted-by":"publisher","first-page":"41286","DOI":"10.1038\/srep41286","volume":"7","author":"JW Foster","year":"2017","unstructured":"Foster JW, Wahlin K, Adams SM, Birk DE, Zack DJ, Chakravarti S (2017) Cornea organoids from human induced pluripotent stem cells. Sci Rep 7:41286. https:\/\/doi.org\/10.1038\/srep41286","journal-title":"Sci Rep"},{"key":"6064_CR131","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/978-1-0716-0599-8_5","volume":"2145","author":"JW Foster","year":"2020","unstructured":"Foster JW, Wahlin KJ, Chakravarti S (2020) A guide to the development of human corneaorganoids from induced pluripotent stem cells in culture. Methods Mol Biol 2145:51\u201358. https:\/\/doi.org\/10.1007\/978-1-0716-0599-8_5","journal-title":"Methods Mol Biol"},{"key":"6064_CR132","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1089\/jop.2013.0028","volume":"29","author":"DD Eveleth","year":"2013","unstructured":"Eveleth DD (2013) Cell-based therapies for ocular disease. J Ocul Pharmacol Ther 29:844\u2013854. https:\/\/doi.org\/10.1089\/jop.2013.0028","journal-title":"J Ocul Pharmacol Ther"},{"key":"6064_CR133","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1089\/jir.2018.0019","volume":"39","author":"KC Conlon","year":"2019","unstructured":"Conlon KC, Miljkovic MD, Waldmann TA (2019) Cytokines in the treatment of cancer. J Interferon Cytokine Res 39:6\u201321. https:\/\/doi.org\/10.1089\/jir.2018.0019","journal-title":"J Interferon Cytokine Res"},{"key":"6064_CR134","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1001\/archopht.116.11.1514","volume":"116","author":"AA Okada","year":"1998","unstructured":"Okada AA (1998) Cytokine therapy in eye disease. Arch Ophthalmol 116:1514\u20131516. https:\/\/doi.org\/10.1001\/archopht.116.11.1514","journal-title":"Arch Ophthalmol"},{"key":"6064_CR135","doi-asserted-by":"publisher","first-page":"108256","DOI":"10.1016\/j.exer.2020.108256","volume":"200","author":"A Tidu","year":"2020","unstructured":"Tidu A, Schanne-Klein MC, Borderie VM (2020) Development, structure, and bioengineering of the human corneal stroma: a review of collagen-based implants. Exp Eye Res 200:108256. https:\/\/doi.org\/10.1016\/j.exer.2020.108256","journal-title":"Exp Eye Res"},{"key":"6064_CR136","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.18240\/ijo.2020.09.23","volume":"13","author":"SF Li","year":"2020","unstructured":"Li SF, Han Y, Wang F, Su Y (2020) Progress in exosomes and their potential use in ocular diseases. Int J Ophthalmol 13:1493\u20131498. https:\/\/doi.org\/10.18240\/ijo.2020.09.23","journal-title":"Int J Ophthalmol"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-023-06064-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-023-06064-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-023-06064-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T09:03:40Z","timestamp":1697706220000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-023-06064-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,19]]},"references-count":136,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["6064"],"URL":"https:\/\/doi.org\/10.1007\/s00417-023-06064-7","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,19]]},"assertion":[{"value":"5 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}