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The MicroShunt group was matched with the trabeculectomy group for age, known duration of disease, and number and classes of intraocular pressure (IOP) lowering medications to have similar conjunctival conditions. The study is part of the Dresden Glaucoma and Treatment Study, using a uniform study design, with the same inclusion and exclusion criteria, follow-ups and standardized definitions of success and failure for both procedures. Primary outcome measures: mean diurnal IOP (mdIOP, mean of 6 measurements), peak IOP, and IOP fluctuations. Secondary outcome measures: success rates, number of IOP lowering medications, visual acuity, visual fields, complications, surgical interventions, and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty eyes of 60 patients, 30 in each group, were analyzed after 1-year follow-ups. Median [Q25, Q75] mdIOP (mmHg) dropped from 16.2 [13.8\u201321.5] to 10.5 [8.9\u201313.5] in the MicroShunt and from 17.6 [15.6\u201324.0] to 11.1 [9.5\u201312.3] in the trabeculectomy group, both without glaucoma medications. Reduction of mdIOP (P\u2009=\u2009.596), peak IOP (P\u2009=\u2009.702), and IOP fluctuations (P\u2009=\u2009.528) was not statistically significantly different between groups. The rate of interventions was statistically significantly higher in the trabeculectomy group, especially in the early postoperative period (P\u2009=\u2009.018). None of the patients experienced severe adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both procedures are equally effective and safe in lowering mdIOP, peak IOP and IOP fluctuations in patients with POAG, one year after surgery.<\/jats:p>\n                    <jats:p>Clinical trial registration: NCT02959242.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00417-023-06075-4","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T05:02:32Z","timestamp":1683090152000},"page":"2901-2915","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["PRESERFLO \u2122 MicroShunt versus trabeculectomy: 1-year results on efficacy and safety"],"prefix":"10.1007","volume":"261","author":[{"given":"Melanie","family":"Jamke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Herber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike A.","family":"Haase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin S.","family":"Jasper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz E.","family":"Pillunat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4400-6004","authenticated-orcid":false,"given":"Karin R.","family":"Pillunat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,3]]},"reference":[{"key":"6075_CR1","unstructured":"Pillunat KR, Herber R, Jamke M, Haase M, Pillunat LE (2022) PRESERFLO MicroShunt versus Trabekulektomie bei prim\u00e4rem Offenwinkelglaukom: 1 Jahres-Ergebnisse. 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