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The aim of this study was to evaluate the long-term efficacy of pars plana vitrectomy (PPV) combined with autologous platelet concentrate (APC) for the treatment of optic disc pit maculopathy (ODP-M).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A retrospective analysis was performed on eleven eyes of ten patients with ODP-M, who received PPV combined with APC. Nine eyes operated primary, four of which had a repeat surgery also with injection of APC and two eyes underwent a rescue surgery, after they have been operated in another eye center without APC. Morphological and functional results were the main outcome parameters, determined by optical coherence tomography (OCT) and best-corrected visual acuity (BCVA), respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The mean duration of visual loss before surgery was 4.7\u2009\u00b1\u20093.89\u00a0months (range 0\u201312\u00a0months). The mean BCVA increased significantly from 0.82\u2009\u00b1\u20090.33 logMAR (range 0.4\u20131.3) preoperatively to 0.51\u2009\u00b1\u20090.36 logMAR (range 0\u20131.2) at the last examination (<jats:italic>p<\/jats:italic>\u2009=\u20090.0022). A significant morphological improvement was also noticed with decrease of the mean foveal thickness from 935.82\u2009\u00b1\u2009248.48\u00a0\u00b5m (range 559\u20131400\u00a0\u00b5m) preoperatively to 226.45\u2009\u00b1\u200976.09\u00a0\u00b5m (range 110\u2013344\u00a0\u00b5m) at the final examination (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). The patients were followed-up for a mean 65.36\u2009\u00b1\u200948.81\u00a0months (range 1\u2013144\u00a0months). Two eyes developed postoperatively a retinal detachment. Cataract surgery was performed in 5 eyes during the follow-up period.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our study demonstrated that PPV with APC can improve functional and morphological outcomes, both as a primary and a rescue therapy, without any recurrence over a long follow-up period. To the best of our knowledge, this was the longest observation period regarding the use of APC in treatment of ODP-M.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00417-023-06159-1","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T13:05:00Z","timestamp":1688994300000},"page":"3177-3185","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Long-term outcomes of autologous platelet treatment for optic disc pit maculopathy"],"prefix":"10.1007","volume":"261","author":[{"given":"Konstantinos","family":"Gklavas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8970-6653","authenticated-orcid":false,"given":"Alexandros","family":"Athanasiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Neubauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelia","family":"Lilou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Pohl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl Ulrich","family":"Bartz-Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spyridon","family":"Dimopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"issue":"1","key":"6159_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/0039-6257(82)90111-4","volume":"27","author":"DJ Apple","year":"1982","unstructured":"Apple DJ, Rabb MF, Walsh PM (1982) Congenital anomalies of the optic disc. 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