{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T13:32:38Z","timestamp":1793280758036,"version":"4.5.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K09840"],"award-info":[{"award-number":["22K09840"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K9820"],"award-info":[{"award-number":["22K9820"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1007\/s00417-023-06304-w","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T10:01:49Z","timestamp":1699351309000},"page":"1329-1335","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Immunophenotypic profiles in chalazion and pyogenic granuloma associated with chalazion"],"prefix":"10.1007","volume":"262","author":[{"given":"Rey","family":"Nemoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1258-3587","authenticated-orcid":false,"given":"Yoshihiko","family":"Usui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinya","family":"Tsubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Sugawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitaka","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"6304_CR1","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1002\/dc.20092","volume":"31","author":"U Dhaliwal","year":"2004","unstructured":"Dhaliwal U, Arora VK, Singh N et al (2004) Cytopathology of chalazia. Diagn Cytopathol 31:118\u2013122","journal-title":"Diagn Cytopathol"},{"key":"6304_CR2","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jtos.2014.12.002","volume":"13","author":"T Suzuki","year":"2015","unstructured":"Suzuki T, Teramukai S, Kinoshita S (2015) Meibomian glands and ocular surface inflammation. Ocul Surf 13:133\u2013149","journal-title":"Ocul Surf"},{"key":"6304_CR3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jtos.2021.12.010","volume":"24","author":"T Suzuki","year":"2022","unstructured":"Suzuki T, Katsuki N, Tsutsumi R et al (2022) Reconsidering the pathogenesis of chalazion. Ocul Surf 24:31\u201333. https:\/\/doi.org\/10.1016\/j.jtos.2021.12.010","journal-title":"Ocul Surf"},{"key":"6304_CR4","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1136\/bjo.82.2.196","volume":"82","author":"JL Brookers","year":"1998","unstructured":"Brookers JL, Bentley C, Verma S et al (1998) Microcystic adnexal carcinoma masquerading as a chalazion. Br J Ophthalmol 82:196\u2013197","journal-title":"Br J Ophthalmol"},{"key":"6304_CR5","first-page":"175","volume":"168","author":"DV Domarus","year":"1976","unstructured":"Domarus DV, Hinzpeter EN, Naumann GO (1976) The clinical misdiagnosis of chalazion. Klin Monatsbl Augenheilkd 168:175\u2013181","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"6304_CR6","first-page":"740","volume":"104","author":"E Enomoto","year":"2000","unstructured":"Enomoto E, Kamura Y, Nohara M et al (2000) A Case of giant sebaceous gland carcinoma without adequate treatment. Nippon Ganka Gakkai Zasshi 104:740\u2013745","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"6304_CR7","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1097\/00002341-200203000-00014","volume":"18","author":"B Esmali","year":"2002","unstructured":"Esmali B, Cleary KL, Ho L et al (2002) Leiomyosarcomas of the esophagus metastatic to the eyelid: a clinicopathologic report. Ophthal Plast Reconstr Surg 18:159\u2013161","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"6304_CR8","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1055\/s-2001-15909","volume":"218","author":"DM Gerber","year":"2001","unstructured":"Gerber DM, Meyer P, Messerli JO et al (2001) Masquerade of sebaceous gland carcinoma as a rapidly recurring \u201cchalazion\u201d: a case report. Klin Monatsbl Augenheilkd 218:391\u2013393","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"6304_CR9","first-page":"101","volume-title":"Principles and Practice of Ophthalmology","author":"AM Bajart","year":"1994","unstructured":"Bajart AM (1994) Lid inflammations. In: Albert DM, Jakobiec FA (eds) Principles and Practice of Ophthalmology. WB Saunders, Philadelphia, pp 101\u2013116"},{"key":"6304_CR10","first-page":"81","volume-title":"Greer\u2019s Ocular Pathology","author":"DR Lucas","year":"1989","unstructured":"Lucas DR (1989) The eyelids. Greer\u2019s Ocular Pathology. Blackwell Scientific, Boston, pp 81\u201398"},{"key":"6304_CR11","volume-title":"Ophthalmic pathology: an illustrated guide for clinicians","author":"KW Sehu","year":"2012","unstructured":"Sehu KW, Lee WR (2012) Ophthalmic pathology: an illustrated guide for clinicians. John Wiley & Sons"},{"key":"6304_CR12","first-page":"1588","volume":"7","author":"JT Pattern","year":"1975","unstructured":"Pattern JT, Hynduik RA (1975) Granuloma pyogenicum of the conjunctiva. Ann Ophthalmol 7:1588\u20131590","journal-title":"Ann Ophthalmol"},{"key":"6304_CR13","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/S0008-4182(01)80019-3","volume":"36","author":"DR Jordan","year":"2001","unstructured":"Jordan DR, Brownstein S, Lee-Wing M et al (2001) Pyogenic granuloma following oculoplastic procedures: an imbalance in angiogenesis regulation? Can J Ophthalmol 36:260\u2013268","journal-title":"Can J Ophthalmol"},{"key":"6304_CR14","first-page":"327","volume":"87","author":"AP Ferry","year":"1989","unstructured":"Ferry AP (1989) Pyogenic granulomas of the eye and ocular adnexa: a study of 100 cases. Trans Am Ophthalmol Soc 87:327\u2013343","journal-title":"Trans Am Ophthalmol Soc"},{"key":"6304_CR15","doi-asserted-by":"publisher","first-page":"584","DOI":"10.3928\/1542-8877-19990701-18","volume":"30","author":"YA Akova","year":"1999","unstructured":"Akova YA, Demirhan B, Cakmakci S et al (1999) Pyogenic granuloma: a rare complications of silicone punctal plugs. Ophthalmic Surg Lasers 30:584\u2013585","journal-title":"Ophthalmic Surg Lasers"},{"key":"6304_CR16","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1016\/j.ophtha.2005.01.048","volume":"112","author":"GM Espinoza","year":"2005","unstructured":"Espinoza GM, Lueder GT (2005) Conjunctival pyogenic granulomas after strabismus surgery. Ophthalmology 112:1283\u20131286","journal-title":"Ophthalmology"},{"key":"6304_CR17","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1136\/bjo.86.4.394","volume":"86","author":"CJ Lin","year":"2002","unstructured":"Lin CJ, Liao SL, Jou JR et al (2002) Complications of motility peg placement for porous hydroxyapatite orbital implants. Br J Ophthalmol 86:394\u2013396","journal-title":"Br J Ophthalmol"},{"key":"6304_CR18","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1097\/01.iop.0000245478.17947.85","volume":"22","author":"N Owji","year":"2006","unstructured":"Owji N, Sadeghipour A, Salour H et al (2006) Pyogenic granuloma as a presenting sign of hydroxyapatite orbital implant exposure: a clinicopathologic study. Ophthalmic Plast Reconstr Surg 22:467\u2013471","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"6304_CR19","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1097\/00002341-199312000-00013","volume":"9","author":"SM Soll","year":"2006","unstructured":"Soll SM, Lisman RD, Charles NC et al (2006) Pyogenic granuloma after transconjunctival blepharoplasty: a case report. Ophthalmic Plast Reconstr Surg 9:298\u2013301","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"6304_CR20","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.ajo.2010.10.026","volume":"151","author":"GJ Ben Simon","year":"2011","unstructured":"Ben Simon GJ, Rosen N, Rosner M et al (2011) Intralesional triamcinolone acetonide injection versus incision and curettage for primary chalazia: a prospective, randomized study. Am J Ophthalmol 151:714\u2013718","journal-title":"Am J Ophthalmol"},{"key":"6304_CR21","first-page":"522","volume":"20","author":"N Nicolaides","year":"1981","unstructured":"Nicolaides N, Kaitaranta JK, Rawdah TN et al (1981) Meibomian gland studies: comparison of steer and human lipids. Invest Ophthalmol Vis Sci 20:522\u2013536","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6304_CR22","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1136\/bjo.2005.080846","volume":"90","author":"PS Tsai","year":"2002","unstructured":"Tsai PS, Evans JE, Green KM et al (2002) Proteomic analysis of human meibomian gland secretions. Br J Ophthalmol 90:372\u2013377","journal-title":"Br J Ophthalmol"},{"key":"6304_CR23","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.resinv.2015.02.005","volume":"53","author":"P Yorozu","year":"2015","unstructured":"Yorozu P, Furukawa A, Uchida K et al (2015) Propionibacterium acnes catalase induces increased Th1 immune response in sarcoidosis patients. Respir Investig 53:161\u2013169","journal-title":"Respir Investig"},{"key":"6304_CR24","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","volume":"155","author":"S Sakaguchi","year":"1995","unstructured":"Sakaguchi S, Sakaguchi N, Asano M et al (1995) Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155:1151\u20131164","journal-title":"J Immunol"},{"key":"6304_CR25","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.cell.2008.05.009","volume":"133","author":"S Sakaguchi","year":"2008","unstructured":"Sakaguchi S, Yamaguchi T, Nomura T et al (2008) Regulatory T cells and immune tolerance. Cell 133:775\u2013787","journal-title":"Cell"},{"key":"6304_CR26","first-page":"158","volume":"18","author":"K Mohan","year":"1986","unstructured":"Mohan K, Dhir SP, Munjal VP, Jain IS (1986) The use of intralesional steroids in the treatment of chalazion. Ann Ophthalmol 18:158\u2013160","journal-title":"Ann Ophthalmol"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-023-06304-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-023-06304-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-023-06304-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T08:06:00Z","timestamp":1712217960000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-023-06304-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,7]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["6304"],"URL":"https:\/\/doi.org\/10.1007\/s00417-023-06304-w","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,7]]},"assertion":[{"value":"9 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}