{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:56:26Z","timestamp":1781650586187,"version":"3.54.5"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1007\/s00417-024-06390-4","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T09:03:27Z","timestamp":1707815007000},"page":"2189-2198","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Monitoring the transition from corneal ulceration to healed scar using a Scheimpflug tomography\u2013based densitometry"],"prefix":"10.1007","volume":"262","author":[{"given":"Yen-Cheng","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ting","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Fang","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hun-Ju","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Chiung","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren-Wen","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Hui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4159-0564","authenticated-orcid":false,"given":"Ming-Tse","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"6390_CR1","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1136\/bjophthalmol-2011-300539","volume":"96","author":"D Pascolini","year":"2012","unstructured":"Pascolini D, Mariotti SP (2012) Global estimates of visual impairment: 2010. Br J Ophthalmol 96:614\u2013618. https:\/\/doi.org\/10.1136\/bjophthalmol-2011-300539","journal-title":"Br J Ophthalmol"},{"key":"6390_CR2","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1038\/s41433-020-01339-3","volume":"35","author":"DSJ Ting","year":"2021","unstructured":"Ting DSJ, Ho CS, Deshmukh R, Said DG, Dua HS (2021) Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance. Eye (Lond) 35:1084\u20131101. https:\/\/doi.org\/10.1038\/s41433-020-01339-3","journal-title":"Eye (Lond)"},{"key":"6390_CR3","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.survophthal.2018.12.003","volume":"64","author":"L Ung","year":"2019","unstructured":"Ung L, Bispo PJM, Shanbhag SS, Gilmore MS, Chodosh J (2019) The persistent dilemma of microbial keratitis: global burden, diagnosis, and antimicrobial resistance. Surv Ophthalmol 64:255\u2013271. https:\/\/doi.org\/10.1016\/j.survophthal.2018.12.003","journal-title":"Surv Ophthalmol"},{"key":"6390_CR4","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.ajo.2018.07.040","volume":"195","author":"WB Khor","year":"2018","unstructured":"Khor WB, Prajna VN, Garg P, Mehta JS, Xie L, Liu Z, Padilla MDB, Joo CK, Inoue Y, Goseyarakwong P, Hu FR, Nishida K, Kinoshita S, Puangsricharern V, Tan AL, Beuerman R, Young A, Sharma N, Haaland B, Mah FS, Tu EY, Stapleton FJ, Abbott RL, Tan DT (2018) The Asia Cornea Society Infectious Keratitis Study: a prospective multicenter study of infectious keratitis in Asia. Am J Ophthalmol 195:161\u2013170. https:\/\/doi.org\/10.1016\/j.ajo.2018.07.040","journal-title":"Am J Ophthalmol"},{"key":"6390_CR5","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1016\/j.ophtha.2017.05.012","volume":"124","author":"A Austin","year":"2017","unstructured":"Austin A, Lietman T, Rose-Nussbaumer J (2017) Update on the management of infectious keratitis. Ophthalmology 124:1678\u20131689. https:\/\/doi.org\/10.1016\/j.ophtha.2017.05.012","journal-title":"Ophthalmology"},{"key":"6390_CR6","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.ajo.2019.03.023","volume":"205","author":"HY Liu","year":"2019","unstructured":"Liu HY, Chu HS, Wang IJ, Chen WL, Hu FR (2019) Microbial keratitis in Taiwan: a 20-year update. Am J Ophthalmol 205:74\u201381. https:\/\/doi.org\/10.1016\/j.ajo.2019.03.023","journal-title":"Am J Ophthalmol"},{"key":"6390_CR7","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1111\/aos.14789","volume":"99","author":"S Xu","year":"2021","unstructured":"Xu S, Guo D, Liu X, Jin X, Shi Y, Wang Y, Zhang N, Zhang H (2021) Ocular pathogens and antibiotic resistance in microbial keratitis over three years in Harbin, Northeast China. Acta Ophthalmol 99:909\u2013915. https:\/\/doi.org\/10.1111\/aos.14789","journal-title":"Acta Ophthalmol"},{"key":"6390_CR8","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.micpath.2016.12.013","volume":"104","author":"S Lakhundi","year":"2017","unstructured":"Lakhundi S, Siddiqui R, Khan NA (2017) Pathogenesis of microbial keratitis. Microb Pathog 104:97\u2013109. https:\/\/doi.org\/10.1016\/j.micpath.2016.12.013","journal-title":"Microb Pathog"},{"key":"6390_CR9","doi-asserted-by":"publisher","first-page":"318","DOI":"10.20344\/amp.12663","volume":"33","author":"MA Oliveira","year":"2020","unstructured":"Oliveira MA, Rosa A, Soares M, Gil J, Costa E, Quadrado MJ, Murta J (2020) Anterior segment optical coherence tomography in the early management of microbial keratitis: a cross-sectional study. Acta Med Port 33:318\u2013325. https:\/\/doi.org\/10.20344\/amp.12663","journal-title":"Acta Med Port"},{"key":"6390_CR10","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1007\/s10792-016-0397-y","volume":"37","author":"N Garz\u00f3n","year":"2017","unstructured":"Garz\u00f3n N, Poyales F, Illarramendi I, Mendicute J, J\u00e1\u00f1ez \u00d3, Caro P, L\u00f3pez A, Arg\u00fceso F (2017) Corneal densitometry and its correlation with age, pachymetry, corneal curvature, and refraction. Int Ophthalmol 37:1263\u20131268. https:\/\/doi.org\/10.1007\/s10792-016-0397-y","journal-title":"Int Ophthalmol"},{"key":"6390_CR11","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1080\/08820538.2019.1620796","volume":"34","author":"TH Dohlman","year":"2019","unstructured":"Dohlman TH, Yin J, Dana R (2019) Methods for assessing corneal opacity. Semin Ophthalmol 34:205\u2013210. https:\/\/doi.org\/10.1080\/08820538.2019.1620796","journal-title":"Semin Ophthalmol"},{"key":"6390_CR12","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1167\/iovs.13-13236","volume":"55","author":"S Nd","year":"2014","unstructured":"Nd S, Rozema JJ, Jongenelen S, Ruiz Hidalgo I, Zakaria N, Tassignon MJ (2014) Normative values for corneal densitometry analysis by Scheimpflug optical assessment. Invest Ophthalmol Vis Sci 55:162\u2013168. https:\/\/doi.org\/10.1167\/iovs.13-13236","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6390_CR13","first-page":"447","volume":"111","author":"J Matsuda","year":"2007","unstructured":"Matsuda J, Hieda O, Kinoshita S (2007) Quantification of corneal opacity after refractive corneal surgery using the anterior segment analyzer. Nippon Ganka Gakkai Zasshi 111:447\u2013453","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"6390_CR14","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1097\/ico.0000000000000711","volume":"35","author":"M Alnawaiseh","year":"2016","unstructured":"Alnawaiseh M, Zumhagen L, Wirths G, Eveslage M, Eter N, Rosentreter A (2016) Corneal densitometry, central corneal thickness, and corneal central-to-peripheral thickness ratio in patients with Fuchs endothelial dystrophy. Cornea 35:358\u2013362. https:\/\/doi.org\/10.1097\/ico.0000000000000711","journal-title":"Cornea"},{"key":"6390_CR15","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1136\/bjophthalmol-2012-302913","volume":"97","author":"HM Elflein","year":"2013","unstructured":"Elflein HM, Hofherr T, Berisha-Ramadani F, Weyer V, Lampe C, Beck M, Pitz S (2013) Measuring corneal clouding in patients suffering from mucopolysaccharidosis with the Pentacam densitometry programme. Br J Ophthalmol 97:829\u2013833. https:\/\/doi.org\/10.1136\/bjophthalmol-2012-302913","journal-title":"Br J Ophthalmol"},{"key":"6390_CR16","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3928\/1081597x-20100618-02","volume":"27","author":"AI Takacs","year":"2011","unstructured":"Takacs AI, Mihaltz K, Nagy ZZ (2011) Corneal density with the Pentacam after photorefractive keratectomy. J Refract Surg 27:269\u2013277. https:\/\/doi.org\/10.3928\/1081597x-20100618-02","journal-title":"J Refract Surg"},{"key":"6390_CR17","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1016\/j.jcrs.2011.03.037","volume":"37","author":"G Cennamo","year":"2011","unstructured":"Cennamo G, Forte R, Aufiero B, La Rana A (2011) Computerized Scheimpflug densitometry as a measure of corneal optical density after excimer laser refractive surgery in myopic eyes. J Cataract Refract Surg 37:1502\u20131506. https:\/\/doi.org\/10.1016\/j.jcrs.2011.03.037","journal-title":"J Cataract Refract Surg"},{"key":"6390_CR18","doi-asserted-by":"publisher","first-page":"18","DOI":"10.5301\/ejo.5000644","volume":"26","author":"MA Anayol","year":"2016","unstructured":"Anayol MA, Sekeroglu MA, Ceran BB, Dogan M, Gunaydin S, Yilmazbas P (2016) Quantitative assessment of corneal clarity in keratoconus: a case control study of corneal densitometry. Eur J Ophthalmol 26:18\u201323. https:\/\/doi.org\/10.5301\/ejo.5000644","journal-title":"Eur J Ophthalmol"},{"key":"6390_CR19","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1097\/ico.0000000000000266","volume":"33","author":"B Lopes","year":"2014","unstructured":"Lopes B, Ramos I, Ambr\u00f3sio R Jr (2014) Corneal densitometry in keratoconus. Cornea 33:1282\u20131286. https:\/\/doi.org\/10.1097\/ico.0000000000000266","journal-title":"Cornea"},{"key":"6390_CR20","doi-asserted-by":"publisher","first-page":"207","DOI":"10.4103\/jovr.jovr_96_17","volume":"13","author":"A Peyman","year":"2018","unstructured":"Peyman A, Pourazizi M (2018) Scheimpflug-based optical densitometry for assessment of corneal opacity: an objective method to monitor interstitial keratitis. J Ophthalmic Vis Res 13:207\u2013209. https:\/\/doi.org\/10.4103\/jovr.jovr_96_17","journal-title":"J Ophthalmic Vis Res"},{"key":"6390_CR21","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.ophtha.2011.08.024","volume":"119","author":"AM Otri","year":"2012","unstructured":"Otri AM, Fares U, Al-Aqaba MA, Dua HS (2012) Corneal densitometry as an indicator of corneal health. Ophthalmology 119:501\u2013508. https:\/\/doi.org\/10.1016\/j.ophtha.2011.08.024","journal-title":"Ophthalmology"},{"key":"6390_CR22","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s10792-013-9736-4","volume":"34","author":"F Orucoglu","year":"2014","unstructured":"Orucoglu F, Talaz S, Aksu A, Muftuoglu O (2014) Corneal densitometry evaluation in archipelago keratitis. Int Ophthalmol 34:99\u2013102. https:\/\/doi.org\/10.1007\/s10792-013-9736-4","journal-title":"Int Ophthalmol"},{"key":"6390_CR23","doi-asserted-by":"publisher","unstructured":"Kuo MT, Hsu SL, You HL, Kuo SF, Fang PC, Yu HJ, Chen A, Tseng CY, Lai YH, Chen JL (2022) Diagnosing fungal keratitis and simultaneously identifying Fusarium and Aspergillus keratitis with a dot hybridization array. J Fungi (Basel) 8. https:\/\/doi.org\/10.3390\/jof8010064","DOI":"10.3390\/jof8010064"},{"key":"6390_CR24","first-page":"614","volume":"23","author":"FC Huang","year":"2017","unstructured":"Huang FC, Hsieh HY, Chang TC, Su SL, Tseng SL, Lai YH, Kuo MT (2017) A DNA dot hybridization model for molecular diagnosis of parasitic keratitis. Mol Vis 23:614\u2013623","journal-title":"Mol Vis"},{"key":"6390_CR25","first-page":"306","volume":"23","author":"PC Fang","year":"2017","unstructured":"Fang PC, Chien CC, Yu HJ, Ho RW, Tseng SL, Lai YH, Kuo MT (2017) A dot hybridization assay for the diagnosis of bacterial keratitis. Mol Vis 23:306\u2013317","journal-title":"Mol Vis"},{"key":"6390_CR26","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1167\/iovs.15-17741","volume":"57","author":"MT Kuo","year":"2016","unstructured":"Kuo MT, Fang PC, Yu HJ, Chao TL, Chien CC, Chen SH, Wang JR, Tseng SL, Lai YH, Hsiao CC, Chang TC (2016) A multiplex dot hybridization assay for detection and differentiation of Acanthamoeba and herpes keratitis. Invest Ophthalmol Vis Sci 57:2158\u20132163. https:\/\/doi.org\/10.1167\/iovs.15-17741","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6390_CR27","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.3758\/brm.41.4.1149","volume":"41","author":"F Faul","year":"2009","unstructured":"Faul F, Erdfelder E, Buchner A, Lang AG (2009) Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods 41:1149\u20131160. https:\/\/doi.org\/10.3758\/brm.41.4.1149","journal-title":"Behav Res Methods"},{"key":"6390_CR28","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1167\/iovs.15-17657","volume":"57","author":"JW McLaren","year":"2016","unstructured":"McLaren JW, Wacker K, Kane KM, Patel SV (2016) Measuring corneal haze by using Scheimpflug photography and confocal microscopy. Invest Ophthalmol Vis Sci 57:227\u2013235. https:\/\/doi.org\/10.1167\/iovs.15-17657","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6390_CR29","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.jtos.2015.05.002","volume":"13","author":"WM Petroll","year":"2015","unstructured":"Petroll WM, Robertson DM (2015) In vivo confocal microscopy of the cornea: new developments in image acquisition, reconstruction, and analysis using the HRT-Rostock Corneal Module. Ocul Surf 13:187\u2013203. https:\/\/doi.org\/10.1016\/j.jtos.2015.05.002","journal-title":"Ocul Surf"},{"key":"6390_CR30","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.ajo.2008.05.030","volume":"146","author":"A Konstantopoulos","year":"2008","unstructured":"Konstantopoulos A, Kuo J, Anderson D, Hossain P (2008) Assessment of the use of anterior segment optical coherence tomography in microbial keratitis. Am J Ophthalmol 146:534\u2013542. https:\/\/doi.org\/10.1016\/j.ajo.2008.05.030","journal-title":"Am J Ophthalmol"},{"key":"6390_CR31","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1038\/eye.2017.107","volume":"31","author":"F Poyales","year":"2017","unstructured":"Poyales F, Garz\u00f3n N, Mendicute J, Illarramendi I, Caro P, J\u00e1\u00f1ez O, Arg\u00fceso F, L\u00f3pez A (2017) Corneal densitometry after photorefractive keratectomy, laser-assisted in situ keratomileusis, and small-incision lenticule extraction. Eye (Lond) 31:1647\u20131654. https:\/\/doi.org\/10.1038\/eye.2017.107","journal-title":"Eye (Lond)"},{"key":"6390_CR32","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1097\/ico.0000000000002451","volume":"40","author":"H Kiziltoprak","year":"2021","unstructured":"Kiziltoprak H, Atesoglu H, Tekin K, Yetkin E, Koc M (2021) Evaluation of densitometric analysis for early detection of corneal blood staining in hyphema. Cornea 40:467\u2013471. https:\/\/doi.org\/10.1097\/ico.0000000000002451","journal-title":"Cornea"},{"key":"6390_CR33","doi-asserted-by":"publisher","unstructured":"Hsieh TH, Yu HJ, Yang IH, Ho RW, Hsiao YT, Fang PC, Kuo MT (2021) Simultaneously monitoring whole corneal injury with corneal optical density and thickness in patients undergoing cataract surgery. Diagnostics (Basel) 11. https:\/\/doi.org\/10.3390\/diagnostics11091639","DOI":"10.3390\/diagnostics11091639"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-024-06390-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-024-06390-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-024-06390-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T14:09:56Z","timestamp":1720015796000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-024-06390-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,13]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["6390"],"URL":"https:\/\/doi.org\/10.1007\/s00417-024-06390-4","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,13]]},"assertion":[{"value":"3 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Institutional review board\/ethics committee approval (No. 201901910B0C501) was obtained from the committee of medical ethics and human experiments of Chang Gung Memorial Hospital.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All participants and their legal representatives were informed about the aim and procedure of this study and signed the informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors have read and agreed to the published version of the manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}