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Analysis of optical coherence tomography (OCT) and OCT angiography (OCTA) of AMN patients may provide insights into disease mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective study of consecutive SARS-Cov-2-related AMN patients that presented in our clinic between Jan 1st, 2022, and April 30th, 2023, within 30\u00a0days of symptom onset. Retinal vessel area density (VAD) of AMN lesions in OCTA was quantified and compared to an adjacent tissue control (ATC). This quantification was performed for the superficial vascular plexus (SVP), the intermediate capillary plexus (ICP), the deep capillary plexus (DCP), the choriocapillaris (CC), and choroid. Furthermore, en face OCT images were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nine AMN patients were identified, 6 of these (4 female, 2 male, average age 25\u00a0years) fulfilled the inclusion criteria and were included into this study. Average time from symptom onset to OCTA was 14.3\u00a0days. No VAD differences between AMN and adjacent tissue were found in either retinal layer (SVP, ICP, DCP). In contrast, VAD in CC was reduced by 27% against the ATC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) and choroidal VAD was reduced by 41% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017). Further analysis of en face OCT could show that the pathognomonic infrared hyporeflectivity in AMN is caused by photoreceptor alterations rather than changes in the inner retinal layers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data suggests that a perfusion deficit in the choroidal layers is responsible for AMN rather than in the DCP, which is the predominant hypothesis in current literature.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00417-024-06436-7","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T05:02:14Z","timestamp":1710997334000},"page":"2471-2479","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Optical coherence tomography angiography suggests choriocapillaris perfusion deficit as etiology of acute macular neuroretinopathy"],"prefix":"10.1007","volume":"262","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2163-5905","authenticated-orcid":false,"given":"Claus","family":"von der Burchard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arved","family":"Gruben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Roider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"6436_CR1","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/0002-9394(75)90387-6","volume":"80","author":"PJ Bos","year":"1975","unstructured":"Bos PJ, Deutman AF (1975) Acute macular neuroretinopathy. 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