{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:43:56Z","timestamp":1773272636044,"version":"3.50.1"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["13N14444"],"award-info":[{"award-number":["13N14444"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["13N14445"],"award-info":[{"award-number":["13N14445"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["13N14443"],"award-info":[{"award-number":["13N14443"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004168","name":"Universit\u00e4t zu L\u00fcbeck","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004168","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To investigate the sensitivity of fluorescence lifetime imaging ophthalmoscopy (FLIO) to detect retinal laser spots by comparative analysis with other imaging modalities.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A diode laser with a wavelength of 514\u00a0nm was applied with\u00a0pulse durations of 5.2, 12, 20, and 50\u00a0\u00b5s. The laser pulse energy was increased so that the visibility of the laser spot by slit-lamp fundus examination (SL) under the irradiator\u2019s observation covers from the subvisible to visible range immediately after irradiation. The irradiated areas were then examined by fundus color photography (FC), optical coherence tomography (OCT), fundus autofluorescence (AF), FLIO, and fluorescein angiography (FA). The visibility of a total of over 2200 laser spots was evaluated by two independent researchers, and effective dose (ED) 50 laser pulse energy values were calculated for each imaging modality and compared.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among examined modalities, FA showed the lowest mean of ED50 energy value and SL the highest, that is, they had the highest and lowest sensitivity to detect retinal pigment epithalium (RPE)-selective laser spots, respectively. FLIO also detected spots significantly more sensitively than SL at most laser pulse durations and was not significantly inferior to FA. AF was also often more sensitive than SL, but the difference was slightly less significant than FLIO.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Considering its high sensitivity in detecting laser spots and previously reported potential of indicating local wound healing and metabolic changes around laser spots, FLIO may be useful as a non-invasive monitoring tool during and after minimally invasive retinal laser treatment<jats:italic>.<\/jats:italic><\/jats:p>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00417-024-06449-2","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T10:02:05Z","timestamp":1712570525000},"page":"2885-2895","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Detection sensitivity of fluorescence lifetime imaging ophthalmoscopy for laser-induced selective damage of retinal pigment epithelium"],"prefix":"10.1007","volume":"262","author":[{"given":"Svenja Rebecca","family":"Sonntag","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Hamann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Seifert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Grisanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Brinkmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1896-7634","authenticated-orcid":false,"given":"Yoko","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"6449_CR1","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1177\/15353702211038891","volume":"246","author":"S Jiao","year":"2021","unstructured":"Jiao S, Jia Y, Yao X (2021) Emerging imaging developments in experimental vision sciences and ophthalmology. Exp Biol Med (Maywood) 246:2137\u20132139. https:\/\/doi.org\/10.1177\/15353702211038891","journal-title":"Exp Biol Med (Maywood)"},{"key":"6449_CR2","doi-asserted-by":"publisher","first-page":"100893","DOI":"10.1016\/j.preteyeres.2020.100893","volume":"81","author":"S Schmitz-Valckenberg","year":"2021","unstructured":"Schmitz-Valckenberg S, Pfau M, Fleckenstein M et al (2021) Fundus autofluorescence imaging. Prog Retin Eye Res 81:100893. https:\/\/doi.org\/10.1016\/j.preteyeres.2020.100893","journal-title":"Prog Retin Eye Res"},{"key":"6449_CR3","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ehj.2018.03.001","volume":"70","author":"NM Taha","year":"2018","unstructured":"Taha NM, Asklany HT, Mahmoud AH et al (2018) Retinal fluorescein angiography: a sensitive and specific tool to predict coronary slow flow. Egypt Heart J 70:167\u2013171. https:\/\/doi.org\/10.1016\/j.ehj.2018.03.001","journal-title":"Egypt Heart J"},{"key":"6449_CR4","doi-asserted-by":"publisher","first-page":"803","DOI":"10.2147\/OPTH.S133637","volume":"11","author":"A Rabiolo","year":"2017","unstructured":"Rabiolo A, Parravano M, Querques L et al (2017) Ultra-wide-field fluorescein angiography in diabetic retinopathy: a narrative review. Clin Ophthalmol 11:803\u2013807. https:\/\/doi.org\/10.2147\/OPTH.S133637","journal-title":"Clin Ophthalmol"},{"key":"6449_CR5","doi-asserted-by":"publisher","unstructured":"Huang D, Swanson EA, Lin CP Schuman JS, Stinson WG, Chang W (1991) Optical coherence tomography. Science 254:1178\u20131181. https:\/\/www.science.org\/doi\/https:\/\/doi.org\/10.1126\/science.1957169","DOI":"10.1126\/science.1957169"},{"key":"6449_CR6","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/s41433-020-01288-x","volume":"35","author":"N Minakaran","year":"2021","unstructured":"Minakaran N, de Carvalho ER, Petzold A, Wong SH (2021) Optical coherence tomography (OCT) in neuro-ophthalmology. Eye (Lond) 35:17\u201332. https:\/\/doi.org\/10.1038\/s41433-020-01288-x","journal-title":"Eye (Lond)"},{"key":"6449_CR7","first-page":"721","volume":"41","author":"HC Orr","year":"1948","unstructured":"Orr HC (1948) Fundus photography in colour. Proc R Soc Med 41:721","journal-title":"Proc R Soc Med"},{"key":"6449_CR8","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1001\/archopht.1977.04450050139018","volume":"95","author":"FC Delori","year":"1977","unstructured":"Delori FC, Gragoudas ES, Francisco R, Pruett RC (1977) Monochromatic ophthalmoscopy and fundus photography. The normal fundus. Arch Ophthalmol 95:861\u2013868. https:\/\/doi.org\/10.1001\/archopht.1977.04450050139018","journal-title":"Arch Ophthalmol"},{"key":"6449_CR9","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1002\/jemt.20427","volume":"70","author":"D Schweitzer","year":"2007","unstructured":"Schweitzer D, Schenke S, Hammer M et al (2007) Towards metabolic mapping of the human retina. Microsc Res Tech 70:410\u2013419. https:\/\/doi.org\/10.1002\/jemt.20427","journal-title":"Microsc Res Tech"},{"key":"6449_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1117\/1.JBO.23.9.099802","volume":"23","author":"L Sauer","year":"2018","unstructured":"Sauer L, Andersen KM, Dysli C, Zinkernagel MS, Bernstein PS, Hammer M (2018) Review of clinical approaches in fluorescence lifetime imaging ophthalmoscopy (Erratum). J Biomed Opt 23:1. https:\/\/doi.org\/10.1117\/1.JBO.23.9.099802","journal-title":"J Biomed Opt"},{"key":"6449_CR11","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1002\/jemt.10421","volume":"63","author":"W Becker","year":"2004","unstructured":"Becker W, Bergmann A, Hink MA, Konig K, Benndorf K, Biskup C (2004) Fluorescence lifetime imaging by time-correlated single-photon counting. Microsc Res Tech 63:58\u201366. https:\/\/doi.org\/10.1002\/jemt.10421","journal-title":"Microsc Res Tech"},{"key":"6449_CR12","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.oret.2019.04.025","volume":"3","author":"L Sauer","year":"2019","unstructured":"Sauer L, Calvo CM, Vitale AS, Henrie N, Milliken CM, Bernstein PS (2019) Imaging of hydroxychloroquine toxicity with fluorescence lifetime imaging ophthalmoscopy. Ophthalmol Retina 3:814\u2013825. https:\/\/doi.org\/10.1016\/j.oret.2019.04.025","journal-title":"Ophthalmol Retina"},{"key":"6449_CR13","doi-asserted-by":"publisher","first-page":"e241","DOI":"10.1111\/aos.12609","volume":"93","author":"S Jentsch","year":"2015","unstructured":"Jentsch S, Schweitzer D, Schmidtke KU, Peters S, Dawczynski J, Bar KJ, Hammer M (2015) Retinal fluorescence lifetime imaging ophthalmoscopy measures depend on the severity of Alzheimer\u2019s disease. Acta Ophthalmol 93:e241-247. https:\/\/doi.org\/10.1111\/aos.12609","journal-title":"Acta Ophthalmol"},{"key":"6449_CR14","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1038\/s41433-019-0406-2","volume":"33","author":"SR Sadda","year":"2019","unstructured":"Sadda SR, Borrelli E, Fan W, Ebraheem A, Marion KM, Harrington M, Kwon S (2019) A pilot study of fluorescence lifetime imaging ophthalmoscopy in preclinical Alzheimer\u2019s disease. Eye (Lond) 33:1271\u20131279. https:\/\/doi.org\/10.1038\/s41433-019-0406-2","journal-title":"Eye (Lond)"},{"key":"6449_CR15","doi-asserted-by":"publisher","first-page":"61106","DOI":"10.1117\/1.JBO.20.6.061106","volume":"20","author":"D Schweitzer","year":"2015","unstructured":"Schweitzer D, Deutsch L, Klemm M et al (2015) Fluorescence lifetime imaging ophthalmoscopy in type 2 diabetic patients who have no signs of diabetic retinopathy. J Biomed Opt 20:61106. https:\/\/doi.org\/10.1117\/1.JBO.20.6.061106","journal-title":"J Biomed Opt"},{"key":"6449_CR16","doi-asserted-by":"publisher","first-page":"AMD65","DOI":"10.1167\/iovs.17-23764","volume":"59","author":"L Sauer","year":"2018","unstructured":"Sauer L, Gensure RH, Andersen KM et al (2018) Patterns of fundus autofluorescence lifetimes in eyes of individuals with nonexudative age-related macular degeneration. Invest Ophthalmol Vis Sci 59:AMD65\u2013AMD77. https:\/\/doi.org\/10.1167\/iovs.17-23764","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6449_CR17","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s00417-007-0639-9","volume":"246","author":"M Hammer","year":"2008","unstructured":"Hammer M, Konigsdorffer E, Liebermann C et al (2008) Ocular fundus auto-fluorescence observations at different wavelengths in patients with age-related macular degeneration and diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 246:105\u2013114. https:\/\/doi.org\/10.1007\/s00417-007-0639-9","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"6449_CR18","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1039\/c0pp00207k","volume":"9","author":"JR Sparrow","year":"2010","unstructured":"Sparrow JR, Wu Y, Nagasaki T, Yoon KD, Yamamoto K, Zhou J (2010) Fundus autofluorescence and the bisretinoids of retina. Photochem Photobiol Sci 9:1480\u20131489. https:\/\/doi.org\/10.1039\/c0pp00207k","journal-title":"Photochem Photobiol Sci"},{"key":"6449_CR19","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/978-3-030-22878-1_7","volume-title":"Fluorescence lifetime imaging ophthalmoscopy","author":"Y Miura","year":"2019","unstructured":"Miura Y, Bernstein P, Dysli C, Sauer L, Zinkernagel M (2019) Fluorophores in the eye. In: Zinkernagel M, Dysli C (eds) Fluorescence lifetime imaging ophthalmoscopy. Springer, Cham, pp 35\u201348"},{"key":"6449_CR20","doi-asserted-by":"publisher","first-page":"11484","DOI":"10.1038\/s41598-023-37484-4","volume":"13","author":"SR Sonntag","year":"2023","unstructured":"Sonntag SR, Kreikenbohm M, B\u00f6hmerle G, Stagge J, Grisanti S, Miura Y (2023) Impact of cigarette smoking on fluorescence lifetime of ocular fundus. Sci Rep 13:11484. https:\/\/doi.org\/10.1038\/s41598-023-37484-4","journal-title":"Sci Rep"},{"key":"6449_CR21","first-page":"51","volume":"302","author":"R Brinkmann","year":"2006","unstructured":"Brinkmann R, Roider J, Birngruber R (2006) Selective retina therapy (SRT): a review on methods, techniques, preclinical and first clinical results. Bull Soc Belge Ophtalmol 302:51\u201369","journal-title":"Bull Soc Belge Ophtalmol"},{"key":"6449_CR22","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1007\/s00417-010-1356-3","volume":"248","author":"J Roider","year":"2010","unstructured":"Roider J, Liew SH, Klatt C et al (2010) Selective retina therapy (SRT) for clinically significant diabetic macular edema. Graefes Arch Clin Exp Ophthalmol 248:1263\u20131272. https:\/\/doi.org\/10.1007\/s00417-010-1356-3","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"6449_CR23","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1167\/iovs.12-11203","volume":"54","author":"JP Wood","year":"2013","unstructured":"Wood JP, Shibeeb O, Plunkett M, Casson RJ, Chidlow G (2013) Retinal damage profiles and neuronal effects of laser treatment: comparison of a conventional photocoagulator and a novel 3-nanosecond pulse laser. Invest Ophthalmol Vis Sci 54:2305\u20132318. https:\/\/doi.org\/10.1167\/iovs.12-11203","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6449_CR24","doi-asserted-by":"publisher","unstructured":"Cohn AC, Wu Z, Jobling AI, Fletcher EL, Guymer RH (2021) Subthreshold nano-second laser treatment and age-related macular degeneration. J Clin Med 10. https:\/\/doi.org\/10.3390\/jcm10030484","DOI":"10.3390\/jcm10030484"},{"key":"6449_CR25","doi-asserted-by":"publisher","unstructured":"Sabal B, Teper S, Wylegala E (2022) Subthreshold micropulse laser for diabetic macular edema: a review. J Clin Med 12. https:\/\/doi.org\/10.3390\/jcm12010274","DOI":"10.3390\/jcm12010274"},{"key":"6449_CR26","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1097\/IAE.0000000000000340","volume":"35","author":"D Lavinsky","year":"2015","unstructured":"Lavinsky D, Palanker D (2015) Nondamaging photothermal therapy for the retina: initial clinical experience with chronic central serous retinopathy. Retina 35:213\u2013222. https:\/\/doi.org\/10.1097\/IAE.0000000000000340","journal-title":"Retina"},{"key":"6449_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000310354","volume":"206","author":"SS Hayreh","year":"1993","unstructured":"Hayreh SS, Rubenstein L, Podhajsky P (1993) Argon laser scatter photocoagulation in treatment of branch retinal vein occlusion. A prospective clinical trial. Ophthalmologica 206:1\u201314. https:\/\/doi.org\/10.1159\/000310354","journal-title":"Ophthalmologica"},{"key":"6449_CR28","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/BF00164672","volume":"233","author":"AW Stitt","year":"1995","unstructured":"Stitt AW, Gardiner TA, Archer DB (1995) Retinal and choroidal responses to panretinal photocoagulation: an ultrastructural perspective. Graefes Arch Clin Exp Ophthalmol 233:699\u2013705. https:\/\/doi.org\/10.1007\/BF00164672","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"6449_CR29","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1007\/s00417-006-0368-5","volume":"244","author":"H Elsner","year":"2006","unstructured":"Elsner H, Porksen E, Klatt C et al (2006) Selective retina therapy in patients with central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol 244:1638\u20131645. https:\/\/doi.org\/10.1007\/s00417-006-0368-5","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"6449_CR30","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s00417-016-3441-8","volume":"255","author":"A Yasui","year":"2017","unstructured":"Yasui A, Yamamoto M, Hirayama K et al (2017) Retinal sensitivity after selective retina therapy (SRT) on patients with central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol 255:243\u2013254. https:\/\/doi.org\/10.1007\/s00417-016-3441-8","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"6449_CR31","doi-asserted-by":"publisher","first-page":"769","DOI":"10.3390\/life13030769","volume":"13","author":"M Yamamoto","year":"2023","unstructured":"Yamamoto M, Miura Y, Hirayama K et al (2023) Comparative treatment study on macular edema secondary to branch retinal vein occlusion by intravitreal ranibizumab with and without selective retina therapy. Life (Basel) 13:769. https:\/\/doi.org\/10.3390\/life13030769","journal-title":"Life (Basel)"},{"key":"6449_CR32","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1016\/j.oret.2021.02.015","volume":"5","author":"RH Guymer","year":"2021","unstructured":"Guymer RH, Chen FK, Hodgson LAB et al (2021) Subthreshold nanosecond laser in age-related macular degeneration: observational extension study of the LEAD clinical trial. Ophthalmol Retina 5:1196\u20131203. https:\/\/doi.org\/10.1016\/j.oret.2021.02.015","journal-title":"Ophthalmol Retina"},{"key":"6449_CR33","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1186\/s12886-021-02188-8","volume":"21","author":"E Richert","year":"2021","unstructured":"Richert E, Papenkort J, von der Burchard C et al (2021) Selective retina therapy and thermal stimulation of the retina: different regenerative properties - implications for AMD therapy. BMC Ophthalmol 21:412. https:\/\/doi.org\/10.1186\/s12886-021-02188-8","journal-title":"BMC Ophthalmol"},{"key":"6449_CR34","doi-asserted-by":"publisher","unstructured":"Sonntag SR, Seifert E, Hamann M et al (2021) Fluorescence lifetime changes induced by laser irradiation: a preclinical study towards the evaluation of retinal metabolic states. Life (Basel) 11. https:\/\/doi.org\/10.3390\/life11060555","DOI":"10.3390\/life11060555"},{"key":"6449_CR35","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1167\/iovs.13-13627","volume":"55","author":"C Dysli","year":"2014","unstructured":"Dysli C, Quellec G, Abegg M et al (2014) Quantitative analysis of fluorescence lifetime measurements of the macula using the fluorescence lifetime imaging ophthalmoscope in healthy subjects. Invest Ophthalmol Vis Sci 55:2106\u20132113. https:\/\/doi.org\/10.1167\/iovs.13-13627","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6449_CR36","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1167\/iovs.15-18033","volume":"57","author":"C Dysli","year":"2016","unstructured":"Dysli C, Wolf S, Hatz K, Zinkernagel MS (2016) Fluorescence lifetime imaging in Stargardt disease: potential marker for disease progression. Invest Ophthalmol Vis Sci 57:832\u2013841. https:\/\/doi.org\/10.1167\/iovs.15-18033","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6449_CR37","doi-asserted-by":"publisher","first-page":"3329","DOI":"10.1167\/iovs.14-16203","volume":"56","author":"C Dysli","year":"2015","unstructured":"Dysli C, Wolf S, Zinkernagel MS (2015) Fluorescence lifetime imaging in retinal artery occlusion. Invest Ophthalmol Vis Sci 56:3329\u20133336. https:\/\/doi.org\/10.1167\/iovs.14-16203","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6449_CR38","doi-asserted-by":"publisher","first-page":"3094","DOI":"10.1167\/iovs.18-23886","volume":"59","author":"L Sauer","year":"2018","unstructured":"Sauer L, Andersen KM, Li B, Gensure RH, Hammer M, Bernstein PS (2018) Fluorescence lifetime imaging ophthalmoscopy (FLIO) of macular pigment. Invest Ophthalmol Vis Sci 59:3094\u20133103. https:\/\/doi.org\/10.1167\/iovs.18-23886","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6449_CR39","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1111\/aos.13587","volume":"96","author":"L Sauer","year":"2018","unstructured":"Sauer L, Klemm M, Peters S et al (2018) Monitoring foveal sparing in geographic atrophy with fluorescence lifetime imaging ophthalmoscopy - a novel approach. Acta Ophthalmol 96:257\u2013266. https:\/\/doi.org\/10.1111\/aos.13587","journal-title":"Acta Ophthalmol"},{"key":"6449_CR40","doi-asserted-by":"publisher","first-page":"4668","DOI":"10.1167\/iovs.14-15335","volume":"56","author":"L Sauer","year":"2015","unstructured":"Sauer L, Schweitzer D, Ramm L, Augsten R, Hammer M, Peters S (2015) Impact of macular pigment on fundus autofluorescence lifetimes. Invest Ophthalmol Vis Sci 56:4668\u20134679. https:\/\/doi.org\/10.1167\/iovs.14-15335","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6449_CR41","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1167\/tvst.8.5.12","volume":"8","author":"A Hutfilz","year":"2019","unstructured":"Hutfilz A, Sonntag SR, Lewke B et al (2019) Fluorescence lifetime imaging ophthalmoscopy of the retinal pigment epithelium during wound healing after laser irradiation. Transl Vis Sci Technol 8:12. https:\/\/doi.org\/10.1167\/tvst.8.5.12","journal-title":"Transl Vis Sci Technol"},{"key":"6449_CR42","doi-asserted-by":"publisher","first-page":"492679","DOI":"10.1155\/2014\/492679","volume":"2014","author":"S Koinzer","year":"2014","unstructured":"Koinzer S, Caliebe A, Portz L et al (2014) Comprehensive detection, grading, and growth behavior evaluation of subthreshold and low intensity photocoagulation lesions by optical coherence tomographic and infrared image analysis. Biomed Res Int 2014:492679. https:\/\/doi.org\/10.1155\/2014\/492679","journal-title":"Biomed Res Int"},{"key":"6449_CR43","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1002\/lsm.20592","volume":"40","author":"C Framme","year":"2008","unstructured":"Framme C, Schuele G, Kobuch K, Flucke B, Birngruber R, Brinkmann R (2008) Investigation of selective retina treatment (SRT) by means of 8 ns laser pulses in a rabbit model. Laser Surg Med 40:20\u201327. https:\/\/doi.org\/10.1002\/lsm.20592","journal-title":"Laser Surg Med"},{"key":"6449_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1117\/1.JBO.25.2.026001","volume":"25","author":"S Lee","year":"2020","unstructured":"Lee S, Wei S, Guo S et al (2020) Selective retina therapy monitoring by speckle variance optical coherence tomography for dosimetry control. J Biomed Opt 25:1\u20139. https:\/\/doi.org\/10.1117\/1.JBO.25.2.026001","journal-title":"J Biomed Opt"},{"key":"6449_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1117\/1.JBO.23.11.115002","volume":"23","author":"E Seifert","year":"2018","unstructured":"Seifert E, Tode J, Pielen A et al (2018) Selective retina therapy: toward an optically controlled automatic dosing. J Biomed Opt 23:1\u201312. https:\/\/doi.org\/10.1117\/1.JBO.23.11.115002","journal-title":"J Biomed Opt"},{"key":"6449_CR46","doi-asserted-by":"publisher","unstructured":"Binter M, Lindziute M, Rosenstein C, Framme C, Tode J (2023) Long-term multimodal imaging analysis of selective retina therapy laser lesions. Life (Basel) 13. https:\/\/doi.org\/10.3390\/life13040886","DOI":"10.3390\/life13040886"},{"key":"6449_CR47","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1007\/s00347-002-0684-z","volume":"99","author":"C Framme","year":"2002","unstructured":"Framme C, Schule G, Brinkmann R, Birngruber R, Roider J (2002) Fundus autofluorescence after selective RPE laser treatment. Ophthalmologe 99:854\u2013860. https:\/\/doi.org\/10.1007\/s00347-002-0684-z","journal-title":"Ophthalmologe"},{"key":"6449_CR48","unstructured":"Yoshimoto K, Yamamoto M, Kohno T et al (2012) Detection of sub-threshold laser irradiation spots with various fundus imaging methods and its correlation with irradiation energy and optoacoustic values in selective retina therapy. ARVO Annual Meeting Abstract. Invest Ophth Vis Sci 53:5198. https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2358911"},{"key":"6449_CR49","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1167\/iovs.62.3.32","volume":"62","author":"E Seifert","year":"2021","unstructured":"Seifert E, Sonntag SR, Kleingarn P et al (2021) Investigations on retinal pigment epithelial damage at laser irradiation in the lower microsecond time regime. Invest Ophth Vis Sci 62:32. https:\/\/doi.org\/10.1167\/iovs.62.3.32","journal-title":"Invest Ophth Vis Sci"},{"key":"6449_CR50","doi-asserted-by":"publisher","first-page":"024001","DOI":"10.1117\/1.1896969","volume":"10","author":"J Neumann","year":"2005","unstructured":"Neumann J, Brinkmann R (2005) Boiling nucleation on melanosomes and microbeads transiently heated by nanosecond and microsecond laser pulses. J Biomed Opt 10:024001. https:\/\/doi.org\/10.1117\/1.1896969","journal-title":"J Biomed Opt"},{"key":"6449_CR51","doi-asserted-by":"publisher","first-page":"114701","DOI":"10.1063\/1.2740348","volume":"101","author":"J Neumann","year":"2007","unstructured":"Neumann J, Brinkmann R (2007) Nucleation dynamics around single microabsorbers in water heated by nanosecond laser irradiation. J Appl Phys 101:114701. https:\/\/doi.org\/10.1063\/1.2740348","journal-title":"J Appl Phys"},{"key":"6449_CR52","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1002\/1096-9101(2000)27:5<451::AID-LSM1006>3.0.CO;2-1","volume":"27","author":"R Brinkmann","year":"2000","unstructured":"Brinkmann R, H\u00fcttmann G, R\u00f6gener J, Roider J, Birngruber R, Lin CP (2000) Origin of retinal pigment epithelium cell damage by pulsed laser irradiance in the nanosecond to microsecond time regimen. Laser Surg Med 27:451\u2013464. https:\/\/doi.org\/10.1002\/1096-9101(2000)27:5%3c451::AID-LSM1006%3e3.0.CO;2-1","journal-title":"Laser Surg Med"},{"key":"6449_CR53","doi-asserted-by":"publisher","first-page":"041112","DOI":"10.1117\/1.2339815","volume":"11","author":"J Neumann","year":"2006","unstructured":"Neumann J, Brinkmann R (2006) Cell disintegration by laser-induced transient microbubbles and its simultaneous monitoring by interferometry. J Biomed Opt 11:041112. https:\/\/doi.org\/10.1117\/1.2339815","journal-title":"J Biomed Opt"},{"key":"6449_CR54","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/lsm.20022","volume":"34","author":"C Framme","year":"2004","unstructured":"Framme C, Schuele G, Roider J, Birngruber R, Brinkmann R (2004) Influence of pulse duration and pulse number in selective RPE laser treatment. Laser Surg Med 34:206\u2013215. https:\/\/doi.org\/10.1002\/lsm.20022","journal-title":"Laser Surg Med"},{"key":"6449_CR55","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1167\/iovs.04-0136","volume":"46","author":"G Schuele","year":"2005","unstructured":"Schuele G, Rumohr M, Huettmann G, Brinkmann R (2005) RPE damage thresholds and mechanisms for laser exposure in the microsecond-to-millisecond time regimen. Invest Ophth Vis Sci 46:714\u2013719. https:\/\/doi.org\/10.1167\/iovs.04-0136","journal-title":"Invest Ophth Vis Sci"},{"key":"6449_CR56","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1167\/tvst.10.10.17","volume":"10","author":"C Burri","year":"2021","unstructured":"Burri C, Al-Nawaiseh S, Wakili P et al (2021) Selective large-area retinal pigment epithelial removal by microsecond laser in preparation for cell therapy. Transl Vis Sci Technol 10:17. https:\/\/doi.org\/10.1167\/tvst.10.10.17","journal-title":"Transl Vis Sci Technol"},{"key":"6449_CR57","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1242\/dmm.017194","volume":"8","author":"J Penn","year":"2015","unstructured":"Penn J, Mihai DM, Washington I (2015) Morphological and physiological retinal degeneration induced by intravenous delivery of vitamin A dimers in rabbits. Dis Model Mech 8:131\u2013138. https:\/\/doi.org\/10.1242\/dmm.017194","journal-title":"Dis Model Mech"},{"key":"6449_CR58","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1167\/tvst.9.5.13","volume":"9","author":"A Lavaud","year":"2020","unstructured":"Lavaud A, Soukup P, Martin L, Hartnack A, Pot S (2020) Spectral domain optical coherence tomography in awake rabbits allows identification of the visual streak, a comparison with histology. Transl Vis Sci Technol 9:13. https:\/\/doi.org\/10.1167\/tvst.9.5.13","journal-title":"Transl Vis Sci Technol"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-024-06449-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-024-06449-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-024-06449-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T14:10:55Z","timestamp":1725545455000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-024-06449-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,8]]},"references-count":58,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["6449"],"URL":"https:\/\/doi.org\/10.1007\/s00417-024-06449-2","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,8]]},"assertion":[{"value":"5 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed. This article does not contain any studies with human participants performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethic approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}