{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T14:27:39Z","timestamp":1769610459504,"version":"3.49.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum RWTH Aachen"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To determine if early central corneal thickness (CCT) and best-corrected visual acuity (BCVA) changes indicate graft detachment after uncomplicated Descemet membrane endothelial keratoplasty (DMEK).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this analysis of our prospectively collected ADDA registry data (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/drks.de\/search\/de\/trial\/DRKS00027180\">https:\/\/drks.de\/search\/de\/trial\/DRKS00027180<\/jats:ext-link>), 45 pseudophakic eyes underwent DMEK surgery at the Department of Ophthalmology, RWTH Aachen University. Anterior segment optical coherence tomography (AS-OCT), the presence of stromal ripples on the posterior corneal surface, and BCVA measurements were assessed prior to, 1\u00a0day, 1\u00a0week, 1\u00a0month, and 6\u00a0months after surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Eyes were categorized into three groups: no graft detachment (group 1) (20\/45; 44.4%),\u2009&lt;\u20091\/3 graft detachment (group 2) (14\/45; 31.1%),\u2009\u2265\u20091\/3 graft detachment followed by rebubbling (group 3) (11\/45; 24.4%). Eyes in group 3 had a greater CCT prior to (746.8\u2009\u00b1\u200995.8\u00a0\u00b5m vs. 665.0\u2009\u00b1\u200974.4\u00a0\u00b5m, <jats:italic>P<\/jats:italic>\u2009=\u20090.041), and 1\u00a0week (666.8\u2009\u00b1\u2009119.5\u00a0\u00b5m vs. 556.5\u2009\u00b1\u200956.8\u00a0\u00b5m, <jats:italic>P<\/jats:italic>\u2009=\u20090.001) after DMEK compared to group 1. By 1\u00a0month, CCT in all groups aligned. Comparing prior to and 1\u00a0week after DMEK, none of the eyes in group 1 had an increase in CCT, while the CCT increased in 25.0% of eyes in group 2 and 22.2% in group 3. In group 1, 90.0% had a CCT of\u2009&lt;\u2009600\u00a0\u00b5m 1\u00a0week after DMEK, compared to only 50.0% in group 2 and 36.4% in group 3. In group 1, 90.0% (18\/20) had an improved BCVA 1\u00a0week after DMEK, while in groups 2 and 3, 86.7% (12\/14) and 18.2% (2\/11) improved, respectively. One patient in group 3 showed posterior stromal ripples 1\u00a0day and 1\u00a0week after DMEK.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>If 1\u00a0week after uncomplicated DMEK CCT is\u2009&lt;\u2009600\u00a0\u00b5m and has decreased from before surgery, BCVA has improved, and there are no posterior stromal ripples, a graft detachment\u2009\u2265\u20091\/3 and the need for rebubbling are very unlikely. In all other cases, meticulous slit-lamp and OCT inspection of the peripheral graft for detachments should be advised.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00417-024-06452-7","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T10:02:02Z","timestamp":1711447322000},"page":"2925-2936","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of graft detachment on the central corneal thickness after uncomplicated Descemet membrane endothelial keratoplasty"],"prefix":"10.1007","volume":"262","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4432-1853","authenticated-orcid":false,"given":"Tibor","family":"Lohmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Baumgarten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"K\u00fcrten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Prinz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklas","family":"Plange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Walter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Fuest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"6452_CR1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.ophtha.2017.08.015","volume":"125","author":"SX Deng","year":"2018","unstructured":"Deng SX, Lee WB, Hammersmith KM, Kuo AN, Li JY, Shen JF, Weikert MP, Shtein RM (2018) Descemet membrane endothelial keratoplasty: safety and outcomes: a report by the American Academy of Ophthalmology. Ophthalmology 125:295\u2013310. https:\/\/doi.org\/10.1016\/j.ophtha.2017.08.015","journal-title":"Ophthalmology"},{"key":"6452_CR2","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.survophthal.2011.10.005","volume":"57","author":"A Anshu","year":"2012","unstructured":"Anshu A, Price MO, Tan DT, Price FW Jr (2012) Endothelial keratoplasty: a revolution in evolution. Surv Ophthalmol 57:236\u2013252. https:\/\/doi.org\/10.1016\/j.survophthal.2011.10.005","journal-title":"Surv Ophthalmol"},{"key":"6452_CR3","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.1016\/j.ophtha.2015.07.003","volume":"122","author":"EC Hamzaoglu","year":"2015","unstructured":"Hamzaoglu EC, Straiko MD, Mayko ZM, S\u00e1les CS, Terry MA (2015) The first 100 eyes of standardized Descemet stripping automated endothelial keratoplasty versus standardized Descemet membrane endothelial keratoplasty. Ophthalmology 122:2193\u20132199. https:\/\/doi.org\/10.1016\/j.ophtha.2015.07.003","journal-title":"Ophthalmology"},{"key":"6452_CR4","doi-asserted-by":"publisher","DOI":"10.1136\/bjo-2022-323162","author":"E Flockerzi","year":"2023","unstructured":"Flockerzi E, Turner C, Seitz B, Collaborators GSG (2023) Descemet\u2019s membrane endothelial keratoplasty is the predominant keratoplasty procedure in Germany since 2016: a report of the DOG-section cornea and its keratoplasty registry. Br J Ophthalmol. https:\/\/doi.org\/10.1136\/bjo-2022-323162","journal-title":"Br J Ophthalmol"},{"key":"6452_CR5","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1097\/01.ico.0000248385.16896.34","volume":"25","author":"GR Melles","year":"2006","unstructured":"Melles GR, Ong TS, Ververs B, van der Wees J (2006) Descemet membrane endothelial keratoplasty (DMEK). Cornea 25:987\u2013990. https:\/\/doi.org\/10.1097\/01.ico.0000248385.16896.34","journal-title":"Cornea"},{"key":"6452_CR6","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1001\/archophthalmol.2010.334","volume":"129","author":"I Dapena","year":"2011","unstructured":"Dapena I, Moutsouris K, Droutsas K, Ham L, van Dijk K, Melles GR (2011) Standardized \u201cno-touch\u201d technique for Descemet membrane endothelial keratoplasty. Arch Ophthalmol (Chicago, Ill: 1960) 129:88\u201394. https:\/\/doi.org\/10.1001\/archophthalmol.2010.334","journal-title":"Arch Ophthalmol (Chicago, Ill: 1960)"},{"key":"6452_CR7","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1097\/ico.0000000000000394","volume":"34","author":"A Brissette","year":"2015","unstructured":"Brissette A, Conlon R, Teichman JC, Yeung S, Ziai S, Baig K (2015) Evaluation of a new technique for preparation of endothelial grafts for Descemet membrane endothelial keratoplasty. Cornea 34:557\u2013559. https:\/\/doi.org\/10.1097\/ico.0000000000000394","journal-title":"Cornea"},{"key":"6452_CR8","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1097\/ICO.0b013e318254fa06","volume":"32","author":"E Yoeruek","year":"2013","unstructured":"Yoeruek E, Bayyoud T, Hofmann J, Bartz-Schmidt KU (2013) Novel maneuver facilitating Descemet membrane unfolding in the anterior chamber. Cornea 32:370\u2013373. https:\/\/doi.org\/10.1097\/ICO.0b013e318254fa06","journal-title":"Cornea"},{"key":"6452_CR9","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1001\/jamaophthalmol.2014.1710","volume":"132","author":"C Monnereau","year":"2014","unstructured":"Monnereau C, Quilendrino R, Dapena I, Liarakos VS, Alfonso JF, Arnalich-Montiel F, B\u00f6hnke M, Pereira NC, Dirisamer M, Parker J, Droutsas K, Geerling G, Gerten G, Hashemi H, Kobayashi A, Naveiras M, Oganesyan O, Ordu\u00f1a Domingo E, Priglinger S, Stodulka P, Torrano Silva J Jr, Venzano D, Vetter JM, Yiu E, Melles GR (2014) Multicenter study of Descemet membrane endothelial keratoplasty: first case series of 18 surgeons. JAMA ophthalmology 132:1192\u20131198. https:\/\/doi.org\/10.1001\/jamaophthalmol.2014.1710","journal-title":"JAMA ophthalmology"},{"key":"6452_CR10","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.ajo.2007.09.021","volume":"145","author":"GR Melles","year":"2008","unstructured":"Melles GR, Ong TS, Ververs B, van der Wees J (2008) Preliminary clinical results of Descemet membrane endothelial keratoplasty. Am J Ophthalmol 145:222\u2013227. https:\/\/doi.org\/10.1016\/j.ajo.2007.09.021","journal-title":"Am J Ophthalmol"},{"key":"6452_CR11","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1007\/s00417-015-2939-9","volume":"253","author":"AK Maier","year":"2015","unstructured":"Maier AK, Gundlach E, Schroeter J, Klamann MK, Gonnermann J, Riechardt AI, Bertelmann E, Joussen AM, Torun N (2015) Influence of the difficulty of graft unfolding and attachment on the outcome in Descemet membrane endothelial keratoplasty. Graefes Arch Clin Exp Ophthalmol 253:895\u2013900. https:\/\/doi.org\/10.1007\/s00417-015-2939-9","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"6452_CR12","doi-asserted-by":"publisher","first-page":"e1334","DOI":"10.1111\/aos.14849","volume":"99","author":"M Fritz","year":"2021","unstructured":"Fritz M, Grewing V, Gruber M, Wagner H, Zander D, Lapp T, Lang SJ, Heinzelmann-Mink S, Maier PC, Reinhard T, Wacker K (2021) Rotational alignment of corneal endothelial grafts and risk of graft detachment after Descemet membrane endothelial keratoplasty: a double-masked pseudo-randomized study. Acta Ophthalmol 99:e1334\u2013e1339. https:\/\/doi.org\/10.1111\/aos.14849","journal-title":"Acta Ophthalmol"},{"key":"6452_CR13","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1097\/ico.0000000000000811","volume":"35","author":"R Siggel","year":"2016","unstructured":"Siggel R, Adler W, Stanzel TP, Cursiefen C, Heindl LM (2016) Bilateral Descemet membrane endothelial keratoplasty: analysis of clinical outcome in first and fellow eye. Cornea 35:772\u2013777. https:\/\/doi.org\/10.1097\/ico.0000000000000811","journal-title":"Cornea"},{"key":"6452_CR14","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.survophthal.2017.07.003","volume":"63","author":"M Parekh","year":"2018","unstructured":"Parekh M, Leon P, Ruzza A, Borroni D, Ferrari S, Ponzin D, Romano V (2018) Graft detachment and rebubbling rate in Descemet membrane endothelial keratoplasty. Surv Ophthalmol 63:245\u2013250. https:\/\/doi.org\/10.1016\/j.survophthal.2017.07.003","journal-title":"Surv Ophthalmol"},{"key":"6452_CR15","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1007\/s00417-021-05203-2","volume":"259","author":"T Lohmann","year":"2021","unstructured":"Lohmann T, Baumgarten S, Plange N, Walter P, Fuest M (2021) Effects of uncomplicated Descemet membrane endothelial keratoplasty on the central retinal thickness. Graefes Arch Clin Exp 259:2731\u20132741. https:\/\/doi.org\/10.1007\/s00417-021-05203-2","journal-title":"Graefes Arch Clin Exp"},{"key":"6452_CR16","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-317041","author":"S Dunker","year":"2021","unstructured":"Dunker S, Winkens B, van den Biggelaar F, Nuijts R, Kruit PJ, Dickman M (2021) Rebubbling and graft failure in Descemet membrane endothelial keratoplasty: a prospective Dutch registry study. Br J Ophthalmol. https:\/\/doi.org\/10.1136\/bjophthalmol-2020-317041","journal-title":"Br J Ophthalmol"},{"key":"6452_CR17","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1007\/s00417-015-2998-y","volume":"253","author":"D Kuerten","year":"2015","unstructured":"Kuerten D, Plange N, Koch EC, Koutsonas A, Walter P, Fuest M (2015) Central corneal thickness determination in corneal edema using ultrasound pachymetry, a Scheimpflug camera, and anterior segment OCT. Graefes Arch Clin Exp Ophthalmol 253:1105\u20131109. https:\/\/doi.org\/10.1007\/s00417-015-2998-y","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"6452_CR18","doi-asserted-by":"publisher","unstructured":"Fu L, Hollick EJ (2022) Rebubbling and graft detachment in Descemet membrane endothelial keratoplasty using a standardised protocol. Eye (London, England). https:\/\/doi.org\/10.1038\/s41433-022-02362-2","DOI":"10.1038\/s41433-022-02362-2"},{"key":"6452_CR19","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1097\/ico.0000000000000829","volume":"35","author":"E Fern\u00e1ndez L\u00f3pez","year":"2016","unstructured":"Fern\u00e1ndez L\u00f3pez E, Baydoun L, Gerber-Hollbach N, Dapena I, Liarakos VS, Ham L, Melles GR (2016) Rebubbling techniques for graft detachment after Descemet membrane endothelial keratoplasty. Cornea 35:759\u2013764. https:\/\/doi.org\/10.1097\/ico.0000000000000829","journal-title":"Cornea"},{"key":"6452_CR20","doi-asserted-by":"publisher","first-page":"e284","DOI":"10.1111\/aos.13256","volume":"95","author":"M Hesse","year":"2017","unstructured":"Hesse M, Kuerten D, Walter P, Plange N, Johnen S, Fuest M (2017) The effect of air, SF6 and C3F8 on immortalized human corneal endothelial cells. Acta Ophthalmol 95:e284\u2013e290. https:\/\/doi.org\/10.1111\/aos.13256","journal-title":"Acta Ophthalmol"},{"key":"6452_CR21","doi-asserted-by":"publisher","first-page":"e170656","DOI":"10.1001\/jamaophthalmol.2017.0656","volume":"135","author":"M Fuest","year":"2017","unstructured":"Fuest M, Mehta JS (2017) Descemet membrane splitting following deep anterior lamellar keratoplasty. JAMA Ophthalmol 135:e170656. https:\/\/doi.org\/10.1001\/jamaophthalmol.2017.0656","journal-title":"JAMA Ophthalmol"},{"key":"6452_CR22","doi-asserted-by":"publisher","first-page":"e205","DOI":"10.1111\/aos.15250","volume":"101","author":"G Coco","year":"2023","unstructured":"Coco G, Levis HJ, Borgia A, Romano D, Pagano L, Virgili G, Kaye SB, Romano V (2023) Posterior stromal ripples increase risk of Descemet\u2019s membrane endothelial keratoplasty graft detachment worsening over time. Acta Ophthalmol 101:e205\u2013e214. https:\/\/doi.org\/10.1111\/aos.15250","journal-title":"Acta Ophthalmol"},{"key":"6452_CR23","unstructured":"GermanClinicalTrialsRegister. https:\/\/drks.de\/search\/de\/trial\/DRKS00027180. Accessed 10 Dec 2023"},{"key":"6452_CR24","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1001\/archophthalmol.2011.343","volume":"130","author":"M Dirisamer","year":"2012","unstructured":"Dirisamer M, van Dijk K, Dapena I, Ham L, Oganes O, Frank LE, Melles GR (2012) Prevention and management of graft detachment in Descemet membrane endothelial keratoplasty. Arch Ophthalmol (Chicago, Ill: 1960) 130:280\u2013291. https:\/\/doi.org\/10.1001\/archophthalmol.2011.343","journal-title":"Arch Ophthalmol (Chicago, Ill: 1960)"},{"key":"6452_CR25","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.1016\/j.ophtha.2011.06.002","volume":"118","author":"FP Guerra","year":"2011","unstructured":"Guerra FP, Anshu A, Price MO, Giebel AW, Price FW (2011) Descemet\u2019s membrane endothelial keratoplasty: prospective study of 1-year visual outcomes, graft survival, and endothelial cell loss. Ophthalmology 118:2368\u20132373. https:\/\/doi.org\/10.1016\/j.ophtha.2011.06.002","journal-title":"Ophthalmology"},{"key":"6452_CR26","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1097\/ico.0000000000003006","volume":"42","author":"MB Muijzer","year":"2023","unstructured":"Muijzer MB, Noordmans HJ, Delbeke H, Dickman MM, Nuijts R, Dunker S, Imhof SM, Wisse RPL (2023) Establishing a biomarker for the prediction of short-term graft detachment after Descemet membrane endothelial keratoplasty. Cornea 42:204\u2013210. https:\/\/doi.org\/10.1097\/ico.0000000000003006","journal-title":"Cornea"},{"key":"6452_CR27","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1007\/s10792-022-02547-4","volume":"43","author":"D Guindolet","year":"2023","unstructured":"Guindolet D, Disegni H, Martin GC, Azar G, Hardy S, Cochereau I, Gabison EE (2023) Predictive factors of graft detachment and rebubbling after Descemet membrane endothelial keratoplasty. Int Ophthalmol 43:1511\u20131521. https:\/\/doi.org\/10.1007\/s10792-022-02547-4","journal-title":"Int Ophthalmol"},{"key":"6452_CR28","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.ophtha.2012.08.011","volume":"120","author":"RY Yeh","year":"2013","unstructured":"Yeh RY, Quilendrino R, Musa FU, Liarakos VS, Dapena I, Melles GR (2013) Predictive value of optical coherence tomography in graft attachment after Descemet\u2019s membrane endothelial keratoplasty. Ophthalmology 120:240\u2013245. https:\/\/doi.org\/10.1016\/j.ophtha.2012.08.011","journal-title":"Ophthalmology"},{"key":"6452_CR29","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.ajo.2011.03.031","volume":"152","author":"M Dirisamer","year":"2011","unstructured":"Dirisamer M, Dapena I, Ham L, van Dijk K, Oganes O, Frank LE, van der Wees J, Melles GR (2011) Patterns of corneal endothelialization and corneal clearance after Descemet membrane endothelial keratoplasty for fuchs endothelial dystrophy. Am J Ophthalmol 152:543-555.e541. https:\/\/doi.org\/10.1016\/j.ajo.2011.03.031","journal-title":"Am J Ophthalmol"},{"key":"6452_CR30","doi-asserted-by":"publisher","first-page":"101883","DOI":"10.1016\/j.ajoc.2023.101883","volume":"32","author":"M Friedrich","year":"2023","unstructured":"Friedrich M, Son HS, Khoramnia R, Auffarth GU, Augustin VA (2023) Late central graft detachment due to double endothelial layer after repeat Descemet membrane endothelial keratoplasty. Am J Ophthalmol Case Rep 32:101883. https:\/\/doi.org\/10.1016\/j.ajoc.2023.101883","journal-title":"Am J Ophthalmol Case Rep"},{"key":"6452_CR31","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1177\/11206721221146579","volume":"33","author":"N Kramer","year":"2023","unstructured":"Kramer N, Unterlauft JD, Girbardt C (2023) The need of rebubbling in case of small graft detachments after Descemet membrane endothelial keratoplasty (DMEK). Eur J Ophthalmol 33:1347\u20131353. https:\/\/doi.org\/10.1177\/11206721221146579","journal-title":"Eur J Ophthalmol"},{"key":"6452_CR32","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.ajo.2020.04.005","volume":"217","author":"I Vasiliauskait\u0117","year":"2020","unstructured":"Vasiliauskait\u0117 I, Oellerich S, Ham L, Dapena I, Baydoun L, van Dijk K, Melles GRJ (2020) Descemet membrane endothelial keratoplasty: ten-year graft survival and clinical outcomes. Am J Ophthalmol 217:114\u2013120. https:\/\/doi.org\/10.1016\/j.ajo.2020.04.005","journal-title":"Am J Ophthalmol"},{"key":"6452_CR33","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1136\/bjophthalmol-2016-309653","volume":"101","author":"F Schaub","year":"2017","unstructured":"Schaub F, Enders P, Snijders K, Schrittenlocher S, Siebelmann S, Heindl LM, Bachmann BO, Cursiefen C (2017) One-year outcome after Descemet membrane endothelial keratoplasty (DMEK) comparing sulfur hexafluoride (SF(6)) 20% versus 100% air for anterior chamber tamponade. Br J Ophthalmol 101:902\u2013908. https:\/\/doi.org\/10.1136\/bjophthalmol-2016-309653","journal-title":"Br J Ophthalmol"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-024-06452-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-024-06452-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-024-06452-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T14:09:35Z","timestamp":1725545375000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-024-06452-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,26]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["6452"],"URL":"https:\/\/doi.org\/10.1007\/s00417-024-06452-7","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,26]]},"assertion":[{"value":"14 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study followed the tenets of the Declaration of Helsinki and was approved by the Institutional Ethical Review Board of the RWTH Aachen University. This study was conducted as part of the ADDA registry [].","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study. The conducted research followed informed consent:<b> \u201c<\/b>Informed Consent is the decision, which must be written, dated and signed, to take part in a clinical trial, taken freely after being duly informed of its nature, significance, implications and risks and appropriately documented, by any person capable of giving consent or, where the person is not capable of giving consent, by his or her legal representative; if the person concerned is unable to write, oral consent in the presence of at least one witness may be given in exceptional cases, as provided for in national legislation.\u201d","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}