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Demographic characteristics and systemic data of the patients were recorded. In addition to a detailed ophthalmological examination, optical coherence tomography (OCT) and OCT angiography (OCTA) imaging were performed. According to the OCTA images, the patients were divided into two categories: SSPiM detected (SSPiM\u2009+) and undetected (SSPiM\u2009\u2212). The patients were followed up at 0, 3, and 6\u00a0months. Treatment responses at 6\u00a0months in treatment-administered patients with and without SSPiM were examined.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The frequency of SSPiM in DME cases was found to be 34.9%. No significant correlation was found between SSPiM and demographic characteristics, systemic, and biochemical parameters (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). It was observed that SSPIM was most frequently localized in the outer nuclear layer adjacent to the outer plexiform (81.6%). SSPiM appearance disappeared in 7 (19.4%) of 36 patients with SSPiM who had regular follow-up for 6\u00a0months. In 4 (11.1%) of these seven patients, hard exudate plaques developed in the areas where SSPiM disappeared. Regarding treatment response at 6\u00a0months, the decrease in CMT was statistically significantly lower in the SSPiM group compared to cases without SSPiM.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>SSPiM is a finding seen in approximately one-third of DME patients and may adversely affect the response to the treatment.<\/jats:p>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00417-024-06457-2","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T10:02:02Z","timestamp":1711447322000},"page":"2491-2502","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The longitudinal follow-up of a newly proposed OCTA imaging finding (SSPiM) and the importance of it as a new biomarker for treatment response in diabetic macular edema"],"prefix":"10.1007","volume":"262","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3989-0720","authenticated-orcid":false,"given":"G\u00fcls\u00fcm","family":"Gen\u00e7","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1822-8703","authenticated-orcid":false,"given":"\u00d6zge","family":"Yan\u0131k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6430-6565","authenticated-orcid":false,"given":"Sibel","family":"Demirel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5834-7512","authenticated-orcid":false,"given":"Figen","family":"Batioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7561-5075","authenticated-orcid":false,"given":"Emin","family":"\u00d6zmert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"6457_CR1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.2337\/diacare.21.1.143","volume":"21","author":"LP Aiello","year":"1998","unstructured":"Aiello LP, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL 3rd, Klein R (1998) Diabetic retinopathy. 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Ophthalmic Surg Lasers 31:287\u2013291","journal-title":"Ophthalmic Surg Lasers"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-024-06457-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00417-024-06457-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-024-06457-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T09:05:47Z","timestamp":1721379947000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00417-024-06457-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,26]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["6457"],"URL":"https:\/\/doi.org\/10.1007\/s00417-024-06457-2","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,26]]},"assertion":[{"value":"24 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All procedures performed in our study involving human participants were in accordance with the ethical standards of the institutional ethics committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Ethical approval for the study was obtained from the Ankara University Faculty of Medicine Ethics Committee (decision number: \u01308-488\u201320, date: 10\/09\/2020).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no potential conflicts of interest with respect to the research, authorship, and\/or publication of this article. Other financial disclosures: G. Gen\u00e7, None; \u00d6. Yan\u0131k, None; S. Demirel, Consultant fee, honorarium for lecturing (Novartis, Bayer, Allergan, Alcon, Baush, and Lomb); F. Bat\u0131o\u011flu, consultant fee, honorarium for lecturing (Novartis, Bayer, Allergan, Thea, Baush & Lomb); E. \u00d6zmert, consultant fee, honorarium for lecturing (Novartis, Bayer, Allergan).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}