{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:14:35Z","timestamp":1785255275326,"version":"3.55.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100019791","name":"Istanbul Medipol University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019791","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To report the results of invivo generated autologous plasmin enzyme(IVAP) assisted vitrectomy, partial circumferential-oral retinotomy and silicone oil injection for surgical treatment of patients with chronic retinal detachment without posterior vitreous detachment(PVD).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Study was performed in retrospective, comparative manner. A total of 16 consecutive eyes with chronic retinal detachment who had intravitreal injection of 50 \u00b5gr of t-PA and 0.1\u00a0ml of autologous whole blood, 3\u00a0days before surgery, underwent lens extraction with phacoemulsification, IVAP assisted vitrectomy, partial circumferential-oral retinotomy, and silicone oil injection(Study Group) were compared to a similar group of 15 eyes who had undergone vitrectomy, with or without lens extraction and silicone oil injection(Control Group) for the treatment of chronic retinal detachment. Primary outcome measures were initial retinal reattachment and number of operations at postoperative 6\u00a0months.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Mean age of 16 patients of whom 7 were female, was 39.31\u2009\u00b1\u200917.76\u00a0years in study group and 15 patients of whom 4 were female, was 35.40\u2009\u00b1\u200911.92\u00a0years (<jats:italic>p<\/jats:italic>\u2009=\u20090.607). Mean follow-up time was 10.68\u2009\u00b1\u20097.15\u00a0months in study group and 29.13\u2009\u00b1\u200918.83\u00a0months in control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). Initial retinal reattachment was achieved in 87.50% (14 out of 16 patients) in the study group, whereas it was 46.66% (7 out of 15 patients) in the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.017). The mean number of operations for reattachment in the study group was 1.12\u2009\u00b1\u20090.34, whereas it was 1.46\u2009\u00b1\u20090.51 in the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.039) at postoperative 6\u00a0months While the preoperative LogMAR visual acuity was 1.25\u2009\u00b1\u20090.64, it was 0.53\u2009\u00b1\u20090.37 at postoperative 6\u00a0months in study group (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). Conversely, in the control group, the preoperative LogMAR visual acuity was 1.22\u2009\u00b1\u20090.33, it was 1.20\u2009\u00b1\u20090.89 at postoperative 6\u00a0months (<jats:italic>p<\/jats:italic>\u2009=\u20090.780). At postoperative 6\u00a0months,, epiretinal membrane developed in 2 eyes of the study group, 1 eye in the control group, and phthisis bulbi occurred in 1 eye of control group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>IVAP assisted vitrectomy, partial circumferential-oral retinotomy and silicone oil injection is effective and safe for the surgical treatment of chronic retinal detachment without PVD.<\/jats:p>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00417-024-06466-1","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T07:02:03Z","timestamp":1713337323000},"page":"3109-3116","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Invivo generated autologous plasmin enzyme assisted vitrectomy, partial circumferential-oral retinotomy, silicone oil injection in patients with chronic retinal detachment without posterior vitreous detachment"],"prefix":"10.1007","volume":"262","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8047-5553","authenticated-orcid":false,"given":"Cengiz","family":"Aras","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fevzi","family":"Senturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevil Karaman","family":"Erdur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmut","family":"Dogramaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Selim","family":"Kocabora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Demircan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunus Emre","family":"Budak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"6466_CR1","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1001\/archopht.116.11.1449","volume":"116","author":"I Ahmed","year":"1998","unstructured":"Ahmed I, McDonald HR, Schatz H et al (1998) Crystalline retinopathy associated with chronic retinal detachment. 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